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Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women

World Journal of Gastroenterology 2012年第3期18卷 237-243页

作者： Masahide Hamaguchi Takao Kojima Akihiro Ohbora noriyuki takeda Michiaki Fukui Takahiro Kato Immunology Frontier Research Centerat Osaka University Department of Gastroenterology Murakami Memorial Hospital Asahi University Department of Endocrinology and Metabolism Murakami Memorial Hospital Asahi University Department of Endocrinology and Metabolism Graduate School of Medical Science Kyoto Prefectural University of Medicine

AIM: To clarify the relationship between age, menopause, and nonalcoholic fatty liver disease (NAFLD) in women. METHODS: We conducted a follow-up study on non-alcoholic fatty liver disease by using abdominal ultrasonography, and investigated the relationship of age and menopause with the development of NAFLD in women. We followed 1829 women and 2572 men (response rate, 86%) selected in 2001 to represent the non-institutionalized adult population of Gifu, Japan. Data collected included self-reported medical history, lifestyle factors, and menopausal status. The postmenopausal state was defined as beginning 1 year after the cessation of menses. We diagnosed NAFLD with the aid of abdominal ultrasonography by using diagnostic criteria describedRESULTS: The prevalence of NAFLD in women increases with age, but does not alter with age in men. Furthermore, the prevalence of NAFLD in premenopausal women (6%) was lower than that in men (24%) and in postmenopausal women (15%). The associations of the postmenopausal state and hormone replacement therapy with NAFLD were statistically significant in a univariate logistic regression model. At the follow-up examination, 67 women (5%) were newly diagnosed with NAFLD. The incidence of NAFLD was 3.5% (28/802) in premenopausal women, 7.5% (4/53) in menopausal women, 6.1% (24/392) in postmenopausal women, and 5.3% (11/206) in women receiving hormone replacement therapy. The weight gain in premenopausal women was equal to that in postmenopausal women. Metabolic syndrome and weight gain were independent risk factors for NAFLD in pre-and postmenopausal women, but age was an independent risk factor in premenopausal women only. CONCLUSION: Aging is a risk factor for NAFLD in premenopausal women, independent of weight gain or influence of metabolic syndrome.

关键词： Nonalcoholic fatty liver disease Cardiovascular disease Risk factor Steatohepatitis Postmenopausal women

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Protective effect of alcohol consumption for fatty liver but not metabolic syndrome

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World Journal of Gastroenterology 2012年第2期18卷 156-167页

作者： Masahide Hamaguchi Takao Kojima Akihiro Ohbora noriyuki takeda Michiaki Fukui Takahiro Kato Immunology Frontier Research Center Osaka UniversityOsaka 565-0871Japan Department of Gastroenterology Murakami Memorial HospitalAsahi UniversityGifu 500-8523Japan Department of Endocrinology and Metabolism Murakami Memorial HospitalAsahi UniversityGifu 500-8523Japan Department of Endocrinology and Metabolism Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 602-8566Japan

AIM:To investigate the effect of alcohol on the metabolic syndrome (MS) and fatty liver in Japanese men and ***:A cross-sectional study was conducted in a medical health checkup program at a general *** study involved 18 571 Japanese men and women,18-88 years of age,with a mean body mass index of 22.6 kg/m 2.A standardized questionnaire was *** total amount of alcohol consumed per week was calculated,and categorized into four *** liver was examined by ultrasound modified criteria of the revised National Cholesterol Educa-tion Program Adult Treatment Panel Ⅲ and the new International Diabetes ***:The prevalence of fatty liver decreased in men and women with light to moderate alcohol consumption,whereas the prevalence of MS was not so *** prevalence of fatty liver of any grade in men was lower than that in those with no or minimal alcohol *** women with light to moderate alcohol consumption,prevalence of fatty liver was lower than that in women with no or minimal alcohol *** logistic regression analysis,the odds ratio (OR) for MS in women with light alcohol consumption was decreased to < 1.0,but this change was not clear in *** OR for fatty liver was clearly < 1.0 in men with any level of alcohol consumption and in women with light to moderate ***:Light to moderate alcohol consumption has a favorable effect for fatty liver,but not for MS in Japanese men and women.

