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Does herbal medicine reduce the risk of hepatocellular carcinoma?

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World Journal of Gastroenterology 2015年第37期21卷 10598-10603页

作者： Yasushi Rino norio Yukawa Naoto Yamamoto Department of Surgery School of Medicine Yokohama City University

Many herbal medicines are effective anti-inflammatory agents and may therefore suppress the development of hepatocellular carcinoma(HCC). Recently, treatment with a single-tablet regimen containing ledipasvir and sofosbuvir resulted in high rates of sustained virologic response among patients with hepatitis C virus genotype1 infection who did not respond to prior interferon-based treatment. Patients with chronic hepatitis C are expected to receive this treatment worldwide. However, many patients have hepatitis-like fatty liver and nonalcoholic steatohepatitis. A strategy to prevent the development of HCC in this subgroup of patients is urgently *** herbal medicines can suppress the development of HCC remains to be established. However, herbal medicines are effective anti-inflammatory agents and may inhibit the development of HCC. Clinical trials exploring the effectiveness of herbal medicines in the prevention and treatment of HCC are therefore warranted. The current lack of knowledge and of educational programs is a barrier to increasing the use of potentially effective herbal medicines and performing prospective clinical trials.

关键词： Herbal medicine Hepatocellular carcinoma Anti-infl

Immune therapy including dendritic cell based therapy in chronic hepatitis B virus infection

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World Journal of Gastroenterology 2006年第18期12卷 2876-2883页

作者： Sk Md Fazle Akbar norio Horiike Morikazu Onji Third Department of Internal Medicine Ehime University School of MedicineEhime 791-0295Japan

Hepatitis B virus （HBV） infection is a global public health problem. Of the approximately 2 billion people who have been infected worldwide, more than 400 million are chronic carriers of HBV. Considerable numbers of chronic HBV carriers suffer from progressive liver diseases. In addition, all HBV carriers are permanent source of this virus. There is no curative therapy for chronic HBV carriers. Antiviral drugs are recommended for about 10% patients, however, these drugs are costly, have limited efficacy, and possess considerable side effects. Recent studies have shown that immune responses of the host to the HBV are critically involved at every stage of chronic HBV infection：（1） These influence acquisition of chronic HBV carrier state, （2） They are important in the context of liver damages, （3） Recovery from chronic HBV-related liver diseases is dependent on nature and extent of HBV-specific immune responses. However, induction of adequate levels of HBV-specific immune responses in chronic HBV carriers is difficult. During the last one decade, hepatitis B vaccine has been administered to chronic HBV carriers as a therapeutic approach （vaccine therapy）. The present regimen of vaccine therapy is safe and cheap, but not so effective. A dendritic cell-based therapeutic vaccine has recently been developed for treating chronic HBV infection. In this review, we will discuss about the concept, scientific logics, strategies and techniques of development of HBV- specific immune therapies including vaccine therapy and dendritic cell-based vaccine therapy for treating chronic HBV infection.

关键词： Hepatitis B virus Dendritic cells Immune therapy Vaccine therapy

Unsteady Flow Analysis of an Axial Flow Hydraulic Turbine with Collection Devices Comprising a Different Number of Blades

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Journal of Thermal Science 2015年第3期24卷 239-245页

作者： Yasuyuki Nishi Terumi Inagaki Yanrong Li Sou Hirama norio Kikuchi Department of Mechanical Engineering Ibaraki University 4-12-1 Nakanarusawa-cho Hitachi-shi Ibaraki 316-8511 JAPAN Graduate School of Science and Engineering Ibaraki University 4-12-1 Nakanarusawa-cho Hitachi-shi Ibaraki 316-8511 JAPAN Ibasei Ltd. 4-7-10 Kamine-cho Hitachi-shi Ibaraki 317-0064 JAPAN

We previously devised a new type of portable hydraulic turbine that uses the kinetic energy of an open-channel flow to improve output power by catching and accelerating the flow. The turbine contains an axial flow runner with an appended collection device and a diffuser section that is not axisymmetric. The objective of this study is to determine how interference between the collection device and the runner influences performance characteristics of the turbine. We investigated the performance characteristics of the turbine and flow field for different numbers of blades during both unsteady and steady flow. During an unsteady flow, the maximum values of power coefficients for three and two blades increased by approximately 8.8% and 21.4%, respectively, compared to those during a steady flow. For the three-blade runner, the power coefficient showed small fluctuations, but for the two-blade runner, the power coefficient showed large fluctuations. These fluctuations in the power coefficient are attributed to fluctuations in the loading coefficient, which were generated by interference between the runner and the diffuser section of the collection device.

