检索结果-南通市图书馆

Development of a highly-specific ^(18)F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping

引用

Acta Pharmaceutica Sinica B 2021年第6期11卷 1686-1695页

作者： Zhen chen Wakana Mori Jian Rong Michael A.Schafroth Tuo Shao Richard S.Van Daisuke Ogasawara Tomoteru Yamasaki Atsuto Hiraishi Akiko Hatori Jiahui chen Yiding Zhang Kuan Hu Masayuki Fujinaga Jiyun Sun Qingzhen Yu Thomas L.collier Yihan Shao Benjamin F.cravatt lee Josephson Ming-Rong Zhang Steven H.Liang Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital&Department of RadiologyHarvard Medical SchoolBostonMA 02114USA Department of Advanced Nuclear Medicine Sciences National Institute of Radiological SciencesNational Institutes for Quantum and Radiological Science and TechnologyChiba 263-8555Japan The Skaggs Institute for chemical Biology and Department of chemical Physiology The Scripps Research InstituteLa JollaCA 92037USA Department of chemistry and Biochemistry University of OklahomaNormanOK 73019USA

As a serine hydrolase,monoacylglycerol lipase(MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol(2-AG) in the central nervous system(cNS),leading to the formation of arachidonic acid(AA).Dysfunction of MAGL has been associated with multiple cNS disorders and symptoms,including neuroinflammation,cognitive impairment,epileptogenesis,nociception and neurodegenerative *** of MAGL provides a promising therapeutic direction for the treatment of these conditions,and a MAGL positron emission tomography(PET) probe would greatly facilitate preclinical and clinical development of MAGL ***,we design and synthesize a small library of fluoropyridyl-containing MAGL inhibitor *** evaluation of these candidates by activity-based protein profiling identified 14 as a lead compound,which was then radiolabeled with fluorine-18 via a facile SNAr reaction to form 2-[^(18)F]fluoropyridine *** blood-brain barrier permeability and high in vivo specific binding was demonstrated for radioligand [^(18)F]14(also named as [^(18)F]MAGL-1902).This work may serve as a roadmap for clinical translation and further design of potent 18F-labeled MAGL PET tracers.

关键词： Monoacylglycerol lipase(MAGL) central nervous system(cNS) 2-Arachidonylglycerol(2-AG) Arachidonic acid(AA) Positron emission tomography(PET) Fluorine-18

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

《濒危语言政策与规划》评介

引用

当代语言学 2018年第4期20卷 623-628页

作者： Mari c.Jones 曾国才四川大学外国语学院

近年来，濒危语言问题不断引起语言学、社会学、政治学等多学科领域的关注。《濒危语言政策与规划》（Policy and Planning for Endangered Languages）一书由***主编，2015年由剑桥大学出版社出版，展示了当前濒危语言复兴政策和规划... 详细信息

近年来，濒危语言问题不断引起语言学、社会学、政治学等多学科领域的关注。《濒危语言政策与规划》（Policy and Planning for Endangered Languages）一书由***主编，2015年由剑桥大学出版社出版，展示了当前濒危语言复兴政策和规划的最新研究成果。***博士是剑桥大学法语系的高级讲师和彼得学院（Peterhouse）的研究员。她发表了大量关于诺曼第语（norman）、威尔士语（Welsh）和布列塔尼语（Breton）的语言濒危现象研究论著，主要致力于濒危语言的复兴研究。

关键词：语言政策规划剑桥大学出版社评介濒危语言语言问题研究成果高级讲师

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

流体包裹体中轻烃有机气体组成及其对矿床成因的制约:以嵩溪大型银(锑)矿为例

引用

地质学报 2003年第2期77卷 287-287页

作者：孙晓明 D I norman 孙凯王敏陈炳辉陈敬德俞受鋆 210093 510275 510275 南京大学成矿作用国家重点实验室 Department of Earth and Environmental Sciences NM87801 New Mexico Institute of Mining and Technology(NMT) Socorro USA 中山大学地球科学系中山大学地球科学系广州

