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Seventy-five gram glucose tolerance test to assess carbohydrate malabsorption and small bowel bacterial overgrowth

World Journal of Gastroenterology 2006年第19期12卷 3092-3095页

作者： Yoshihisa Urita Susumu Ishihara Tatsuo Akimoto Hiroto Kato noriko Hara Yoshiko Honda Yoko Nagai Kazushige Nakanishi Nagato Shimada Motonobu Sugimoto Kazumasa Miki Department of General Medicine and Emergency Care Toho University School of Medicine Omori HospitalTokyoJapan Division of Gastroenterology and Hepatology Department of Internal Medicine Toho University School of MedicineOmori HospitalTokyoJapan

AIM： To investigate non-invasively the incidence of absorption of carbohydrates in diabetic patients during an oral glucose tolerance test （OGTT） and to determine whether malabsorption may be associated with insulin secretion and insulin resistance. METHODS： A standard 75-g OGTT was performed in 82 diabetic patients. The patients received 75 g of anhydrous glucose in 225 mL of water after an overnight fasting and breath samples were collected at baseline and up to 120 rain after ingestion. Breath hydrogen and methane concentrations were measured. Blood glucose and serum insulin concentrations were measured before ingestion and at 30, 60, 90, 120 rain post-ingestion. RESULTS： When carbohydrate malabsorption was defined as subjects with an increase of at least 10 ppm （parts per million） in hydrogen or methane excretion within a 2-h period, 28 （34%） had carbohydrate malabsorption. According to the result of increased breath test, 21 （75%） patients were classified as small bowel bacterial overgrowth and 7 （25%） as glucose malabsorption. Patients with carbohydrate malabsorption were older and had poor glycemic control as compared with those without carbohydrate malabsorption. The HOMA value, the sum of serum insulin during the test and the AinsulinlAglucose ratio were greater in patients with carbohydrate malabsorption. CONCLUSION： Insulin resistance may be overestimated by using these markers if the patient has carbohydrate malabsorption, or that carbohydrate malabsorption may be present prior to the development of insulin resistance. Hence carbohydrate malabsorption should be taken into account for estimating insulin resistance and β-cell function.

关键词： 75-g OGTT Carbohydrate malabsorption Bacterial overgrowth Breath test Insulin resistance

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Usability of Deformable Image Registration for Adaptive Radiotherapy in Head and Neck Cancer and an Automatic Prediction of Replanning

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第1期6卷 10-20页

作者： Masao Tanooka Hiroshi Doi Toshihisa Ishida Kazuhiro Kitajima Tsukasa Wakayama Toshiyuki Sakai Hiroyuki inoue noriko Kotoura Kengo Kosaka Kazuo Tarutani Masayuki Fujiwara Norihiko Kamikonya Department of Radiological Technology Hyogo College of Medicine College Hospital Nishinomiya Japan Department of Radiology Hyogo College of Medicine Hyogo Nishinomiya Japan

Deformable image registration (DIR) has been an important component in adaptive radiotherapy (ART). Our goal was to examine the accuracy of ART using the dice similarity coefficient (DSC) and to determine the optimal timing of replanning. A total of 22 patients who underwent volume modulated arc therapy (VMAT) for head and neck (H&N) cancers were prospectively analyzed. The planning target volume (PTV) was to receive a total of 70 Gy in 33 fractions. A second planning CT scan (rescan) was performed at the 15th fraction. The DSC was calculated for each structure on both CT scans. The continuous variables to predict the need for replanning were assessed. The optimal cut-off value was determined using receiver operating characteristic (ROC) curve analysis. In the correlation between body weight loss and DSC of each structure, weight loss correlated negatively with DSC of the whole face (rs = -0.45) and the face surface (rs = -0.51). Patients who required replanning tended to have experienced rapid weight loss. The threshold DSC was 0.98 and 0.60 in the whole face and the face surface, respectively. Patients who showed low DSC in the whole face and the face surface required replanning at a significantly high rate (P < 0.05 and P < 0.01). Weight loss correlated with DSC in both the whole face and the face surface (P < 0.05 and P < 0.05). The DSC values in the face predicted the need for replanning. In addition, weight loss tended to correlate with DSC. DIR during ART was found to be a useful tool for replanning.