关键词： Hydraulic Turbine Runner Collection Device Performance Unsteady Flow Analysis

EFFECT OF LOADING TYPE ON FATIGUE CRACK GROWTH BEHAVIOR OF SOLDER JOINT IN ELECTRONIC PACKAGING

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Acta Mechanica Solida Sinica 2014年第3期27卷 245-258页

作者： Xishu Wang Huaihui Ren Bisheng Wu Su Ja norio Kawagoishi Department of Engineering Mechanics AML Tsinghua University China Longyuan Power Group Corporation Limited China Goudian CSIRO Earth Science and Resource Engineering Clayton VIC 3168 Australia Department of Mechanical System Engineering Daiichi Institute of TechnologyKagoshima 899-4395 Japan

Fatigue cracking tests of a solder joint were carried out using in-situ scanning electron microscopy （SEM） technology under tensile and bending cyclic loadings. The method for predicting the fatigue life is provided based on the fatigue crack growth rate of the solder joint. The results show that the effect of the loading type on the fatigue crack growth behavior of a solder joint cannot be ignored. In addition, the finite element analysis results help quantitatively estimate the response relationship between solder joint structures. The fatigue crack initiation life of a solder joint is in good agreement with the fatigue life （N50%） of a totally electronic board with 36 solder joints.

关键词： microcracking fatigue MEMS experimental techniques finite element method

AN EDGE CRACK PROBLEM IN A SEMI-INFINITE PLANE SUBJECTED TO CONCENTRATED FORCES

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Applied Mathematics and Mechanics(English Edition) 2001年第11期22卷 1279-1290页

作者： CHEN Yi-zhou(陈宜周) norio Hasebe(长谷部宣男) Division of Engineering Mechanics Jiangsu University of Science and Technology Zhenjiang 212013 P R China Department of Civil Engineering Nagoya Institute of Technology Gokiso-cho Showa-ku Nagoya 466 Japan

An oblique edge crack problem in a semi-infinite plane is discussed. Re concentrated forces are applied on the edge crack face, or on the line boundary of the cracked semi-infinite plane. The rational mapping function approach is suggested to solve the boundary value problem and a solution in a closed form is obtained. Finally, several numerical examples with the calculated results are given.

关键词： rational mapping function approach edge crack problem stress intensity factor

Analysis of flow around impermeable groynes on one side of symmetrical compound channel:An experimental study

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Water Science and Engineering 2010年第1期3卷 56-66页

作者： Hassan SafiAHMED Mohammad Mahdi HASAN norio TANAKA Civil Engineering Department Faculty of EngineeringSouth Valley University Graduate School of Science and Engineering Saitama University Institute for Environmental Science and Technology Saitama University

This paper presents the results of an experimental study on the influences of floodplain impermeable groynes on flow structure, velocity, and water depth around the groyne（s）. A wooden symmetrical compound channel was used. Groyne models with three different groyne relative lengths, 0.5, 0.75, and 1.0, were used on one floodplain with single and series arrangements. Analysis of the experimental results using the measured flow velocity and water depth values showed that flow structure, velocity, and water depth mainly depend on groyne relative length and the relative distance between series groynes. The flow velocity at the main channel centerline increased by about 40%, 60%, and 85%, and in other parts on the horizontal plane at the floodplain mid-water, depth by about 75%, 125%, and 175% of its original value in eases of one-side floodplain groyne（s） with relative lengths of 0.5, 0.75, and 1.0, respectively. The effective distance between two groynes in series arrangement ranges from 3 to 4 times the groyne length. Using an impermeable groyne with a large relative length in river floodplains increases the generation of eddy and roller zones downstream of the groyne, leading to more scouring and deposition. To avoid that, the groyne relative length must be kept below half the floodplain width,

关键词： impermeable groyne symmetrical compound channel floodplain flow structure

Activation of Trifluoromethylthio Moiety by Appending Iodonium Ylide under Copper Catalysis for Electrophilic Trifluoromethylation Reaction

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Chinese Journal of Chemistry 2016年第5期34卷 485-489页

作者： Ibrayim Saidalimu Shugo Suzuki Etsuko Tokunaga norio Shibata Department of Frontier Materials Nagoya Institute of Technology Gokiso Showa-ku Nagoya 466-8555 Japan Department of Nanopharmaceutical Sciences Nagoya Institute oF Technology Gokiso Showa-ku Nagoya 466-8555 Japan

