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Chrononutrition in traditional European medicine-Ideal meal timing for cardiometabolic health promotion

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Journal of Integrative Medicine 2024年第2期22卷 115-125页

作者： nora Selena Eberli Ludivine Colas Anne Gimalac Department of Traditional European Medicine Navi Institute of Research in Integrative HealthEcole Professionnelle Superieure de NaturopathieCentre Andre Henzelin1066 EpalingesSwitzerland

Meal timing plays a crucial role for cardiometabolic health,given the circadian regulation of cardiometabolic ***,to the best of our knowledge,no concept of meal timing exists in traditional European medicine(TEM).Therefore,in this narrative review,we aim to define the optimal time slot for energy intake and optimal energy distribution throughout the day in a context of TEM and explore further *** reviewing literature published between 2002 and 2022,we found that optimal timing for energy intake may be between 06:00 and 09:00,12:00 and 14:00,and between 15:00 and18:00,with high energy breakfast,medium energy lunch and low energy dinner and possibly further adjustments according to one’s chronotype and ***,timing and distribution of energy intake may serve as a novel therapeutic strategy to optimize coction,a concept describing digestion and metabolism in TEM.

关键词： Circadian rhythm Chrononutrition Naturopathy Traditional European medicine Metabolic syndrome Meal timing

Friction and wear performance of polyether ether ketone(PEEK)polymers in three lubrication regimes

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Friction 2024年第4期12卷 670-682页

作者： Davide MASSOCCHI nora LECIS Marco LATTUADA Davide SCAGLIA Steven CHATTERTON Paolo PENNACCHI Department of Mechanical Engineering Politecnico di MilanoMilan 20156Italy Eni SpA Downstream product R&DLombardia 20097Italy Eurobearings S.R.L. Lombardia 29016Italy

This experimental study investigates the friction and wear of three coatings commonly used in industrial applications,particularly in hydrodynamic *** three materials under investigation were Babbitt,polyether ether ketone(PEEK)reinforced with 15%carbon fibers,and PEEK reinforced with 20%carbon *** first polymer material was extruded,while the other was produced by fused deposition modelling(FDM).The materials were subjected to sliding tests in a pin-on-disc configuration,with a steel ball serving as the counter *** tests were conducted at room temperature,with a load of 10 N and under three different lubrication conditions:dry,grease,and *** linear speed was set at 0.3 m/s for the dry and semi-solid lubrication tests,while for the oil tests,the speed was set at 0.25 m/*** greases used had consistency grades of NGLI 000 and NGLI *** ISO VG 68 circulation oil was used for the oil lubrication ***,thermodynamic analyses were performed under the most severe conditions(i.e.,dry)to investigate the steel-Babbitt and steel-PEEK contact.

关键词： hydrodynamic bearings polyether ether ketone(PEEK)polymers additive manufacturing grease lubrication sliding oil lubrication ball-on-disk tribology

Non-pancreatic hyperlipasemia:A puzzling clinical entity

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World Journal of Gastroenterology 2024年第19期30卷 2538-2552页

作者： Krisztina Eszter Feher David Tornai Zsuzsanna Vitalis Laszlo Davida nora Sipeki Maria Papp Division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversity of DebrecenDebrecen H-4032Hajdu-BiharHungary Kalman Laki Doctoral School of Biomedical and Clinical Sciences Faculty of MedicineUniversity of DebrecenDebrecen H-4032Hungary