嵩溪银（锑）矿是一个新发现的大型独立银矿。矿物流体包裹体超高真空四极气相质谱系统测定显示,该矿成矿流体中存在多种轻烃有机气体,主要由c;—c;饱和烷烃组成,仅含微量c;—c;不饱和烯烃和芳烃,说明成矿过程基本未受到高温岩浆作用的... 详细信息

嵩溪银（锑）矿是一个新发现的大型独立银矿。矿物流体包裹体超高真空四极气相质谱系统测定显示,该矿成矿流体中存在多种轻烃有机气体,主要由c;—c;饱和烷烃组成,仅含微量c;—c;不饱和烯烃和芳烃,说明成矿过程基本未受到高温岩浆作用的影响。化学平衡研究表明,这些轻烃气体为微生物成因和沉积岩围岩中Ⅱ类干酪根热解成因的混合气

关键词：成矿流体嵩溪微生物

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

针灸疗法对接受胚胎移植妇女妊娠率的影响

引用

世界核心医学期刊文摘（妇产科学分册） 2006年第11期2卷 24-24页

作者： Smith c. coyle M. norman R.J. 马艳华 School of Health Science The University of South Australia SA Australia Dr.

Objective: To evaluate the effects of acupuncture on clinical pregnancy rates for women undergoing ET. Design: Single-blind, randomized controlled trial using a noninvasive sham acupuncture control. Setting: Repromed, The Reproductive Medicine Unit of The University of Adelaide. Patient(s): Women undergoing IVF. Intervention(s): Women were randomly allocated to acupuncture or noninvasive sham acupuncture with the placebo needle. All women received three sessions, the first undertaken on day 9 of stimulating injections, the second before ET, and the third immediately after ET. Main Outcome Measure(s): The primary outcome was pregnancy. Secondary outcomes were implantation, ongoing pregnancy rate at 18 weeks, adverse events, and health status. Result(s): Two hundred twenty-eight subjects were randomized. The pregnancy rate was 31% in the acupuncture group and 23% in the control group. For those subjects receiving acupuncture, the odds of achieving a pregnancy were 1.5 higher than for the control group, but the difference did not reach statistical significance. The ongoing pregnancy rate at 18 weeks was higher in the treatment group (28% vs. 18% ), but the difference was not statistically significant. conclusion(s): There was no signifi cant difference in the pregnancy rate between groups; however, a smaller treatment effect can not be excluded. Our results suggest that acupuncture was safe for women undergoing ET.

关键词：胚胎移植针灸法卵巢刺激随机对照试验生殖医学中心体外受精种植率单盲妊娠情况

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

流产后再次妊娠间隔时间对妊娠结局的影响：苏格兰医院回顾性资料分析（摘要）

引用

英国医学杂志中文版 2010年第6期13卷 368-368页

作者： Eleanor R Love Siladitya Bhattacharya norman c Smith Sohinee Bhattacharya 沈洁(译) 杨孜(校) University of Aberdeen Aberdeen Department of Obstetrics and Gynaecology Aberdeen Maternity Hospital Aberdeen Dug aid Baird Centre for Research on Women ' s Health Aberdeen Maternity Hospital Aberdeen AB25 2ZD 北京大学第三医院妇产科

目的探讨初次有记录的妊娠流产后再次妊娠的最佳时间间隔。设计基于人群的回顾性队列研究。地点苏格兰医院，1981年至2000年研究对象 30937名首次妊娠记录为流产的再次妊娠妇女。

关键词：再次妊娠妊娠结局流产后苏格兰间隔时间医院摘要时间间隔

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multistage interband cascade photovoltaic devices with a bandgap of 0.23 eV operating above room temperature

引用

chinese Science Bulletin 2014年第10期59卷 950-955页

作者： Hao Ye Hossein Lotfi Lu Li Robert T.Hinkey Rui Q.Yang Lin Lei Joel c.Keay Matthew B.Johnson Tetsuya D.Mishima Michael B.Santos School of Electrical and computer Engineering University of Oklahoma Norman OK USA Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman OK USA

