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Senescent mesenchymal stem/stromal cells in pre-metastatic bone marrow of untreated advanced breast cancer patients

Oncology Research 2023年第3期31卷 361-374页

作者： FRANCISCO RAÚL BORZONE mARÍA BELÉN GIORELLO LEANDRO mARCELO mARTINEZ mARÍA CECILIA SANmARTIN LEONARDO FELDmAN FEDERICO DImASE EmILIO BATAGELJ GUSTAVO YANNARELLI norma ALEJANDRA CHASSEING Laboratorio de Inmunohematología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Buenos AiresArgentina Division of Hematology and medical Oncology Department of MedicineWeill Cornell Medical CollegeNew YorkUSA Laboratorio de Regulación Génica y Células madre Instituto de Medicina TraslacionalTrasplante y Bioingeniería(IMeTTyB)Universidad Favaloro-CONICETBuenos AiresArgentina Facultad de Ciencias de la Salud Universidad Nacional del Centro de la Provincia de Buenos Aires(UNCPB)TandilBuenos AiresArgentina Servicio de Hematología Hospital Militar CentralBuenos AiresArgentina Servicio de Oncología Hospital Militar CentralBuenos AiresArgentina

Breast cancer is the predominant form of carcinoma among women worldwide,with 70%of advanced patients developing bone metastases,with a high mortality *** this sense,the bone marrow(Bm)mesenchymal stem/stromal cells(mSCs)are critical for Bm/bone homeostasis,and failures in their functionality,transform the Bm into a premetastatic niche(PmN).We previously found that Bm-mSCs from advanced breast cancer patients(BCPs,infiltrative ductal carcinoma,stage III-B)have an abnormal *** work aims to study some of the metabolic and molecular mechanisms underlying mSCs shift from a normal to an abnormal profile in this group of patients.A comparative analysis was undertaken,which included self-renewal capacity,morphology,proliferation capacity,cell cycle,reactive oxygen species(ROS)levels,and senescence-associatedβ‑galactosidase(SA‑β‑gal)staining of Bmderived mSCs isolated from 14 BCPs and 9 healthy volunteers(HVs).Additionally,the expression and activity of the telomerase subunit TERT,as well as telomere length,were *** levels of pluripotency,osteogenic,and osteoclastogenic genes(OCT-4,SOX-2,m-CAm,RUNX-2,BmP-2,CCL-2,m-CSF,and IL-6)were also *** results showed that mSCs from BCPs had reduced,self-renewal and proliferation *** cells also exhibited inhibited cell cycle progression and phenotypic changes,such as an enlarged and flattened ***,there was an increase in ROS and senescence levels and a decrease in the functional capacity of TERT to preserve telomere *** also found an increase in pro-inflammatory/pro-osteoclastogenic gene expression and a decrease in pluripotency gene *** conclude that these changes could be responsible for the abnormal functional profile that mSCs show in this group of patients.

关键词： mesenchymal stem/stromal cells Senescence Breast cancer Bone marrow Pre-metastatic niche Bone metastasis

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Second-growth and small forest clearings have little effect on the temporal activity patterns of Amazonian phyllostomid bats

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Current Zoology 2020年第2期66卷 145-153页

作者： Ricardo ROCHA Adria Lopez-Baucells Fabio Z.Farneda Diogo F.Ferreira Ines silva marta AcAcio Jorge m.Palmeirim Christoph F.J.m eyer Centre for Ecology Evolution and Environmental ChangesFaculty of SciencesUniversity of LisbonLisbon1749-016Portugal Biological Dynamics of Forest Fragments Project National Institute for Amazonian Research and Smithsonian Tropical Research InstituteManaus69011-970Brazil Conservation Science Group University of CambridgeCambridgeCB23EJUK Granollers museum of Natural Sciences Granollers08402Spain Department of Ecology Federal University of Rio de JaneiroRio de Janeiro21941-902Brazil CIBI0-lnBI0 Research Centre in Biodiversity and Genetic ResourcesUniversity of PortoVairao4485-661Portugal Conservation Ecology Program School of Bioresources and TechnologyKing Mongkufs University of Technology ThonburiBangkok10150Thailand School of Environmental Sciences University of East AngliaNorwichNR47TJUKand'Ecosystems Environment Research Centre(EERC) School of ScienceEngineering and EnvironmentUniversity of SalfordSalfordM54WTUK

