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口腔幽门螺杆菌感染与胃幽门螺杆菌感染的相关性探讨

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中华消化杂志 2011年第7期31卷 470-473页

作者：叶国钦 Karin Everett noriko Taylor 美国西雅图美利泰格诊断试剂有限公司螺旋杆菌研究所98208

目的分析口腔和胃幽门螺杆菌（Hp）感染的检测结果，探讨口腔Hp感染与胃Hp感染的相关性，及口腔Hp感染对Hp根除治疗的影响。方法采用唾液测定螺旋杆菌抗原技术（HPS）和^13C／^14C尿素呼气试验（UBT）同步检测的方法，对114例有上消化... 详细信息

目的分析口腔和胃幽门螺杆菌（Hp）感染的检测结果，探讨口腔Hp感染与胃Hp感染的相关性，及口腔Hp感染对Hp根除治疗的影响。方法采用唾液测定螺旋杆菌抗原技术（HPS）和^13C／^14C尿素呼气试验（UBT）同步检测的方法，对114例有上消化道症状的初诊患者（第1组），129例确诊为胃Hp感染经根除治疗后4周复查的患者（第2组）和33例无消化道症状的健康志愿者（第3组），进行口腔和胃Hp检测。结果第1组、第2组和第3组HPS阳性检出率分别为77．19％、75．97％和81．82％，3组比较差异无统计学意义（x^2=0．47，P值均〉0．05）；UBT阳性检出率第1组（52．63％）比第2组（34．11％）和第3组（21．21％）高，第1组与第2组和第3组比较，差异有统计学意义（x^2=8．48和10．19，P均〈0．05），第2组与第3组之间差异无统计学意义（x^2=2．03，P〉0．05）；在UBT阳性者中，HPS阳性检出率差异无统计学意义（3组分别为81．67％、88．64％和100％，x^2=2．25，P值均〉O．05）。结论唾液中存在高Hp抗原检出现象，口腔可能是Hp在胃以外的“第二定居地”。口服药物治疗对口腔Hp感染几乎无效，口腔Hp的存在可能是胃病发病和复发的一个重要和直接的原因。

关键词：螺杆菌幽门口腔胃抗原细菌唾液尿素碳放射性同位素

Two new triterpenoid saponins from Ardisia mamillata

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Two new triterpenoid saponins from Ardisia mamillata

Effect of Soy Bean Isoflavon on Lipid Accumulation in 3T3-L1 Adipocytes

第八届全国中药和天然药物学术研讨会与第五届全国药用植物...

作者： noriko Shimizu Tadahiro Takeda Kyoritsu College of Pharmacy Minato-kuTokyo 105-8512Japan

Ardisia mamillata Hance (Myrsinaceae) is a widely occurring shrub in southern China. Its roots have been traditionally used to treat respiratory tract infections and menstrual disorders. Other plants of this genus have also been used for this purpose, and are well documented in traditional medicine in Southeast Asia. Recently, we have isolated six new triterpenoid saponins, ardisimamillosides A-F from A. mamillata. In this paper, we report the isolation and structural elucidation of two additional new triterpenoid saponins (1 and 2) from this species.

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Journal of Biosciences and Medicines 2015年第9期3卷 52-54页

作者： Teruhiko Matsushima noriko Yoshimura Yuumi Koseki Department of Human Life Science Jissen Women’s University Tokyo Japan

Several nutrition and food ingredients are supposed to have beneficial effects, but precise cell biological mechanism has not been elucidated. Among food ingredients, polyphenols such as soy bean isoflavon genistein and wine resveratrol have been reported to have effects on lipid metabolism and cardiovacular diseases (1). In order to elucidate the effect of genistein on obesity, we cultured adipocyte and observed of genisten to lipid accumulation in cells. Triglyceride accumulation was suppressed by genistein when it was added at the time of differentiation but not when added after differentiation. Genistein is considered to suppress lipid accumulation by suppressing the differtiation of adipocytes.

关键词： Obesity Adipocyte Genistein Resveratrol

A Study on Ecotourism Considered from Viewpoint of Landscape

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A Study on Ecotourism Considered from Viewpoint of Landscape

Cervical Castleman's disease mimicking lymph node metastasis of esophageal carcinoma

作者： noriko HORIE Sadatoshi TABATA Parks and Recreation Foundation The Nature Conservation Society of Japan

