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Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury

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Neural Regeneration Research 2019年第11期14卷 1961-1967页

作者： norio tanabe Tomoharu Kuboyama Chihiro Tohda Division of Neuromedical Science Institute of Natural Medicine University of Toyama

In chronic phase of spinal cord injury, functional recovery is more untreatable compared with early intervention in acute phase of spinal cord injury. In the last decade, several combination therapies successfully improved motor dysfunction in chronic spinal cord injury. However, their effectiveness is not sufficient. We previously found a new effective compound for spinal cord injury, matrine, which induced axonal growth and functional recovery in acute spinal cord injury mice via direct activation of extracellular heat shock protein 90. Although our previous study clarified that matrine was an activator of extracellular heat shock protein 90, the potential of matrine for spinal cord injury in chronic phase has not been sufficiently evaluated. Thus, this study aimed to investigate whether matrine ameliorates chronic spinal cord injury in mice. Once daily intragastric administration of matrine(100 μmol/kg per day) to spinal cord injury mice were starte at 28 days after injury, and continued for 154 days. Continuous mat rine treatment improved hindlimb motor function in chronic spinal cord injury mice. In injured spinal cords of the matrine-treated mice, the density of neurofilament-H-positive axons was increased. Moreover, matrine treatment increased the density of bassoon-positive presynapses in contact with choline acetyltransferase-positive motor neurons in the lumbar spinal cord. These findings suggest that matrine promotes remodeling and reconnection of neural circuits to regulate hindlimb movement. All protocols were approved by the Committee for Animal Care and Use of the Sugitani Campus of the University of Toyama(approval No. A2013 INM-1 and A2016 INM-3) on May 7, 2013 and May 17, 2016, respectively.

关键词： matrine chronic spinal cord injury axonal growth synaptogenesis hindlimb locomotor presynapse immunohistochemistry Basso Mouse Scale Body Support Score Sophora flavescens

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Study on the flow structure around discontinued vertically layered vegetation in an open channel

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Journal of Hydrodynamics 2020年第3期32卷 454-467页

作者： Naveed Anjum norio Tanakia Graduate School of Science and Engineering Saitama UniversitySaitama-shiJapan International Institute for Resilient Society Saitama UniversitySaitama-shiJapan

The flow structure and geomorphology of rivers are significantly affected by vegetation patterns. In the present study, the effect of vegetation in the form of discontinuous and vertically double layered patches particularly on the resulting flow turbulence was examined computationally in an open channel. A k-ɛ model was implemented in this research work which was developed using 3-D numerical code FLUENT (ANSYS). After the validation process of numerical model, the impact of discontinuous layered vegetation patches on the flow turbulence was investigated against varying vegetation density and patch length. The mean stream-wise velocities at specified positions showed larger spatial fluctuations directly upstream and downstream of vegetation elements, whereas sharp inflections in the profiles were witnessed at the top of smaller submerged elements i.e. z/hs= 1 (where z is the flow depth and hs is the smaller vegetation height). The reduction in flow velocity due to tall vegetation structure was more as compared with that of short vegetation. The mean velocity in the patch regions was visibly higher than that in the gap regions. The profiles of turbulent flow properties showed more rise and fall within the patches with a high vegetation density i.e. Ss/d= 4;and St/d= 8 (where Ss/d and St/d are the smaller and taller vegetation spacing, while d is the vegetation diameter) as compared with low vegetation density i.e. Ss/d= 8;and St/d= 16. The turbulent flow structure in the large patch and gap regions was found to be more stable than that in the small patches and gaps;whereas, due to the variation in distribution form of the patch, turbulence is relatively unaffected, and the flow structure variation is low. Turbulence was observed to be large, followed by a saw-tooth distribution within the patches;whereas, low turbulence is observed in the non-vegetation regions. The turbulent intensity acquired maximum of 13% turbulence for dense vegetation arrangement as compared t

关键词： Discontinuous and layered vegetation patches open channel flow numerical simulation mean flow velocity turbulence modeling flow characteristics