关键词： Deformable Image Registration Adaptive Radiotherapy Head and Neck Can-cer Dice Similarity Coefficient Volume Modulated Arc Therapy

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Stimulation of in vitro bone formation by canine prostate cancer

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 511-523页

作者： Shiyu Yuan noriko Kantake Daniel E.Hellmann Said M.Elshafae Thomas J.Rosol Department of Biomedical Sciences Heritage College of Osteopathic MedicineOhio UniversityAthensOH 45701USA Molecular and Cellular Biology Program Ohio UniversityAthensOH 45701USA Faculty of Veterinary Medicine Benha UniversityTukhQalyobiya 13736Egypt Ohio Musculoskeletal and Neurological Institute Ohio UniversityAthensOH 45701USA

Aim:Patients with prostate cancer frequently develop osteoblastic bone *** models are important because dogs are the only mammal to develop spontaneous prostate cancer with osteoblastic bone metastases similar to *** mechanism by which prostate cancer induces bone formation is unclear;however,it depends on the complex interaction between prostate cancer cells and bone *** study investigated the effects of three canine prostate cancer cell lines(Ace-1,LuMa,and Probasco)on bone formation and resorption in ***:Mouse calvaria were treated with conditioned medium(CM)from cell *** were evaluated by histology,fluorescent calcein uptake at sites of bone mineralization,medium calcium assay,and alkaline phosphatase *** expression of bone-related genes was measured using quantitative reverse transcription ***:A novel calcein uptake assay was developed to measure bone formation and mineralization in ***-1 CM induced predominantly bone resorption in calvaria,while Probasco CM induced marked bone formation,mineralization,and healing of calvaria *** expression of osteoblast-related genes in calvaria showed that Probasco CM stimulated the maturation and differentiation of osteoblasts and inhibited *** bone modeling and remodeling were involved in Probasco CM-induced bone formation and mineralization by inhibiting remodeling with zoledronic *** of WNT activity by DKK-1 decreased the osteoblastic activity of Probasco ***:Probasco cells induced bone formation and mineralization in vitro that depended on the WNT signaling *** cells will serve as a valuable model for studying the mechanisms of osteoblastic bone metastasis in prostate cancer.

关键词： Bone canine dog metastasis osteoblast prostate cancer zoledronic acid DKK-1

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Faults and Claims about Thermal Environments in Relation to Energy Saving Measures in Smaller Office Buildings

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Journal of Civil Engineering and Architecture 2014年第4期8卷 413-424页

作者： noriko Umemiya Taiji Obuchi Ryota Matsui Graduate School of Engineering Osaka City University Osaka 558-8585 Japan

Building equipment, energy-saving systems, and claims of inappropriate indoor thermal environments were analyzed in relation to the floor area using responses to a questionnaire survey of service managers of 157 buildings built in Osaka, Kyoto and Hyogo prefectures in Kinki area of Japan. Results show the following：（1） In smaller buildings （〈 5,000 m2）, setting temperatures are higher in summer and lower in winter, effects of ＂uncomfortable radiation from windows＂ are greater, energy-saving systems decrease indoor thermal comfort, but claims of ＂hot＂ and ＂cold＂ are fewer; （2） Claims of ＂hot＂ and ＂cold＂ are unrelated to the setting temperature and whether the air-conditioning control system is central or local; （3） The adoption rates of mitigation of dress codes （＂COOL-BIZ＂ and ＂WARM-BIZ＂） are higher than those of temperature mitigation of air conditioning.

关键词： Smaller office buildings energy management energy saving measures COOL-BIZ user claims of hot and cold.

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An effective and safe gastric endoscopic submucosal dissection in the right lateral position using an inverted overtube

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World Journal of Gastroenterology 2014年第6期20卷 1623-1625页

作者： Hirohito Mori Kazi Rafiq Hideki Kobara noriko Nishiyama Shintaro Fujihara Tatsuo Yachida Maki Ayagi Joji Tani Hisaaki Miyoshi Tsutomu Masaki Department of Gastroenterology and Neurology Kagawa University

Previously, we reported the efficacy of a newly developed inverted overtube in shortening the hemostatic time and obtaining a clear endoscopic view in emergency endoscopic hemostasis. This device also helped us to perform gastric endoscopic submucosal dissection(ESD) more safely by changing the direction of gravity in the right lateral position. To perform a safe ESD, it is important to make an appropriate angle and distance between the electric knife and the gastric mucosa. In this position, the distance to gastric mucosa is reduced, and the angle of the electric knife changes from vertical to somewhat oblique, facilitating safer cutting.