BACKGROUND Increased lipase level is a serological hallmark of the diagnosis of acute pancreatitis(AP)but can be detected in various other diseases associated with lipase leakage due to inflammation of organs surrounding the pancreas or reduced renal clearance and/or hepatic *** non-pancreatic hyperlipasemia(NPHL)is puzzling for attending physicians during the diagnostic procedure for *** would be clinically beneficial to identify the clinical and laboratory variables that hinder the accuracy of lipase diagnosis with the aim of improve it.A more precise description of the NPHL condition could potentially provide prognostic factors for adverse outcomes which is currently *** To perform a detailed clinical and laboratory characterization of NPHL in a large prospective patient cohort with an assessment of parameters determining disease *** A Hungarian patient cohort with serum lipase levels at least three times higher than the upper limit of normal(ULN)was prospectively evaluated over 31 *** were identified using daily electronic laboratory reports developed to support an ongoing observational,multicenter,prospective cohort study called the EASY trial(ISRCTN10525246)to establish a simple,easy,and accurate clinical scoring system for early prognostication of *** of NPHL was established based on≥3×ULN serum lipase level in the absence of abdominal pain or abdominal imaging results characteristic of *** A total of 808 patients[male,n=420(52%);median age(IQR):65(51-75)years]were diagnosed with≥3×ULN serum lipase levels.A total of 392 patients had AP,whereas 401 had NPHL with more than 20 different *** and acute kidney injury(AKI)were the most prevalent etiologies of NPHL(27.7%and 33.2%,respectively).The best discriminative cut-off value for lipase was≥666 U/L(sensitivity,71.4%;specificity,88.8%).The presence of AKI or sepsis negatively affected the diagnostic performance of *** w

关键词： Non-pancreatic hyperlipasemia Acute pancreatitis Glycoprotein 2 Acute kidney injury Sepsis Mortality

Flavone improves liver damage in nicotine-exposed rats via the Nrf2/HO-1 pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 341-349页

作者： nora A.Elsayed Fatma SM Moawed Esraa SA Ahmed Ahmed Hammad Omayma AR Abo-Zaid Biochemistry and Molecular Biology Department Faculty of Vet.Med.Benha UniversityBenha cityEgypt Health Radiation Research National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt Radiation Biology Department National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt

Objective:To assess the hepatoprotective effects of flavone on nicotine-induced liver ***:Thirty-six rats were allocated into six groups:the control group,the nicotine group,the flavone alone groups(10 and 25 mg/kg/body weight),and the nicotine groups treated with flavone(10 and 25 mg/kg/body weight).Liver function,oxidative stress,Nrf2 pathway(HO-1,Nrf2,and Keap-1),and inflammatory markers(IL-17,TNF-α,and NF-κB)were ***,a histopathological examination of liver tissues was ***:Nicotine increased liver damage,inflammation,and oxidative ***,flavone suppressed nicotine-induced liver enzymes,oxidative stress,and inflammation,as manifested by increased antioxidants and decreased malondialdehyde level,liver enzymatic activities,and inflammatory ***(10 and 25 mg/kg/body weight)also reduced the level of Keap-1 and increased HO-1 and Nrf2 levels in the liver of nicotine-exposed ***:Flavone has hepatoprotective properties and may slow the progression of liver injury by reducing oxidative stress,liver enzymes,and inflammation possibly via the Nrf2 pathway.

关键词： Flavone Nicotine Liver Nrf2 HO-1 NF-κB

Metabolic dysfunction-associated steatotic liver disease-associated fibrosis and cardiac dysfunction in patients with type 2 diabetes

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World Journal of Cardiology 2024年第10期16卷 580-594页

作者： Simona Cernea Danusia Onișor Andrada Larisa Roiban Theodora Benedek nora Rat Department M3/Internal Medicine I George Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureșTârgu Mureş540142Romania Diabetes Nutrition and Metabolic Diseases Outpatient UnitEmergency County Clinical HospitalTârgu Mureş540136Romania Department ME2/Internal Medicine VII George Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureşTârgu Mureş540142Romania Gastroenterology Clinic MureșCounty Clinical HospitalTârgu Mureş540103Romania Diabetes Compartment MediașMunicipal HospitalMediaș551030Romania Doctoral School of Medicine and Pharmacy George Emil Palade University of MedicinePharmacyScienceand Technology of Târgu MureşTârgu Mureş540142Romania Department M3/Internal Medicine VI George Emil Palade University of MedicinePharmacyScienceand Technology of Târgu MureşTârgu Mureş540142Romania Department of Cardiology Emergency County Clinical HospitalTârgu Mureş540136Romania

