检索结果-南通市图书馆

Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer

World Journal of Gastroenterology 2014年第31期20卷 10813-10824页

作者： Daisuke Kyuno Hiroshi Yamaguchi Tatsuya Ito Tsuyoshi Kono Yasutoshi Kimura Masafumi Imamura Takumi Konno Koichi Hirata norimasa sawada Takashi Kojima Department of Surgery Sapporo Medical University School of Medicine Department of Cell Science Research Institute for Frontier Medicine Sapporo Medical University School of Medicine Department of Pathology Sapporo Medical University School of Medicine

Pancreatic cancer continues to be a leading cause of cancer-related death worldwide and there is an urgent need to develop novel diagnostic and therapeutic strategies to reduce the mortality of patients with this disease. In pancreatic cancer, some tight junction proteins, including claudins, are abnormally regulated and therefore are promising molecular targets for diagnosis, prognosis and therapy. Claudin-4 and-18 are overexpressed in human pancreatic cancer and its precursor lesions. Claudin-4 is a high affinity receptor of Clostridium perfringens enterotoxin(CPE). The cytotoxic effects of CPE and monoclonal antibodies against claudin-4 are useful as novel therapeutic tools for pancreatic cancer. Claudin-18 could be a putative marker and therapeutic target with prognostic implications for patients with pancreatic cancer. Claudin-1,-7, tricellulin and marvelD3 are involved in epithelial to mesenchymal transition(EMT) of pancreatic cancer cells and thus might be useful as biomarkers during disease. Protein kinase C is closely related to EMT of pancreatic cancer and regulates tight junctions of normal human pancreatic duct epithelial cells and the cancer cells. This review focuses on the regulation of tight junctions via protein kinase C during EMT in human pancreatic cancer for the purpose of developing new diagnostic and therapeutic modalities for pancreatic cancer.

关键词： Tight junctions Claudins Tricellulin MarvelD3 Normal human pancreatic duct epithelial cells Pancreatic cancer Protein kinase C Epithelial to mesenchymal transition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Occludin modulates perijunctional actin at a discrete apico-lateral membrane domain in a rat endothelial cell line (RLE)

Occludin modulates perijunctional actin at a discrete apico-...

引用

Third Congress of the Asian-Pacific Organization for Cell Biology

作者： Yasuo Kokai Shin-ichi Atsumi Hiroki Kuwabara Hirotoshi Tobioka norimasa sawada Toshihiro Mitaka Yoichi Mochizuki Michio Mori Dept.Pathol.and Dept. Pathol.Cancer Res.Inst. Sapporo Med.Univ.Sch.Med.SapporoHokkaido 060-8556Japan

The tight junction localizes in a particular lineage of blood vessels, such as blood-brain barrier and is believed to be pivotal for the given barrier function. Although occludin is found as a component of endothelial...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Ultrasound-guided peripheral nerve blocks for anterior cutaneous nerve entrapment syndrome after robot-assisted gastrectomy: A case report

引用

World Journal of Gastrointestinal Surgery 2024年第8期16卷 2719-2723页

作者： Yukiko Saito Hirohisa Takeuchi Joho Tokumine Ryuji sawada Kunitaro Watanabe Tomoko Yorozu Department of Anesthesiology Kyorin University School of MedicineTokyo 181-8611Japan Department of Surgery Kyorin University School of MedicineTokyo 181-8611Japan

BACKGROUND Anterior cutaneous nerve entrapment syndrome(ACNES)is a condition mani-festing with pain caused by strangulation of the anterior cutaneous branch of the lower intercostal *** case report aims to provide new insight into the selection of peripheral nerve blocks for the ACNES *** SUMMARY A 66-year-old woman manifested ACNES after a robot-assisted distal *** ultrasound-guided rectal sheath block was effective for pain triggered by the port ***,the sudden severe pain,which radiated laterally from the previous site,remained.A transversus abdominis plane block was performed for the remaining pain and effectively relieved *** In this case,the trocar port was inserted between the rectus and transverse abdominis *** intercostal nerves might have been entrapped on both sides of the rectus and transversus abdominis ***,rectus sheath and transverse abdominis plane blocks were required to achieve complete pain *** the best of our knowledge,this is the first report on use of a combination of rectus sheath and transverse abdominis plane blocks for pain relief in ACNES.