Interband cascade(Ic)photovoltaic(PV)device structures,consisting of multiple discrete InAs/GaSb superlattice absorbers sandwiched between electron and hole barriers,were grown by molecular beam *** of the molecular beam epitaxy growth and material characterization of the structures are *** discrete absorber architecture enables certain advantages,such as high open-circuit voltage,high collection efficiency,high operating temperature,and smooth integration of cascade stages with different *** two-and three-stage IcPV devices presented in this article operate at room temperature with substantial open-circuit voltages at a cutoff wavelength of 5.3 lm(corresponding to a bandgap of 0.23 eV),the longest ever reported for room temperature PV *** device characteristics indicate a high level of current matching and demonstrate the advantages of the interband cascade approach in thermophotovoltaic cell design.

关键词： InAs GaSb superlattice Thermophotovoltaic Interband cascade devices

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

chalcogenoviologen Enhanced Host–Guest Recognition

引用

ccS chemistry 2024年第11期6卷 2679-2691页

作者： Yuanning Feng Xingang Zhao Daniel A.Appleton Han Han Ryan M.Young Wenqi Liu christopher K.lee Weixingyue Li Bai-Tong Liu Yong Wu chun Tang Aspen X-Y.chen charlotte L.Stern Dong Jun Kim Michael R.Wasielewski Yunyan Qiu J.Fraser Stoddart Department of chemistry and Biochemistry The University of OklahomaNormanOklahoma 73019 Weinberg college of Arts and Sciences Northwestern UniversityEvanstonIllinois 60208 Department of chemistry The University of Hong KongHong Kong SAR 999077 Paula M.Trienens Institute for Sustainability and Energy Northwestern UniversityEvanstonIllinois 60208 Department of chemistry University of South FloridaTampaFlorida 33620 School of chemistry University of New South WalesSydneyNSW 2052 Department of chemistry National University of SingaporeSingapore 117543 center for Regenerative Nanomedicine Northwestern UniversityChicagoIllinois 60611 Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310027 ZJU-Hangzhou Global Scientific and Technological Innovation center Hangzhou 311215

In the field of supramolecular chemistry,cyclophanes with novel properties are highly sought after since they can be tailored to fulfill specific *** this article,we incorporate chalcogenoviologen-based units into tetracationic cyclophanes,resulting in enhanced host–guest *** cyclophanes can be tuned through the addition of chalcogen bridging atoms—S,Se,and Te—which enhance their rigidity,regulate bond rotation and introduce additional steric *** cyclophanes containing chalcogen bridging atoms were synthesized and characterized in both the solution and solid *** energy barriers for their interconversion between syn-and anti-conformations in solution were found to be correlated with chalcogen atom *** photophysical properties of the cyclophanes are strongly dependent on the chalcogen atomic number,with intersystem crossing rates increasing from S to Se to ***–vis-NIR spectroscopic and fluorometric titrations revealed that the chalcogenoviologenbased cyclophanes exhibit significantly stronger binding with electron-rich guests compared to the well-known,unsubstituted cyclobis(paraquat-pphenylene).This enhancement in binding can be attributed to restricted rotation within the chalcogenoviologen *** research provides insight into the rational design and tailored synthesis of cationic cyclophanes.

关键词： binding titrations chalcogens host–guest systems molecular recognition supramolecular chemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PNPLA8是调控三阴性乳腺癌磷脂代谢并促进肿瘤增殖和转移的关键分子（英文）

PNPLA8是调控三阴性乳腺癌磷脂代谢并促进肿瘤增殖和转移的关键分...

