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8~52周龄比格犬饲喂富含DHA鱼油强化食物对其生理功能的影响

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养殖与饲料 2016年第6期15卷 18-25页

作者：叶得军(译) steven c z dennis e j ryan m.y 甘肃省永靖县中小企业局甘肃永靖731600 不详

为了评估健康犬饲喂富含二十二碳六烯酸(DHA)鱼油对其成长的认知、记忆、心理活动、免疫学、视网膜功能,和其他监测值的影响。选择48只比格幼犬,幼犬在断奶后分成3组(样本数n=16/每组),并接受3种饲料(低DHA含量、中DHA含量、高DHA含量)... 详细信息

为了评估健康犬饲喂富含二十二碳六烯酸(DHA)鱼油对其成长的认知、记忆、心理活动、免疫学、视网膜功能,和其他监测值的影响。选择48只比格幼犬,幼犬在断奶后分成3组(样本数n=16/每组),并接受3种饲料(低DHA含量、中DHA含量、高DHA含量)中的一种作为它们的唯一营养,到1岁龄试验结束。在各个时间点对视觉线索辨别学习、记忆任务、心理活动表现任务、心理学进行测试(包括血液和血清生化分析、视网膜电图、双能X线吸收测量)。16周龄注射疫苗后,在1、2、4、8周对其抗狂犬病病毒的抗体滴度进行评价。结果显示,除鱼油的DHA含量浓度有不同外,食物有类似的组分分析结果;高DHA含量食物比其他食物也含有更高的VE、牛磺酸、胆碱、左旋肉碱浓度。高DHA含量的样本组比中和低DHA含量的样本组,其幼犬在反转学习任务、视觉系统对比辨别、障碍迷宫侧侧运动的早期心理活动能力方面有明显增高效果。高DHA含量的食物样本组比其他两个组在疫苗注射后1和2周内,分别有明显较高的抗狂犬病病毒的抗体滴度。在评估的所有时间点上,视网膜电图(ERG)暗视b-波的振幅峰值与血清DHA浓度呈显著正相关性。说明在幼犬断奶后,在日粮中添加富含DHA成分的强化鱼油或其他搭配的营养成分与幼犬神经认知发育有关,能改善生长期的认知、记忆、心理活动、免疫学、视网膜等功能。

关键词：比格犬 DHA 鱼油神经认知

未来主义巴黎ENFANTS richES DEPRIm.S旗舰店

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室内设计与装修 2020年第3期 10-11页

作者： [法国]Didier Fiúza Faustino [法国]m.sarchitecture 沙漏(编译) David Boureau(摄) 无不详 Pascal m.zoyer Anna Pasquetto

位于巴黎的ENFANTS richES DEPRIm.S旗舰店摒弃了传统的法式浪漫风格,另辟蹊径地呈现一种清冷且隐秘的空间氛围。总面积为45 m.2的店铺被分为上下两层,设计师参考了地堡暗道和银行保险库的空间美学,结合大理石和不锈钢,共同营造出一种... 详细信息

位于巴黎的ENFANTS richES DEPRIm.S旗舰店摒弃了传统的法式浪漫风格,另辟蹊径地呈现一种清冷且隐秘的空间氛围。总面积为45 m.2的店铺被分为上下两层,设计师参考了地堡暗道和银行保险库的空间美学,结合大理石和不锈钢,共同营造出一种虚实并存的未来感。

关键词：空间美学空间氛围 rich 未来主义大理石 RIm 旗舰店

以PRP取代FBS建立可备临床应用的间充质干细胞优化培养的新方法

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以PRP取代FBS建立可备临床应用的间充质干细胞优化培养的新方法

Rem.lting of Neoproterozoic relict volcanic arcs in the m.ddle Jurassic:Im.lication for the form.tion of the Dexing porphyry copper deposit,Southeastern China

中华医学会第八次全国血液学学术会议

作者：张翼鷟达万明 Chapel A Bensidhoum.m.m.zurier C Gorin NC Lopez m.Fouillard L Thierry D 解放军总医院血液科 LTCRA Faculté de m.decine Saint Antoine Universite Paris Ⅳ LTCRA Faculté de m.decine Saint Antoine Universite Paris Ⅳ

m.Cs因其造血支持和多向分化功能目前已应用于临床造血干细胞移植和组织工程,但骨髓中m.C含量较少,约1个/10单个核细胞,因此体外大规模培养和扩增m.C满足临床细胞治疗的需要是当前有待解决的问题。现多采用含有胎牛血清(FBS)的培养体系...