关键词： Anterior cutaneous nerve entrapment syndrome Rectus sheath block Trans-verse abdominal plane block Hydrodissection Robot-assisted gastrectomy Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Risk and Protective Factors Associated with Depression and Anxiety among Pregnant Women during the COVID-19 Pandemic

引用

Health 2024年第1期16卷 37-51页

作者： Maiko Manaka Miyako Tsuda Moe Fujitani Ai sawada Nanae Akatsuka Ayako Sasaki Faculty of Nursing Osaka Medical and Pharmaceutical University Takatsuki Japan Osaka City Juso Hospital Osaka Japan Osaka City General Hospital Osaka Japan

Background: The coronavirus disease (COVID-19) pandemic has impacted perinatal women’s mental health. However, protective factors associated with depression among pregnant Japanese women during the pandemic have not been reported. Purpose: The present study investigated the risk and protective factors associated with depression and anxiety among pregnant women during the COVID-19 pandemic. Methods: An online questionnaire was administered to 157 pregnant women between October 2022 and May 2023 at two general hospitals in Japan. The Japanese versions of the Patient Health Questionnaire-9 (PHQ-9) and General Anxiety Disorder-7 (GAD-7) were used to assess symptoms of depression and anxiety. The χ2 test or Fisher’s exact test and multivariate logistic regression model were used to examine factors associated with depression and anxiety among pregnant women. Results: Overall, 47.1% and 35.7% of the pregnant women reported depressive and anxiety symptoms, respectively. A “history of mental illness” was a risk factor for depression and anxiety among pregnant women during the COVID-19 pandemic. Additionally, unmarried status was a risk factor for anxiety among pregnant women, whereas outdoor and indoor exercises were protective factors against depression and anxiety, respectively. Conclusions: Exercise may have protected pregnant women from depression and anxiety during the COVID-19 pandemic. Encouraging exercise may help maintain the mental health of pregnant women who do not have exercise restrictions.

关键词： Depression Anxiety Factors Pregnancy COVID-19 Pandemic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

日本百年石质文物保护:从技术演进到大遗址保护的全景探析

引用

华夏考古 2024年第3期 125-129页

作者： [日]泽田正昭雷欣怡(译) 日本奈良文化财研究所成都博物馆四川成都市610015

人类创造并传承至今的历史,启示着人类社会的理想状态和前进方向。此中,文化遗产更被誉为人类社会的指南针,是历史的重要物证。尤其近年来,政府极力主张它们应作为旅游资源被有效利用,许多地方率先加强行政效能到地方文化的振兴中,依托... 详细信息

人类创造并传承至今的历史,启示着人类社会的理想状态和前进方向。此中,文化遗产更被誉为人类社会的指南针,是历史的重要物证。尤其近年来,政府极力主张它们应作为旅游资源被有效利用,许多地方率先加强行政效能到地方文化的振兴中,依托当地历史文化,通过世界遗产名录活动的开展和文化遗产的认定,达到地方振兴的目的。像这样将文化遗产作为媒介,举办地域认同感的文化活动也成为近年的趋势。

关键词：世界遗产名录文化遗产石质文物保护日本百年大遗址保护技术演进重要物证指南针

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A case study of seismic response of earth embankment foundation on liquefiable soils

引用

Journal of Central South University 2009年第6期16卷 994-1000页

作者：黄雨 YASHIMA A sawada K 张锋 Department of Geotechnical Engineering Tongji University Key Laboratory of Geotechnical and Underground Engineering Ministry of EducationTongji University Department of Civil Engineering Gifu University Department of Civil Engineering Nagoya Institute of Technology

A case study of seismic response of an earth embankment foundation on liquefiable soils in Kansai area,western Japan was presented. Based on a calibrated cyclic elasto-plastic constitutive model for liquefiable sand and Biot dynamic coupled theory,the seismic analysis was carried out by using a dynamic effective stress finite element method under plane strain condition. A recent design study was illustrated in detail for a river earth embankment subjected to seismic excitation on the saturated deposits with liquefiable sands. Simulated results of the embankment foundation during liquefaction were obtained for acceleration,displacement,and excess pore water pressures,which were considered to yield useful results for earthquake geotechnical design. The results show that the foundation soil reaches a fully liquefied state with high excess pore pressure ratios approaching to 1.0 due to the earthquake shaking. At the end of the earthquake,the extensive liquefaction causes about 1.0 m lateral spreading at the toe and 60 cm settlement at the crest of the earth embankment.

关键词： earth embankment earthquake liquefaction cyclic plasticity finite element method case study

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Full polarimetric PALSAR-based land cover monitoring in Cambodia for implementation of REDD policies

引用

International Journal of Digital Earth 2013年第3期6卷 255-275页

作者： Ram Avtar Wataru Takeuchi Haruo sawada Institute of Industrial Science The University of TokyoTokyoJapan

Forest cover monitoring plays an important role in the implementation of climate change mitigation policies such as Kyoto protocol and Reducing Emissions from Deforestation and Forest Degradation(REDD).In this study,we have monitored land cover using the PALSAR(Phased Array type L-band Synthetic Aperture Radar)full polarimetric data based on incoherent target *** classification technique has been applied on CloudePottier decomposition,FreemanDurden three component,and Yamaguchi four component decomposition for accurate mapping of different types of land cover *** on confusion matrix derived from the predicted and defined pixels,the evergreen and sparsely deciduous forests have shown high producer’s accuracy by FreemanDurden three component and Yamaguchi four component classifica*** overall accuracy of Maximum Likelihood Classification by Yamaguchi four component is 94.1%with 0.93 kappa coefficient as compared to the 90.3%with 0.88 kappa coefficient by FreemanDurden three component and 89.7%with 0.88 kappa coefficient by CloudePottier *** accuracy of classification in a forested area using full polarimetric PALSAR data may have been because of high penetration of L-band *** content of this study could be useful for the forest cover mapping during cloudy days needed for proper implementation of REDD policies in Cambodia.