关键词： Alcoholic hepatitis Epidemiology Fatty liver Metabolic syndrome Alcohol consumption

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Identification of individuals with non-alcoholic fatty liver disease by the diagnostic criteria for the metabolic syndrome

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World Journal of Gastroenterology 2012年第13期18卷 1508-1516页

作者： Masahide Hamaguchi noriyuki takeda Takao Kojima Akihiro Ohbora Takahiro Kato Hiroshi Sarui Michiaki Fukui Chisato Nagata Jun takeda Immunology Frontier Research Center at Osaka University Osaka 5650871Japan Department of Endocrinology and Metabo lism Murakami Memorial HospitalAsahi UniversityGifu 5008523Japan Department of Gastroenterology Murakami Memorial HospitalAsahi UniversityGifu 5008523Japan Department of Endocrinology and Metabolism Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 6028566Japan Department of Epidemiology and Preventive Medicine Graduate School of MedicineGifu UniversityGifu 5008523Japan Department of Diabetes and Endocrinology Division of Molecule and StructureGraduate School of MedicineGifu UniversityGifu 5008523Japan

AIM:To clarify the efficiency of the criterion of metabolic syndrome to detecting non-alcoholic fatty liver disease(NAFLD).METHODS:Authors performed a cross-sectional study involving participants of a medical health checkup program including abdominal *** study involved 11 714 apparently healthy Japanese men and women,18 to 83 years of *** was defined by abdominal ultrasonography without an alcohol intake of more than 20 g/d,known liver disease,or current use of *** revised criteria of the National Cholesterol Education Program Adult Treatment PanelⅢ were used to characterize the metabolic ***:NAFLD was detected in 32.2%(95%CI:31.0%-33.5%)of men(n=1874 of 5811)and in 8.7%(95%CI:8.0%-9.5%)of women(n=514 of 5903).Among obese people,the prevalence of NAFLD was as high as 67.3%(95%CI:64.8%-69.7%)in men and 45.8%(95%CI:41.7%-50.0%)in *** NAFLD was thought of as being the liver phenotype of metabolic syndrome,the prevalence of the metabolic syndrome among subjects with NAFLD was low both in men and women.66.8%of men and 70.4%of women with NAFLD were not diagnosed with the metabolic syndrome.48.2%of men with NAFLD and 49.8%of women with NAFLD weren't overweight[body mass index(BMI)≥25 kg/m2].In the same way,68.6%of men with NAFLD and 37.9%of women with NAFLD weren't satisfied with abdominal classification(≥90 cm for men and≥80 cm for women).Next,authors defined it as positive at screening for NAFLD when participants satisfied at least one criterion of metabolic *** sensitivity of the definition"at least 1 criterion"was as good as 84.8%in men and 86.6%in *** subjects by BMI,the sensitivity was higher in obese men and women than in non-obese men and women(92.3%vs 76.8%in men,96.1%vs 77.0%in women,respectively).CONCLUSION:Authors could determine NAFLD effectively in epidemiological study by modifying the usage of the criteria for metabolic syndrome.

关键词： Nonalcoholic fatty liver Metabolic syndrome Population based study Methodology

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Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease

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World Journal of Gastroenterology 2007年第10期13卷 1579-1584页

作者： Masahide Hamaguchi Takao Kojima noriyuki takeda Chisato Nagata Jun takeda Hiroshi Sarui Yutaka Kawahito Naohisa Yoshida Atsushi Suetsugu Takahiro Kato Junichi Okuda Kazunori Ida Toshikazu Yoshikawa Inflammation and Immunology Graduate School of Medical ScienceKyoto Prefectural University of MedicineJapan Department of Gastroenterology Murakami Memorial HospitalAsahi UniversityJapan Department of Endocrinology and Metabolism Murakami Memorial HospitalAsahi UniversityJapan Department of Epidemiology & Preventive Medicine Graduate School of MedicineGifu UniversityJapan Department of Diabetes and Endocrinology Division of Molecule and StructureGraduate School of MedicineGifu UniversityJapan