关键词： Gastric endoscopic submucosal dissection Direction of gravity Right lateral position Appropriate angle and distance

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Characteristics of Body Composition and Relationship between Muscle Mass and Muscle Strength among Elderly Women in Different Age Groups

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Advances in Aging Research 2022年第5期11卷 135-149页

作者： Nao Nishioka Nishi noriko Tanaka Naomi Hirano Graduate School of Life Sciences Kobe Women’s University Kobe Japan Department of Arts and Science Kobe Women’s Junior College Kobe Japan Department of Food and Nutrition Science Kobe Women’s Junior College Kobe Japan

Age-related changes in the body composition of older adults differ among age groups. The purpose of the present study was to clarify the characteristics of body compositions in young (age, 65 - 74 years;yE group) and old (age, ≥75 years;oE group) elderly women, and compare the relationship between muscle mass and strength in elderly women with that in young women for preventing motor function loss in older adults. A total of 30 elderly and 45 young women aged ≥ 65 and 19 - 22 years, respectively, participated in this study. The participants underwent body composition measurement via bioelectrical impedance analysis and examinations of handgrip and leg muscle strength. The age-related body composition changes varied among age groups. Compared with young women, fat-free mass (FFM) in the yE group did not decrease significantly;however, fat mass (FM) and waist-hip ratio (WHR) were significantly greater. Compared with the yE group, decreases in FFM, FM, and WHR in the oE group were significant;furthermore, the decrease in FM measurements was attributed to the loss of FM in the trunk and limbs (upper and lower). The measurement results suggested that the greater FM decrease in the oE group was characterized by decreases in both visceral and subcutaneous fat. In the yE group, the muscle mass was comparable to that in young women;however, there was a remarkable reduction in the lower-limb muscle mass (9% - 10%). In the oE group, muscle mass was reduced in all body parts, including upper and lower limbs and trunk. In young women, significant positive correlations between muscle mass and muscle strength in the upper and lower limbs were observed. No such correlations in the lower limbs were found in elderly women, indicating that muscle mass is not proportionally reflected in muscle strength. In conclusion, for improving and maintaining the health of elderly women, especially those above the age of 75 years, it is important to maintain muscle mass, including muscle strength,

关键词： Elderly Women Body Composition Muscle Mass Muscle Strength

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Constipation, hard stools, fecal urgency, and incomplete evacuation, but not diarrhea is associated with diabetes and its related factors

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World Journal of Gastroenterology 2016年第11期22卷 3252-3260页

作者： noriko Ihana-Sugiyama Naoyoshi Nagata Ritsuko Yamamoto-Honda Eiko Izawa Hiroshi Kajio Takuro Shimbo Masafumi Kakei Naomi Uemura Junichi Akiyama Mitsuhiko Noda Department of Diabetes Endocrinology and Metabolism National Center for Global Health and Medicine Tokyo 162-8655 Japan Division of General Medicine Jichi Medical University Graduate School of Medicine Tochigi 329-0498 Japan Department of Gastroenterology and Hepatology National Center for Global Health and Medicine Tokyo 162-8655 Japan Department of Endocrinology and Metabolism Toranomon Hospital Tokyo 105-0001 Japan Diabetes Research Diabetes Research Center National Center for Global Health and Medicine Tokyo 162-8655 Japan Center for Clinical Sciences National Center for Global Health and Medicine Tokyo 162-8655 Japan Ohta Nishinouchi Hospital Fukushima 963-8022 Japan First Department of Comprehensive Medicine Saitama Medical Center Jichi Medical University School of Medicine Saitama 330-0834 Japan Department of Gastroenterology and Hepatology Kohnodai Hospital National Center for Global Health and Medicine Chiba 272-8516 Japan Department of Endocrinology and Diabetes Saitama Medical University Saitama 350-0495 Japan

AIM: To determine the bowel symptoms associated with diabetes and diabetes-related factors after excluding gastrointestinal (GI) organic ***: Participants were 4738 (603 diabetic and 4135 non-diabetic) patients who underwent colonoscopy and completed a questionnaire. On the day of pre-colonoscopy, 9 symptoms (borborygmus, abdominal distension, increased flatus, constipation, diarrhea, loose stools, hard stools, fecal urgency, and incomplete evacuation) were prospectively evaluated on a 7-point Likert scale. The test-retest reliability of the bowel symptom scores from the baseline and second questionnaires was analyzed using kappa statistics. Associations between bowel symptom scores and diabetes or diabetes-related factors were analyzed by a rank-ordered logistic model adjusted for related confounders, and odds ratios (ORs) were ***: In multivariate analysis, constipation [adjusted odds ratio (AOR) = 1.57, CI: 1.33-1.85, P < 0.01] and hard stools (AOR = 1.56, CI: 1.33-1.84, P < 0.01) were associated with diabetes, and fecal urgency (AOR = 1.16, CI: 0.99-1.37, P = 0.07) and incomplete evacuation (AOR = 1.16, CI: 1.00-1.36, P = 0.06) were marginally associated with diabetes. These symptoms remained associated even after excluding organic GI diseases on colonoscopy. Test-retest reliability of symptom score with a mean duration of 3.2 mo was good (mean kappa, 0.69). Associations of symptoms with diabetes-related factors were found; constipation with HbA1c ≥ 8.0% (AOR = 2.11, CI: 1.19-3.73), body mass index (BMI) < 25 (AOR = 2.11, CI: 1.22-3.66), and insulin use (AOR = 1.90, CI: 1.08-3.36); hard stools with diabetes duration (AOR = 1.03, CI: 1.00-1.07); fecal urgency with BMI < 25 (AOR = 1.73, CI: 1.00-2.98); and incomplete evacuation with BMI < 25 (AOR = 2.60, CI: 1.52-4.43), serum creatinine level (AOR = 1.27, CI: 1.10-1.47), and insulin use (AOR = 1.92, CI: 1.09-3.38).CONCLUSION: Diabetes is as