引用

2024中国肿瘤标志物学术大会暨cAcA整合肿瘤学高峰论坛暨第十七届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者：谭哲琼 Pragney Deme Keerti Boyapati Annet A.M.Duivenvoorden Ron M.A.Heeren caitlin M.Tressler norman James Haughey Kristine Glunde

Background Triple-negative breast cancer(TNBc) is the most aggressive breast cancer subtype and leads to the poorest patient outcomes despite surgery and chemotherapy treatment. Exploring new molecular mechanisms of TNBc that could lead to the development of novel molecular targets are critically important for improving therapeutic options for treating *** We sought to identify novel therapeutic targets in TNBc by combining genomic and functional studies with lipidomic analysis, which included mechanistic studies to elucidate the pathways that tie lipid profile to critical cancer cell properties. Our studies were performed in a large panel of human breast cancer cell lines and patient *** comprehensive lipid profiling revealed that phospholipid metabolism is reprogrammed in TNBc cells. We discovered that patatin-like phospholipase domain-containing lipase 8(PNPLA8)is overexpressed in TNBc cell lines and tissues from breast cancer patients. Silencing of PNPLA8disrupted phospholipid metabolic reprogramming in TNBc, particularly affecting the levels of phosphatidylglycerol(PG), phosphatidylcholine(Pc), lysophosphatidylcholine(LPc) and glycerophosphocholine(GPc). We showed that PNPLA8 is essential in regulating cell viability,migration and antioxidation in TNBc cells and promoted arachidonic acid and eicosanoid production, which in turn activated PI3K/Akt/Gsk3β and MAPK *** Our study highlights PNPLA8 as key regulator of phospholipid metabolic reprogramming and malignant phenotypes in TNBc, which could be further developed as a novel molecular treatment target.

关键词： PNPLA8 Breast cancer Triple negative Phospholipid Metabolism reprogramming Eicosanoids Migration Invasion Proliferation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Experimental Quantum Teleportation of Laser Beams

引用

量子光学学报 2002年第B9期8卷 4-4页

作者： ZHANG T c GOH K W cHOU c W LODAHL P KIMBLE H J norman Bridge Laboratory of Physics 12-33 California Institute of Technology Pasadena CA 91125 USA State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-Electronics Shanxi University Taiyuan 030006 P.R. China norman Bridge Laboratory of Physics 12-33 California Institute of Technology Pasadena CA 91125 USA

We experimentally demonstrate quantum teleportation for continuous variables by using squeezed-state entanglement. A fidelity expression for a real experimental system is presented, where all the imperfection factors are considered, including losses and phase fluctuations. The measured fidelity for input coherent states is 0.62 and the prospective result with our measured entanglement and efficiencies is 0.69. We will show the details of the quantum teleportation for continuous variable and discuss the problems for further improvement in this experiment.

关键词：纠缠态量子光学激光束传输过程

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

白细胞介素2脂质体的制备及其抗肿瘤作用的研究

引用

中国生化药物杂志 1997年第4期18卷 166-169页

作者：裴瑾杨成君杨翰仪陈梅白求恩医科大学长春130021 长春生物制品研究所

采用逆相蒸发法制备稳定的白细胞介素2（IL－2）大单层脂质体，对其包封率、稳定性及活性进行了测定。建立c57BL／6小鼠荷瘤动物模型，通过给荷瘤小鼠腹腔注射空白脂质体、单纯IL-2及IL-2脂质体来比较其在肿瘤生长中的抑制作用，结果3... 详细信息

采用逆相蒸发法制备稳定的白细胞介素2（IL－2）大单层脂质体，对其包封率、稳定性及活性进行了测定。建立c57BL／6小鼠荷瘤动物模型，通过给荷瘤小鼠腹腔注射空白脂质体、单纯IL-2及IL-2脂质体来比较其在肿瘤生长中的抑制作用，结果3组抑癌率分别为4．26％、34．04％和54.60％。空白脂质体组与单纯对照组相比尤显著性差异（P＞0．05），脂质体-IL-2组与单纯IL-2组之间存在显著性差异（P＜0．05），抑瘤率提高了20.6％。

关键词：白细胞介素2 脂质体抑瘤率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：