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Gastric precancerous lesions are associated with gene variants in Helicobacter pylori -susceptible ethnic Malays

World Journal of Gastroenterology 2013年第23期19卷 3615-3622页

作者： Sathiya Maran Yeong Yeh Lee Shuhua Xu Nur-Shafawati Rajab norhazrini hasan Syed Hassan Syed Abdul Aziz Noorizan Abdul Majid Bin Alwi Zilfalil Human Genome Center School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia Department of Medicine School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia Max Planck Independent Research Group on Population Genomics Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences200031 Shanghai China Department of Immunology School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia Department of Surgery School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia Department of Paediatrics School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia

AIM: To identify genes associated with gastric pre-cancerous lesions in Helicobacter pylori (H. pylori )susceptible ethnic Malays. METHODS: Twenty-three Malay subjects with H. pylori infection and gastric precancerous lesions identified during endoscopy were included as "cases". Thirtyseven Malay subjects who were H. pylori negative and had no precancerous lesions were included as "controls". Venous blood was collected for genotyping with Affymetrix 50K Xba1 kit. Genotypes with call rates 0.5 was considered as significant markers. RESULTS: Of the 23 H. pylori -positive subjects recruited, one sample was excluded from further analysis due to a low genotyping call rate. Of the 22 H. pylori positive samples, atrophic gastritis only was present in 50.0%, complete intestinal metaplasia was present in 18.25%, both incomplete intestinal metaplasia and dysplasia was present in 22.7%, and dysplasia only was present in 9.1%. SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively. Allele frequencies in "cases" vs "controls" for rs9315542, rs6878265, rs1042194 and rs10505799 were 0.4 vs 0.06, 0.6 vs 0.01, 0.6 vs 0.01 and 0.5 vs 0.02, respectively. CONCLUSION: Genetic variants possibly related to gastric precancerous lesions in ethnic Malays susceptible to H. pylori infection were identified for testing in subsequent trials.

关键词： Gastric precancerous lesions Gene polymorphisms Genome-wide association Helicobacter pylori Malays

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