关键词： Functional bowel disease Gastrointestinal symptom rating scale Decreased passage of stools Diabetic complications

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Effect of Soy Bean Isoflavon on Lipid Accumulation in 3T3-L1 Adipocytes

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Journal of Biosciences and Medicines 2015年第9期3卷 52-54页

作者： Teruhiko Matsushima noriko Yoshimura Yuumi Koseki Department of Human Life Science Jissen Women’s University Tokyo Japan

Several nutrition and food ingredients are supposed to have beneficial effects, but precise cell biological mechanism has not been elucidated. Among food ingredients, polyphenols such as soy bean isoflavon genistein and wine resveratrol have been reported to have effects on lipid metabolism and cardiovacular diseases (1). In order to elucidate the effect of genistein on obesity, we cultured adipocyte and observed of genisten to lipid accumulation in cells. Triglyceride accumulation was suppressed by genistein when it was added at the time of differentiation but not when added after differentiation. Genistein is considered to suppress lipid accumulation by suppressing the differtiation of adipocytes.

关键词： Obesity Adipocyte Genistein Resveratrol

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Caspase-11 mediated inflammasome activation in macrophages by systemic infection of *** exacerbates arthritis

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International Journal of Oral Science 2024年第3期16卷 499-514页

作者： Tokuju Okano Hiroshi Ashida noriko Komatsu Masayuki Tsukasaki Tamako Iida Marie Iwasawa Yuto Takahashi Yasuo Takeuchi Takanori Iwata Miwa Sasai Masahiro Yamamoto Hiroshi Takayanagi Toshihiko Suzuki Department of Bacterial Pathogenesis Infection and Host ResponseGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Lifetime Oral Health Care Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunoparasitology Research Institute for Microbial DiseasesOsaka UniversityOsakaJapan

Clinical studies have shown that Aggregatibacter actinomycetemcomitans(***)is associated with aggressive periodontitis and can potentially trigger or exacerbate rheumatoid arthritis(RA).However,the mechanism is poorly ***,we show that systemic infection with *** triggers the progression of arthritis in mice anti-collagen antibody-induced arthritis(CAIA)model following IL-1βsecretion and cell infiltration in paws in a manner that is dependent on caspase-11-mediated inflammasome activation in *** administration of polymyxin B(PMB),chloroquine,and anti-CD11b antibody suppressed inflammasome activation in macrophages and arthritis in mice,suggesting that the recognition of lipopolysaccharide(LPS)in the cytosol after bacterial degradation by lysosomes and invasion via CD11b are needed to trigger arthritis following inflammasome activation in *** data reveal that the inhibition of caspase-11-mediated inflammasome activation potentiates aggravation of RA induced by infection with *** work highlights how RA can be progressed by inflammasome activation as a result of periodontitis-associated bacterial infection and discusses the mechanism of inflammasome activation in response to infection with ***.

关键词： CD11b inflam infection

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Changes in Air Temperatures on Mount Fuji, Japan

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Atmospheric and Climate Sciences 2011年第4期1卷 186-188页

作者： noriko Sakano Nobuyuki Miyatake Shoko Murakami 不详

The changes in air temperatures on Mount (Mt.) Fuji, Japan were evaluated. Various parameters of air temperatures on Mt Fuji in Japan were obtained from Japan Metrological Agency. Parameters of air temperatures were positively correlated with years on Mt. Fuji. In addition, the number of days under –24°C in January was negatively correlated with years. Global warming was also proved on Mt. Fuji in Japan, especially in winter. Therefore, we need to deal with global warming effect.

关键词： Air Temperature Mount Fuji Global Warming

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