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Update on quinolone-containing rescue therapies for Helicobacter pylori infection

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World Journal of Gastroenterology 2020年第15期26卷 1733-1744页

作者： Hideki Mori Hidekazu suzuki Department of Clinical and Experimental Medicine Translational Research Center for Gastrointestinal DisordersUniversity of LeuvenLeuven 3000Belgium Division of Gastroenterology and Hepatology Department of Internal MedicineTokai University School of MedicineIsehara 259-1193Japan

Third generation of quinolones,such as levofloxacin and moxifloxacin,-containing regimens are often used in second-line or rescue treatment of Helicobacter pylori infection.However,the increasing antibiotic resistance to quinolones affects the efficacies of quinolones-containing therapies in recent years.Therefore,there is a need to enhance the effectiveness of quinolonescontaining therapies.Sitafloxacin,a fourth-generation quinolone,and vonoprazan,a novel potassium-competitive acid blocker,are now available as more effective treatment options.The aim of this paper is to summarize the current evidence of quinolone-containing therapies in rescue treatments,and to discuss the importance of drug sensitivity tests or analysis of gyrA mutation before treatments.

关键词： Helicobacter pylori Levofloxacin Sitafloxacin Moxifloxacin gyrA Vonoprazan

Therapeutic potential of stem cells in subarachnoid hemorrhage

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Neural Regeneration Research 2025年第4期20卷 936-945页

作者： Hideki Kanamaru Hidenori suzuki Department of Neurosurgery Mie University Graduate School of MedicineTsuJapan

Aneurysm rupture can result in subarachnoid hemorrhage,a condition with potentially severe consequences,such as disability and death.In the acute stage,early brain injury manifests as intracranial pressure elevation,global cerebral ischemia,acute hydrocephalus,and direct blood–brain contact due to aneurysm rupture.This may subsequently cause delayed cerebral infarction,often with cerebral vasospasm,significantly affecting patient outcomes.Chronic complications such as brain volume loss and chronic hydrocephalus can further impact outcomes.Investigating the mechanisms of subarachnoid hemorrhage-induced brain injury is paramount for identifying effective treatments.Stem cell therapy,with its multipotent differentiation capacity and anti-inflammatory effects,has emerged as a promising approach for treating previously deemed incurable conditions.This review focuses on the potential application of stem cells in subarachnoid hemorrhage pathology and explores their role in neurogenesis and as a therapeutic intervention in preclinical and clinical subarachnoid hemorrhage studies.

关键词： delayed cerebral ischemia early brain injury matricellular protein neurogenesis stem cell therapy subarachnoid hemorrhage

Spatiotemporal changes in antlerless proportion of culled Sika deer in relation to deer density

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Journal of Forestry Research 2022年第3期33卷 1095-1101页

作者： Kei K.suzuki Teruki Oka Masatoshi Yasuda Kyushu Research Center Forestry and Forest Products Research InstituteKumamoto860-0862Japan Shikoku Research Center Forestry and Forest Products Research InstituteKochi780-8077Japan

Population management of herbivores is widely applied to decrease damage to forests in the northern hemisphere. Culling more antlerless deer, including females and fawns, is an effective means of reducing the population and helps to improve management efficiency. To increase the efficiency of antlerless-biased culling, we assessed the spatiotemporal distribution of the antlerless ratio in culled sika deer (Cervus nippon) in relation to population density. We hypothesized that the antlerless ratio is higher at the center of the distribution than at the margins of the deer’s range, because dispersal processes differ according to sex and age: Young male deer first disperse into an unoccupied area, and then males may become established in the new area for approximately 10–15 years before the number of females increases. A statistical model revealed spatiotemporal changes in the antlerless ratio of culled sika deer. The change in the ratio basically fit the density distribution of the deer, which was estimated independently on the basis of fecal pellet count surveys. The antlerless ratio estimated from the model increased asymptotically as deer density rose. The results support our hypothesis and suggest that antlerless sika deer will be more easily culled at the center rather than at the margins of the distribution range. These findings should help to increase the efficiency of managing the deer via antlerless-biased culling.

