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Bifidobacteria Upregulate Expression of Toll-Like Receptor Negative Regulators Counteracting Enterotoxigenic <i>Escherichia coli</i>Mediated Inflammation in Bovine Intestinal Epitheliocytes

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Open Journal of Veterinary Medicine 2013年第2期3卷 143-155页

作者： Kozue Murata Julio Villena Yohsuke Tomosada Risa Hara Eriko Chiba Tomoyuki Shimazu Hisashi Aso Yoshihito Suda noriyuki iwabuchi Jin-Zhong Xiao Tadao Saito Haruki Kitazawa Food and Feed Immunology Group Laboratory of Animal Products Chemistry Graduate School of Agricultural Science Tohoku University Sendai Japan

We previously established a bovine intestinal epithelial cell line (BIE cells) and showed that BIE cells are useful in vitro model system for the study of interactions between pathogenic and beneficial microorganisms and bovine intestinal epithelial cells (IECs). In the present study, we aimed to select potential immunomodulatory bifidobacteria that may be used to beneficially modulate the inflammatory response in bovine IECs. We also aimed to gain insight into the molecular mechanisms involved in the anti-inflammatory effect of bifidobacteria by evaluating the role of Toll-like receptor (TLR)-2 and TLR negative regulators in the regulation of proinflammatory cytokines production and MAPK, NF-κB and PI3K pathways activation in BIE cells. Five bifidobacteria strains were evaluated in this study and according to their capacity to modulate the inflammatory response of BIE cells. Despite the unique effect of each strain, four common points were found when comparing the effect of the high and moderate anti-inflammatory strains: 1) Upregulation of TLR negative regulators and the intensity of that upregulation was related to the different immunomodulatory capacity of each bifidobacteria strain;2) The balance between MAPK activation and MKP-1 upregulation affected the anti-inflammatory effect of bifidobacteria in BIE cells;3) The inhibition of PI3K pathway was related to the anti-inflammatory effect of bifidobacteria;4) The immunoregulatory effect of bifidobacteria in BIE cells is partially dependent on TLR2. This study shows that BIE cells can be used for the selection of immunoregulatory bifidobacteria and for studying the mechanisms involved in the protective activity of immunobiotics against TLR4-induced inflammatory damage. In addition, we have demonstrated that the anti-inflammatory effect of bifidobacteria was achieved by a complex interaction of multiple TLRs negative regulators as well as the inhibition/activation of multiple signaling pathways.

关键词： Bovine Intestinal Epithelial Cells Bifidobacteria ETEC TLRs Negative Regulators

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Gastrointestinal polyposis with esophageal polyposis is useful for early diagnosis of Cowden's disease

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World Journal of Gastroenterology 2008年第37期14卷 5755-5759页

作者： Ken Umemura Sho Takagi Yasushi Ishigaki Masahiro iwabuchi Shigeru Kuroki Yoshitaka Kinouchi Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of MedicineSendai 980-8574 Japan Division of Molecular Metabolism and Diabetes Tohoku University Graduate School of MedicineSendai 980-8574 Japan Department of Gastroenterology Sendai Medical CenterSendai 980-8574 Japan Department of Dermatology Kurihara Central HospitalKurihara 228-0014 Japan

Cowden's disease, one of the several hamartoma syndromes, is characterized by hyperplastic lesions and hamartomas distributed in the whole body. About thirty percent of patients with Cowden's disease have been reported to be complicated by malignant tumors. Based on the criteria of the International Cowden Consortium, this disease is mainly diagnosed as trichilemmoma of the face and oral mucosal papillomatosis. However, Cowden's disease patients themselves often do not recognize trichilemmoma of the face and oral mucosal papillomatosis. We report a case of Cowden's disease in a 33-year-old female patient who was diagnosed based on the characteristic findings at gastrointestinal endoscopy. Clinically, the patient was aware of having bloody stools. Multiple polyps found endoscopically in the esophagus, stomach, ileum, colon and rectum showed histopathologically hamartomatous changes and epithelial hyperplasia. Physical examination revealed oral papillomatosis and facial trichilemmomas. A germline mutation in exon 8 of the phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene was found in this case. It was a point mutation of C to T at codon 1003 (CGA→TGA, arginine→stop codon). The characteristic findings on gastrointestinal endoscopy led us to a diagnosis of Cowden's disease. It has been reported that gastrointestinal polyposis with esophageal polyposis is found in about 85.7% of Japanese patients with Cowden's disease. The characteristic findings on gastrointestinal endoscopy can be a useful diagnostic clue to Cowden's disease.