Secondary forests and human-made forest gaps are conspicuous features of tropical ***,behavioral responses to these aspects of anthropogenically modified forests remain poorly ***,we analyze the effects of small human-made clearings and secondary forests on tropical bats by examining the guild-and species-level activity patterns of phyllostomids sampled in the Central Amazon,***,we contrast the temporal activity patterns and degree of temporal overlap of 6 frugivorous and 4 gleaning animalivorous species in old-growth forest and second-growth forest and of 4 frugivores in old-growth forest and forest *** activity patterns of frugivores and gleaning animalivores did not change between old-growth forest and second-growth,nor did the activity patterns of frugivores between old-growth forest and ***,at the species level,we detected significant differences for Artibeus obscurus(old-growth forest ***-growth)and ***(old-growth forest ***).The degree of temporal overlap was greater than random in all sampled ***,for frugivorous species,the degree of temporal overlap was similar between old-growth forest and second-growth;whereas for gleaning animalivores,it was lower in second-growth than in old-growth *** the contrary,forest clearings were characterized by increased temporal overlap between *** in activity patterns and temporal overlap may result from differential foraging opportunities and dissimilar predation ***,our analyses suggest that activity patterns of bats in second-growth and small forest clearings,2 of the most prominent habitats in humanized tropical landscapes,varies little from the activity patterns in old-growth forest.

关键词： Amazon behavior forest gaps niche partitioning secondary forest temporal overlap

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Particulate matter geochemistry of a highly industrialized region in the Caribbean:Basis for future toxicological studies

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Geoscience Frontiers 2022年第1期13卷 376-387页

作者： Luis F.O.silva Ismael L.Schneider Paulo Artaxo Yuleisy Núñez-Blanco Diana Pinto Érico m.m.Flores Leandro Gómez-Plata Omar Ramírez Guilherme L.Dotto Department of Civil and Environmental Universidad de la CostaCUCCalle 58#55–66BarranquillaAtlánticoColombia Department of Applied Physics Institute of PhysicsUniversity of São PauloBrazil Department of Chemistry Universidade Federal de Santa MariaRSBrazil Universidad militar Nueva Granada(UmNG) Faculty of EngineeringEnvironmental EngineeringKm 2 Cajicá-ZipaquiráColombia Chemical Engineering Department Federal University of Santa Maria-UFSM1000Roraima Avenue97105-900 Santa MariaRSBrazil

Air pollution has become an important issue,especially in Caribbean urban areas,and,particulate matter(Pm)emitted by different natural and anthropogenic sources causes environmental and health *** this work,we studied the concentrations of Pm_(10) and Pm_(2.5) sources in an industrial and port urban area in the Caribbean region of *** samples were collected within 48-h periods between April and October 2018 by using a Partisol 2000 i-D *** geochemical characterization was performed by X-ray fluorescence(XRF)***,ionic species and black carbon(BC)were quantified by ion chromatography and reflectance spectroscopy,*** the Positive matrix Factorization(PmF)receptor model,the contributions of Pm sources were *** average concentration of Pm_(10) was 46.6±16.2μg/m^(3),with high concentrations of Cl and *** Pm_(2.5),the average concentration was 12.0±3.2μg/m^(3),and the most abundant components were BC,S,and *** receptor model identified five sources for Pm_(10) and Pm_(2.5).For both fractions,the contributions of marine sea spray,re-suspended soil,and vehicular traffic were *** addition,Pm_(2.5) included two mixed sources were found to be fuel oil combustion with fertilizer industry emissions,and secondary aerosol sources with building construction ***,Pm_(10) was found to also include building construction emissions with re-suspended soil,and metallurgical industry *** obtained geochemical atmospheric results are important for the implementation of strategies for the continuous improvement of the air quality of the Caribbean region.

