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Difficulty in differentiating two cases of sigmoid stenosis by diverticulitis from cancer

World Journal of Gastroenterology 2012年第27期18卷 3623-3626页

作者： noriko Nishiyama Hirohito Mori Hideki Kobara Kazi Rafiq Shintarou Fujihara Mitsuyoshi Kobayashi Tsutomu Masaki Department of Gastroenterology and Neurology Faculty of MedicineKagawa UniversityKagawa 761-0793Japan Department of Pharmacology Faculty of MedicineKagawa UniversityKagawa 761-0793Japan

The incidence of colonic diverticulosis with or without diverticulitis has increased in the Japanese population due to the modernization of food and *** rate of diverticulitis in colon diverticulosis ranges from 8.1% to 9.6%.However,few cases of stenosis due to diverticulitis have been *** reports suggest that the differentiation between sigmoid diverticulitis and colon cancer is *** report describes two cases of colon stenosis due to diverticulitis that were difficult to differentiate from colon *** 1 was a 70-year-old woman with narrowed stools for 1 month who underwent colonofiberscopy (CFS).CFS revealed a diverticulum and circumferential stenosis in the sigmoid *** enema revealed a marked,hourglassshaped,2-cm circumferential stenosis in the sigmoid *** (FDG)-positron emission tomography computed tomography (CT) revealed an increased FDG uptake at the affected portion of the sigmoid *** colon cancer was suspected,and laparoscopic sigmoidectomy was *** examination demonstrated active inflammation with no evidence of *** 2 was a 50-yearold man who presented to a nearby clinic with reduced stool output despite the urge to *** detected severe stenosis in the sigmoid colon approximately 25 cm from the dentate ***-enhanced abdominal CT revealed multiple diverticula,wall thickening,and swelling of the lymph nodes around the peritoneal aorta and the inferior mesenteric artery.A partial sigmoidectomy was *** examination of the resected specimen revealed no changes in the mucosal epithelial surface,but a marked infiltration of inflammatory cells was observed.

关键词：结肠癌狭窄正电子发射断层扫描计算机断层扫描癌症食物安全病理检查脱氧葡萄糖

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Quantitative index calculated by ^(99m)Tc-GSA scintigraphy

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Chinese Journal of Cancer Research 2014年第6期26卷 641-643页

作者： Morikatsu Yoshida Shinya Shiraishi noriko Tsuda Fumi Sakamoto Seiji Tomiguchi Yasuyuki Yamashita Department of Diagnostic Radiology Graduate School of Life Sciences Kumamoto University Department of Diagnostic Medical Imaging School of Health Faculty of Life Sciences Kumamoto University

99mTc-galactosyl human serum albumin（GSA） scintigraphy is useful to evaluate hepatic function and hepatic functional reserve. A reliable SPECT and CT integrated system is now commercially available. Using this system, we can obtain 99mTc-GSA SPECT/CT fused imaging with a small registration error. Therefore, the 99mTc-GSA scintigraphy techniques prove more useful in clinical practice than have been previously reported. In the latest Annals of Surgical Oncology on Oct 2014, the uptake index（UI） values calculated from 99mTc-GSA scintigraphy are reported to be useful for predicting the functional reserve of the future remnant liver. In this paper, we describe the usefulness of 99mTc-GSA scintigraphy as well as some cautions that are necessary as regards using the system.

关键词： 99mTc-GSA scintigraphy SPECT/CT uptake index(UI)

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Determination of reactive oxygen generated from natural medicines and their antibacterial activity

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Journal of Pharmaceutical Analysis 2016年第4期6卷 214-218页

作者： noriko Tajima Makiko Takasaki Haruka Fukamachi Takeshi Igarashi Yoshijiro Nakajima Hidetoshi Arakawa Analytical Chemistry School of PharmacyShowa Univ. Oral Microbiology and Immunology School of DentistryShowa Univ. Ohta's Isan Co. Ltd.

Extracts of 16 natural medicine powders {Galla chinensis,Malloti cortex,Cassiae semen,Sophorae radix,Myricae cortex,Crataegi fructus,Gambit,Mume fructus,Geranii herba,Phellodendri cortex,Coptidis rhizoma,Swertiae herba,and Cinnamomi cortex） were assayed for reactive oxygen concentrations using the peroxyoxalate chemiluminescent detection *** luminescence intensity was observed in Galla chinensis,Geranii herba,Malloti cortex,Myricae cortex,and Cinnamomi *** experiments identified the reactive oxygen species as hydrogen *** chinensis generated 2.4 × 10^（-4） mol/L hydrogen peroxide from a 1 mg/mL *** bacterial growth tests,Galla chinensis extract had antibacterial activity against Escherichia *** aureus,Bacteroides thetaiotaomicron,Campylobacter sputorum biovar *** salivarius thermophilus,Lactobacillus casei,and Bifidobacterium longum *** antibacterial activity was decreased by the addition of *** revealed that hydrogen peroxide which Galla chinensis produced participated in antibacterial activity.

