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Characteristics of multiple nodules in a patient with pulmonary Langerhans cell histiocytosis: A case report

World Journal of Clinical Cases 2019年第17期7卷 2519-2525页

作者： Nobuhiro Kanaji Yoshimasa Tokunaga Ryou Ishikawa Naoki Watanabe norimitsu kadowaki Department of Internal Medicine Division of HematologyRheumatology and Respiratory MedicineFaculty of MedicineKagawa UniversityKagawa 761-0793Japan Department of General Thoracic Surgery Breast and Endocrinological SurgeryFaculty of MedicineKagawa UniversityKagawa 761-0793Japan Department of Diagnostic Pathology Faculty of MedicineKagawa UniversityKagawa 761-0793Japan

BACKGROUND The common computed tomography findings of pulmonary Langerhans cell histiocytosis (PLCH) are multiple cysts and micronodules predominantly in middle to upper lung ***-cystic nodules and large nodules are atypical findings of *** SUMMARY The patient was a 48-year-old Japanese man with a smoking history (20 cigarettes/d,28 years) and no *** nodules existed in all lung lobes,predominantly in the right lower *** nodules seemed to be distributed randomly,and others were adjacent to *** nodules were solid;some small ones were *** largest nodule was 22 mm in *** metastatic lung tumors were suspected,thoracoscopic lung biopsy led to the diagnosis of *** 6 months after he quit smoking,all nodules had almost *** investigated the characteristics of nodules at diagnosis in *** 349 nodules in total,116 were in upper and 199 were in lower ***-six (27.5%) were cystic;the remaining 253 (72.5%) were *** prevalence of cystic nodules was higher in upper lobes than in lower lobes (right upper 37.5% vs lower 18.2%,P = 0.0068;left upper 48.1% vs lower 24.4%,P = 0.0078).The average size (dia.) of cystic nodules was smaller than that of noncystic nodules (5.03 mm vs 7.40 mm,respectively,P < 0.0001).CONCLUSION Although multiple non-cystic nodules including large nodules (over 20 mm) are atypical,PLCH should be included in differential *** presence of small cystic nodules predominantly in upper lobes and asymptomatic situation are also important for differential diagnoses to distinguish from metastatic cancers.

关键词： Langerhans cell histiocytosis Multiple Non-cystic Nodule Distribution Size Case report

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Rotational Motions Excited by Vertical Harmonic Motions

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第1期35卷 51-57页

作者： Tadokoro Chiharu kadowaki Kei Mori Hiroki Nagamine Takuo Department of Mechanical Engineering Saitama University Department of Mechanical Engineering Kyushu University

Rotation of a pair of wings was driven by the vertical harmonic motion of a pin inserted into the center hole of the *** elucidate the mechanism by which the rotational motion of the wings was excited,the relationship between the wings and the pin was examined by tracking their motions using both displacement measurements and high-speed *** motion modes occurred in this study were categorized into five types:slipping,rolling,jumping(without eccentricity),jumping(with eccentricity),and *** the case that the hole of the wings was located at a distance from the center of the wings,referred to as″with eccentricity,″the slipping,jumping(with eccentricity),and non-rotation modes *** experimental results showed that the mechanism of the jumping(with eccentricity)was different from that of the other modes(slipping,rolling,jumping(without eccentricity)),which are well known to be driven by the periodical reaction of the wings against the vertical vibration of the *** was found that the jumping(with eccentricity)was driven by the non-periodical force with the collision between the wing hole and the pin.

关键词： motion transformation rotation vibration hula-hoop

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Identification of key pathways and gene expression in the activation of mast cells via calcium flux using bioinformatics analysis

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BIOCELL 2021年第2期45卷 395-415页

作者： XIAOYU WANG TAKESHI YAMAMOTO MAKOTO kadowaki YIFU YANG Laboratory of Immunology and Virology Experiment Center for Science and TechnologyShanghai University of Traditional Chinese MedicineShanghai201203China Division of Gastrointestinal Pathophysiology Institute of Natural MedicineUniversity of ToyamaToyama9300194Japan

Mast cells are the main effector cells in IgE-associated allergic disorders,and we have reported that mucosal mast cells(MMCs)play a more important role in the development of food allergy(FA).IgE with antigen or calcium ionophore stimulation can lead to the activation of MMCs via a calcium-dependent *** purpose of the present study was to identify gene signatures with IgE/antigen(dinitrophenyl-bovine serum albumin,DNP-BSA)or calcium ionophore(A23187)on the activation of *** expressed genes between the two types of samples were identified with microarray *** ontology functional and pathway enrichment analyses of differentially expressed genes were performed using the database for annotation,visualization,and integrated discovery *** results showed that IgE/antigen and A23187 could induce degranulation,increase vacuoles,and elevate the cytosolic calcium concentration in ***,GeneChip analysis showed that the same 134 mRNAs were altered with IgE/DNP-BSA and A23187,suggesting that DNP-BSA/IgE and A23187 affect the same signal pathway partly in *** analysis showed that the data were enriched in NF-κB,TNF,MAPK,transcription factor activity,DNA binding,and nucleic acid binding,suggesting that activation of MMCs is a complex *** results provide new insights on MMCs activation.