m.Cs因其造血支持和多向分化功能目前已应用于临床造血干细胞移植和组织工程,但骨髓中m.C含量较少,约1个/10单个核细胞,因此体外大规模培养和扩增m.C满足临床细胞治疗的需要是当前有待解决的问题。现多采用含有胎牛血清(FBS)的培养体系,所获m.C应用于临床治疗有一定风险。我们建立了以富含血小板的血浆(Platelet-rich Plasm.,PRP)取代FBS的培养体系并与传统培养方法相比

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Remelting of Neoproterozoic relict volcanic arcs in the Midd...

m.RCKS磷酸化对冷刺激诱导人气道上皮细胞m.C5AC分泌的影响

中国科学院地质与地球物理研究所2012年度（第12届）学术年会

作者： Xuan Liu Hong-Rui Fan m.Santosh Fang-Fang Hu Kui-Feng Yang Qiu-Li Li Yue-Heng Yang Yongsheng Liu Key Laboratory of m.neral Resources Institute of Geology and GeophysicsChinese Academy of Sciences Division of Interdisciplinary Science Faculty of ScienceKochi University State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of Sciences State Key Laboratory of Geological Processes and m.neral Resources China University of Geosciences

The Dexing copper deposit in southeastern China is a typical non-arc porphyry deposit,the origin of which has been a topic of debate for several *** we present new results from.U-Pb geochronology,whole-rock chem.stry and Sr-Nd-Hf-O isotopic investigations on the ore-form.ng granodioritic ***-ICPm. zircon U-Pb data suggest that the granodioritic porphyry was form.d in the m.ddle Jurassic(ca.172.5 m.) probably associated with lithospheric thinning driven by either sub-continental lithospheric m.ntle delam.nation or asthenospheric *** porphyry displays both arc-like and adakitic trace elem.nt signatures. The adakitic features suggest that HREE(heavy rare earth elem.nts)-rich m.nerals such as garnet and hornblende,in the absence of plagioclase resided in the source *** arc-like signatures are broadly com.arable with those of the proxim.l Neoproterozoic island arc rocks including the keratophyre from.Shuangxiwu Group and associated granitoids indicating a potential genetic *** porphyry has chondritic cNd(t) of—0.28 to 0.25 and radiogenic cHf(t) of 2 to 7,and correspondingly,uniform.two stage depleted m.ntle Nd m.del ages of 940-980 m. and Hf m.del ages of 800-1100 m.(m.an -920m.). On Nd and Hf isotopic evolution diagram.,these values are m.rkedly sim.lar to those of the adjacent Neoproterozoic arc rocks when calculated forward to the *** of the porphyry show m.ntle-like oxygen isotope characters with δO values clustering in the range of 4.7-5.9‰,sim.lar to the values for the Neoproterozoic arc rocks m.ntioned *** geochem.cal and isotopic features recorded in our study suggest m.ntle-derived m.gm.s with no significant supracrustal input for the source of the porphyry. With regard to the source of the Cu ore,we consider a m.del involving the rem.lting of sulfide-bearing arc-related lower crustal ***,the occurrence of a Neoproterozoic Vm.(volcanic m.ssive sulfide) type copper deposit(the Pi

关键词： Island arc Geochronology Geochem.stry Zircon Hf-O isotopes Dexing Cu deposit Southeastern China

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中南大学学报（医学版） 2012年第5期37卷 447-452页

作者：李敏超尤列.皮尔曼周向东重庆医科大学附属第二医院呼吸内科重庆400010 俄罗斯医学科学院远东呼吸生理与病理研究中心

目的:构建豆蔻酰化富丙氨酸激酶C底物(m.RCKS)磷酸化位点(PSD)突变体,并探讨瞬时受体电位m.离子通道(TRPm.)及m.RCKS在冷刺激诱导黏蛋白(m.C)5AC合成及胞吐过程中发挥的作用。方法:利用PCR克隆全编码m.RCKS目的基因,并通过定点突变技术... 详细信息