＜正＞Recently, ecotourism has been acknowledged as one form of sightseeing. Ecotourism is an idea of sightseeing that aims at uniting the protection of regional resources such as nature, the history, and the culture, the sightseeing industry, and revitalization of local economy. Landscape architects have been playing a constant role to the sightseeing development and the regional plan in the area of conventional sightseeing. Then, what sort of relationship are ecotourism and ’Landscape’ building now? What does ecotourism have to do with ’Landscape’? Do actual ecotours as marketed tour packages make a point of ’Landscape’ ? In this study, we consider ecotourism from the aspect of ’Landscape’. Specifically, we examine the definition of ecotourism, the history of ecotourism and sightseeing, and actual ecotours. Firstly, definitions of ecotourism were examined by searching for terms related to ’Landscape’, and were examined how the terms were described. Secondly, the chronology was made in connection with ecotourism and ’Landscape’, and was analyzad. Thirdly, terms related ’Landscape’ were searched in the description of actual ecotours registered in ECOTOUR SOURAN, and the results were compared with that of the general sightseeing tours. As a result, we could not find remarkable sign that ’Landscape’ has special recognition in the definition, the history, and ecotour programs of ecotourism. In the definitions of ecotourism, only NACS-J use the term of ’nature （keikan）’ The landscape may be indirectly expressed as in ’nature’, history’, ’culture’, and an inclusive word ’environment’. But, we may say that the concept of ’Landscape’ is not clearly considered in ecotourism. In the history of ecotourism, landscape seems to have stayed as one of sightseeing objects while both objects and forms of the sightseeing are diversified. In the tours registered as ecotours, the number of tours for which the term related to the landscape was used limited to 22 out of 757. The occurrences

关键词： ecotourism landscape the definition of ecotourism the history of ecotourism ecotour

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World Journal of Gastrointestinal Oncology 2017年第9期9卷 397-401页

作者： Takumi Yamabuki Masanori Ohara Mototsugu Kato noriko Kimura Tomohide Shirosaki Kunishige Okamura Aki Fujiwara Ryo Takahashi Kazuteru Komuro Nozomu Iwashiro Satoshi Hirano Department of Surgery National Hospital Organization Hakodate Hospital Department of Gastroenterology National Hospital Organization Hakodate Hospital Department of Pathology National Hospital Organization Hakodate Hospital Department of Gastroenterological Surgery Ⅱ Hokkaido University Hospital

Castleman's disease(CD) is an uncommon benign lymphoproliferative disorder of unknown etiology. A rare case of cervical CD diagnosed at lymph node dissection for esophageal carcinoma is reported. An esophageal tumor was identified in a 67-year-old man during a follow-up examination after surgery for oral carcinoma. Esophagoscopy revealed a type 1 tumor in the cervical esophagus. Histology of esophagoscopic biopsies indicated squamous cell carcinoma. Contrastenhanced computed tomography revealed swollen lymph nodes of the right cervical region. No distant metastasis was detected. Esophageal carcinoma, T2N2M0, Stage ⅢA was diagnosed. Neoadjuvant chemotherapy was recommended, but the patient rejected the chemotherapy. The patient underwent laparoscopic-assisted transhiatal esophagectomy. The histopathological diagnosis was moderately differentiated squamous cell carcinoma with pT1bN0M0, Stage ⅠA. On histology, the swollen lymph nodes of the right cervical region revealed CD. The patient's postoperative course was relatively good.

关键词： Castleman’s disease Lymph node metastasis Esophageal carcinoma

Roles of sphingosine-1-phosphate signaling in angiogenesis

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World Journal of Biological Chemistry 2010年第10期1卷 298-306页

作者： Yoh Takuwa Yasuo Okamoto noriko Takuwa Kazuaki Yoshioka Department of Health and Medical Sciences Ishikawa Prefectural Nursing University7-1 Nakanumatu KahokuIshikawa 929-1212Japan

Sphingosine-1-phosphate (S1P) is a blood-borne lipid mediator with pleiotropic biological activities. S1P acts via the specific cell surface G-protein-coupled receptors, S1P1-5. S1P1 and S1P2 were originally identified from vascular endothelial cells (ECs) and smooth muscle cells, respectively. Emerging evidence shows that S1P plays crucial roles in the regulation of vascular functions, including vascular formation, barrier protection and vascular tone via S1P1, S1P2 and S1P3. In particular, S1P regulates vascular formation through multiple mechanisms; S1P exerts both positive and negative effects on angiogenesis and vascular maturation. The positive and negative effects of S1P are mediated by S1P1 and S1P2, respectively. These effects of S1P1 and S1P2 are probably mediated by the S1P receptors expressed in multiple cell types including ECs and bone-marrow-derived cells. The receptor-subtype-specific, distinct effects ofS1P favor the development of novel therapeutic tactics for antitumor angiogenesis in cancer and therapeutic angiogenesis in ischemic diseases.

