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Cancer-associated fibroblasts in hepatocellular carcinoma

World Journal of Gastroenterology 2016年第30期22卷 6841-6850页

作者： norio kubo Kenichiro Araki Hiroyuki Kuwano Ken Shirabe Department of Hepatobiliary and Pancreatic Surgery Gunma University Graduate School of Medicine Department of General Surgical Science Gunma University Graduate School of Medicine

The hepatic stellate cells in the liver are stimulated sustainably by chronic injury of the hepatocytes, activating myofibroblasts, which produce abundant collagen. Myofibroblasts are the major source of extracellular proteins during fibrogenesis, and may directly, or secreted products, contribute to carcinogenesis and tumor progression. Cancer-associated fibroblasts(CAFs) are one of the components of the tumor microenvironment that promote the proliferation and invasion of cancer cells by secreting various growth factors and cytokines. CAFs crosstalk with cancer cells stimulates tumor progression by creating a favorable microenvironment for progression, invasion, and metastasis through the epithelial-mesenchymal transition. Basic studies on CAFs have advanced, and the role of CAFs in tumors has been elucidated. In particular, for hepatocellular carcinoma, carcinogenesis from cirrhosis is a known fact, and participation of CAFs in carcinogenesis is supported. In this review, we discuss the current literature on the role of CAFs and CAF-related signaling in carcinogenesis, crosstalk with cancer cells, immunosuppressive effects, angiogenesis, therapeutic targets, and resistance to chemotherapy. The role of CAFs is important in cancer initiation and progression. CAF-targeted therapy may be effective for suppression not only of fibrosis but also cancer progression.

关键词： Cancer associated fibroblast Hepatic stellate cell Hepatocellular carcinoma Immunosuppression Therap

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中日将在新概念的SoC测试中展开新的合作(英文)

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电子工业专用设备 2004年第11期33卷 4-8页

作者： norio kubo Yokogawa Electric Corporation 2-9-32 NakachoMusashino-shiTokyo180-8750 Japan.

1 PrefaceChina is becoming one of the leading semiconductor supply hubs in the world. In digital consumer electronics it is a world leader, and so it is crucial to improve the productivity of System-On-Chips (SoC),which are at the heart of digital consumer *** boost productivity, testing is critical. Today, we would like to propose a new concept of SoC testing for a new partnership between China and Japan. We wish to develop our partnership for SoC design and manufacturing by sharing roles appropriately.

关键词：中日新概念展开 SoC测试

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Xanthogranulomatous cholecystitis:Difficulty in differentiating from gallbladder cancer

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World Journal of Gastroenterology 2015年第35期21卷 10166-10173页

作者： Hideki Suzuki Satoshi Wada Kenichiro Araki norio kubo Akira Watanabe Mariko Tsukagoshi Hiroyuki Kuwano Department of General Surgical Science (Surgery I) Gunma University Graduate School of Medicine Gunma University

AIM: To compare cases of xanthogranulomatous cholecystitis(XGC) and advanced gallbladder cancer and discuss the differential diagnoses and surgical ***: From April 2000 to December 2013, 6 XGC patients received extended surgical resections. During the same period, 16 patients were proven to have gallbladder(GB) cancer, according to extended surgical resection. Subjects chosen for analysis in this study were restricted to cases of XGC with indistinct borders with the liver as it is often difficult to distinguish these patients from those with advanced GB cancer. We compared the clinical features and computed tomography findings between XGC and advanced GB cancer. The following clinical features were retrospectively assessed: age, gender, symptoms, and tumor markers. As albumin and the neutrophil/lymphocyte ratio(NLR) are prognostic in several cancers, we compared serum albumin levels and the NLR between the two groups. The computerized tomography findings were used to compare the two diseases, determine the coexistence of gallstones, the pattern of GB thickening(focal or diffuse), the presence of a hypoattenuated intramural nodule, and continuity of the mucosal ***: Based on the preoperative image findings, we suspected GB carcinoma in all cases includingXGC in this series. In addition, by pathological examination, we found that the group of patients with XGC developed inflammatory disease after surgery. Patients with XGC tended to have abdominal pain(4/6, 67%). However, there was no significant difference in clinical symptoms, including fever, between the two groups. Serum albumin and NLR were also similar in the two groups. Serum tumor markers, such as carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9), tended to increase in patients with GB cancer. However, no significant differences in tumor markers were identified. On the other hand, gallstones were more frequently observed in patients with XGC(5/6, 83%) than in patients wit

关键词： Xanthogranulomatous cholecystitis Advanced gallbla

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Reconstruction of the hepatic artery with the middle colic artery is feasible in distal pancreatectomy with celiac axis resection: A case report

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World Journal of Gastrointestinal Surgery 2013年第7期5卷 224-228页

作者： Hideki Suzuki Yasuo Hosouchi Shigeru Sasaki Kenichiro Araki norio kubo Akira Watanabe Hiroyuki Kuwano Department of General Surgical Science (SurgeryⅠ) Gunma University Graduate School of MedicineMaebashi 371-8511 Japan

Despite the advance of diagnostic modalities, carcinoma in the body and tail of the pancreas are commonly presented at a late stage. With unresectable lesions, long-term survival is extremely rare, and surgery remains the only curative option for pancreatic cancer. An aggressive approach by applying extended distal pancreatectomy with the resection of the celiac axis may increase the resectability and analgesic effect but great care must be taken with the arterial blood supply to the liver and stomach. Sometimes, accidental injury to the pancreatoduodenal artery compromises collateral blood flow and leads to fatal complications. Therefore, knowledge of any alternative restoration of the compromised collateral flow before surgery is essential. The present case report shows a patient with a pancreatic body cancer in whom the splenic, celiac, and common hepatic arteries were involved with the tumor, which extended almost to the root of the gastroduodenal artery. We modified the procedure by reanastomosis between the proper hepatic artery and middle colic artery without vascular graft. The postoperative course was uneventful, and the patient was discharged on post-operative day 19. The patient was immediately free of epigastric and back pain.

关键词： Pancreatic body-tail cancer Celiac artery resection Arterial reconstruction

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