关键词： Galla Chinensis Natural medicines Hydrogen peroxide Antibacterial activity

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Bleeding duodenal hemangioma: Morphological changes and endoscopic mucosal resection

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World Journal of Gastroenterology 2012年第22期18卷 2872-2876页

作者： noriko Nishiyama Hirohito Mori Hideki Kobara Shintarou Fujihara Takako Nomura Mitsuyoshi Kobayashi Tsutomu Masaki Department of Gastroenterology and Neurology Faculty of Medicine Kagawa Medical University

Recently, the development of endoscopic procedures has increased the availability of minimally invasive treatments; however, there have been few case reports of duodenal hemangioma treated by endoscopic mucosal resection. The present report describes a case of duodenal hemangioma that showed various endoscopic changes over time and was treated by endoscopic mucosal resection. An 80-year-old woman presented with tarry stools and a loss of appetite. An examination of her blood revealed severe anemia, and her hemoglobin level was 4.2 g/dL. An emergency upper gastrointestinal endoscopy was performed. A red, protrusive, semipedunculated tumor (approximately 20 mm in diameter) with spontaneous bleeding on its surface was found in the superior duodenal angle. Given the semipedunculated appearance of the tumor, it was suspected to be an epithelial tumor with a differential diagnosis of hyperplastic polyp. The biopsy results suggested a telangiectatic hemangioma. Because this lesion was considered to be responsible for her anemia, endoscopic mucosal resection was performed for diagnostic and treatment purposes after informed consent was obtained. A histopathological examination of the resected specimen revealed dilated and proliferated capillary lumens of various sizes, which confirmed the final diagnosis of duodenal hemangioma. Neither anemia nor tumor recurrence has been observed since the endoscopic mucosal resection (approximately 1 year). Duodenal hemangiomas can be treated endoscopically provided that sufficient consideration is given to all of the possible treatment strategies. Interestingly, duodenal hemangiomas show morphological changes that are influenced by various factors, such as mechanical stimuli.

关键词：毛细血管扩张十二指肠形态学变化切除术内镜黏膜出血鉴别诊断

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Clinical features in proven and probable invasive fungal disease in children and adolescents at a pediatric referral center: a 5-year experience

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World Journal of Pediatrics 2019年第3期15卷 270-275页

作者： Kenji Kishimoto Masashi Kasai noriko Kawamura Yusuke Ito Makiko Yoshida Daiichiro Hasegawa Keiichiro Kawasaki Yoshiyuki Kosaka Department of Hematology and Oncology Children’s Cancer CenterKobe Children’s HospitalMinatojima—Minamimachi 1—6-7Chuo—kuKobe 650—0047 Japan Department of Infectious Disease Kobe Children’s Hospital KobeJapan Department of Clinical Laboratory Kobe Children’s HospitalKobeJapan Department of Diagnostic Pathology Kobe Children’s HospitalKobeJapan Department of Pediatrics Kita—Harima Medical Center KobeJapan

Background There is limited information concerning the overall epidemiology of invasive fungal disease (IFD) in *** aim of this study was to clarify the clinical features of IFD in a tertiary pediatric care *** Patients diagnosed with proven or probable IFD at our hospital between 2011 and 2015 were retrospectively *** and probable IFD were defined according to the European Organization for Research and Treatment of Cancer/Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group *** with possible IFD were *** The incidence of proven or probable IFD was 26 of 20,079 hospitalized patients (0.13%).The predominant underlying disease was malignancy (54%) and congenital anomaly (27%).The most common diagnosis was candidemia among the patients with proven IFD (8 of 13,62%).All the isolated pathogens in the candidemia patients were non-albicans Candida *** most common site of infection was the lungs in patients with probable IFD (11 of 13 patients,85%).In probable IFD episodes,positive β-D-glucan and galactomannan were found in 12 of 13 (92%) and 5 of 13 (38%) patients,*** but one patient (96%) received empirical antifungal *** patients underwent surgical resection of residual *** overall mortality was 23% and the attributable mortality of IFD was 12%.Conclusion Our results suggest the emergence of non-albicans Candida species as important pathogens in childhood IFD.