关键词： Mucosal mast cell Antigen Calcium ion Bioinformatics analysis

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gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus

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World Journal of Gastroenterology 2017年第36期23卷 6694-6704页

作者： Midori Fujishiro Akifumi Kushiyama Hiroki Yamazaki Sunao Kaneko Yuko Koketsu Takeshi Yamamotoya Takako Kikuchi Hideyuki Sakoda Ryo Suzuki Takashi kadowaki Department of Diabetes and Metabolic Diseases Graduate School of Medicine the University of Tokyo Division of Diabetes and Metabolism Institute for Adult Diseases Asahi Life Foundation Department of Diabetes and Metabolic Diseases Shinko Hospital Department of Medical Science Graduate School of Medicine University of Hiroshima Division of Neurology Respirology Endo-crinology and Metabolism Department of Internal Medicine Faculty of Medicine University of Miyazaki

AIM To unravel relationships between gastrointestinal(GI)symptoms impairing quality of life(QOL)and clinical profiles of diabetes mellitus(DM)patients. METHODS We enrolled 134 outpatients with type 2 *** age was 64.7 years,mean body mass index was 24.7 RESULTS Lower abdominal symptoms were found to be more frequent than those affecting the upper *** duration and medications showed associations with GI *** identified differences in peak prevalences of the five ***(P=0.02vs 10-14 years)and total GI symptoms(P=0.01 and P=0.02 vs 5-9 years and 10-14 years,respectively)peaked at a diabetes duration of 15-19 ***(P=0.004)and postprandial fullness(P=0.03)tended to increase with disease *** and diarrhea showed bimodal peaks,with the first early and the second late(e.g.,P=0.03 at 15-19 years vs 10-14years for diarrhea)in the disease ***,GI symptoms showed clustering that reflected the region of the GI tract affected,i.e.,constipation and diarrhea had similar frequencies(P<0.0001). CONCLUSION Our study highlights the importance of questioning patients about QOL impairment due to abdominal symptoms,especially in the early and the late periods of diabetes.

关键词： Gastrointestinal symptoms Questionnaire survey Disease duration Type 2 diabetes Quality of life Gastrointestinal tract regions

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Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer

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World Journal of Gastroenterology 2015年第4期21卷 1275-1283页

作者： Shigenori kadowaki Miho Kakuta Shuhei Takahashi Akemi Takahashi Yoshiko Arai Yoji Nishimura Toshimasa Yatsuoka Akira Ooki Kensei Yamaguchi Keitaro Matsuo Kei Muro Kiwamu Akagi Division of Gastroenterology Saitama Cancer CenterSaitama 362-0806Japan Department of Clinical Oncology Aichi Cancer Center HospitalAichi 464-8681Japan Division of Molecular Diagnosis and Cancer Prevention Saitama Cancer Center Saitama 362-0806Japan Division of Gastroenterological Surgery Saitama Cancer CenterSaitama 362-0806Japan Department of Preventive Medicine Kyushu University Faculty of Medical Sciences Fukuoka 812-8582Japan

AIM: To investigate the prognostic role of KRAS and BRAF mutations after adjustment for microsatellite instability(MSI) status in Japanese colorectal cancer(CRC) ***: We assessed KRAS and BRAF mutations and MSI status in 813 Japanese patients with curatively resected, stage Ⅰ-Ⅲ CRC and examined associations of these mutations with disease-free survival(DFS) and overall survival(OS) using uni- and multivariate Cox proportional hazards ***: KRAS and BRAF mutations were detected in 312(38%) of 812 and 40(5%) of 811 tumors, respectively. KRAS mutations occurred more frequently in females than in males(P = 0.02), while the presence of BRAF mutations was significantly associated with the female gender(P = 0.006), proximal tumor location(P < 0.001), mucinous or poorly differentiated histology(P < 0.001), and MSI-high tumors(P < 0.001). After adjusting for relevant variables, including MSI status, KRAS mutations were associated with poorer DFS(HR = 1.35; 95%CI: 1.03-1.75) and OS(HR = 1.46; 95%CI: 1.09-1.97). BRAF mutations were poor prognostic factors for DFS(HR = 2.20; 95%CI: 1.19-4.06) and OS(HR = 2.30; 95%CI: 1.15-4.71). Neither the BRAF by MSI interaction test nor the KRAS by MSI interaction test yielded statistically significant results for DFS and ***: KRAS and BRAF mutations are associated with inferior survival, independent of MSI status, inJapanese patients with curatively resected CRC.

