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Preliminary studies of acute and sub-chronic toxicity of the aqueous extract of Guibourtia tessmannii(Harms) *** stem barks (Caesalpiniaceae) in mice and rats

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Asian Pacific Journal of Tropical Biomedicine 2016年第6期6卷 506-510页

作者： noreen orianna koumba madingou Aristide Traore Alain Souza Marlaine Michelle Boukandou Mounanga Raissa Reine Aworet Samseny Sylvin Ouedraogo Alfred Sababenedyo Traore Laboratory of Pharmacology and Toxicology Pharmacopoeia and Traditional Medicines Institute Research Center in Biological Food and Nutritional SciencesUniversity of Ouagadougou Department of Medicine and Traditional Pharmacopoeia/Pharmacy Health Science Research Institute Department of Biology Faculty of SciencesUniversity of Sciences and Technique of Masuku(USTM)

Objective: To investigate the toxicity of aqueous extract of Guibourtia tessmannii(Harms) J. Leonard(G. tessmannii) and evaluate its ***: NMRI mice were used to determine the acute toxicity of G. *** concentrations of the plant extracts were administered intraperitoneally or by force-feeding. General behavior and death were monitored and recorded daily for 7 *** order to determine the sub-acute toxicity of the extract, several doses were administered by oral gavage daily for 28 days in adult Wistar rats. Different parameters were assessed including body weight, food and water intake, biochemical parameters and several vital organ ***: LD50 of 328.78 mg/kg was obtained by i.p. route and more than 5 000 mg/kg was obtained in acute toxicity by oral route. In sub-acute toxicity, no significant alteration was observed in body weight or vital organs, food and water intake, and biochemical ***: The results showed that the aqueous extract of G. tessmannii has low toxicity intraperitoneally and no sub-acute toxicity via oral intake.

关键词： Guibourtia tessmannii Stem barks Plant extract Herbal medicine Toxicity

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