关键词： Children Invasive fungal disease Incidence Mortality

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Oval mucosal opening bloc biopsy after incision and widening by ring thread traction for submucosal tumor

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World Journal of Gastroenterology 2017年第39期23卷 7185-7190页

作者： Hirohito Mori Hideki Kobara Yu Guan Yasuhiro Goda Nobuya Kobayashi noriko Nishiyama Tsutomu Masaki Department of Gastroenterology and Neurology Kagawa University Departments of Pharmacology Kagawa University

Gastric submucosal tumors(SMTs) less than 2 cm are generally considered benign neoplasms, and endoscopic observation is recommended, but SMTs over 2 cm, 40% of which are gastrointestinal stromal tumors(GISTs), have malignant potential. Although the Japanese Guidelines for GIST recommend partial surgical resection for GIST over 2 cm with malignant potential as well as en bloc large tissue sample to obtain appropriate and large specimens of SMTs, several reports have been published on tissue sampling of SMTs, such as with endoscopic ultrasound sound fine needle aspiration, submucosal tunneling bloc biopsy, and the combination of bite biopsy and endoscopic mucosal resection. Because a simpler, more accurate method is needed for appropriate treatment, we developed oval mucosal opening bloc biopsy after incision and widening by ring thread traction for submucosal tumor(OMOB) approach. OMOB was simple and enabled us to obtain large samples under direct procedure view as well as allowed us to restore to original mucosa.

关键词：胃的 submucosal 肿瘤胃肠的 stromal 肿瘤可逆开始活体检视内视镜的 ultrasonography 大样品

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Association of non-synonymous variants in WIPF3 and LIPA genes with ab- dominal aortic aneurysm： an autopsy study

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Journal of Geriatric Cardiology 2016年第12期13卷 960-967页

作者： Yuko Maeda noriko Sato Makiko Naka-Mieno Seijiro Mori Tomio Arai Masashi Tanaka Masaaki Muramatsu Motoji Sawabe Department of Molecular Epidemiology Medical Research Institute Tokyo Medical and Dental University Tokyo Japan Department of Medical Informatics Center of Inormation Jichi Medical University Tochigi Japan Center for Promotion of Clinical Investigation Tokyo Metropolitan Geriatric Hospital Tokyo Japan Department of Pathology Tokyo Metropolitan Geriatric Hospital Tokyo Japan Research Teams for Geriatric Pathology Tokyo Metropolitan Institute of Gerontology Tokyo Japan Department of Genomics for Longevity and Health Tokyo Metropolitan Institute of Gerontology Tokyo Japan Department of Molecular Pathology Graduate School of Health Care Sciences Tokyo Medical and Dental University Tokyo Japan

腹的大动脉的动脉瘤(AAA ) 是有强壮的基因部件的 multifactorial 疾病。各种各样的基因 loci 与临床的 AAA 被联系了，但是很少研究调查了病理学的 AAA， *** 的中间的显型在日本个人(JG-SNP 学习) 在衰老老人疾病上从研究检验了更老... 详细信息

腹的大动脉的动脉瘤(AAA ) 是有强壮的基因部件的 multifactorial 疾病。各种各样的基因 loci 与临床的 AAA 被联系了，但是很少研究调查了病理学的 AAA， *** 的中间的显型在日本个人(JG-SNP 学习) 在衰老老人疾病上从研究检验了更老的日本题目的 2263 具连续尸体。AAA 的存在在尸体期间与病理学的诊断被决定。与 AAA 联系的单个核苷酸变体(SNV ) 与一个 Illumina HumanExome Beadchip 数组被决定。逻辑回归分析被执行决定基因协会。当有 AAA 的 ***118 题目和没有 AAA 的 2145 个题目在一个盒子控制背景被分析，年龄，性，和 AAA 的另外的风险因素被分析。没有变体在使用 Bonferroni 修正以后到达了意义(P < 2.05 ???????  ???????????????????? 瀠瑡敩瑮 ? 潃据畬楳湯味敨 ?????????????? 吗？？

关键词：腹的大动脉的动脉瘤 Lysosomal 酸脂肪分解酵素 A WAS/WASL 交往蛋白质家庭 3

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Rectal perforations and fistulae secondary to a glycerin enema:Closure by over-the-scope-clip

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World Journal of Gastroenterology 2012年第24期18卷 3177-3180页