关键词： Sphingosine-1-phosphate Angiogenesis Angiogenic therapy Rac Akt Vascular maturation Endothelial cells Bone-marrow-derived cells

Developing a Scale for Measuring Uncertainty in Patients with Unruptured Intracranial Aneurysms Undergoing Endovascular Coiling

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Open Journal of Nursing 2015年第10期5卷 917-926页

作者： Mitsumi Masuda Hidenori Ohishi noriko Terunuma Ikuko Tojima Department of Critical Care Nursing Graduate School of Nursing Kitasato University Tokyo Japan Department of Medical Science Graduate School of Medicine Juntendo University Tokyo Japan Nursing Department Juntento University Hospital Tokyo Japan

A measure called the Uncertainty in Unruptured Intracranial Aneurysm Patients Undergoing Endovascular Coiling Scale (UUIACS) was developed and its validity and reliability were examined. The 49 questions that comprised the original draft of the UUIACS were created based on interview data. Based on data from 172 participants, exploratory and confirmatory factor analyses were conducted. As a result of exploratory factor analysis, the UUIACS e retained 17 items and extracted four factors (“Lack of decision-making cues”, “Lack of information and complexity of information interpretation”, “The ambiguous nature of the disease”, and “The unpredictable living with UIA”). All of the UUIACS items showed adequate internal consistency. Between the UUIAC scale and the Universal Uncertainty in Illness Scale (UUIS), the Health Locus of Control (HLC) scale, and the SF-36v2® (Japanese version), positive correlations were found between the UUIACS and UUIS, and the HLC scale at a 1% significance level indicating concurrent validity. According to confirmatory factor analysis, the UUIACS had an acceptable goodness of fit. Given these findings, the UUIACS was judged to have satisfied the criteria for use in a clinical setting, although further investigation was required.

关键词： Unruptured Intracranial Aneurysms Endovascular Coiling Uncertainty Scale

Inhibition of Lon protease by bacterial lipopolisaccharide (LPS) though inhibition of ATPase

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Advances in Bioscience and Biotechnology 2013年第4期4卷 590-598页

作者： Nahoko Sugiyama noriko Minami Yoshiyuki Ishii Fumio Amano Division of Molecular Genetics National Institute of Infectious Diseases Tokyo Japan Laboratory of Biodefense & Regulation Osaka University of Pharmaceutical Sciences Osaka Japan

Lon protease, an ATP-dependent protease in Escherichia coli, degrades abnormal proteins and regulates several important cellular functions. Here we show novel inhibitory effects of lipopolysaccharide (LPS) on Lon protease activities. LPS inhibited the peptidase, protease, and ATPase activities of Lon;and a dose-response study showed that LPS at low doses more effectively inhibited the ATPase activity than the peptidase one, suggesting different susceptibility to LPS of these activities associated with Lon. Structure-activity relationship studies revealed that ReLPS, detoxified LPS, and mono-phosphoryl as well as diphosphoryl lipid A, also showed similar inhibition, suggesting that neither O-antigen polysaccharide nor O-acyl chain, but rather phosphate groups in the lipid A domain, seem to have been responsible for the inhibitory effects. Besides, LPS was co-precipitated with Lon by an anti-Lon antibody, showing the direct binding of LPS to Lon. These results suggest that LPS bound to Lon and inhibited the protease activity of Lon by inhibiting its ATPase activity. These results also seem to be another example of a negatively charged phosphate group in membrane components of Escherichia coli being involved in the regulation of protease activity of Lon through binding to Lon and inhibiting its ATPase activity, as in the case of cardiolipin.

关键词： ATPase Lipid A Lipopolysaccharide (LPS) Lon Protease

Factors influencing self-efficacy in breastfeeding support among public health nurses in Japan

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Health 2013年第12期5卷 2051-2058页

作者： noriko Toyama Kayoko Kurihara Mineko Muranaka Kiyoko Kamibeppu Department of Family Nursing Graduate School of Medicine The University of Tokyo Tokyo Japan Japanese Nursing Association Tokyo Japan

This study investigated self-efficacy in breastfeeding support among public health nurses (PHNs) working at maternal and child health (MCH) services in Japanese municipalities, and its related factors such as education, working experience, breastfeeding experience, and postgraduate/continuous education. Directors of the MCH divisions were requested to select one PHN to answer the self-report questionnaires sent. The questionnaires were collected from October 2010 to January 2011. Of the 1750 questionnaires sent, 831 were returned (response rate: 47.5%);102 were excluded from analysis because of missing data (valid response rate: 41.7%). After adjusting the weights of PHN sampling and collection rates by prefecture and population size, Model 1 of the multiple regression analysis showed that the self-efficacy in breastfeeding support was significantly higher in large/urban municipalities (β = 0.13) and in the Kanto district. Model 2 revealed that self-efficacy was significantly associated with working experience (β = 0.13) and breastfeeding experience (β = 0.22) but not with educational background. Model 3 showed that self-efficacy was significantly associated with postgraduate education (β = 0.14) and continuous education (β = 0.12). This suggested that PHNs’ self-efficacy increased through self-enrichment. It is necessary to create training opportunities about breastfeeding support for PHNs—especially those working in remote and/or small municipalities— and to provide them with new and important information.

关键词： Breastfeeding Support Public Health Nurse Self-Efficacy Postgraduate/Continuous Education