关键词： Colorectal cancer KRAS BRAF Microsatellite instabi

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Effect of the Pixel Interpolation Method for Downsampling Medical Images on Deep Learning Accuracy

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Journal of Computer and Communications 2021年第11期9卷 150-156页

作者： Daisuke Hirahara Eichi Takaya Mizuki kadowaki Yasuyuki Kobayashi Takuya Ueda Department of AI Research Lab Harada Academy Kagoshima Japan Department of Clinical Imaging Graduate School of Medicine Tohoku University Sendai Japan Department of Advanced Biomedical Imaging Informatics St. Marianna University School of Medicine Kawasaki Japan Tohoku University Hospital AI Lab Sendai Japan

Background: High-resolution medical images often need to be downsampled because of the memory limitations of the hardware used for machine learning. Although various image interpolation methods are applicable to downsampling, the effect of data preprocessing on the learning performance of convolutional neural networks (CNNs) has not been fully investigated. Methods: In this study, five different pixel interpolation algorithms (nearest neighbor, bilinear, Hamming window, bicubic, and Lanczos interpolation) were used for image downsampling to investigate their effects on the prediction accuracy of a CNN. Chest X-ray images from the NIH public dataset were examined by downsampling 10 patterns. Results: The accuracy improved with a decreasing image size, and the best accuracy was achieved at 64 × 64 pixels. Among the interpolation methods, bicubic interpolation obtained the highest accuracy, followed by the Hamming window.

关键词： Downsampling Interpolation Deep Learning Convolutional Neural Networks Medical Images Nearest Neighbor Bilinear Hamming Window Bicubic Lanczos

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The Lower Infusion Rate of Glucose to Maintain Ketogenesis within Normal Level during Surgery

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Open Journal of Anesthesiology 2017年第8期7卷 264-274页

作者： Jun Hirokawa Sayuri kadowaki Masanori Tsukamoto Takashi Hitosugi Takeshi Yokoyama Department of Dental Anesthesiology Faculty of Dental Science Kyushu University Fukuoka Japan

Background: Intraoperative low-dose glucose infusions suppress ketogenesis and attenuate postoperative insulin resistance (IR). However, the appropriate rate for intraoperative glucose infusion remains unclear, although a postoperative infusion of 0.08 g/kg/h effectively suppressed ketogenesis at the next morning. Therefore, we investigated the effects of an intraoperative rate of 0.08 g/kg/h on ketogenesis and postoperative IR. Methods: The present study included 15 patients who were undergoing maxillofacial surgery. The patients received glucose-free Ringer’s solution and a continuous glucose infusion (0.08 g/kg/h) during the surgery. Blood samples were collected to evaluate the concentrations of noradrenaline, cortisol, glucose, insulin, ketone bodies, and free fatty acid before anesthesia induction (T1), at 1 h after induction (T2), at 3 h after induction (T3), and at the end of surgery (T4). The glucose clamp test was performed on the days before and after surgery using the STG-55TM device. IR was quantified using the mean glucose infusion rate (M-value). Results: All 15 patients exhibited intraoperative blood glucose concentrations of 90 - 130 mg/dL. There was a non-significant trend towards higher plasma concentrations of total ketone bodies at T3 (p = 0.058). The plasma concentrations of acetoacetic acid at T3 and T4 were significantly higher than that at T1 (p = 0.0217 and p = 0.0306, respectively). All patients exhibited lower M-values after surgery (mean reduction: 48.0% ± 17.9%). Conclusion: Continuous intraoperative glucose at 0.08 g/kg/h helped maintain blood glucose concentrations, although it may suppress the ketogenesis to increase during surgery.