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Adaptive Process for SMART Community Governance under Persistent Disruptive Risks

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International Journal of Disaster Risk Science 2018年第4期9卷 454-463页

作者： norio Okada Institute of Disaster Area Revitalization Regrowth and Governance Kwansei Gakuin University

This article addresses the increasing need for participatory approaches to disaster reduction at the community level. Based on the author's 30-year engagement in the mountainous community Chizu Town, Tottori Prefecture, Japan, a unique participatory approach called ‘‘Zeroto-One Movement'' has been strategically studied. The study areas are found to have adaptively increased their coping capacity. Their unique participatory process is shown to be an adaptive process for SMART community governance under persistent disruptive risks—‘‘S'' represents small-sized and survivability-minded, ‘‘M'' modestscale and multiple-stakeholder involved, ‘‘A'' anticipatory and adaptive, ‘‘R'' risk-concerned and responsive, and ‘‘T''is transformative. Finally, the Case Station-Field Campus scheme is proposed to serve as a platform for studying the adaptive processes over a long period of time.

关键词： Case Station-Field Campus scheme Japan Persistent disruptive risks SMART governance Zero-to-One movement

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Numerical investigation of velocity distribution of turbulent flow through vertically double-layered vegetation

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Water Science and Engineering 2019年第4期12卷 319-329页

作者： Naveed Anjum norio Tanaka Graduate School of Science and Engineering Saitama UniversitySaitama 338-8570Japan International Institute for Resilient Society Saitama UniversitySaitama 338-8570Japan

The velocity structures of flow through vertically double-layered vegetation(VDLV)as well as single-layered rigid vegetation(SLV)were investigated computationally with a three-dimensional(3D)Reynolds stress turbulence model,using the computational fluid dynamics(CFD)code *** detailed velocity distribution was explored with a varying initial Froude number(Fr),with consideration of the steady subcritical flow conditions of an inland *** VDLV flows,the numerical model successfully captured the inflection point in the profiles of mean streamwise velocities in the mixing-layer region around the top of short submerged *** upward and downward movement of flow occurred at the positions located just behind the tall and short vegetation,***,higher streamwise velocities were observed in the upper vegetation layer due to high porosity,with Pr=98%(sparse vegetation,where Pr is the porosity),as compared to those in the lower vegetation layer,which had comparatively low porosity,with Pr=91%(dense vegetation).A rising trend of velocities was found as the flow passed through the vegetation region,followed by a clear sawtooth distribution,as compared to the regions just upstream and downstream of vegetation where the flow was almost *** VDLV flows,a rising trend in the flow resistance was observed with the increase in the initial Froude number,i.e.,Fr?0.67,0.70,and ***,the flow resistance in the case of SLV was relatively very *** numerical results also show the flow structures within the vicinity of short and tall vegetation,which are difficult to attain through experimental measurements.

关键词： Vertically double-layered vegetation Single-layered rigid vegetation Numerical modeling FLUENT Velocity distribution Turbulent flow

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Origins of building blocks of life: A review

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Geoscience Frontiers 2018年第4期9卷 1117-1153页

作者： norio Kitadai Shigenori Maruyama Earth-Life Science Institute Tokyo Institute of Technology