关键词： Cowden's disease Gastrointestinal polyposis PTEN Early diagnosis Hamartoma

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Flexible electricity price forecasting by switching mother wavelets based onwavelet transform and Long Short-Term Memory

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Energy and AI 2022年第4期10卷 95-102页

作者： Koki iwabuchi Kenshiro Kato Daichi Watari Ittetsu Taniguchi Francky Catthoor Elham Shirazi Takao Onoye Osaka University 1-5 YamadaokaSuitaOsaka 565-0871Japan imec Kapeldeef 753001 HeverleeBelgium ESAT KULeuvenKasteelpark Arenberg 103001 HeverleeBelgium EnergyVille Dennenstraat 7B-3600 GenkBelgium University of Twente Enschede7500 AENetherlands

Under dynamic pricing, stable and accurate electricity price forecasting on the demand side is essential forefficient energy management. We have developed a new electricity price forecasting model that providesconsistently accurate forecasts. The base prediction model decomposes the time series using wavelet transformand then predicts it by Long Short-Term Memory. Previous studies using this model have always decomposedtime series in the same way without changing the mother wavelet. However, this makes it difficult to respond tochanges in time series that vary daily or seasonally. Therefore, we periodically switch the mother wavelet, i.e.,flexibly change the time series decomposition method, to achieve stable and highly accurate electricity priceforecasting. In an experiment, the model improved prediction accuracy by up to 42.8% compared to predictionwith a fixed mother wavelet. Experimental results show that the proposed flexible forecasting method canconsistently provide highly accurate forecasts.

关键词： Dynamic pricing Electricity price forecast Wavelet transform Long Short-Term Memory neural network

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Interplay of neuropilin-1 and semaphorin 3A after partial hepatectomy in rats

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World Journal of Gastroenterology 2012年第36期18卷 5034-5041页

作者： Ling Fu Tsuneo Kitamura Kazuhisa iwabuchi Syozo Ichinose Mitsuaki Yanagida Hideoki Ogawa Sumio Watanabe Toshihide Maruyama Masafumi Suyama Kenji Takamori Institute for Environmental and Gender Specific Medicine Juntendo University Graduate School of Medicine Urayasu 279-0021 Japan Department of Gastroenterology Juntendo University Urayasu Hospital Urayasu 279-0021 Japan Department of Gastroenterology Juntendo University School of Medicine Tokyo 113-8421 Japan

AIM： To elucidate the role of neuropilin-1 （Nrp-1） and semaphorin 3A （Sema3A） in sinusoidal remodeling dur- ing liver regeneration in rats. METHODS： Male Wistar/ST rats at 7 wk of age, weigh- ing about 200 g, were used for all animal experiments. In vivo, at 24, 48, 72, 96, 144 and 192 h after two- thirds partial hepatectomy （PHx）, the remnant livers were removed. Liver tissues were immunohistochemi- cally stained for Nrp-1, Sema3A and SE-1, a liver sinu- soidal endothelial cell （SEC） marker. Total RNA of the liver tissue was extracted and reversely transcribed into cDNA. The mRNA expression of Sema3A was ana- lyzed by quantitative real-time polymerase chain reac- tion and normalized to that of ribosomal protein $18. In vitro, SECs were isolated from rat liver and cultured in endothelial growth medium containing 20 ng/mL vascular endothelial cell growth factor. Migration of SECs in primary culture was assessed by cell transwell assay with or without recombinant Sema3A. Apoptotic cells were determined by a terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling method. RESULTS： In vitro, immunohistochemistry study re- vealed that Sema3A and Nrp-1 were constitutively ex- pressed in hepatocytes and SECs, respectively, in normal rat liver tissues. Nrp-1 expression in SECs was quantified by the percentage of immunostained area with anti- Nrp-1 antibody in relation to the area stained with SE-1. Between 24 h and 96 h following resection of liver, Nrp-1 expression in SECs was transiently increased. Compared with the baseline （5.2% ± 0.1%）, Nrp-1 expression in SECs significantly increased at 24 h （17.3% ± 0.7%, P 〈 0.05）, 48 h （39.1% ± 0.6%, P 〈 0.01）, 72 h （46.9% ± 4.5%, P 〈 0.01） and 96 h （29.9% ±3.8%, P 〈 0.01） after PHx, then returned to the basal level at termination of liver regeneration. Interestingly, the expression of Sema3A was inversely associated with that of Nrp-1 in liver after PHx. Sema3A mRNA expres- sion was significantly