关键词： Glucose Administration Insulin Resistance Metabolism Ketogenesis General Anesthesia

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Current approaches and questions yet to be resolved for the prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis

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World Journal of Gastrointestinal Endoscopy 2022年第11期14卷 657-666页

作者： Hirokazu Saito Atsushi Fujimoto Kana Oomoto Yoshitaka kadowaki Shuji Tada Department of Gastroenterology Kumamoto City HospitalKumamoto City 862-8505KumamotoJapan

Prophylaxis is important for post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP),which is the most common and serious complication of *** the current guidelines include independent patient-and procedure-related risk factors for PEP and available PEP prophylactic measures,the synergistic effect of these risk factors on PEP should also be considered,given that patients often harbor multiple risk ***,a combination of prophylactic measures is often selected in clinical ***,established methods estimating the synergistic effect of independent risk factors on PEP incidence are lacking,and evidence on the impact of combining prophylactic measures on PEP should be *** of appropriate candidate patients for ERCP is also important to reduce the incidence of PEP associated with unnecessary *** indications in patients with asymptomatic common bile duct stones(CBDSs)and in those with suspected CBDSs with no imaging-based evidence of stones are *** studies are warranted to predict the synergistic effect of independent risk factors on PEP,determine the best prophylactic PEP measures,and identify appropriate candidates for ERCP in patients with asymptomatic CBDSs and those with suspected CBDSs.

关键词： Endoscopic retrograde cholangiopancreatography Post-endoscopic retrograde cholangiopancreatography pancreatitis Prophylaxis Guidelines

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Glycemiccontrol and hypoglycemia prevalence in Japanese participants with type 2 diabetes according to body mass index:a sub-analysis of the ALOHA data

Glycemiccontrol and hypoglycemia prevalence in Japanese part...

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中华医学会糖尿病学分会第十六次全国学术会议

作者： Masato Odawara Jay Lin Karim Admane Takayuki Ito Tetsuya Ohtani Takashi kadowaki Department of Diabetology Metabolismand EndocrinologyTokyo Medical University

Objective The aim of this analysis was to determine the reduction in HbA and prevalence of hypoglycemia among Japanese people with type 2 diabetes(T2DM) receiving treatment with insulin glargine with oral antidiabetic drugs(OADs) according to BMI. Methods Patientswith T2DM requiring insulin therapy with OADs were offered insulin *** Objective The aim of this analysis was to determine the reduction in HbA and prevalence of hypoglycemia among Japanese people with type 2 diabetes(T2DM) receiving treatment with insulin glargine with oral antidiabetic drugs(OADs) according to BMI. Methods Patientswith T2DM requiring insulin therapy with OADs were offered insulin *** who met the inclusion criteria were observed for 24 weeks in a real-life *** and endpoint glycated hemoglobin Alc(HbAlc),fasting blood glucose(FPG),postprandial plasma glucose(PPG),body weight,and body mass index(BMI) were measured and are presented using summary *** between the cohorts of patients with high(≥25 kg/m ) and low BMI(< 25 kg/m ) were compared by using Student’ s t-test or chi-squared test for continuous and categorical variables,respectively. Results BMI was 3=25 kg/m2(mean(SD) 27.2(1.4) kg/m) in 1410 patients and <25 kg/m(21.8(2.2) kg/m) in 2496 *** levels were reduced significantly in both BMI groups(P<0.01),and there was a significant difference in HbAlc between groups(≥25 kg/m:mean -1.27(1.27)%;<25 kg/m:mean -1.50(1.22)%;P<0.001).A significantly greater percentage of patients with a low BMI achieved a target HbAlc of <7%(≥25 kg/m:13.2%;<25 kg/m:18.3%;P<0.001),and the incidence of severe hypoglycemia was low in both groups(≥25 kg/m:0.07%;<25 kg/m :0.12%;P=0.64).A significantly lower dose of insulin glargine was used in the low BMI group(≥25 kg/m: mean 10.31(7.03) U/day);<25 kg/m:mean 8.71(5.27) U/day);P<0.001).The insulin glargine with OADs regimen resulted in a significant reduction in FBG and PPG levels and an increase in body

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Role of innate lymphoid cells(ILCs) in the induction of diet induced obesity

Role of innate lymphoid cells(ILCs) in the induction of diet...

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第九届全国免疫学学术大会

作者： Takaharu Sasaki Kazuyo Moro Tetsuya Kubota Naoto Kubota Takashi kadowaki Shigeo Koyasu Laboratory for Immune Cell System RIKEN Center for Integrative Medical Sciences(IMS) Graduate School of Pharmaceutical Sciences The University of Tokyo Division of Immunobiology Department of Medical Life Science Graduate School of Medical Life ScienceYokohama City University precursory Research for Embryonic Science and Technology(PRESTO) Japan Science and Technology Agency Laboratory for Metabolic Homeostasis RIKEN Center for Integrative Medical Sciences(IMS) Department of Diabetes and Metabolic Diseases Graduate School of MedicineUniversity of Tokyo Department of Microbiology and Immunology Keio University School of Medicine

Obesity is now recognized as a global *** this pathological condition,low grade inflammation takes place but how the immune system is involved in the initiation of obesity is *** this study,we aimed to elucidate the r...

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