AIM:To clarify whether nonalcoholic fatty liver disease(NAFLD)increases the risk of cardiovascular ***:We carried out a prospective observational study with a total of 1637 apparently healthy Japanese men and women who were recruited from a health check-up *** was diagnosed by abdominal *** metabolic syndrome(MS)was defined according to the modified National Cholesterol Education Program(NCEP)ATP Ⅲ *** years after the baseline evaluations,the incidence of cardiovascular disease was assessed by a self-administered ***:Among 1221 participants available for outcome analyses,the incidence of cardiovascular disease was higher in 231 subjects with NAFLD at baseline(5 coronary heart disease,6 ischemic stroke,and 1 cerebral hemorrhage)than 990 subjects without NAFLD(3 coronary heart disease,6 ischemic stroke,and 1 cerebral hemorrhage).Multivariate analyses indicated that NAFLD was a predictor of cardiovascular disease independent of conventional risk factors(odds ratio 4.12,95% CI,1.58 to 10.75,P = 0.004).MS was alsoindependently associated with cardiovascular *** simultaneous inclusion of NAFLD and MS in a multivariate model revealed that NAFLD but not MS retained a statistically significant correlation with cardiovascular ***:Although both of them were predictors of cardiovascular disease,NAFLD but not MS retained a statistically significant correlation with cardiovascular disease in a multivariate *** is a strong predictor of cardiovascular disease and may play a central role in the cardiovascular risk of MS.

关键词： Nonalcoholic fatty liver disease Metabolic syndrome Coronary heart disease Cardiovascular disease Risk factors

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Performance Comparison of Vision Transformer- and CNN-Based Image Classification Using Cross Entropy: A Preliminary Application to Lung Cancer Discrimination from CT Images

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Journal of Biomedical Science and Engineering 2024年第9期17卷 157-170页

作者： Eri Matsuyama Haruyuki Watanabe noriyuki Takahashi Faculty of Informatics The University of Fukuchiyama Kyoto Japan School of Radiological Technology Gunma Prefectural College of Health Sciences Gunma Japan School of Health Sciences Fukushima Medical University Fukushima Japan

This study evaluates the performance and reliability of a vision transformer (ViT) compared to convolutional neural networks (CNNs) using the ResNet50 model in classifying lung cancer from CT images into four categories: lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), large cell carcinoma (LULC), and normal. Although CNNs have made significant advancements in medical imaging, their limited capacity to capture long-range dependencies has led to the exploration of ViTs, which leverage self-attention mechanisms for a more comprehensive global understanding of images. The study utilized a dataset of 748 lung CT images to train both models with standardized input sizes, assessing their performance through conventional metrics—accuracy, precision, recall, F1 score, specificity, and AUC—as well as cross entropy, a novel metric for evaluating prediction uncertainty. Both models achieved similar accuracy rates (95%), with ViT demonstrating a slight edge over ResNet50 in precision and F1 scores for specific classes. However, ResNet50 exhibited higher recall for LULC, indicating fewer missed cases. Cross entropy analysis showed that the ViT model had lower average uncertainty, particularly in the LUAD, Normal, and LUSC classes, compared to ResNet50. This finding suggests that ViT predictions are generally more reliable, though ResNet50 performed better for LULC. The study underscores that accuracy alone is insufficient for model comparison, as cross entropy offers deeper insights into the reliability and confidence of model predictions. The results highlight the importance of incorporating cross entropy alongside traditional metrics for a more comprehensive evaluation of deep learning models in medical image classification, providing a nuanced understanding of their performance and reliability. While the ViT outperformed the CNN-based ResNet50 in lung cancer classification based on cross-entropy values, the performance differences were minor and may not hold c

关键词： Lung Cancer Classification Vision Transformers Convolutional Neural Networks Cross Entropy Deep Learning

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Investigation of HO_(2) uptake mechanisms onto multiple-component ambient aerosols collected in summer and winter time in Yokohama,Japan

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Journal of Environmental Sciences 2024年第3期137卷 18-29页

