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Prenatal bisphenol A exposure impairs the aversive and spatial memory reduces the level of NMDA receptor subunits in the hippocampus of male Sprague Dawley rats

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Brain Science Advances 2022年第1期8卷 57-69页

作者： norazirah mat nayan Andrean Husin Siti Hamimah Sheikh Abd Kadir Che Badariah Abd Aziz Musalmah Mazlan Rosfaiizah Siran Centre for Neuroscience Research(NeuRon) Faculty of MedicineUniversiti Teknologi MARASungai Buloh 47000SelangorMalaysia Institute of Molecular Medicine Biotechnology(IMMB) Faculty of MedicineUniversiti Teknologi MARASungai Buloh 47000SelangorMalaysia Faculty of Dentistry Universiti Teknologi MARASungai Buloh 47000SelangorMalaysia Neuroscience Research Group(NRG) Faculty of MedicineUniversiti Teknologi MARASungai Buloh 47000SelangorMalaysia Faculty of Medicine Universiti Sains MalaysiaKubang Kerian 15200Kota Bharu KelantanMalaysia

Memory impairment in children is an ongoing issue worldwide related to a learning disability. This neurobiological condition has been suggested to associate with bisphenol A (BPA) exposure during pregnancy. BPA is an inorganic compound used to produce polycarbonate plastics and epoxy resins. We conduct this study to investigate the effects of prenatal BPA exposure on the level of the N-methyl-D-aspartate (NMDA) receptor subunits, synaptic markers of the hippocampus and neurobehavioral outcomes in rats. The pregnant rats were given a daily dose of 5 mg/kg and 50 mg/kg of BPA with 0.5% Tween 80 orally from gestation day 2 until 21 (GD21). The level of GluN2A, GluN2B, PSD-95 and synapsin I in the hippocampus and its neurobehaviour outcomes were quantified and evaluated in the male foetus and adolescent rat. Prenatal BPA exposure reduced GluN2A, GluN2B, synapsin I and PSD-95 (Postsynaptic Density-95) in the male foetus and adolescent rat hippocampus compared to the control group. The prenatal BPA exposed rats demonstrated anxiety-related behaviour and impairment in aversive and spatial memory. The findings suggested that the impairment in neurobehavioral performance may inhibit the signalling pathway in the NMDA receptor subunits in the male foetus rat hippocampus leading to learning and memory deficits when reaching adolescence.

关键词： bisphenol A memory NMDA receptor subunits neurobehavioral

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