关键词： Antlerless Culling Density Distribution Large herbivore Wildlife management

Lessons from tenascin-C knockout mice and potential clinical application to subarachnoid hemorrhage

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Neural Regeneration Research 2019年第2期14卷 262-264页

作者： Masato Shiba Hidenori suzuki Department of Neurosurgery Mie University Graduate School of Medicine

Subarachnoid hemorrhage by a ruptured cerebral aneurysmremains the most devastating cerebrovascular disorderswith high morbidity and mortality (suzuki et al.,2017), which are mainly caused by early brain injury anddelayed cerebral ischemia. Despite many experimentaland clinical research efforts, the mechanisms of earlybrain injury as well as delayed cerebral ischemia remainunclarified. However, recent works have suggested thattenascin-C, which is a special type of secreted extracellularmatrix proteins, is promising as a novel therapeutictarget against post-subarachnoid hemorrhage early braininjury and delayed cerebral ischemia.

关键词： cerebral clinical ischemia hemorrhage

Influence of bile contamination for patients who undergo pancreaticoduodenectomy after biliary drainage

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World Journal of Gastroenterology 2019年第47期25卷 6847-6856页

作者： Keiichi Okano Yasuyuki suzuki Departments of Gastroenterological Surgery Kagawa University

BACKGROUND The influence of bile contamination on the infectious complications of patients undergoing pancreaticoduodenectomy(PD)has not been thoroughly evaluated.AIM To evaluate the effect of preoperative biliary drainage and bile contamination on the outcomes of patients who undergo PD.METHODS The database of 4101 patients who underwent PD was reviewed.Preoperative biliary drainage was performed in 1964 patients(47.9%),and bile contamination was confirmed in 606 patients(14.8%).RESULTS The incidence of postoperative infectious complications was 37.9%in patients with preoperative biliary drainage and 42.4%in patients with biliary contamination,respectively.Patients with extrahepatic bile duct carcinoma,ampulla of Vater carcinoma,and pancreatic carcinoma had a high frequency of preoperative biliary drainage(82.9%,54.6%,and 50.8%)and bile contamination(34.3%,26.2%,and 20.2%).Bile contamination was associated with postoperative pancreatic fistula(POPF)Grade B/C,wound infection,and catheter infection.A multivariate logistic regression analysis revealed that biliary contamination(odds ratio 1.33,P=0.027)was the independent risk factor for POPF Grade B/C.The three most commonly cultured microorganisms from bile(Enterococcus,Klebsiella,and Enterobacter)were identical to those isolated from organ spaces.CONCLUSION In patients undergoing PD,bile contamination is related to postoperative infectious complication including POPF Grade B/C.The management of biliary contamination should be standardised for patients who require preoperative biliary drainage for PD,as the main microorganisms are identical in both organ spaces and bile.

关键词： Bile contamination Complication Pancreaticoduodenectomy Preoperative biliary drainage Postoperative pancreatic fistula Grade B/C

Physical fitness before and during the COVID-19 pandemic:Results of annual national physical fitness surveillance among 16,647,699 Japanese children and adolescents between 2013 and 2021

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Journal of Sport and Health Science 2023年第2期12卷 246-254页

作者： Tetsuhiro Kidokoro Grant R.Tomkinson Justin JLang Koya suzuki Research Institute for Health and Sport Science Nippon Sport Science UniversityTokyo 158-8508Japan Graduate School of Health and Sports Science Juntendo UniversityInzai City 270-1695Japan Alliance for Research in Exercise Nutrition and Activity(ARENA)University of South AustraliaAdelaideSA 5000Australia Centre for Surveillance and Applied Research Public Health Agency of CanadaOttawaON K1A 0K9Canada School of Epidemiology and Public Health University of OttawaOttawaON K1H 8M5Canada Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada

Background:Limited nationally representative evidence is available on temporal trends in physical fitness(PF)for children and adolescents during the coronavirus disease 2019(COVID-19)pandemic.The primary aim was to examine the temporal trends in PF for Japanese children and adolescents before and during the COVID-19 pandemic.The secondary aim was to estimate the concurrent trends in body size(measured as body mass and height)and movement behaviors(exercise,screen,and sleep time).Methods:Census PF data for children in Grade 5(aged 10-11 years)and adolescents in Grade 8(aged 13-14 years)were obtained for the years 2013-2021 from the National Survey of Physical Fitness,Athletic Performance,and Exercise Habits in Japan(n=16,647,699).PF and body size were objectively measured,and movement behaviors were self-reported.Using sample-weighted linear regression,temporal trends in mean PF were calculated before the pandemic(2013-2019)and during the pandemic(2019-2021)with adjustments for age,sex,body size,and exercise time.Results:When adjusted for age,sex,body size,and exercise time,there were significant declines in PF during the pandemic,with the largest declines observed in 20-m shuttle run(standardized(Cohen’s)effect size(ES)=-0.109 per annum(p.a.))and sit-ups performance(ES=-0.133p.a.).The magnitude of the declines in 20-m shuttle run and sit-ups performances were 18-and 15-fold larger,respectively,than the improvements seen before the pandemic(2013-2019),after adjusting for age,sex,body size,and exercise time.During the pandemic,both body mass and screen time significantly increased,and exercise time decreased.Conclusion:Declines in 20-m shuttle run and sit-ups performances suggest corresponding declines in population health during the COVID-19pandemic.

关键词： Census Physical inactivity Public health Temporal trends Youth

Codiversification of gut microbiota with humans

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四川生理科学杂志 2022年第9期44卷 1660-1660页

作者： Taichi A suzuki Department of Microbiome Science Max Planck Institute for Biology Tübingen Germany Interfaculty Institute of Microbiology and Infection Medicine University of Tübingen Tübingen Germany Institute for Tropical Medicine University of Tübingen Tübingen Germany Centre de Recherches Médicales de Lambaréné Lambaréné Gabon German Center for Infection Research Tübingen Germany Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections University of Tübingen Tübingen Germany Vietnamese German Center for Medical Research Hanoi Vietnam Fondation pour la Recherche Scientifique Cotonou Bénin 108 Military Central Hospital Hanoi Vietnam Department of Twin Research and Genetic Epidemiology King’s College London London UK Department of Ecology Evolution and Behavior University of Minnesota Minneapolis MN USA Eco-anthropologie Muséum National d’Histoire Naturelle CNRS Université de Paris Paris France Department of Environmental Health Sciences Graduate School of Public Health Seoul National University Seoul Republic of Korea Department of Genetics Cell Biology and Development University of Minnesota Minneapolis MN USA Laboratoire de Biométrie et Biologie Evolutive CNRS Université Lyon 1 Villeurbanne France.

The gut microbiomes of human populations worldwide have many core microbial species in common.However,within a species,some strains can show remarkable population specificity.The question is whether such specificity arises from a shared evolutionary history(codiversification)between humans and their microbes.To test for codiversification of host and microbiota,we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe,Asia,and Africa,including mothers and their children.Between and within countries,a parallel evolutionary history was evident for humans and their gut microbes.Moreover,species displaying the strongest codiversification independently evolved traits characteristic of host dependency,including reduced genomes and oxygen and temperature sensitivity.These findings all point to the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease phenotypes.

关键词： specificity mother gut

A contract theory analysis to fiscal relations between the central and local governments in China

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Economic and Political Studies 2019年第3期7卷 281-313页

作者： Yutaka suzuki Faculty of Economics Hosei UniversityTokyoJapan

We use a contract theory/mechanism design framework to analyse the fiscal relations and reforms between the central and local governments in China,which are said to have made great contributions to economic growth since the‘economic reform’.First,we present the mechanism(a fiscal incentive contract model),which has created incentives for the development agent(local government),and clarify theoretically how the concept of bao(contract)works.We then comprehend the concept of bisai(contest)within the framework of the yardstick competition between local governments,and review the mechanism which encourages proper information revelation through intergovernmental comparison and competition.Lastly,we make a theoretical comparative analysis on the fiscal system reform(from the fiscal contracting system to the tax sharing system),from the perspective of how much room was left for the‘ratchet effect’in the dynamic relation between the central and local governments,and how it was solved(or mitigated)in the two fiscal systems.

关键词： Fiscal contracting tax sharing adverse selection mechanism design yardstick competition ratchet effect

Implications of periostin in the development of subarachnoid hemorrhage-induced brain injuries

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Neural Regeneration Research 2017年第12期12卷 1982-1984页

作者： Hirofumi Nishikawa Hidenori suzuki Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan

Target of research in subarachnoid hemorrhage（SAH）：The outcome of aneurysmal SAH remains poor despite advances in the diagnosis and treatment.Although many factors related to patients,aneurysms,and institutions,as ... 详细信息

关键词： Implications of periostin the development subarachnoid hemorrhage-induced brain injuries