作者： Jun Zhou Yukiko Fukusaki Kentaro Murano Tania Gautam Yu Bai Yoshimi Inomata Hiroaki Komatsu Mayuko takeda Bin Yuan Min Shao Yosuke Sakamoto Yoshizumi Kajii Institute for Environmental and Climate Research Jinan UniversityGuangzhou 511443China Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation forEnvironmental Quality Guangzhou 511443China Graduate School of Global Environmental Studies Kyoto UniversityKyoto606-8501Japan Yokohama Environmental Science Research Institute Yokohama Kanagawa 221–0024Japan Department of Chemistry University of AlbertaAlbertaEdmonton T6G 2G2Canada Graduate School of Human and Environmental Studies Kyoto UniversityKyoto 606-8501Japan Kanagawa Environmental Research Center Kanagawa 254-0014Japan Center for Regional Environmental Research National Institute for Environmental StudiesIbaraki305-8506Japan

The heterogeneous loss of HO_(2)radicals onto ambient aerosols plays an important role in tropospheric ***,sparse investigation of the dominating parameters controlling the HO_(2)uptake coefficients onto ambient aerosols(γHO_(2))has largely hindered the application of the measuredγHO_(2)to the global spatial *** we induced an offine method using LFP-LIF technique to measure the kinetics of HO_(2)uptake onto ambient aerosols collected in summertime and wintertime in Yokohama city,a regional urban site near Tokyo,*** controlling the dominating parameters which infuenceγHO_(2),we were able to investigate the detailed HO_(2)uptake *** characterized the chemical composition of the collected ambient aerosols,including organics,inorganics,transition metals ions,*** modeledγHO_(2)using different *** show thatγHO_(2)increased with the increase in RH,and the aerosol states(“dry”or wet/aqueous)have large effects onγHO_(2).With fixed RH and aerosol chemical composition,γHO_(2)was highly dependent on pH and inversely correlated with[HO_(2)]_*** combing the measuredγHO_(2)values with the modeled ones,we found that both the HO_(2)self-reaction and transition metal-catalyzed reactions should be accounted for to yield a single parameterization to predictγHO_(2),and different chemical compositions may have collective effects onγHO_(2).Results may serve for extending theγHO_(2)values measured at one observation site to different environmental conditions,which will help us to achieve more accurate modeling results concerning secondary pollutant formation(i.e.,ozone).

关键词： HO_(2)uptake kinetics Offine method Impacting factors Mechanism

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Using Cross Entropy as a Performance Metric for Quantifying Uncertainty in DNN Image Classifiers: An Application to Classification of Lung Cancer on CT Images

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Journal of Biomedical Science and Engineering 2024年第1期17卷 1-12页

作者： Eri Matsuyama Masayuki Nishiki noriyuki Takahashi Haruyuki Watanabe Faculty of Informatics University of Fukuchiyama Kyoto Japan Graduate School of Radiological Sciences International University of Health and Welfare Tochigi Japan School of Health Sciences Fukushima Medical University Fukushima Japan School of Radiological Technology Gunma Prefectural College of Health Sciences Gunma Japan

Cross entropy is a measure in machine learning and deep learning that assesses the difference between predicted and actual probability distributions. In this study, we propose cross entropy as a performance evaluation metric for image classifier models and apply it to the CT image classification of lung cancer. A convolutional neural network is employed as the deep neural network (DNN) image classifier, with the residual network (ResNet) 50 chosen as the DNN archi-tecture. The image data used comprise a lung CT image set. Two classification models are built from datasets with varying amounts of data, and lung cancer is categorized into four classes using 10-fold cross-validation. Furthermore, we employ t-distributed stochastic neighbor embedding to visually explain the data distribution after classification. Experimental results demonstrate that cross en-tropy is a highly useful metric for evaluating the reliability of image classifier models. It is noted that for a more comprehensive evaluation of model perfor-mance, combining with other evaluation metrics is considered essential. .

