检索结果-南通市图书馆

Preliminary study on overproduction of reactive oxygen species by neutrophils in diabetes mellitus

World Journal of Diabetes 2016年第13期7卷 271-278页

作者： noridzzaida ridzuan Cini Mathew John Pratheep Sandrasaigaran Maryam Maqbool Lee Chuen Liew Jonathan Lim Rajesh Ramasamy Immunology Laboratory Department of PathologyFaculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang 43400 Selangor Malaysia Stem Cell Research Laboratory Genetic and Regenerative Medicine Research Center Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang 43400 SelangorMalaysia Department of Physiology and Pharmacology Faculty of Medicine University of Calgary CalgaryAB T2N 4N1 Canada Department of Medicine Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang 43400Selangor Malaysia

AIM:To assess the amount and pattern of reactive oxygen species(ROS)production in diabetic patientderived ***:Blood samples from type 2 diabetes mellitus(DM)patients and volunteers(controls)were subjected to neutrophil isolation and the assessment of neutrophil oxidative burst using chemiluminescence *** were activated by using phorbol myristate acetate(PMA)and neutrophils without activation were kept as a negative *** chemilu-minescence readings were obtained by transferring cell suspension into a 1.5 m L Eppendorf tube,with PMA and *** mixtures were gently vortexed and placed inside luminometer for a duration of 5 ***:Our results showed that in the resting condition,the secretion of ROS in normal non-diabetic individuals was relatively low compared to diabetic ***,the time scale observation revealed that the secreted ROS declined accordingly with time in non-diabetic individuals,yet such a reduction was not detected in diabetic patients where at all the time points,the secretion of ROS was maintained at similar *** preliminary study demonstrated that ROS production was significantly higher in patients with DM compared to non-diabetic subjects in both resting and activated ***:The respiratory burst activity of neutrophils could be affected by DM and the elevation of ROS production might be an aggravating factor in diabetic-related complications.

关键词： Neutrophils Diabetes mellitus Reactive oxygen species Chemiluminescence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：