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An extremely rare case of pancreatic metastasis of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2014年第2期20卷 593-597页

作者： Hiroshi Okamoto Yasuyuki Hara Masahiro Chin Motohisa Hagiwara Yuji Onodera Shinichiro Horii Yasuhiro Shirahata Takashi Kamei Eiji Hashizume noriaki ohuchi Department of Surgery Nihonkai General HospitalSakata 998-8501Japan Division of Advanced Surgical Science and Technology Graduate School of MedicineTohoku UniversitySendai 980-8574Japan

We report a rare case of a 68-year-old male with metachronous pancreatic metastasis that was resected2 years after salvage esophagectomy for local recurrence of esophageal squamous cell carcinoma(ESCC).Two years and 8 mo ago,he had undergone definitive chemoradiotherapy for the lower thoracic ESCC and achieved a complete response.Chemoradiotherapy used the protocol of the Japan Clinical Oncology Group trial 9906.Approximately 8 mo later,he developed a local recurrence of the ESCC and underwent thoracoscopic salvage esophagectomy followed by reconstruction with a conduit colon graft via a subcutaneous route.Recently,a tumor of the pancreatic body was found on routine follow-up computed tomography(CT).The tumor diameter was 15 mm on CT,and the maximum standardized uptake value of the lesion was 5.49at 18F-2-fluoro-2-deoxy-D-glucose positron-emission tomography,strongly suggesting pancreatic cancer.In addition,all tumor markers were within the reference intervals.Therefore,distal pancreatectomy was performed with the resultant histological diagnosis being confirmed as pancreatic metastasis of the ESCC.He was treated with adjuvant chemotherapy,and there has been no evidence of recurrence 9 mo after the surgery.Resection of pancreatic metastasis offers a good prognosis and should be considered for solitary ESCC metastasis.

关键词： Metachronous pancreatic metastasis Esophagus Squam

立位X线立体定位真空辅助空心针穿刺活检术在诊断乳腺微小钙化性病变中的作用(英文)

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The Chinese-German Journal of Clinical Oncology 2009年第10期8卷 567-571页

作者： Ming Yang Takanori Ishida Motohiro Takeda noriaki ohuchi Department of Breast Surgery the First Hospital of Jilin University Changchun 130021 China Department of Surgical Oncology Tohoku University School of Medicine Sendai Japan

Objective: The aim of this study was to evaluate the utility of an upright-type 11-gauge stereotactic vacuumassisted biopsy device (Mammotome) for the diagnosis of breast microcalcifications Methods: Between May 2001 and October 2005, 154 biopsies in 152 patients with microcalcifications were performed using the upright-type 11-gauge stereotactic vacuum-assisted biopsy device. Patients in whom this biopsy was diagnosed as carcinoma or a borderline lesion, had a subsequent surgical excision of the lesion. Histopathological and radiological features of the two specimens were then compared with each other. Results: Microcalcification was identified on specimen mammograms and microscopic slides in 97.4% of cases. Of 154 Mammotome biopsies 98 (63.6%) were benign, 51 (33.1%) were malignant, 3 (1.9%) showed atypical hyperplasia, and 2 (1.3%) were indeterminate, respectively. Of the 48 cases that received surgical excision, 6 of 36 ductal carcinomas in situ (16.7%) upstaged to invasive ductal carcinoma and 1 of 2 atypical ductal hyperplasias was upstaged to ductal carcinoma in situ. The positive predictive value of the 11-gauge Mammotome for the diagnosis of invasion in breast cancer was 100%. Linear calcification and pleomorphic calcification linear/segmental distribution was reliable indications of malignancy. The mean follow-up time of the benign lesions was 22 months, and without evidence of lesion growth. Complications included vasovagal reactions (6.3%), bleeding (0.6%) and hematoma (2.6%). Conclusion: The upright stereotactic 11-gauge Mammotome procedure is an effective and reliable method for the diagnosis of breast microcalcifications. It has minimal side effects. For lesions diagnosed as ADH or DCIS with the 11-gauge Mammotome, subsequent surgical excision should be performed.

