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Identification of shared and unique gene families associated with oral clefts

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International Journal of Oral Science 2017年第2期9卷 104-109页

作者： noriko Funato Masataka Nakamura Department of Signal Gene Regulation Research Center for Medical and Dental SciencesTokyo Medical and Dental University1-5-45 YushimaBunkyo-kuTokyoJapan

Oral clefts, the most frequent congenital birth defects in humans, are multifactorial disorders caused by genetic and environmental factors. Epidemiological studies point to different etiologies underlying the oral cleft phenotypes, cleft lip(CL),CL and/or palate(CL/P) and cleft palate(CP). More than 350 genes have syndromic and/or nonsyndromic oral cleft associations in humans. Although genes related to genetic disorders associated with oral cleft phenotypes are known, a gap between detecting these associations and interpretation of their biological importance has remained. Here, using a gene ontology analysis approach, we grouped these candidate genes on the basis of different functional categories to gain insight into the genetic etiology of oral clefts. We identified different genetic profiles and found correlations between the functions of gene products and oral cleft phenotypes. Our results indicate inherent differences in the genetic etiologies that underlie oral cleft phenotypes and support epidemiological evidence that genes associated with CL/P are both developmentally and genetically different from CP only, incomplete CP, and submucous CP. The epidemiological differences among cleft phenotypes may reflect differences in the underlying genetic causes. Understanding the different causative etiologies of oral clefts is important as it may lead to improvements in diagnosis, counseling, and prevention.

关键词： cleft palate epidemiology gene ontology mutations soft palate syndrome

The impact of AI: can a robot get into the University of Tokyo?

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National Science Review 2015年第2期2卷 135-136页

作者： noriko H.Arai National Institute of Informatics

The ‘Todai Robot Project(Can a robot get into the University of Tokyo?)’ was initiated by the National Institute of Informatics(NII),the Japan’s only general academic research institution of informatics,in 2011 as ... 详细信息

关键词： can a robot get into the University of Tokyo The impact of AI

IgSF11-mediated phosphorylation of pyruvate kinase M2 regulates osteoclast differentiation and prevents pathological bone loss

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Bone Research 2023年第1期11卷 215-227页

作者： Hyunsoo Kim noriko Takegahara Yongwon Choi Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of MedicinePhiladelphiaPA19104USA

Osteoclasts are primary bone-resorbing cells,and receptor-activated NF-k B ligand(RANKL)stimulation is the key driver of osteoclast *** late-stage differentiation,osteoclasts become multinucleated and enlarged(so-called“maturation”),suggesting their need to adapt to changing metabolic demands and a substantial increase in ***,we demonstrate that immunoglobulin superfamily 11(Ig SF11),which is required for osteoclast differentiation through an association with the postsynaptic scaffolding protein PSD-95,regulates osteoclast differentiation by controlling the activity of pyruvate kinase M isoform2(PKM2).By using a system that directly induces the activation of Ig SF11 in a controlled manner,we identified PKM2 as a major Ig SF11-induced tyrosine-phosphorylated *** SF11 activates multiple Src family tyrosine kinases(SFKs),including c-Src,Fyn,and Hc K,which phosphorylate PKM2 and thereby inhibit PKM2 ***,Ig SF11-deficient cells show higher PKM2activity and defective osteoclast ***,inhibiting PKM2 activities with the specific inhibitor Shikonin rescues the impaired osteoclast differentiation in Ig SF11-deficient cells,and activating PKM2 with the specific activator TEPP46 suppresses osteoclast differentiation in wild-type ***,PKM2 activation further suppresses osteoclastic bone loss without affecting bone formation in *** together,these results show that Ig SF11 controls osteoclast differentiation through PKM2 activity,which is a metabolic switch necessary for optimal osteoclast maturation.

关键词： SF11 osteoclast impaired

Hydrogen production at intermediate temperatures with proton conducting ceramic cells:Electrocatalytic activity,durability and energy efficiency

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Journal of Energy Chemistry 2023年第11期86卷 437-446,I0010页

作者： Haoyu Zheng Feng Han noriko Sata Rémi Costa Institute of Engineering Thermodynamics German Aerospace Center (DLR) Institute for Building Energetics Thermotechnology and Energy Storage (IGTE) University of Stuttgart