A novel iodonium-ylide compound 2 that appends a trifluoromethylthio （SCF3） group is disclosed as a new, shelf-stable electrophilic trifluoromethylation reagent. Unlike known shelf-stable electrophilic trifluoromethylation reagents, 2 has a stable SCF3 group which is activated by appending iodonium ylide under copper catalysis via sul- fonium ylide to generate a cationic trifluoromethyl （CF3） species. Reagent 2 was found to be an efficient electro- philic trifluoromethylation reagent for a wide range of silyl enol ethers 3 under copper catalysis. Cyclic and acyclic a-trifiuoromethyl ketones 4 were obtained by reagent 2 in moderate to good yields. On the other hand, a difluoro- methylthio analogue 5 did not affect intermolecular transfer difluoromethylation to substrates. Instead, intramolecu- lar 1,4-migration proceeded similar to the Stevens rearrangement to provide 6 in 21% yield, independent of the presence of nucleophiles 3.

关键词： trifluoromethylation difluoromethylation iodine sulfur ylide

Sensing Characteristics of Mixed-Potential-Type YSZ-Based NO_x Sensor Using Au-Doped NiO Sensing Electrode

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稀有金属材料与工程 2006年第A3期35卷 36-39页

作者： Vladimir V.Plashnitsa Taro Ueda norio Miura Art Science and Technology Center for Cooperative ResearchKyushu UniversityKasuga-ShiFukuoka 816-8580Japan Interdisciplinary Graduate School of Engineering Sciences Kyushu UniversityKasuga-shiFukuoka 816-8580Japan

The nano-structured NiO powder obtained by sol-gel method was doped with 10 wt% gold in order to modify its morphology as well as its electrochemical catalytic *** NO_x sensing characteristics of mixed-potential-type YSZ-based planar sensors attached with each of the nano-NiO and the Au-doped nano-NiO materials as a sensing electrode SE) were examined at temperatures of 700℃～800℃.The Au-doped NiO-SE was found to give a large enhancement in the NO_2 sensitivity as well as the NO_2 selectivity at 800℃under wet condition,in comparison with the pure *** reason for the improvement in the NO_2 sensitivity was examined based on the data of polarization curves,impedance spectra and catalytic activity for the gas-phase NO_2 decomposition.

关键词： NO_x sensor mixed potential NiO nanostructure YSZ Au

Effect of gemcitabine on the expression of apoptosis-related genes in human pancreatic cancer cells

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World Journal of Gastroenterology 2006年第10期12卷 1597-1602页

作者： Pei-Hong Jiang Yoshiharu Motoo norio Sawabu Toshinari Minamoto Department of Internal Medicine and Medical Oncology Cancer Research Institute Kanazawa University Kanazawa Japan Department of Medical Oncology Kanazawa Medical University Uchinada Ishikawa Japan Division of Diagnostic Molecular Oncology Cancer Research InstituteKanazawa University Kanazawa Japan

AIM： TO investigate the expression of genes involved in the gemcitabine-induced cytotoxicity in human pancreatic cancer cells. METHODS： A human pancreatic cancer cell line, PANC-1, was cultured. 1 × 10^4 PANG-1 cells were plated in 96-well microtiter plates. After being incubated for 24 h, gemcitabine was added to the medium at concentrations ranging 2.5 -1 000 mg/L. The AlamarBlue dye method was used for cell growth analysis. DNA fragmentation was quantitatively assayed using a DNA fragmentation enzyme-linked immunosorbent assay （ELISA） kit. PAP and TP53INP1 mRNA expression was determined using the reverse transcription-polymerase chain reaction with semi-quantitative analysis. The expression of GSK-3β and phospho-GSK-3β proteins was examined with Western blot analysis. RESULTS： The IC50 for the drug after a 48-h exposure to gemcitabine was 16 mg/L. The growth of PANC-1 cells was inhibited by gemcitabine in a concentration-dependent manner （P〈 0.0001） and the cell growth was also inhibited throughout the time course （P〈0.0001）. The DNA fragmentation rate in the gemcitabine-treated group at 48 h was 44.7 %, whereas it was 25.3 % in the untreated group. The PAP mRNA expression was decreased after being treal^l with gemcitabine, whereas the TP53INP1 mRNA was increased by the gemcitabine treatment. Western blot analysis showed that phospho- GSK-3βZ^ser9 was induced by the gemcitabine treatment. CONCLUSION： Gemcitabine suppresses PANC-1 cell proliferation and induces apoptosis. Apoptosis is considered to be associated with the inhibition of PAPand GSK-3β, and the activation of TP53INP1 and pospho- GSK-3β^ser9 .

关键词： Gemcitabine Pancreatitis-associated protein TPS3INP1 GSK-3β PANC-1