关键词：乳腺癌诊断钙化装置活检真空立体 1型

Use of water jet instruments in gastrointestinal endoscopy

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World Journal of Gastrointestinal Endoscopy 2016年第3期8卷 122-127页

作者： Toru Nakano Chiaki Sato Tadashi Sakurai Takashi Kamei Atsuhiro Nakagawa noriaki ohuchi Division of Advanced Surgical Science and Technology Tohoku University Graduate School of MedicineSendai 980-8574Japan Department of Neurosurgery Tohoku University Graduate School of MedicineSendai 980-8574Japan

In recent years, water jet instruments have been used in the field of gastrointestinal endoscopy, mainly in two clinical situations: Investigation and treatment under endoscopic view. Injecting water jet into the gastrointestinal lumen is helpful for maintaining a clear endoscopic view, washing away blood or mucous in the lumen or on the surface of the tip of the endoscope. This contributes to reducing time and discomfort of examination. Water jet technology is an alternative method for dissecting soft tissue; this method does not harm the small vessels or cause mechanical or thermal damage. However, its use in clinical settings has been limited to the transmucosal injection of water into the submucosal layer that elevates the mucosa to prepare for endoscopic mucosal resection or endoscopic submucosal dissection, instead of tissue dissection, which may occur because of the continuous water jet. A preclinical study has been conducted using a pulsed water jet system as an alternative method for submucosal dissection by reducing intraoperative water consumption and maintenance of dissection capability. This review introduces recent studies pertaining to using a water jet in gastrointestinal endoscopy and discusses future prospects.

关键词： Endoscopy Water jet Endoscopic submucosaldissection Endoscopic mucosal resection Pulse

用单克隆抗体在良性和恶性乳腺组织中RAS P21表达的免疫组化分析

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细胞与分子免疫学杂志 1987年第1期 12-12页

作者： noriaki ohuchi,杨成勇 Laboratory of Tumor Immunology and Department of pathology and Biology National Cancer Institute NIH Bethesda MD and Department of Pathology Vanderdilt University School of Medicine Nashville TN

通过免疫组化法,用直接抗ras基因产物P21的单克隆抗体RAP-580Y13-259评价ras p21在良性和恶性乳腺癌组织中的表达。已证实浸润性肿瘤可增强ras p21表达,而在原位癌中不典型增生及增生中ras p21在原发和继发性肿瘤中的表达均减弱。并在... 详细信息

通过免疫组化法,用直接抗ras基因产物P21的单克隆抗体RAP-580Y13-259评价ras p21在良性和恶性乳腺癌组织中的表达。已证实浸润性肿瘤可增强ras p21表达,而在原位癌中不典型增生及增生中ras p21在原发和继发性肿瘤中的表达均减弱。并在扩散性与原始病灶一样观

关键词：单克隆抗体 RAS P21 乳腺组织

An effective method for laboratory acoustic emission detection and location using template matching

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第5期14卷 1642-1651页

作者： Xinglin Lei Tomohiro ohuchi Manami Kitamura Xiaying Li Qi Li National Institute of Advanced Industrial Science and Technology(AIST) Tsukuba305-8567Japan Geodynamics Research Center Ehime UniversityMatsuyama790-8577Japan State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

In this paper, a template matching and location method, which has been rapidly adopted in microseismic research in recent years, is applied to laboratory acoustic emission(AE) monitoring. First, we used traditional methods to detect P-wave first motions and locate AE hypocenters in three dimensions. In addition, we selected events located with sufficient accuracy(normally corresponding AE events of relatively larger energy, showing clear P-wave first motion and a higher signal-to-noise ratio in most channels) as template events. Then, the template events were used to scan and match other poorly located events in triggered event records or weak events in continuous records. Through crosscorrelation of the multi-channel waveforms between the template and the event to be detected, the weak signal was detected and located using a grid-searching algorithm(with the grid centered at the template hypocenter). In order to examine the performance of the approach, we calibrated the proposed method using experimental data of different rocks and different types of experiments. The results show that the proposed method can significantly improve the detection capability and location accuracy, and can be applied to various laboratory and in situ experiments, which use multi-channel AE monitoring with waveforms recorded in either triggering or continuous mode.

关键词： Acoustic emission Template matching and location Waveform cross-correlation Grid search

Electron Temperature Measurement by Floating Probe Method Using AC Voltage

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Plasma Science and Technology 2016年第11期18卷 1089-1094页

作者： Satoshi NODOMI Shuichi SATO Mikio ohuchi Department of Electrical and Electronic Engineering Tokyo Denki University

This study presents a novel floating probe method to measure electron temperatures using a hollow cathode-type discharge tube. The proposed method detects a shift in the floating potential when an AC voltage is applied to a probe through an intermediary blocking capacitor. The shift in the floating potential is described as a function of the electron temperature and the applied AC voltage. The floating probe method is simpler than the Langmuir probe method because it does not require the measurement of volt-ampere characteristics. As the input AC voltage increases, the electron temperature converges. The electron temperature measured using the floating probe method with an applied sinusoidal voltage shows a value close to the first （tail） electron temperature in the range of the floating potential.