关键词： Cross Entropy Performance Metrics DNN Image Classifiers Lung Cancer Prediction Uncertainty

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Effect of Wearing a Maxillofacial Prosthesis on Masticatory Rhythm Improvement in Mandibulectomy Patients

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Health 2024年第7期16卷 717-729页

作者： Xuewei Han Mihoko Haraguchi Yuka I. Sumita Marwa Ahmed Aboelez noriyuki Wakabayashi Department of Advanced Prosthodontics Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU) Tokyo Japan Department of Partial and Complete Denture School of Life Dentistry at Tokyo The Nippon Dental University Tokyo Japan Department of Prosthodontics Faculty of Dentistry Mansoura University Mansoura Egypt

Background: Recording jaw movement rhythms in patients with jaw defects is challenging using conventional tracking devices. However, masticatory rhythm is crucial for masticatory performance and nutritional intake. This study aimed to explore the impact of using a maxillofacial prosthesis to restore masticatory rhythm in mandibulectomy patients with a novel wearable device. Methods: Twelve patients who underwent mandibulectomy and were rehabilitated with maxillofacial prosthesis were recruited. Chewing rate, cycle durations, coefficient of variation of cycle durations (CV), changing times of skin morphology on the back of the ear pinna area (SM), and masticatory performance were measured during gum chewing without and with a denture using a wearable jaw movement rhythm tracking device. A paired t-test and the Pearson correlation coefficient were used for statistical analysis. Results: The chewing rate increased by 8.6 cycles/min with dentures (P P = 0.01). The CV and SM decreased with dentures (P = 0.004 and P = 0.01, respectively). Significant correlations were found between the CV and SM without dentures (P = 0.004). Conclusion: 1. Wearing maxillofacial prostheses can improve masticatory rhythm in patients who undergo mandibulectomy with Eichner B2 occlusal supports. 2. The wearable device is available for measuring masticatory rhythm in patients with jaw defects in clinics. 3. Changing times of the skin morphology on the back of the ear pinna indicate jaw movement stability through a simpler process than the coefficient of variation of cycle durations.

关键词： Masticatory Rhythm Jaw Movement Rhythm Tracking Device Maxillofacial Prosthesis Head and Neck Tumor Mandibulectomy

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Is resilience socially emerging or embedded?A review of“resilience”under climate change in Sri Lanka

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Journal of Safety Science and Resilience 2021年第4期2卷 258-266页

作者： Ryo Tsuchida Shutaro takeda Graduate School of Advanced Integrated Studies in Human Survivability Kyoto UniversityKyotoJapan

Since the advent of a new academic regime that examines the nexus of humans and water,resilience studies of the coevolution of human-water systems have advanced rapidly because of the climate ***,the concept of resilience poses a new social *** study analyzes the gap in resilience studies through a Sri Lankan water-related disaster research ***,the authors discuss the potential and challenges for resilience evolution under climate change in Sri *** the nuance of resilience,the review showed that resilience is complementarily emerging and embedded in culture and society,such as traditional knowledge and local history,and from scientific research-oriented translation and wide international policy view in *** is the accumulation of stable states and supporting mechanisms found in the interaction between normal phases and emergencies in elements unique to the *** study suggests that it is critical to support the resilience and mechanisms of the whole and each layer,leveraging the diverse and sustainable livelihoods in the Sri Lankan context against climate change.

关键词： Resilience Climate change Water-related disasters Adaptation Sri Lanka

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Redox active ionic liquid as efficient mediator and solvent for visible light-driven B_(12) catalytic reactions

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Green Energy & Environment 2019年第2期4卷 116-120页

作者： Hisashi Shimakoshi noriyuki Houfuku Li Chen Yoshio Hisaeda Department of Chemistry and Biochemistry Graduate School of Engineering Kyushu University

The redox active ionic liquid, 1-ethyl-4-(methoxycarbonyl)pyridinium bis(trifluoromethanesulfonyl)amide(RIL), was synthesized from its iodide form by an anion exchange reaction of Li(NTf_2) with viscos liquid(η= 122 cP at 25C) and characterized by NMR, IR, and elemental analysis. The compound showed reversible redox couples at -0.65 V and -1.48 V vs. Ag/AgCl and worked as an electron mediator in the B_(12) complex/[Ru(bpy)_3]Cl_2 photosensitizer catalytic system under visible light irradiation. The catalytic efficiency in the RIL was higher than those in DMF, MeOH, and the redox inactive ionic liquid, 1-butyl-3-methyl imidazolium bis(trifluoromethylsulfonyl)amide.

关键词： Ionic liquid Photosensitizer Redox active Visible light Vitamin B12

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