关键词： Urban air pollution Particulate matter Geochemical composition Aerosol source apportionment Receptor models PmF

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Variations in productivity and wood properties of Amazonian tachi-branco trees planted at diff erent spacings for bioenergy purposes

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Journal of Forestry Research 2021年第1期32卷 211-224页

作者： marilene Olga dos Santos silva marcela Gomes da silva Lina Bufalino maíra Reis de Assis Delman de Almeida Goncalves Paulo Fernando Trugilho Thiago de Paula Protásio Rural Federal University of Amazonia/UFRA Perimetral Ave.Terra FirmeBelémPA 66077-830Brazil Federal University of Lavras/UFLA Francisco Sales St.CentroLavrasMG 37200-000Brazil Brazilian Agricultural Research Corporation/Eastern Amazonia Embrapa Dr.Enéas Pinheiro BySt.MarcoBelémPA 66095-903Brazil Rural Federal University of Amazonia/UFRA PA-275 Rd.Zona RuralParauapebasPA 68515-000Brazil

marilene Olga dos Santos silva 1·marcela Gomes da silva 1·LTachi-branco(Tachigali vulgaris,*** da silva&***)is a leguminous tree species native to the Amazon rainforest that has drawn attention for its remarkably fast growth,a required trait for biomass/bioenergy *** evaluations of biomass production and wood properties of *** planted in homogeneous plantations at diff erent spacings in the Amazonian state of Pará,Brazil,biomass of 7-year-old trees was quantifi ed for individual trees and the entire *** was also sampled to assess properties relevant to bioenergy *** choice for spacing dimension for planting nonclonal *** should consider whether the priority is greater productivity per tree,achieved with greater spacings(9.0 m 2 and 12.0 m 2),or productivity per area,achieved with closerina Bufalino 1·maíra Reis de Assis 2·Delman de Almeida Goncalves 3·Paulo Fernando Trugilho 2·Thiago de Paula Protásio 4 spacings(6.0 m 2 and 7.5 m 2).Genetic variability of the *** seed stand and/or high heritability of wood traits overcame the eff ect of diff erent spacing on all morphological,physical,chemical and energetic properties of *** *** species has moderate basic density when cultivated at spacings larger than 6 m 2 and net heating value above 7.95 mJ/kg,which is suitable for bioenergy *** high variation in wood properties within tree spacing is strongly indicative of great potential for genetic *** fast growth and the suitable moderate wood basic density confi rm the outstanding potential of homogeneous plantations of *** for providing wood for bioenergy.

关键词： Basic density Heating value Planting density Tachigali vulgaris

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Unveiling an important interaction in forestry:Ectomyelois muriscis and Khaya grandifoliola cankers and tree growth

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Journal of Forestry Research 2021年第3期32卷 1287-1293页

作者： Lísias Coelho AndréRTerra Nascimento Jean Carlos Santos Vinícius Flabes silva Instituto de Ciências Agrárias Universidade Federal de UberlandiaUberlandiaBrazil Instituto de Biologia Universidade Federal de UberlandiaUberlandiaBrazil Departamento de Ecologia Universidade Federal de SergipeSergipeBrazil

African mahogany,Khaya grandifoliola ***.,is the most planted mahogany species in Brazil,and became the choice species when plantations of Brazilian mahogany,Swietenia macrophyla King became unsustainable due to their susceptibility to the shoot borer Hypsipyla grandella *** study evaluated plantation growth and the occurrence of cankers associated with Ectomyelois muriscis Dyar *** recorded plantation volume,survival,and canker incidence of a plantation established in 2010 at 6 m×5.5 m *** were collected and reared on canker bark fragments until final adult *** were frequently associated with Ectomyelois muriscis *** average incidence of the moth(2.9%)was not a significant concern,however,an extreme incidence of 45%would indicate that management strategies should be *** is the first report of Ectomyelois muriscis attacking the bark of Khaya grandifoliola in the Cerrado biome.