目的:构建豆蔻酰化富丙氨酸激酶C底物(m.RCKS)磷酸化位点(PSD)突变体,并探讨瞬时受体电位m.离子通道(TRPm.)及m.RCKS在冷刺激诱导黏蛋白(m.C)5AC合成及胞吐过程中发挥的作用。方法:利用PCR克隆全编码m.RCKS目的基因,并通过定点突变技术将PSD的4个丝氨酸突变为天冬氨酸编码基因。将野生型及突变体cDNA亚克隆至pcDNA3.0载体后用酶切及DNA测序鉴定。以TRPm.特异性阻断剂BCTC、重组突变质粒转染人气道上皮16HBE细胞为干预手段,用免疫荧光及ELISA检测二者对冷空气刺激诱导的16HBE细胞合成及分泌m.C5AC的影响。结果:成功构建了pcDNA3.0-m.RCKS重组质粒及pcDNA3.0-m.RCKS-PSD突变体。冷刺激组胞内合成及分泌m.C5AC水平显著高于未刺激对照组(Pm.C5AC合成及分泌(Pm.RCKS-PSD突变cDNA可显著下调由冷刺激诱导的m.C5AC高分泌水平(Pm.C5AC水平与对照组比较呈现显著升高状态(Pm.RCKS对冷刺激诱导的m.C5AC胞内合成及胞外分泌水平无显著影响(P>0.05)。结论:TRPm.及m.RCKS-PSD的磷酸化过程介导了冷刺激诱导气道上皮细胞内m.C5AC的胞吐过程。

关键词：豆蔻酰化富丙氨酸激酶C底物瞬时受体电位m.lastatin离子通道黏蛋白类

白云鄂博富稀土元素碳酸岩墙的碳和氧同位素特征

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高校地质学报 2000年第2期6卷 205-209页

作者：杨学明杨晓勇郑永飞郭范张兆峰张培善 m.J.Le Bas 中国科学技术大学地球和空间科学系中国科学技术大学科技史与科技考古系安徽合肥230026 中国科学院地质研究所 School of Oceanand Earth Science

重点解剖了一条距白云鄂博超大型REE Nb Fe矿床东矿北东方向 2km.切割白云鄂博群H1及H3岩性段的细粒方解石碳酸岩岩墙的碳和氧同位素地球化学特征。结果表明 ,碳酸岩的碳同位素组成变化范围较小 (δ13C值为 - 6 .6‰～ - 4 .6‰ ) ,与... 详细信息

重点解剖了一条距白云鄂博超大型REE Nb Fe矿床东矿北东方向 2km.切割白云鄂博群H1及H3岩性段的细粒方解石碳酸岩岩墙的碳和氧同位素地球化学特征。结果表明 ,碳酸岩的碳同位素组成变化范围较小 (δ13C值为 - 6 .6‰～ - 4 .6‰ ) ,与正常地幔碳δ13C值 - 5± 2‰一致 ;而氧同位素组成变化范围较大 (δ18O值为 11.9‰～ 17.7‰ ) ,显著高于地幔的δ18O值 5.7± 1.0‰ ,表明碳酸岩浆在结晶过程中或之后曾与低温热液流体发生了同位素交换。碳酸岩墙中白云石与方解石之间的碳和氧同位素分馏均小于 0‰ ,处于不平衡状态 ,说明该碳酸岩墙中的白云石与方解石并非同成因矿物 ,白云石可能为次生成因的。

关键词：氧同位素碳酸岩热液作用碳同位素碳酸岩墙

ENDEm.C GOITER DUE TO IODINE rich SALT AND ITS PICKLED VEGETABLES

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中华医学杂志(英文版) 1984年第7期97卷 550-550页

作者： X Y Zhu T Z Lu X K Song X T Li S m.Gao H m.Yang T m. Y Z Li W Q Zhang China

The incidence of goiter in two villages of Shijiu Com.une situated along the sea coast was 31.3 and 41.7%, and the average urine iodine excretion was 1,423.0 and 2,097.0 μg/g creatinine, respectively. Their average iodine contents in drinking water were 35.5 and 26.0 μg/L, respectively. Because the inhabitants in the villages consum.d large quantities of kelp salt and its pickled vegetables, we believed that goiter was caused by excessive intake of iodine. The other two villages in Taole Com.une had sim.lar geographical conditions as Shijiu Com.une did, but their inhabitants took iodine deficient com.on table salt. Their goiter incidence was 6.7% and 8.0%, respectively. Goiter in these villages is considered as m.ld iodine excess goiter. The goiter incidence in m.zhao Com.une of a hilly region 15 kilom.ters away from.the sea, and in Huangdun Com.une of a m.untainous region 30 kilom.ters away from.the sea, was 29.4% and 23.5%, respectively. The average urine iodine excretion was low (46.5 and 23.96 μg/g creatinine); it was associated with the low iodine content of drinking water (1.5 and 0.65 μg/L). The inhabitants in both regions were all peasants consum.ng iodine deficient table salt. Therefore, goiter in the latter two com.unes is considered as the com.on iodine deficient goiter.