关键词： electrostatic probe Langmuir probe floating potential electron temperature sheath

散发型甲状腺髓样癌及正常甲状腺组织RET基因第13外显子碱基序列分析

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内分泌外科杂志 2008年第5期2卷 292-294页

作者：盖保东森隆弘滕盛启成大内宪名里见进张德恒郑泽霖刘晶吉林大学中日联谊医院基本外科长春130031 日本东北大学医学部肿瘤外科日本东北大学医学部先进外科

目的研究散发型甲状腺髓样癌酪氨酸激酶受体基因（RET）第13外显子的突变情况。方法提取17例散发型甲状腺髓样癌和4例正常甲状腺组织基因组的DNA,PCR扩增该基因第13外显子全部序列,纯化目的基因DNA后直接序列测定。结果与Genebank比较... 详细信息

目的研究散发型甲状腺髓样癌酪氨酸激酶受体基因（RET）第13外显子的突变情况。方法提取17例散发型甲状腺髓样癌和4例正常甲状腺组织基因组的DNA,PCR扩增该基因第13外显子全部序列,纯化目的基因DNA后直接序列测定。结果与Genebank比较全部散发型甲状腺髓样癌和正常甲状腺组织在RET基因第18973和18974位点之间均有一个鸟嘌呤插入,插入点位于该基因的第13外显子和第13内含子之间。结论该位点处鸟嘌呤插入不是基因突变,可能为不同人种间基因组差异或Genebank存在错误。

关键词：散发型甲状腺髓样癌酪氨酸激酶受体基因基因突变 Genebank

Frequency dependence of electron temperature in hollow cathode-type discharge as measured by several different floating probe methods

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Plasma Science and Technology 2018年第8期20卷 50-57页

作者： Shuichi SATO Hiromu KAWANA Tatsushi FUJIMINE Mikio ohuchi Department of Electronic Engineering Tokyo Denki University

We measured electron temperatures through a hollow cathode-type discharge tube using several different floating probe methods. This method detected a shift in the floating potential when an AC voltage was applied to a probe through an intermediary blocking capacitor. The shift in the floating potential is described as a function of the electron temperature and the applied AC voltage. In this study, the effects of the frequency and waveform on the electron temperatures were systematically investigated. The electron temperature measured when using the floating probe method with applied sinusoidal and triangular voltages was lower than that measured with an applied rectangular voltage.The value in the high frequency range was close to that of the tail electron temperature.

关键词： electrostatic probe Langmuir probe floating potential electron temperature sheath

Preliminary Deformation Experiment of Ringwoodite at 20 GPa and 1 700 K Using a D-DIA Apparatus

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Journal of Earth Science 2010年第5期21卷 517-522页

作者： Takaaki Kawazoe Tomohiro ohuchi Norimasa Nishiyama Yu Nishihara Tetsuo Irifune Geodynamics Research Center Ehime University Senior Research Fellow Center Ehime University

A deformation experiment of ringwoodite with a strain of 9% was achieved at 20 GPa and 1 700 K and at a strain rate of 3×10^-5 s^-1 using a deformation-DIA （D-DIA） apparatus and a multi-anvil 6-6 （MA 6-6） assembly. The crystallographic orientations of the deformed sample were successfully analyzed by the electron backscatter diffraction （EBSD） method, although any notable latticepreferred orientation （LPO） was not observed presumably due to the insufficient strain in the present experiment. In this study, the deformation experiment on ringwoodite succeeded at P-T conditions consistent with the lower part of the mantle transition zone and at a controlled strain rate for the first time. The present study extended the pressure range of deformation experiments in the D-DIA apparatus from 16 GPa in our earlier study to 20 GPa at 1 700 K. The successful extension of the pressure range demonstrates potential importance of the D-DIA apparatus in studying rheological properties of minerals under the P-T conditions of the whole mantle transition zone.

关键词： ringwoodite mantle transition zone rheology viscosity mantle dynamics.