关键词： African mahogany Stem cankers Potential pest Stand growth

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A model and Treatment for Autism at the Convergence of Chinese medicine and Western Science:First 130 Cases

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Chinese Journal of Integrative medicine 2011年第6期17卷 421-429页

作者： Louisa m.T.silva mark Schalock Robert Ayres Teaching Research Institute Western Oregon University

Objective：To present a model for autism showing that impairment of sensory and self-regulation is the core deficit that underlies delays in social/language skills and abnormal behavior in autism;and to demonstrate the efficacy of a treatment for autism based on Chinese ***：Children with autism under 6 years of age were assigned to treatment or wait-list conditions.A total of 130 children were treated and the results compared with 45 wait-list *** is a tuina methodology directed at sensory impairment——Kai Qiao *** treatment was a five-month protocol that was implemented daily by trained parents via trained support *** effects of treatment on the main symptoms,autistic behavior,social/ language delay,sensory and self-regulatory impairment,as well as on parenting stress,were observed and ***：The treatment had a large effect size（P0.0001） on measures of sensory and self-regulation. The evaluations done by pre-school teachers demonstrated improvement in the measures of autism（P0.003）, and were confirmed by evaluations done by parents（P0.0001）.There was a large decrease（P0.0001） in parenting ***：Sensory and self-regulatory impairment is a main factor in the development and severity of *** of young children with autism with Kai Qiao Tuina resulted in a decrease in sensory and self-regulatory impairment and a reduction in severity of measures of autism.

关键词： Kai Qiao Tuina Qigong sensory training autism treatment for children sensory impairment abnormal sensory responses autism early intervention for autism

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How do greenhouse gas emissions vary with biofertilizer type and soil temperature and moisture in a tropical grassland?

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Pedosphere 2020年第5期30卷 607-617页

作者： Abmael da silva CARDOSO Juliana Bega JUNQUEIRA Ricardo Andrade REIS Ana Claudia RUGGIERIAnimal Science Departament College of Agricultural and Veterinarian SciencesSao Paulo State UniversityJaboticabal 14884-900(Brazil) Kenji Agricultural and Environmental Consultancy Ribeirdo Preto 14010-079(Brazil)

Greenhouse gases are known to play an important role in global *** this study,we determined the effects of selected soil and climate variables on nitrous oxide(N2O),methane(CH4),and carbon dioxide(CO2)emissions from a tropical grassland fertilized with chicken slurry,swine slurry,cattle slurry,and cattle *** N2O emissions did not differ between treatments and varied from 29.26 to 32.85 mg N m^-***,cumulative CH4 emissions were not significantly different among the treatments and ranged from 6.34 to 57.73 mg CH4 m^-*** and compost application induced CO2 emissions that were significantly different from those in the control *** CH4 conversion factors measured were 0.21%,1.39%,4.39%,and 5.07%for cattle compost,chicken slurry,swine slurry,and cattle slurry,respectively,differing from the recommendations of the Intergovernmental Panel on Climate Change(IPCC).The fraction of added Nemitted as N2O was 0.39%,which was lower than the IPCC default value of 2%.Our findings suggest that N2O emissions could be mitigated by replacing synthetic fertilizer sources with either biofertilizer or *** results indicate the following:N2O emission was mainly controlled by soil temperature,followed by soil moisture and then soil NH^"content;CH4 fluxes were mainly controlled by soil moisture and chamber headspace temperature;and CO2 fluxes were mainly controlled by chamber headspace temperature and soil moisture.

关键词： emission factor methane conversion factor methane oxidation methane production capacity slurry fertilizer soil moisture

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Almond cold-pressed oil by-product as ingredient for cookies with potential health benefits:Chemical and sensory evaluation

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Food Science and Human Wellness 2019年第3期8卷 292-298页

作者： Joao C.m.Barreira m.Antonia Nunes Beatriz Vieira da silva Filipa B.Pimentel Anabela S.G.Costa m.Alvarez-Ortic J.E.Pardo m.Beatriz P.P.Oliveira REQUImTE/LAQV Faculdade de Farmácia da Universidade do PortoR.Jorge Viterbo Ferreira 2284050-313PortoPortugal Centro de Investigacade montanha(CImO) Instituto Politécnico de BragancaCampus de Santa Apolónia5300-253PortoPortugal Escuela Técnica Superior de Ingenieros Agrónomos y de montes Universidad de Castilla-La ManchaCampus Universitario02071AlbaceteSpain

