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Rare combination of familial adenomatous polyposis and gallbladder polyps

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World Journal of Gastroenterology 2014年第46期20卷 17661-17665页

作者： Yasuhisa Mori norihiro Sato Nobutaka Matayoshi Toshihisa Tamura Noritaka Minagawa Kazunori Shibao Aiichiro Higure Mitsuhiro Nakamoto Masashi Taguchi Koji Yamaguchi Department of Surgery School of MedicineUniversity of Occupational and Environmental HealthKitakyushuFukuoka 807-8555Japan Department of Pathology and Cell Biology School of MedicineUniversity of Occupational and Environmental HealthKitakyushuFukuoka 807-8555Japan Department of Internal Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushuFukuoka 807-8555Japan

Familial adenomatous polyposis is associated with a high incidence of malignancies in the upper gastrointestinal tract (particularly ampullary adenocarcinomas). However, few reports have described a correlation between familial adenomatous polyposis and gallbladder neoplasms. We present a case of a 60-year-old woman with familial adenomatous polyposis who presented with an elevated mass in the neck of the gallbladder (measuring 16 mm × 8 mm in diameter) and multiple small cholecystic polyps. She had undergone a total colectomy for ascending colon cancer associated with familial adenomatous polyposis 22 years previously. The patient underwent laparoscopic cholecystectomy under a preoperative diagnosis of multifocal gallbladder polyps. Pathologic examination of the resected gallbladder revealed more than 70 adenomatous lesions, a feature consistent with adenoma of the gallbladder. This case suggests a requirement for long-term surveillance of the biliary system in addition to the gastrointestinal tract in patients with familial adenomatous polyposis.

关键词： Adenoma Adenomatous polyposis coli Biliary system Familial adenomatous polyposis Gallbladder polyp

Transarterial chemoembolization for hepatocellular carcinoma: A review of techniques

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World Journal of Hepatology 2014年第12期6卷 844-850页

作者： norihiro Imai Masatoshi Ishigami Yoji Ishizu Teiji Kuzuya Takashi Honda Kazuhiko Hayashi Yoshiki Hirooka Hidemi Goto Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Aichi 466-8560 Japan

Hepatocellular carcinoma(HCC)is one of the most common malignant diseases *** curative therapies,including resection,liver transplantation,and percutaneous ablation(percutaneous ethanol injection and radiofrequency ablation),are applicable for only a portion of the HCC population,transcatheter arterial chemoembolization(TACE)has been recognized as an effective palliative treatment option for patients with advanced *** is also used even for single HCCs in which it is difficult to perform surgical resection or locoregional treatment due to systemic co-morbidities or anatomical *** has become widely adopted in the treatment of *** using computed tomography-angiography,TACE is capable of performing diagnosis and treatment at the same ***,TACE plays an important role in the multidisciplinary treatment for HCC when combined with other *** this review,we first discuss the history of TACE,and then review the previous findings about techniques of achieving a locoregional treatment effect(liver infarction treatment,e.g.,ultra-selective TACE,balloon-occluded TACE),and the use of TACE as a drugdelivery system for anti-cancer agents(palliative,e.g.,platinum complex agents,drug-eluting beads)for multiple lesions.

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Balloon-occluded transcatheter arterial chemoembolization Drug-eluting bead

Effects of sclerostin antibody on bone healing

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World Journal of Orthopedics 2021年第9期12卷 651-659页

作者： Atsushi Mihara Kiminori Yukata Toshihiro Seki Ryuta Iwanaga norihiro Nishida Kenzo Fujii Yuji Nagao Takashi Sakai Department of Orthopedic Surgery Yamaguchi University Graduate School of MedicineUbe 755-8505Japan

Promoting bone healing after a fracture has been a frequent subject of ***,sclerostin antibody(Scl-Ab)has been introduced as a new anabolic agent for the treatment of ***-Ab activates the canonical Wnt(cWnt)-β-catenin pathway,leading to an increase in bone formation and decrease in bone *** of its rich osteogenic effects,preclinically,Scl-Ab has shown positive effects on bone healing in rodent models;researchers have reported an increase in bone mass,mechanical strength,histological bone formation,total mineralized callus volume,bone mineral density,neovascularization,proliferating cell nuclear antigen score,and bone morphogenic protein expression at the fracture site after Scl-Ab *** addition,in a rat critical-size femoral-defect model,the Scl-Ab-treated group demonstrated a higher bone healing *** the other hand,two clinical reports have researched Scl-Ab in bone healing and failed to show positive effects in the femur and *** review discusses why Scl-Ab appears to be effective in animal models of fracture healing and not in clinical cases.

