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Current status of sperm banking for young cancer patients in Japanese nationwide survey

Asian Journal of Andrology 2018年第4期20卷 336-341页

作者： Yasushi Yumura Akira Tsujimura Hiroshi Okada Kuniaki Ota Masahumi Kitazawa Tatsuya suzuki Tosiyuki Kakinuma Seido Takae Nao suzuki Teruaki Iwamoto Reproduction Center Yokohama City University Medical Center Yokohama 232-0024 Japan Department of Urology Juntendo University Urayasu Hospital Chiba 279-0021 Japan Department of Urology Dokkyo Medical University Koshigaya Hospital Saitama 343-8555 Japan Department of Obstetrics and Gynecology Nasu Red Cross Hospital Tochigi 324-8686 Japan Department of Obstetrics and Gynecology Dokkyo Medical University Tochigi 321-0293 Japan Department of Obstetrics and Gynecology Jichi Medical University Tochigi 329-0498 Japan Department of Obstetrics and Gynecology International University of Health and Welfare Tochigi 329-2763 Japan Department of Obstetrics and Gynecology St. Marianna University School of Medicine Kawasaki 216-8511 Japan Division Male Infertility Center for Human Reproduction International University of Health and Welfare Sanno Hospital Tokyo 107-0052 Japan

This study aimed to ascertain the current status of Japanese sperm banking for young cancer patients. During 2015, we mailed the directors of 695 institutes where sperm cryopreservation might be performed with questionnaires requesting information on the number of patients, age, precryopreservation chemotherapy, semen analyses results and diagnoses, cryopreservation success rate, and causes of unsuccessful cryopreservation. Of these 695 institutes, 92 had cryopreserved sperm before chemotherapy within the study period. In all, 820 cancer patients （237 testicular, 383 hematological, 46 bone and soft tissue, 20 brain, and 134 other malignancy） consulted the responding institutes for sperm cryopreservation. Except for testicular tumor, the number of patients whose sperm was preserved before cancer treatment was low compared to that of young cancer patients. Approximately 20% of patients with malignancies other than testicular tumor underwent chemotherapy before cryopreservation. The success rate of cryopreservation in hematological malignancy was 82.5%, significantly lower than that of both the testicular cancer （93.6%） and other malignancy groups （95.6%）（P 〈 0.05）. The primary reasons for preservation failure were azoospermia and poor semen quality. Patients with hematological malignancies had a higher rate of unsuccessful cryopreservation compared to those in other groups, possibly due to the large number of patients requesting sperm cryopreservation after chemotherapy induction. In Japan, information regarding sperm banking prior to cancer treatment appears to be lacking. Information regarding sperm preservation before chemotherapy should be provided to all Japanese oncologists.

关键词： cancer chemotherapy fertility preservation sperm preservation survey

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Design Method of Guide Vane for Wells Turbine

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Journal of Thermal Science 2006年第2期15卷 126-131页

作者： Masami suzuki Department of Mechanical Engineering Graduate School of Engineering The University of Tokyo

指南翼在井汽轮机被安装以便改进它的效率，自我旋转的特征并且离开设计性能与拖延。这个工作试图根据动量理论解释这些指南翼的角色。在上游的翼在比下游的提高效率是更有效的，这被显示出。为指南翼的一个设计方法基于试验性的数据和... 详细信息

指南翼在井汽轮机被安装以便改进它的效率，自我旋转的特征并且离开设计性能与拖延。这个工作试图根据动量理论解释这些指南翼的角色。在上游的翼在比下游的提高效率是更有效的，这被显示出。为指南翼的一个设计方法基于试验性的数据和潜在的理论被建议。作者执行的试验性的研究证实理论求婚了。关键词井汽轮机 - 指南翼 - 串联 - 潜在的流动 - 波浪精力变换器 - 海洋工程 CLC 数字

关键词：韦尔斯涡轮叶片导向喷流位势流波能变流器海洋工程学

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Activation of Trifluoromethylthio Moiety by Appending Iodonium Ylide under Copper Catalysis for Electrophilic Trifluoromethylation Reaction

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Chinese Journal of Chemistry 2016年第5期34卷 485-489页

作者： Ibrayim Saidalimu Shugo suzuki Etsuko Tokunaga Norio Shibata Department of Frontier Materials Nagoya Institute of Technology Gokiso Showa-ku Nagoya 466-8555 Japan Department of Nanopharmaceutical Sciences Nagoya Institute oF Technology Gokiso Showa-ku Nagoya 466-8555 Japan