Nowadays,food security is a global concern and a great scientific ***-industrial by-products can be used as potential ingredients of innovative food products,contributing to solve this societal ***-products of high specialty oils processing,for instance,have remarkable nutritional and organoleptic ***,the partially delipidified almond flour(PDAF)remaining from almond oil extraction,was used as an alternative ingredient in a highly appreciated almond-based cookie(“almendrados”).For comparison purposes,four different“almendrados”formulations(one industrial,two with PDAF,and one with whole almond flour),were compared regarding nutritional composition,vitamin E and fatty acids *** assess the cookie sensory properties,seventy-four consumers evaluated“appearance”,“taste”,“sweetness”,“crunchiness”,“hardness”,“overall quality”using adequate hedonic *** and protein levels showed significant differences among industrial and the other three *** with PDAF presented similar tocopherols and fatty acids to the traditional(more expensive)formulation,besides reaching the highest scores on“appearance”,“sweetness”,“hardness”,“overall quality”and“buying predisposition”***,the incorporation of PDAF might represent an effective way of adding value to an industrial by-product,while providing a pleasant novel cookie formulation.

关键词： By-products Almond Food security Cookie formulation Principal component analysis

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Chemical Reactivity Theory (CRT) Study of the melanoidin m8: Local Conceptual Density Functional Theory Descriptors

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Computational molecular Bioscience 2018年第2期8卷 80-90页

作者： Juan Frau norma Flores-Holguín Daniel Glossman-mitnik Departament de Química Universitat de les Illes Balears Palma de Mallorca Spain Laboratorio Virtual NANOCOSmOS Departamento de Medio Ambiente y Energía Centro de Investigación en Materiales Avanzados Chihuahua México

This study evaluated a fixed long-range corrected range-separated hybrid (RSH) density functional associated with the Def2TZVP basis set alongside the Solvation model based on Density (SmD) for the computation of the structure, molecular properties and chemical reactivity of the m8 intermediate melanoidin pigment. The preference of the active sites pertinent to radical, nucleophilic and electrophilic attacks is made through linking them with the electrophilic and nucleophilic Parr functions, Fukui function indices, and condensed Dual Descriptor. This study showed that the mN12SX density functional is the most suitable one for predicting the chemical reactivity of this system.

关键词： melanoidin m8 Conceptual DFT Chemical Reactivity Dual Descriptor Parr Function

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未固结流砂地层采油过程中出砂情况模拟实验

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石油勘探与开发 2017年第5期44卷 811-816页

作者： PERERA m S A RANJITH P G RATHNAWEERA T D DE silva G P D LIU T Department of Civil Engineering Monash University Department of Infrastructure Engineering The University of Melbourne

为了研究未固结流砂储集层在采油过程中的出砂情况和影响出砂的主要因素,进行了不同条件下的出砂过程模拟实验。使用水洗白砂、黏土(高岭土)和蒸馏水制成未固结流砂地层模型,利用新开发的出砂模拟装置进行了模拟实验,并分析了作用于地... 详细信息

为了研究未固结流砂储集层在采油过程中的出砂情况和影响出砂的主要因素,进行了不同条件下的出砂过程模拟实验。使用水洗白砂、黏土(高岭土)和蒸馏水制成未固结流砂地层模型,利用新开发的出砂模拟装置进行了模拟实验,并分析了作用于地层的拖曳力和地层胶结特征对出砂的影响。研究表明,随着拖曳力的增加,出砂速度和产油速度都加快;随着胶结物含量的增加,出砂量和产油量明显降低,甚至在胶结物含量较高的情况下出砂量几乎为零。地层压力大的油藏在开采期间由于产生了较大的拖曳力更可能出砂,而拖曳力和有效地层应力共同影响油藏的总体产油量。可以根据地层黏土含量估计出砂情况,从而通过采取适当的防砂措施尽可能减少出砂量。某些情况下油藏比气藏更容易出砂。

关键词：流砂地层出砂采油工艺黏土含量胶结程度拖曳力

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