Proton conducting ceramic cells(PCCs)are an attractive emerging technology operating in the intermediate temperature range of 500 to 700℃.In this work,we evaluate the production of hydrogen at intermediate temperatures by proton conducting ceramic cell electrolysis(PCCEL).We demonstrate a highperformance steam electrolysis owing to a composite positrode based on BaGd_(0.8)La_(0.2)Co_(2)O_(6-δ)(BGLC1082)and BaZr0.5Ce0.4Y0.1O3-δ(BZCY541).The high reliability of PCCEL is demonstrated for 1680 h at a current density as high as-0.8 A cm^(-2)close to the thermoneutral cell voltage at 600℃.The electrolysis cell showed a specific energy consumption ranging from 54 to 66 kW h kg^(-1)that is comparable to state-of-the-art low temperature electrolysis technologies,while showing hydrogen production rates systematically higher than commercial solid oxide ceramic cells(SOCs).Compared to SOCs,the results verified the higher performances of PCCs at the relevant operating temperatures,due to the lower activation energy for proton transfer comparing with oxygen ion ***,because of the p-type electronic conduction in protonic ceramics,the energy conversion rate of PCCs is relatively lower in steam *** faradaic efficiency of the PCC in electrolysis mode can be increased at lower operating temperatures and in endothermic conditions,making PCCEL a technology of choice to valorize high temperature waste heat from industrial processes into *** increase the faradaic efficiency by optimizing the materials,the cell design,or the operating strategy is a key challenge to address for future developments of PCCEL in order to achieve even more superior techno-economic merits.

关键词： Steam electrolysis Hydrogen production Proton conducting ceramics Intermediate temperature Energy efficiency

NF-κB Regulates B-Cell-Derived Nerve Growth Factor Expression

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Cellular & Molecular Immunology 2006年第1期3卷 63-66页

作者： Klaus Heese noriko Inoue Tohru Sawada Department of Molecular and Cell Biology School of Biological SciencesNanyang Technological University60 Nanyang DriveSingapore 637551Singapore BF Research Institute Inc.Itoyoshi Building 2012-5-9 DoshomachiChuo-kuOsaka 541-0045Japan BF Research Institute Inc. Itoyoshi Building 2012-5-9 DoshomachiChuo-kuOsaka 541-0045Japan

In the mammalian brain, four neurotrophins have been identified： nerve growth factor （NGF）, brain-derived neurotrophic factor （BDNF）, neurotrophin-3 （NT-3） and neurotrophin-4/5 （NT-4/5）. NGF exerts an important role in the development and functions of the central and peripheral nervous system. However, it has recently been documented that several types of immune cells, such as mast ceils, iymphocytes, basophils and eosinophils, produce, store and release NGF. Accumulating preclinical and clinical data indicate that dysfunctions of NGF and the other neurotrophins may contribute to impaired immune responses and concentration of NGF frequently correlates with disease severity. Thus, the aim of this study was to elucidate the potential signaling mechanisms of cytokineneurotrophins interactions contributing to increased NGF levels. Our data show that the transcription factor NF-κB plays a pivotal role in regulating B-cell-derived NGF expression.

关键词： immune system inflammation interleukin NGF neurotrophin

Temporal adjustment of short calls according to a partner during vocal turn-taking in Japanese macaques

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Current Zoology 2019年第1期65卷 99-105页

作者： noriko KATSu Kazunori Yamada Kazuo Okanoya Masayuki Nakamichi Graduate School of Arts and Sciences The University of Tokyo Meguro Tokyo Japan Graduate School of Human Sciences Osaka University Suita Osaka Japan Japan Society for the Promotion of Science Tokyo Japan

Turn-taking is a common feature in human speech, and is also seen in the communication of other primate species. However, evidenee of turn-taking in vocal exchanges within a short time frame is still scarce in non human primates. This study in vestigated whether dynamic adjustme nt during turn-taking in short calls exists in Japanese macaques Macaca fuscata. We observed exchanges of short calls such as grunts, girneys, and short, low coos during social interactions in a free-ranging group of Japanese macaques. We found that the median gap between the turns of two callers was 250 ms. Call intervals varied among individuals, suggesting that call intervals were not fixed among individuals. Solo call intervals were shorter than call intervals interrupted by responses from partn ers (i.e., excha nges) and Ion ger than those between the partner's reply and the reply to that call, indicating that the monkeys did not just repeat calls at certain intervals irrespective of the social situation. The differences in call intervals during exchanged and solo call sequences were explained by the response interval of the partner, suggesting an adjustment of call timing according to the tempo of the part ner's call utterance. These findi ngs suggest that mon keys display dyn amic temporal adjustment in a short time window, which is comparable with turn-taking in human speech.