关键词： Neuropilin-1 Semaphorin 3A Sinusoidal re-modeling Liver regeneration Two-thirds partial hepa-tectomy Angiogenesis Liver sinusoidal endothelial cells

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Self-consistent Microscopic Description of Charging Effect on Phase Coherence

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兰州交通大学学报 2007年第6期26卷 149-150页

作者： iwabuchi Shuichi Wang Yang Department of Physics Nara Womens University Kitauoya-Nishimachi Nara 630-8506 Japan Key Laboratory of Opto-Electric Technology and Intelligent Control Ministry of Education Lanzhou Jiaotong University Lanzhou 730070 China

Introduction Recently there have been extensive studies in quantum computing,which is a new interdisciplinary field of device physics,information science and fundamental *** computing process is nothing but

关键词：相位相干性一致性显微描述量子论哈密尔敦函数

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13Cr-4Ni型铸钢的回火脆化现象

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大型铸锻件 1988年第2期 81-88页

作者： Yoshitaka iwabuchi 慷为 JSW室兰工厂

本文研究了13Cr-4Ni型马氏体不锈钢中因回火脆化而导致的韧性下降的机理。韧性的变化、脆断的模式以及残留奥氏体的份额均被作为回火温度和550～450℃范围中的随后等温处理的函数而进行了考察。在较低的温度下回火和在较高的温度下进行... 详细信息

本文研究了13Cr-4Ni型马氏体不锈钢中因回火脆化而导致的韧性下降的机理。韧性的变化、脆断的模式以及残留奥氏体的份额均被作为回火温度和550～450℃范围中的随后等温处理的函数而进行了考察。在较低的温度下回火和在较高的温度下进行随后等温处理之后,FATT的提高和晶间断裂在份额上的增加,被认为是回火脆化现象。业已发现,脆化及晶间断裂,与沿原始奥氏体晶界上的碳化物沉淀有关。脆化的程度,实质上与原始奥氏体晶界上的磷的偏析无关。晶间碳化物的沉淀,源自回火期间逆变奥氏体中碳的溶解度降低。随着回火温度的升高,该钢种的回火脆化敏感性受到了抑制。

关键词：回火脆化碳化物沉淀奥氏体晶界回火温度铸钢马氏体不锈钢晶间断裂等温处理

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柴油机新型燃烧系统的研究——预混合压缩着火燃烧

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汽车与新动力 2002年第6期34卷 43-50页

作者： Yoshinori iwabuchi Kenji Kawai Takeshi Shoji 姬芬竹

研究了一种高效低排放的稀混合燃烧——预混合压缩着火（PCI）燃烧系统,阐述了其优点及存在的问题。在PCI燃烧系统中,早在压缩行程就将燃油喷入燃烧室,经过较长时间的混合形成预混合稀混合气。试验发动机就由这种预混合的稀混合气自行... 详细信息

研究了一种高效低排放的稀混合燃烧——预混合压缩着火（PCI）燃烧系统,阐述了其优点及存在的问题。在PCI燃烧系统中,早在压缩行程就将燃油喷入燃烧室,经过较长时间的混合形成预混合稀混合气。试验发动机就由这种预混合的稀混合气自行着火燃烧而工作,从对燃烧的观察和数值模拟的结果可见,有必要防止油束附着在气缸壁和燃烧室壁上。因此,制造了低贯穿距的冲击-雾化油嘴并进行了试验。结果表明,可以实现很低的NOx排放,燃油耗却增加很少,同时也发现PCI燃烧的发动机工作范围限制在部分负荷工况内,并引起HC排放增加。然而,由于它能获得放热等容度高的燃烧特性,因此,PCI燃烧系统可能代表着比传统柴油机更有效、更清洁的燃烧系统（超低NOx和低烟度）。

关键词：柴油机燃烧系统研究

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Analysis of Serum Antibody Level after COVID-19 Vaccine and Side Effects after Vaccine