How and where did life on Earth originate？ To date, various environments have been proposed as plausible sites for the origin of life. However, discussions have focused on a limited stage of chemical evolution, or emergence of a specific chemical function of proto-biological systems. It remains unclear what geochemical situations could drive all the stages of chemical evolution, ranging from condensation of simple inorganic compounds to the emergence of self-sustaining systems that were evolvable into modern biological ones. In this review, we summarize reported experimental and theoretical findings for prebiotic chemistry relevant to this topic, including availability of biologically essential elements（N and P） on the Hadean Earth, abiotic synthesis of life＇s building blocks（amino acids, peptides, ribose, nucleobases, fatty acids, nucleotides, and oligonucleotides）, their polymerizations to bio-macromolecules（peptides and oligonucleotides）, and emergence of biological functions of replication and compartmentalization. It is indicated from the overviews that completion of the chemical evolution requires at least eight reaction conditions of（1） reductive gas phase,（2） alkaline pH,（3） freezing temperature,（4）fresh water,（5） dry/dry-wet cycle,（6） coupling with high energy reactions,（7） heating-cooling cycle in water, and（8） extraterrestrial input of life＇s building blocks and reactive nutrients. The necessity of these mutually exclusive conditions clearly indicates that life＇s origin did not occur at a single setting; rather, it required highly diverse and dynamic environments that were connected with each other to allow intratransportation of reaction products and reactants through fluid circulation. Future experimental research that mimics the conditions of the proposed model are expected to provide further constraints on the processes and mechanisms for the origin of life.

关键词： Astrobiology Biochemistry Chemical evolution Extraterrestrial life Hadean Earth Hydrothermal systems

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DISTRIBUTED WATER BALANCE WITH RIVER DYNAMIC-DIFFUSIVE FLOW ROUTING MODEL

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Journal of Hydrodynamics 2009年第4期21卷 564-572页

作者： HASSAN Ahmed norio Tanaka NOBUYUKI Tamai Graduate School of Science and Engineering Saitama University Graduate School Kanazawa Gakuin University

This article focuses on the application of coupling both river dynamic and river diffusive modeling techniques that can be used with distributed water balance model. In an upstream watershed, both overland and river diffusive flows are routed by diffusive wave approximation of the free surface flow equations. In river downstream reaches, the river dynamic flow is routed by one-dimensional dynamic wave equations （full dynamic St. Venant equations with lateral flow）. The developed model is applied in a part of Arakawa River basin, Kanto area, Japan. The geographic data of river cross sections could be accurately represented by an 11-point cross-section approximation. The effects of both the grid size and lateral flow on the simulated results of the river dynamic flow model were studied. The grid size should be greater than the average width of the river cross-sections. The lateral flow from small drainage systems has significant effects on the simulated results using the river dynamic flow model. The simulated results show good and acceptable agreements with the observed flow discharges and water depths. Both the river discharge and water depth at any location of river network of compound channels with one/two complex floodplains could be correctly estimated.

关键词： diffusive model dynamic model natural compound channels floodplains

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EFFECTS OF UNDERSCOUR DEPTH AND HORIZONTAL SPACING BETWEEN TWO BED PROTECTION BLOCKS ON STABILITY OF FRONTAL BLOCK

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Journal of Hydrodynamics 2012年第4期24卷 579-588页

作者： SHAH Prem TANAKA norio YAGISAWA Junji Graduate School of Science and Engineering Saitama University Sakura-ku Saitama-shi Saitama Japan

The stability of a river-bed protection block in a flood event is affected by underscouring of the block. The effects of block spacing on block stability were investigated in different underscour conditions. Three blocks were placed at the bottom in a flume, and the underscour depth of the frontal block and distance between the first and second blocks were changed. Drag and lift forces were measured directly in each experimental condition. Particle Image Velocimetry （PIV） was used to visualize the flow and eva- luate the streamline pattern. Pressure measurements around the block to understand the pressure distribution show that the pressure distribution on the rear and bottom surfaces of the block is significantly affected by changes in block spacing and underscour depth. The experimental results show that for the same underscour gap, lift, and drag coefficients decreased with increasing space between the two blocks. In addition, if the underscour gap is increased with the same horizontal spacing, the lift coefficient increases and drag coefficient decreases. These results demonstrate that wider spacing enhance stability of the frontal block in the underscour condition. Moreover, analysis of block stability with changing underscouring and horizontal spacing shows that bed protection blocks seem to have more stability when the gap between two bed protection blocks was equal to height of the blocks.