关键词： turn-taking rhythm vocalization primate

Berberine for prevention of dementia associated with diabetes and its comorbidities:A systematic review

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Journal of Integrative Medicine 2020年第2期18卷 125-151页

作者： noriko Shinjyo James Parkinson Jimmy Bell Tatsuro Katsuno Annie Bligh Department of Infection and Host Defense Graduate School of MedicineChiba UniversityChuo-kuChiba 260-8670Japan Department of Life Sciences Faculty of Science and Technology at the University of WestminsterLondon W1W 6UWUnited Kingdom Kashiwanoha Clinic of East Asian Medicine Chiba University HospitalKashiwaChiba 277-0882Japan School of Health Sciences Caritas Institute of Higher EducationTseung Kwan ONT 999077Hong KongChina

Background: A growing number of epidemiological studies indicate that metabolic syndrome(MetS) and its associated features play a key role in the development of certain degenerative brain disorders, including Alzheimer’s disease and vascular dementia. Produced by several different medicinal plants, berberine is a bioactive alkaloid with a wide range of pharmacological effects, including antidiabetic ***, it is not clear whether berberine could prevent the development of dementia in association with ***: To give an overview of the therapeutic potential of berberine as a treatment for dementia associated with *** strategy: Database searches A and B were conducted using Pub Med and Science Direct. In search A,studies on berberine’s antidementia activities were identified using “berberine” and “dementia” as search terms. In search B, recent studies on berberine’s effects on diabetes were surveyed using “berberine” and“diabetes” as search *** criteria: Clinical and preclinical studies that investigated berberine’s effects associated with Met S and cognitive dysfunction were *** extraction and analysis: Data from studies were extracted by one author, and checked by a second;quality assessments were performed independently by two ***: In search A, 61 articles were identified, and 22 original research articles were selected. In search B, 458 articles were identified, of which 101 were deemed relevant and selected. Three duplicates were removed, and a total of 120 articles were reviewed for this study. The results demonstrate that berberine exerts beneficial effects directly in the brain: enhancing cholinergic neurotransmission, improving cerebral blood flow, protecting neurons from inflammation, limiting hyperphosphorylation of tau and facilitating b-amyloid peptide clearance. In addition, evidence is growing that berberine is effective against diabetes and associated disorders, such as atherosclerosis

关键词： Berberine Diabetes Dementia Alzheimer’s disease Vascular dementia

Drug resistance mechanisms of cancer stem-like cells and their therapeutic potential as drug targets

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Cancer Drug Resistance 2019年第3期2卷 457-470页

作者： Takahiko Murayama noriko Gotoh Division of Cancer Cell Biology Cancer Research InstituteKanazawa UniversityKanazawa 920-1192Japan.

Despite of recent advances in cancer research and development of new anti-cancer drugs,tumor patients’prognoses have not yet been improved well *** failure of tumors is highly attributed to the drug resistance of a small population of cancer cell known as cancer stem-like cells(CSCs).CSCs also have the self-renewal activity and differentiation potency,conferring strong tumorigenicity on ***,development of CSC targeting therapy is urgently needed in order to overcome possible recurrence and metastasis by them after *** show some characteristic features that are not observed in other differentiated cancer cells,which give them higher resistance against conventional chemotherapy or *** such specific features could be useful for CSC *** review will summarize the recent advances in the study of CSC characteristics along with the promising therapeutic strategies targeting them.

关键词： Cancer stem-like cell drug resistance epithelial-to-mesenchymal transition hypoxia quiescence

Virus-induced gene silencing and virusinduced flowering in strawberry(Fragaria×ananassa)using apple latent spherical virus vectors

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Horticulture Research 2019年第1期6卷 1428-1437页

作者： Chunjiang Li noriko Yamagishi Ichiro Kasajima Nobuyuki Yoshikawa Faculty of Agriculture Iwate UniversityMorioka 3-18-8Iwate 020-8550Japan Agri-Innovation Research Center Iwate UniversityMorioka 3-18-8Iwate 020-8550Japan

Apple latent spherical virus(ALSV)vector is a convenient alternative to genetic transformation in horticultural plants,especially in species recalcitrant to genetic ***,an RNA virus,can infect a wide variety of plant species including major horticultural plants without inducing ***,methodologies were developed for infection of ALSV vectors to strawberry seedlings and plantlets cultured in vitro.A seed-propagated F1 hybrid strawberry cultivar'Yotsuboshi'was aseptically grown on half-strength Murashige–Skoog medium for 1 month and true leaves were inoculated with an ALSV RNA preparation by particle *** vector infection rates varied from 58 to 100%according to the insertion sequences,in‘Yotsuboshi’***(‘Dover’)propagated in vitro could also be infected with ALSV vector at a similar infection *** virus-induced gene silencing(VIGS),we prepared an ALSV vector carrying a 201 nucleotide segment of the strawberry phytoene desaturase gene.‘Yotsuboshi’and‘Dover’plants infected by this vector generated completely white leaves at fifth or sixth true leaves and *** virus-induced flowering(VIF),we used an ALSV vector expressing the Arabidopsis thaliana flowering locus T *** seedlings infected by this vector started to flower from about 2 months post inoculation and bore fruits with viable *** ALSV vector was no longer detected in any of the seedlings from early-flowered ***,the ALSV vector may be beneficial for examination of gene functions by VIGS in strawberry,and VIF using ALSV vector constitutes an effective new plant breeding technique for the promotion of cross-breeding in strawberry.

关键词： straw breeding Fragaria