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Advances in Infectious Diseases 2023年第2期13卷 249-262页

作者： Hiromi Nagashima Shinji Chiba Shinnosuke Oura Itaru Fujimura Masachika Akiyama Yu Utsumi Hironori Sakai Wataru Hojo Takuya iwabuchi Makoto Maemondo Department of Internal Medicine Division of Pulmonary Medicine Iwate Medical University Yahaba Japan R&D Cellspect Co. Ltd. Morioka Japan Department of Medicine Division of Pulmonary Medicine Jichi Medical University Shimotsuke Japan

Background: COVID-19 has caused a large number of deaths, in the elderly. In this situation, vaccines have been considered the main strategy to combat COVID-19 and were developed worldwide in 2020. One problem with COVID-19 vaccination is side effects after vaccination. In this report, we identify the relationship between side effects and elevation of antibodies as determined by monitoring several kinds of antibodies against COVID-19. Objective: We investigated whether the antibody level changed depending on side effects after COVID-19 vaccination. Methods: Healthy volunteers, who received two vaccinations between 10 March and 7 May 2021, were collected for this study. Information including age, gender, smoking history, medical history including allergies and side reactions after vaccination was obtained by questionnaire. Serum levels of antibodies of IgG and IgM against each S1, SP, and NP antigens of COVID-19 were evaluated frequently for 3 - 4 months after the first vaccination. Result: Ten employees working at Iwate Medical University were evaluated in this study. Side effects were observed in 7 of 10 patients, and grade 2 side effects in all 3 patients with a history of allergic disease. Serum S1 and SP IgG were elevated sufficiently in all patients. In all patients, IgG antibody titers fell below the cutoff point in approximately 3 months. No cases had elevated NP antibodies. SP IgM was elevated in three cases;all three cases with elevated IgM had allergic disease and the degree of side effects was relatively higher. Subjects with long-lasting elevated SPIgM were observed. Conclusion: S1 IgG and SP IgG exceeded the cutoff in all subjects after vaccination but decreased below the cutoff in all subjects within 4 months, regardless of side effects or allergic history. On the other hand, elevated SPIgM was suspected to be related to side effects and history of allergies, and cases with persistent elevation of SPIgM were observed.

关键词： COVID-19 Vaccination History of Allergic Disease Side Effect S1 IgG SP IgG SP IgM

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Anterior mediastinal abscess diagnosed in a young sumo wrestler after closed blunt chest trauma

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Chinese Journal of Traumatology 2015年第6期18卷 360-362页

作者： Tatsuro Sassa Ken-ichiro Kobayashi Masayuki Ota Takuya Washino Mayu Hikone Naoya Sakamoto Sentaro iwabuchi Mizuto Otsuji Kenji Ohnishi Department of Infectious Disease Tokyo Metropolitan Bokutoh General Hospital 4-23-15 kohtohbashi Sumida City Tokyo 130-0022 Japan

Most mediastinal abscesses result from infections after thoracotomy, esophageal perforation or pene- trating chest trauma. This disease is rarely caused by closed blunt chest trauma. All previously reported such cases after closed blunt chest trauma presented with hematoma and sternal osteomyelitis resulting from sternal fracture. Here we report a 15-year-old sumo wrestler who presented with an anterior mediastinal abscess without any mediastinal fracture. The mediastinal abscess resulted from the he- matogenous spread of Staphylococcus aureus to a hematoma that might have been caused by a closed blunt chest trauma incurred during sumo wrestling exercises.

关键词： Mediastinal abscess Staphylococcus aureus Sumo wrestler Chest trauma

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空心阴极气流溅射法快速沉积具有高活性光催化作用的TiO_2薄膜(下)

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太阳能 2014年第10期 10-11页

作者：范崇治 Yoshiyuki Kubo Yoshinori iwabuchi Masato Yoshikawa 清华大学

图4a和4b分别为在UV-近红外光谱，刚沉积和经后退火工艺两种情况下的TiO2膜。以上两种情况在可见光区域透射比几乎相同，与后退火无关。O2流量为10～50sccm时，沉积的TiO2膜在可见光区域具有的高透射比约为0．70。

关键词： TiO2薄膜快速沉积光催化作用空心阴极高活性溅射法 TiO2膜后退火工艺

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