关键词： Canonical Wnt-β-catenin pathway Fracture healing Osteoporosis Romosozumab Sclerostin antibody

Power-Assisted Cart Control Method with Motor Torque Limiter Based on Prediction of Torque Saturation

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Journal of Energy and Power Engineering 2012年第8期6卷 1349-1357页

作者： norihiro Kobayashi Takayuki Tanaka Shun' ichi Kaneko Graduate School of Information Science and Technology Hokkaido University Sapporo 060-0814 Japan

In this article, a method to control power-assisted carts with motor torque limiter that achieves the desired load-reduction ratio even if torque saturation occurs, is proposed to reduce the size and power consumption of power-assist systems. This method uses the ratio of the assist-force impulse to the operator-force impulse as an indicator for evaluating proposed method. Proposed method predicts the needs of the operator and delivers the desired load-reduction ratio by predicting operation. The results show that the target load-reduction ratio can be obtained with proposed control method and indicate that the target load-reduction ratio can be obtained with 80% force. By applying our proposed method, short available time of power-assisted carts will be improved.

关键词： Torque saturation power assisted cart minimum jerk model energy regeneration.

Combination of Cyclamen persicum Mill. floral gene promoters and chimeric repressors for the modification of ornamental traits in Torenia fournieri Lind.

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Horticulture Research 2017年第1期4卷 324-334页

作者： Ichiro Kasajima norihiro Ohtsubo Katsutomo Sasaki Institute of Vegetable and Floriculture Science National Agriculture and Food Research Organization(NARO)Ibaraki305-8519Japan Department of Agriculture Iwate UniversityIwate 020-8550Japan Graduate School of Life and Environmental Sciences Kyoto Prefectural UniversityKyoto 606-8522Japan

Although chimeric repressors such as the Arabidopsis TCP3 repressor are known to have significant effects on flower morphology and color,their cellular-level effects on flower petals are not *** promoter sequences of the genes expressed in the flowers of cyclamen,a representative potted flower grown during the winter season,are also ***,we isolated eight promoters from cyclamen genes that are reportedly expressed in the *** promoters were then fused to four chimeric repressors and introduced into the model flower torenia to screen for effective combinations of promoters and repressors for flower *** expected,some of the constructs altered flower phenotypes upon *** further analyzed the effects of chimeric repressors at the cellular *** observed that complicated petal and leaf serrations were accompanied by excessive vascular *** in purple anthocyanin was inferred to result in bluish flowers,and imbalanced cell proliferation appeared to result in epinastic ***,the genetic constructs and phenotypic changes described in this report will benefit the future breeding and characterization of ornamental flowers.

关键词： traits flowers breeding

Optimization Design of Open Spaces Based on Wind Tunnel and CFD Simulation： Case Study of a Street Canyon in Northern China

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Journal of Civil Engineering and Architecture 2017年第10期11卷 897-914页

作者： Zhiming Guo Tsuyoshi Setoguchi norihiro Watanabe Takuya Tsutsumi Faculty of Engineering Graduate School of Engineering Hokkaido University Sapporo 0608628 Japan Northern Regional Building Research Institute Hokkaido Research Organization .Asahikawa 0788801 Japan

Airflow in open spaces can significantly affect spatial quality. Therefore, according to the type of building structures, the airflow also has different forms. Studies have been conducted on the relation between airflow and pedestrian comfort; however, only few of them have focused on comprehensive urban planning that considers different weather conditions and people＇s ability to adapt. This research focuses on the differences in wind conditions caused by different spatial forms in different seasons. On the basis of a field survey in both summer and winter in a public open space, evaluation standards developed from environmental meteorological data and public feedback were used to evaluate simulation results. Next, several assumptions about canyon orientation and building types were proposed. Wind tunnel and CFD （computational fluid dynamics） simulations were conducted to evaluate the assumptions. The results showed that the canyon orientation significantly affected overall wind conditions and different building structures affected airflow. This research also provides a method to evaluate urban areas that have complicated wind environments.

关键词： Urban form outdoor comfort open space wind tunnel simulation optimization design.

Optimization Design of Open Space Based on Microclimate and Behavior in China

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Journal of Civil Engineering and Architecture 2017年第7期11卷 617-634页

作者： Zhiming Guo Tsuyoshi Setoguchi norihiro Watanabe Ke Huo Faculty of Engineering Graduate School of Engineering Hokkaido University Sapporo 060-8628 Japan JangHo Architecture College Northeastern University Shenyang 110-169 China

Traditionally, microclimate, behavior and space design are characterized by a separation among climatologists, behavior researchers and designers. It is also unrealizable to apply the research results to the space design because of the gap created by the interdisciplinarity. In addition, although the relationships among space form, urban microclimate and people are intuitively understood, there are still not reasonable predictions on how a space affects the microclimate, and how the microclimate and space will affect people＇s sensation and behavior. By recording the microclimate and people＇s responses, this paper discusses the relationship between people＇s sensation and microclimate as well as people＇s behavior and open space in a busy downtown pedestrian street during hot summer. The research finds that shade plays a crucial role in outdoor comfort. All of the other objectively comfortable and acceptable microclimates differ significantly different shade situation. Simultaneously, space contradiction can be considered an essential factor for spatial utilization. This paper also provides proposal on canyon open space design based on this case study.