作者： Hirohito Mori Hideki Kobara Shintaro Fujihara noriko Nishiyama Mitsuyoshi Kobayashi Tsutomu Masaki Kunihiko Izuishi Yasuyuki Suzuki Department of Gastroenterology and Neurology Kagawa Medical University School of MedicineKagawa 761-0793Japan Department of Gastroenterological Surgery Kagawa Medical University School of MedicineKagawa 761-0793Japan

Rectal perforations due to glycerin enemas(GE) typically occur when the patient is in a seated or lordotic standing *** the perforation occurs and peritonitis results,death is usually *** describe two cases of rectal perforation and fistula caused by a *** 88-year-old woman presented with a large rectal perforation and a fistula just after receiving a *** case was further complicated by an abscess in the right rectal *** second patient was a 78-year-old woman who suffered from a rectovesical fistula after a *** both cases,we performed direct endoscopic abscess lavage with a saline solution and closed the fistula using an over-the-scope-clip(OTSC) *** procedures resulted in dramatic improvement in both *** endoscopic lavage and OTSC closure are very useful for pararectal abscess lavage and fistula closure,respectively,in elderly patients who are in poor general *** two cases are the first reports of the successful endoscopic closure of fistulae using double OTSCs after endoscopic lavage of the debris and an abscess of the rectum secondary to a GE.

关键词：直肠穿孔封闭剪辑灌肠甘油继发盐水溶液

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Case of pediatric traditional serrated adenoma resected via endoscopic submucosal dissection

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World Journal of Gastroenterology 2017年第24期23卷 4462-4466页

作者： Sonoko Kondo Hirohito Mori noriko Nishiyama Takeo Kondo Ryuichi Shimono Hitoshi Okada Takashi Kusaka Department of Pediatrics Faculty of MedicineKagawa University Department of Gastroenterology and Neurology Faculty of MedicineKagawa University Department of Pediatric Surgery Faculty of MedicineKagawa University

Traditional serrated adenoma(TSA)is a type of serrated polyp of the colorectum and is thought to be a precancerous *** are three types of serrated polyps,namely,hyperplastic polyps,sessile serrated adenomas/polyps,and *** is the least common of the three types and accounts for about 5% of serrated *** we report a pediatric case of TSA that was successfully resected by endoscopic submucosal dissection(ESD).This rare case report describes a pediatric patient with no family history of colonic polyp who was admitted to our hospital with *** colonoscopy,we found a polypoid lesion measuring 10 mm in diameter in the lower *** selected ESD as a surgical option for en bloc resection,and histopathological examination revealed *** findings in this case suggest that TSA with precancerous potential can occur in children,and that ESD is useful for treating this lesion.

关键词：小儿科的结肠的息肉 Hematochezia Colorectal serrated 损害传统的 serrated 腺瘤内视镜的 mucosal 切除术内视镜的 submucosal 解剖

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Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway

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The Journal of Biomedical Research 2017年第5期31卷 408-418页

作者： Zhongbo Liu U-Syn Ha Ke Yu Chunli Wu noriko Yokoyama Xiaolin Zi Departments of Urology University of CaliforniaIrvine Orange CA 92868 USA. Pharmacology University of CaliforniaIrvine Orange CA 92868 USA. Chao Family Comprehensive Cancer Center University of CaliforniaIrvine Orange CA 92868 USA.

Consumption of kava(Piper methysticum Forst) has been linked to reduced cancer risk in the South Pacific *** are major bioactive components in kava root extracts, which have recently demonstrated anti-cancer activities. However, molecular mechanisms of kavalactones' anti-cancer action remain largely unknown. We have identified two kavalactones, yangonin and 5' 6'-dehydrokawain, as potent inducers of autophagic cell death in bladder cancer cells. The effect of yangonin inducing autophagy is associated with increased expression of beclin and *** addition, yangonin increases the expression of LKB1 and decreases the phosphorylation of Akt, PRAS40, rpS6,p70S6 K and 4E-BP1, leading to increased binding of 4E-BP1 to m7 GTP. The growth inhibitory effects of yangonin were attenuated in TSC1 or LKB1 knockout mouse embryonic fibroblasts, suggesting that TSC1 and LKB1 expression may contribute to optimal growth inhibition by yangonin. Furthermore, yangonin reduces the viability of bladder cancer cell lines derived from different stages of human bladder cancer, and acts synergistically with apoptosis-inducing agents such as docetaxel and flavokawain A. Our results support a novel anti-bladder cancer mechanism by yangonin and further studies are needed to assess the potential use of yangonin for bladder cancer prevention and treatment

关键词： yangonin bladder cancer autophagy mTOR

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