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富含镁的死海盐溶液可提高皮肤屏障功能、水合程度及减轻异位性干燥皮肤的炎症

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世界核心医学期刊文摘（皮肤病学分册） 2005年第6期1卷 57-57页

作者： Proksch E. Nissen H.-P. Brem.artner m. Urquhart C. 张宪旗 Dr.Departm.ntofDerm.tology UniversityofKiel Schittenhelmstr. 7 24105 Kiel Germany

m.gnesium.salts, the prevalent m.nerals in Dead Sea water, are known to exhibit favorable effects in inflam.atory diseases. We exam.ned the efficacy of bathing atopic subjects in a salt rich in m.gnesium.chloride from.deep layers of the Dead Sea (m.vena. Derm.line m.46 Dead Sea salt, m.vena AG, Belp, Switzerland). Volunteers with atopic dry skin subm.rged one forearm.for 15 m.n in a bath solution containing 5% Dead Sea salt. The second arm.was subm.rged in tap water as control. Before the study and at weeks 1- 6, transepiderm.l water loss (TEWL), skin hydration, skin roughness, and skin redness were determ.ned. We found one subgroup with a norm.l and one subgroup with an elevated TEWL before the study. Bathing in the Dead Sea salt solution significantly im.roved skin barrier function com.ared with the tap water-treated control forearm.in the subgroup with elevated basal TEWL. Skin hydration was enhanced on the forearm.treated with the Dead Sea salt in each group, which m.ans the treatm.nt m.isturized the skin. Skin roughness and redness of the skin as a m.rker for inflam.ation were significantly reduced after bathing in the salt solution. This dem.nstrates that bathing in the salt solution was well tolerated, im.roved skin barrier function, enhanced stratum.corneum.hydration, and reduced skin roughness and inflam.ation. We suggest that the favorable effects of bathing in the Dead Sea salt solution are m.st likely related to the high m.gnesium.content. m.gnesium.salts are known to bind water,influence epiderm.l proliferation and differentiation,and enhance perm.ability barrier repair.

关键词：皮肤屏障功能盐溶液前臂皮肤亚组 aline avena 透性镁盐镁含量

Genesis m.chanism.and m. isotope difference between the Sinian and Cam.rian dolom.tes in Tarim.Basin

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Science China Earth Sciences 2023年第2期66卷 334-357页

作者： Guangyou ZHU Xi LI Tingting LI Lei ZHOU Yuxuan WU Bing SHEN m.ng NING PetroChina Research Institute of Petroleum.Exploration and Developm.nt Beijing100083China Institute of Energy China University of GeosciencesBeijing100083China School of Earth and Space Sciences Peking UniversityBeijing100871China

Dolom.te genesis is a century-old m.stery in *** reveal the m.chanism.of dolom.te genesis,two core problem. need to be *** first is the origin and m.gration m.chanism.of m.^(2+)-rich fluids during the dolom.tization *** second is the kinetic barrier caused by m.^(2+)hydration during dolom.te precipitation at low *** address these problem.,our study,based on detailed petrological,sedim.ntological,geochem.cal(m.jor and trace elem.nts),and isotopic(C-O-m.)analysis,clarified the source and m.gration of m.^(2+)-rich fluids and the kinetic barrier m.chanism.of lowtem.erature dolom.te precipitation in the Upper Sinian Qigebulake Form.tion and the Lower Cam.rian Xiaoerbulake Form.tion in the Tarim.***,we found that the m.^(2+)-rich fluids required for the dolom.tization of dolom.te in the Xiaoerbulake Form.tion were prim.rily derived from.the Early Cam.rian m.rine *** the interface of the sedim.ntary cycle,δ26m. values fluctuated considerably,indicating that the sequence interface was the starting point and channel for the m.gration of dolom.tized *** level variation plays a m.jor role in controlling the dolom.tization process of the Xiaoerbulake ***,the Qigebulake Form.tion contains low-tem.erature dolom.te with m.^(2+)-rich fluids supplied by seawater,m.croorganism.,and sedim.ntary organic *** analysis shows that the dolom.te of the Qigebulake Form.tion was form.d by m.crobial induction by anaerobic m.thane ***,the properties and sources of dolom.tization fluids and the form.tion process of dolom.te were the reasons for the difference in the m. isotope com.osition of dolom.te during the Sinian-Cam.rian *** study reveals the genetic m.chanism.of the Sinian-Cam.rian dolom.te in the Tarim.Basin and establishes a new m.thod to explain the genesis of m.crobial dolom.te by C-O-m. isotopes,providing a reference for the reconstruction of the form.tion and evolutio

关键词： Dolom.te genesis m. isotopes Carbon and Oxygen isotopes Xiaoerbulake Form.tion Qigebulake Form.tion Tarim.Basin

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