关键词： Activities outdoor comfort urban design street canyon northern city

Effects of fluctuating glucose concentrations on oxidative metabolism of glucose in cultured neurons and astroglia

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Journal of Diabetes Mellitus 2012年第1期2卷 19-26页

作者： Shinichi Takahashi Takato Abe Yoshikane Izawa norihiro Suzuki Department of Neurology School of Medicine Keio University Tokyo Japan

The objective of the present study was to evaluate the effects of hyperglycemia on glucose metabolism of brain cells. Not only a sustained hyperglycemic state, but also a fluctuating plasma glucose concentration has been implicated in the pathogenesis of diabetic angiopathy. Acutely increasing plasma glucose levels have not been reported to alter glucose utilization of the brain as a whole. In the present study, we examined the effects of chronic (3 weeks) or short-term (24-hour) exposure to a high glucose concentration on the oxidative metabolism of neurons and astroglia. Cells were prepared from Sprague-Dawley rats and cultured in the presence of a high (22 mM) or low (5 mM) concentration of glucose. The high or low glucose media did not alter either the rates of [14C]deoxyglucose phosphorylation (an indicator of total glucose utilization) or [14C]lactate and [14C]pyruvate oxidation (indicators of oxidative glucose metabolism) in neurons. In contrast, chronic or short-term exposure to a high glucose concentration resulted in significant decreases in oxidation of [14C]acetate, an astrocyte-specific reporter molecule, or [14C]lactate and [14C]pyruvate oxidation in the astroglia. Thus, either chronic or short-term increases in the glucose concentration suppressed oxidative metabolism only in astroglia, indicating neuro-protective roles against hyperglycemic brain cell injury in diabetes mellitus. These different responses of neurons and astroglia may also shed new light on brain energy metabolism in diabetic patients with either chronic high or fluctuating plasma glucose concentrations.

关键词： Astrocyte Diabetic Encephalopathy Hyperglycemia [14C]acetate [14C]deoxyglucose [14C]lactate [14C]pyruvate

Pegylated interferon α-2b plus ribavirin for older patients with chronic hepatitis C

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World Journal of Gastroenterology 2010年第35期16卷 4400-4409页

作者： Mosaburo Kainuma norihiro Furusyo Eiji Kajiwara Kazuhiro Takahashi Hideyuki Nomura Yuichi Tanabe Takeaki Satoh Toshihiro Maruyama Makoto Nakamuta Kazuhiro Kotoh Koichi Azuma Junya Shimono Shinji Shimoda Jun Hayashi Department of General Internal Medicine Kyushu University Hospital Department of Internal Medicine Nippon Steel Yawata Memorial Hospital Department of Medicine Hamanomachi Hospital The Center for Liver Disease Shin-Kokura Hospital Department of Medicine Fukuoka City HospitalYoshiduka-honmachi Center for Liver Disease National Hospital Organization Kokura Medical Center Department of Medicine Kitakyushu Municipal Medical Center Department of Gastroenterology Kyushu Medical CenterNational Hospital Organization Department of Medicine and Bioregulatory Science Graduate School of Medical ScienceKyushu University Department of Medicine and Clinical Science Graduate School of Medical SciencesKyushu University Saiseikai Yahata General Hospital Harunomachi Department of Medicine and Biosystemic Science Graduate School of Medical ScienceKyushu University

AIM:To analyze the efficacy and safety of a combination therapy of pegylated interferon(PEG-IFN) α-2b plus ribavirin(RBV) in older Japanese patients(65 years or older) infected with hepatitis C virus(HCV).METHODS:This multicenter study included 938 patients with HCV genotype 1 who received 1.5 μg/kg per week PEG-IFN α-2b plus RBV 600-1000 mg/d for 48 wk and 313 HCV genotype 2 patients who received this treatment for 24 ***:At 24 wk after the end of combination therapy,the overall sustained virological response(SVR) for genotypes 1 and 2 were 40.7% and 79.6%,*** SVR rate decreased signif icantly with age in each genotype,and was markedly reduced in genotype 1(P<0.001).Moreover,the SVR was significantly higher in patients with genotype 1 who were less than 65 years(47.3% of 685) than in those 65 years or older(22.9% of 253)(P<0.001) and was higher in patients with genotype 2 who were less than 65 years(82.9% of 252) than in those 65 years or older(65.6% of 61)(P=0.004).When patients received a dosage at least 80% or more of the target dosage of PEG-IFN α-2b and 60% or more of the target dosage of RBV,the SVR rate significantly increased to 66.5% in patients less than 65 years and to 45.2% in those 65 years or older(P<0.001).Adverse effects resulted in treatment discontinuation more often in patients with genotype 1(14.4%) than in patients with genotype 2(7.3%),especially by patients 65 years or older(24.1%).CONCLUSION:PEG-IFN α-2b plus RBV treatment was effective in chronic hepatitis C patients 65 years or older who completed treatment with at least the minimum acceptable treatment dosage.

关键词： Hepatitis C virus Gerontology Pegylated interferon Ribavirin