A novel iodonium-ylide compound 2 that appends a trifluoromethylthio （SCF3） group is disclosed as a new, shelf-stable electrophilic trifluoromethylation reagent. Unlike known shelf-stable electrophilic trifluoromethylation reagents, 2 has a stable SCF3 group which is activated by appending iodonium ylide under copper catalysis via sul- fonium ylide to generate a cationic trifluoromethyl （CF3） species. Reagent 2 was found to be an efficient electro- philic trifluoromethylation reagent for a wide range of silyl enol ethers 3 under copper catalysis. Cyclic and acyclic a-trifiuoromethyl ketones 4 were obtained by reagent 2 in moderate to good yields. On the other hand, a difluoro- methylthio analogue 5 did not affect intermolecular transfer difluoromethylation to substrates. Instead, intramolecu- lar 1,4-migration proceeded similar to the Stevens rearrangement to provide 6 in 21% yield, independent of the presence of nucleophiles 3.

关键词： trifluoromethylation difluoromethylation iodine sulfur ylide

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近二十年日本的中国现代文学研究

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现代中文学刊 2023年第2期 25-31页

作者：铃木将久东京大学大学院人文社会系研究科

20世纪日本的中国现代文学研究以1970年代末到1980年代为分界,研究目的发生了由理解中国革命到获得学术意义的转向,新世纪以来也基本循着这个方向发展。在研究方法上,20世纪日本的中国现代文学研究始终都有重视史料的特点,但伴随着21世... 详细信息

20世纪日本的中国现代文学研究以1970年代末到1980年代为分界,研究目的发生了由理解中国革命到获得学术意义的转向,新世纪以来也基本循着这个方向发展。在研究方法上,20世纪日本的中国现代文学研究始终都有重视史料的特点,但伴随着21世纪,尤其是近十年来数字化的发展,史料的获取与阅读方法发生了巨变,这使得研究者不得不调整研究方法。在这样的背景下,近二十年来的日本中国现代文学研究的焦点由鲁迅转向张爱玲,反映了从研究“中国”到研究“文学”的转变。同时,何谓“中国现代文学”也成为了近二十年来日本学界的热点话题,研究者们有意为其“扩容”,以更广大的视野在更广的平台上进行研究。笔者认为新一代研究者可以在两个方向延续探索:一是继承并重新激活1950年代研究的丰富遗产,重新接近中国老百姓的精神世界;二是接受并消化文化研究、日本文学研究等邻近学科的突破性成果,最终产生新时代的中国文学研究范式。

关键词： 21世纪日本的中国现代文学研究史料鲁迅张爱玲电影研究

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Upregulation of epidermal growth factor receptor 4 in oral leukoplakia

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International Journal of Oral Science 2013年第1期5卷 14-20页

作者： Hiroshi Kobayashi Kenichi Kumagai Akito Gotoh Takanori Eguchi Hiroyuki Yamada Yoshiki Hamada Satsuki suzuki Ryuji suzuki Department of Oral and Maxillofacial Surgery Tsurumi University Department of Rheumatology and Clinical Immunology Clinical Research Center for Rheumatology and AllergySagamihara National HospitalNational Hospital Organization Section of Biological Science Research Center for Odontology Nippon Dental University School of Dentistry

In the present study,we investigate the expression profile of the epidermal growth factor receptor family,which comprises EGFR/ ErbBl,HER2/ErbB2,HER3/ErbB3 and HER4/ErbB4 in oral leukoplakia(LP).The expression of four epidermal growth factor receptor (EGFR) family genes and their ligands were measured in LP tissues from 14 patients and compared with levels in 10 patients with oral lichen planus(OLP) and normal oral mucosa(NOM) from 14 healthy donors by real-time polymerase chain reaction(PCR) and immunohistochemistry.Synchronous mRNA coexpression of ErbBl,ErbB2,ErbB3and ErbB4 was detected in LP lesions.Out of the receptors,only ErbB4 mRNA and protein was more highly expressed in LP compared with NOM tissues.These were strongly expressed by epithelial keratinocytes in LP lesions,as shown by immunohistochemistry.Regarding the ligands,the mRNA of Neuregulin2 and 4 were more highly expressed in OLP compared with NOM tissues.Therefore,enhanced ErbB4 on the keratinocytes and synchronous modulation of EGFR family genes may contribute to the pathogenesis and carcinogenesis of LP.