关键词： bed protection block stability underscouring Particle Image Velocimetry (PIV)

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Information for Disaster Preparedness: A Social Network Approach to Rainwater Harvesting Technology Dissemination

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International Journal of Disaster Risk Science 2014年第2期5卷 95-109页

作者： Subhajyoti Samaddar Makoto Murase norio Okada Disaster Prevention Research Institute Kyoto UniversityGokashoUjiKyoto 6110011Japan Institute for Sky Water Harvesting 1201-2 FukasawaGotemba CityShizuoka Prefecture 4120023Japan Institute for the Research of Disaster Area Reconstruction Kwansei Gakuin UniversityHyogo 6628501Japan

Rainwater harvesting technology is considered an innovative and effective mechanism for reducing drinking water risks due to arsenic contamination and water salinity in coastal Bangladesh. However, adoption of such tanks remains elusive. Most studies on disaster risk communication are predominantly based on individuallevel cognitive modeling approaches, which fail to address the role of social groups, human relations, and other collective social factors in the dissemination process of disaster preventive measures. From the viewpoint of social implementation, community adoption of unfamiliar technology for disaster risk mitigation and preparedness requires another approach. Given the challenge to promote rainwater harvesting technology in the study area of coastal Bangladesh, this study examines the role of various social networks including cohesive groups(friends), structural equivalent groups(individuals who have the same position in society), and spatial groups(neighbors) in three information sharing and processing activities—hearing, observation, and discussion. Results show that those individuals who have similar cohesive affiliations tend to become hearing and discussion partners. Cohesive groups share a learning opportunity and are bounded by normative constraints in terms of direct and intimate social *** groups facilitate observation, which provides visual learning. Structurally equivalent groups are not relevant in adoption dissemination;therefore competition or similar social environment did not influence the rainwater tank dissemination activities.

关键词： disaster harvesting tank

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Driving force and structural strength evaluation of a flexible mechanical system with a hydrostatic skeleton

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第4期11卷 255-262页

作者： Daisuke MARUYAMA Hitoshi KIMURA Michihiko KOSEKI norio INOU Department of Mechanical and Control Engineering Tokyo Institute of Technology

The purpose of this study was to build a flexible mechanical system with a hydrostatic *** main components of this system are two type flexible *** is a structural bag with constant inner *** other is an actuator bag with controlled inner *** design the system,it was necessary to estimate both structural deformation and driving *** analysis of flexible bags,however,is difficult because of large nonlinear *** study analyzed structural strength and driving force of flexible bags with the nonlinear finite element analysis (FEA) software *** stress concentration dependency on the bag shape is described and the driving force is calculated to include the large *** the analytical results,this study derives an empirical equation of driving *** validity of the equation was confirmed by condition-changed analyses and experimental results.

关键词： Flexible mechanical system Hydrostatic skeleton Design method Nonlinear finite element analysis (FEA)

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Development of a Leg Mechanism for Soft Landing Based on Biological Motion

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Chinese Journal of Mechanical Engineering 2011年第5期24卷 731-737页

作者： KIMURA Hitoshi OTAKI Yoshihiko ITO Shusaku INOU norio Department of Mechanical and Control Engineering Tokyo Institute of Technology NSK Ltd.

With jumping mechanisms,soft landing motion is important to protect loads and the *** study proposes a leg mechanism for soft landing based on biological *** jumping motion with a load suggests a unique motion for soft *** landing model consists of two *** is minimized in the first period and force is minimized in the second *** comparison with other landing models,this model is specialized for soft landing motion protecting an objective *** all mechanisms have mass,such model is useful in practical *** the purpose of realizing soft landing motion,this study proposes a new leg *** mechanism achieves quick variable transmission with cam and *** process of the cam is explained with dynamics and *** the calculated cam shape,the leg mechanism can be driven by constant input voltage for simple *** against height change is also verified with landing *** 50mm falling experiment,prototype leg mechanism performed soft landing without bounce motion and large *** acceleration profile of the body also agrees with the proposed soft landing model.

关键词： soft landing biological motion leg mechanism cam and wire mechanism

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