关键词： global climate change REDD PALSAR forest cover mapping

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic pressure change in a rotating, laterally oscillating cylindrical container

引用

Journal of Ocean Engineering and Science 2018年第2期3卷 91-95页

作者： Yusuke Saito Tatsuo sawada Department of Mechanical Engineering Keio University3-14-1 HiyoshiKohoku-kuYokohama 223-8522Japan

We examined wave phenomena pertinent to water in a rotating,laterally oscillating cylindrical *** particular,we measured the time-dependent dynamic water pressure and pressure change by fast Fourier transform *** swirling of water in the container had three frequency components;the frequency responses of each frequency component are reported *** swirling occurs in a rotating cylindrical container,it was found that the wave rotating in the same direction as the rotation of the cylindrical container and the wave rotating in the opposite direction to the cylindrical container exist at the same *** swirling direction was determined by the relationship of these magnitude.

关键词： Sloshing Dynamic pressure Cylindrical container Rotation Oscillation Swirling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

NF-κB Regulates B-Cell-Derived Nerve Growth Factor Expression

引用

Cellular & Molecular Immunology 2006年第1期3卷 63-66页

作者： Klaus Heese Noriko Inoue Tohru sawada Department of Molecular and Cell Biology School of Biological SciencesNanyang Technological University60 Nanyang DriveSingapore 637551Singapore BF Research Institute Inc.Itoyoshi Building 2012-5-9 DoshomachiChuo-kuOsaka 541-0045Japan BF Research Institute Inc. Itoyoshi Building 2012-5-9 DoshomachiChuo-kuOsaka 541-0045Japan

In the mammalian brain, four neurotrophins have been identified： nerve growth factor （NGF）, brain-derived neurotrophic factor （BDNF）, neurotrophin-3 （NT-3） and neurotrophin-4/5 （NT-4/5）. NGF exerts an important role in the development and functions of the central and peripheral nervous system. However, it has recently been documented that several types of immune cells, such as mast ceils, iymphocytes, basophils and eosinophils, produce, store and release NGF. Accumulating preclinical and clinical data indicate that dysfunctions of NGF and the other neurotrophins may contribute to impaired immune responses and concentration of NGF frequently correlates with disease severity. Thus, the aim of this study was to elucidate the potential signaling mechanisms of cytokineneurotrophins interactions contributing to increased NGF levels. Our data show that the transcription factor NF-κB plays a pivotal role in regulating B-cell-derived NGF expression.

关键词： immune system inflammation interleukin NGF neurotrophin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synchrotron X-ray diagnostics of cutoff shape of nonthermal electron spectrum at young supernova remnants

引用

Research in Astronomy and Astrophysics 2014年第2期14卷 165-178页

作者： Ryo Yamazaki Yutaka Ohira Makoto sawada Aya Bamba Department of Physics and Mathematics Aoyama Gakuin University5-10-1 FuchinobeSagamihara 252-5258Japan

Synchrotron X-rays can be a useful tool to investigate electron accelera- tion at young supemova remnants （SNRs）. At present, since the magnetic field con- figuration around the shocks of SNRs is uncertain, it is not clear whether electron acceleration is limited by SNR age, synchrotron cooling, or even escape from the ac- celeration region. We study whether the acceleration mechanism can be constrained by the cutoff shape of the electron spectrum around the maximum energy. We derive analytical formulae of the cutoff shape in each case where the maximum electron en- ergy is determined by SNR age, synchrotron cooling and escape from the shock. They are related to the energy dependence of the electron diffusion coefficient. Next, we discuss whether information on the cutoff shape can be provided by observations in the near future which will simply give the photon indices and the flux ratios in the soft and hard X-ray bands. We find that if the power-law index of the electron spectrum is independently determined by other observations, then we can constrain the cutoff shape by comparing theoretical predictions of the photon indices and/or the flux ratios with observed data which will be measured by NuSTAR and/or ASTRO-H. Such study is helpful in understanding the acceleration mechanism. In particular, it will supply another independent constraint on the magnetic field strength around the shocks of SNRs.

关键词： acceleration of particles -- ISM: cosmic rays -- ISM: supernova rem-nants -- turbulence -- X-rays: ISM

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：