关键词： epidermal growth factor receptor immunohistochemistry oral leukoplakia quantitative real-time polymerase chain reaction

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Tracing sediment transport history using mineralogical fingerprinting in a river basin with dams utilizing sediment sluicing

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International Journal of Sediment Research 2023年第3期38卷 469-480页

作者： Kenichi Ito Motohide Matsunaga Tomoya Itakiyo Hiroyuki Oishi Kei Nukazawa Mitsuteru Irie Yoshihiro suzuki Center for International Relations University of Miyazaki Department of Civil and Environmental Engineering Faculty of Engineering University of Miyazaki Oita Prefectural Government West Japan Engineering Consultants Inc.

Sediment causes a serious problem in relation to dam function. A cooperative sediment sluicing operation has been under way since 2017 to prevent sediment from accumulating in dams in the Mimi River,Miyazaki, Japan. To achieve a smooth and stable operation, it is very important to determine the sediment source and a sediment transport system to maintain the dam’s function. In the current study, the source and transport of sediment from the Mimi River basin have been analyzed with X-ray diffraction(XRD) to reveal the peaks of mineral species. The sediment samples were collected in the Mimi River basin from the Tsukabaru Dam to the sea in an area including 4 dams and 5 tributaries. In addition, the minerals in samples collected in 2014, before the start of the sediment sluicing operation, and from 2018 to 2020, after the start of the operation, were analyzed. An evaluation of the similarity of the sediment at each sampling point based on the X-ray diffraction peaks of mineral species showed that sediment distributed upstream was transported downstream in the year when the sediment sluicing was done.This result indicates that the sediment sluicing operation at dams ensured the continuity of the sediment distribution in the Mimi River basin. In addition, an investigation done in 2020 showed that sediment particles very similar to those of the upstream tributaries were deposited downstream because of extensive flooding caused by a large typhoon. The management of sediment transport has the greatest importance in a river basin where a dam is to be constructed. It is possible to trace the history of the sediment distribution and movement resulting from the operation of sediment sluicing by using sediment mineral analysis.

关键词： Sediment sluicing Sediment source X-ray diffraction (XRD) Mineralogical analysis Cluster analysis

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Redescription of five tintinnine ciliates (Alveolata: Ciliophora: Oligotrichea) from coastal waters of Qingdao, China

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Marine Life Science & Technology 2020年第3期2卷 209-221页

作者： Yang Bai Rui Wang Wen Song Toshikazu suzuki Xiaozhong Hu Institute of Evolution and Marine Biodiversity&Key Laboratory of Mariculture Ministry of EducationOcean University of ChinaQingdao 266003China Marine College Shandong UniversityWeihai 264209.China Faculty of Fisheries Nagasaki University1-14 BunkyoNagasaki 852-8521Japan

Tintinnine ciliates are widely distributed around the world and are characterized by the possession of a lorica that is highly diverse in structure and morphology.In the present study,five tintinni nes,namely Tintinnopsis cf.radix,T.evert a Kofoid and Campbell,1929,T.mulctrella Kofoid and Campbell,1929,Eutintinnus inflatus Marshall,1969,and Favella ehrenbergii(Claparede and Lachmann,1858)Jorgensen,1924,were collected from coastal waters of Qingdao,China.Three are newly recorded from China,i.e.,T.evert a,T.mulctrella,and E.inflatus.The morphology of the lorica and cell proper of all five species are described and compared with original and subsequent descriptions.The morphology in vivo of the lorica and cell proper of all five species are described and compared with original and subsequent descriptions.In addition,the ciliary patterns of F.ehrenbergii and T.cf.radix are revealed based on protargol-stained specimens.

关键词： Cell proper Lorica New record Tintinnina

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Neointimal coverage of sirolimus-eluting stents 6 months and 12 months after implantation： evaluation by optical coherence tomography

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Chinese Medical Journal 2008年第6期121卷 503-507页

作者： YAO Zhu-hua Tetsuo Matsubara Tsuyoshi Inada Yasuyoshi suzuki Takahiko suzuki Department of Cardiology Toyohashi Heart Center Toyohaslai441-8530 Japan

Optical coherence tomography （OCT） is a new imaging modality with resolution of approximately 10 pm and can be employed to visualize intracoronary characteristics. Sirolimus-eluting stents （SES） are susceptible to late thrombosis due to delayed reendothelialization over the stent struts, which may result in acute myocardial infarction or death. This study was designed to evaluate the re-endothelialization and neointimal coverage of SES with OCT 6 months and 12 months after implantation.Methods A total of 36 patients enrolled in the study underwent OCT examination 6 months （17 patients） and 12 months （19 patients） after SES implantation, The strut apposition to the vessel wall and neointimal coverage on SES struts were evaluated by OCT, Results Forty-six SES and 6561 struts were analyzed, At 6 months, 3041 struts （98.7%） were well-apposed and 39 struts （1,3%） were malapposed, At 12 months, 3434 struts （98,6%） were well-apposed and 47 struts （1,4%） were malapposed, Furthermore, only 4 SES at 6 months （18,2%） and 10 SES at 12 months （41,7%） were fully covered by neointimal growth, The average neointimal thicknesses covering the analyzed struts at 6 months and 12 months were （42±28） μm and （88±32） μm, respectively, There were 1989 struts at 6 months （72,1%） and 1461 struts at 12 months （45,6%） with neointimal thickness 〈100 μm, Conclusions OCT was able to visualize the strut apposition to the vessel wall and neointimal coverage on SES struts, At 6-month and 12-month follow-up examinations most struts were covered with thin neointima, but few of the entire SES showed full coverage. To prevent late-stent thrombosis in the presence of uncovered stent struts, longer dual antiplatelet drugs therapy should be recommended,

关键词： optical coherence tomography sirolimus-eluting stents neointima intravascular ultrasound

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Up-grading of natural ilmenite ore by combining oxidation and acid leaching

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International Journal of Minerals,Metallurgy and Materials 2018年第7期25卷 729-736页

作者： takehito hiraki yuichi maruyama yuta suzuki satoshi itoh tetsuya nagasaka Department of Metallurgy Graduate School of EngineeringTohoku UniversitySendai 980-8579Japan Toho Titanium Co. Ltd.Kanagawa 253-8510Japan Fanuc Co. Ltd.Oshino-muraYamanashi 401-0511Japan Before retirement:Graduate School of Environmental Studies Tohoku UniversitySendai 980-8579Japan

Rutile （TiO2） is heavily used in pigments mid colormlts, mid the most abundmlt source of rutile is ilmeinte. Upon oxidation of ilmeinte, mtile cml be formed wiffl modest energy consumption; furfflermore, after leaching, only a few byproducts are formed. Unfortunate- ly, one drawback is file necessarily long oxidative process of typically used mefflods. In fflis study, we show fflat a fluidized bed reactor cml be used to oxidize ilmeinte ore to rapidly form ruffle mid pseudobrookite （Fe2TiOs） phases. Ilmeinte was oxidized wiffl 5vo1% 02 in Ar at temperatures of 1173 K or 1223 K mid subsequently leached using a diluted H2SO4 solution to dissolve file pseudobrookite phase. The effects of acid concentration, temperature, mid cooling rate after oxidation were investigated. We show fflat file ilmeinte was rapidly oxidized to form rutile mid pseudobrookite phases at 1173 mid 1223 K in a 5vo1% O2/95vo1% Ar environment wifflin 40 min. The fmal maximum mtile yield was 84.2mo1% after leaching in （1 ＋ 1） H2SO4 solution at 393 K for 12 h.

关键词： ilmenite oxidation fluidized bed reactor acid leaching rutile pseudobrookite

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Development of Helicobacter pylori treatment: How do we manage antimicrobial resistance?

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World Journal of Gastroenterology 2019年第16期25卷 1907-1912页

作者： Sho suzuki Mitsuru Esaki Chika Kusano Hisatomo Ikehara Takuji Gotoda Division of Gastroenterology and Hepatology Department of Medicine Nihon University School of Medicine

Helicobacter pylori(H. pylori) antimicrobial resistance is an urgent, global issue. In2017, the World Health Organization designated clarithromycin-resistant H.pylori as a high priority bacterium for antibiotic research and development. In addition to clarithromycin, resistance to metronidazole and fluoroquinolones has also increased worldwide. Recent international guidelines for management of H.pylori infection recommend bismuth or non-bismuth quadruple therapy for 14 d as a first-line treatment for H. pylori in areas of high clarithromycin and/or metronidazole resistance. Although these treatment regimens provide acceptable H. pylori eradication rates, the regimens used should not contribute to future resistance of H. pylori to antimicrobials. Moreover, these regimens can promote resistance, due to prolonged therapy with multiple antibiotics. A new strategy that can eradicate H. pylori as well as reduce the antibiotics used is required to prevent future antimicrobial resistance in H. pylori. Dual-therapy with vonoprazan and amoxicillin could be a breakthrough for H. pylori eradication in an era of growing antimicrobial resistance. This regimen may provide a satisfactory eradication rate of H. pylori and also minimize antimicrobial resistance due to single antibiotic use and the strong inhibitory effect of vonoprazan on gastric acid secretion.

关键词： Helicobacter pylori Antibiotic resistance Antimicrobial resistance Dual therapy Vonoprazan

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