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),particularly in the presence of liver fibrosis,increases the risk of cardiovascular morbidity and mortality,but the nature of the cardio-hepatic interaction in the context type 2 diabetes mellitus(T2DM)is not fully *** To evaluate the changes in cardiac morphology and function in patients with T2DM and MASLD-associated liver *** T2DM patients with MASLD underwent a medical evaluation that included an assessment of lifestyle,anthropometric measurements,vital signs,an extensive laboratory panel,and a standard *** fibrosis was evaluated using two scores[Fibrosis-4(FIB4)and Non-alcoholic fatty liver disease-Fibrosis Score(NFS)],and subjects were classified as having advanced fibrosis,no fibrosis,or an indeterminate *** correlations between structural and functional cardiac parameters and markers of liver fibrosis were evaluated through bivariate and multiple regression *** significance was set at P<*** Data from 267 T2DM-MASLD subjects with complete assessment was *** with scores indicating advanced fibrosis exhibited higher interventricular septum and left ventricular(LV)posterior wall thickness,atrial diameters,LV end-systolic volume,LV mass index(LVMi),and epicardial adipose tissue thickness(EATT).Their mean ejection fraction(EF)was significantly lower(49.19%±5.62%vs 50.87%±5.14%vs 52.00%±3.25%;P=0.003),and a smaller proportion had an EF≥50%(49.40%vs 68.90%vs 84.21%;P=0.0017).Their total and mid LV wall motion score indexes were higher(P<0.05).Additionally,they had markers of diastolic dysfunction,with a higher E/e’ratio[9.64±4.10 vs 8.44(2.43-26.33)vs 7.35±2.62;P=0.026],and over 70%had lateral e’values<10 cm/second,though without significant differences between *** multiple regression analyses,FIB4 correlated with left atrium diameter(LAD;β=0.044;P<0.05),and NFS with both LAD(β=0.039;P<0.05)and right

关键词： Metabolic dysfunction-associated steatotic liver disease Type 2 diabetes mellitus Liver fibrosis Cardiac dysfunction Sex-hormone binding protein

Hard life for sons in the nest?Sex-dependent offspring mortality in Great Tits in urban and forest areas

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Avian Research 2024年第1期15卷 91-97页

作者： nora Agh Henriett Anna Dalvári Krisztián Szabó Ivett Pipoly András Liker HUN-REN-PE Evolutionary Ecology Research Group University of PannoniaH-8200VeszpremPf.1158.Hungary Behavioral Ecology Research Group Center for Natural SciencesUniversity of PannoniaH-8200Pf.1158.VeszpremHungary Molecular Ecology Research Group Department of EcologyUniversity of Veterinary Medicine BudapestH-1400Pf.2.BudapestHungary Synlab Hungary Ltd. H-1211Weiss Manfr´ed Str.5-7BudapestHungary

Sex-biased mortality can occur in birds during development,for example due to sexual differences in energy requirement and/or environmental sensitivity,or the effects of sex hormones or sex differences in the expression of mutations linked to sex *** extent of sex-bias in mortality may also be related to environmental conditions that influence offspring development and *** areas often provide poorer conditions for nestling development resulting in higher offspring mortality compared to natural areas,which may accelerate sex differences in offspring mortality in *** test this hypothesis,we examined the sex ratio of dead offspring in Great Tits(Parus major),using 427 samples of unhatched eggs and dead nestlings collected in two urban and two forest sites between 2013 and *** ratio of males in the whole sample of dead offspring(56.9%)was significantly higher than expected by an 1:1 ratio,and the strongest sex biases were detected in urban areas(57.6%males)and in young nestlings(<14 days old,59.0%males).However,the sex ratios of dead offspring did not differ significantly among study sites and between offspring developmental stages.29.3%of unhatched eggs contained a visible embryo,and the proportion of embryo-containing unhatched eggs did not differ significantly between urban and forest study *** results suggest male-biased offspring mortality in Great Tits,and highlight the need of large datasets to detect subtle differences between habitats and developmental stages.

关键词： Great Tit Urbanization Nestling mortality Sex related differences

Recovery rates and long-term olfactory dysfunction following COVID-19 infection

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 121-128页

作者： Melanie Dias Zara Shaida nora Haloob Claire Hopkins ENT Department Guy's HospitalLondonUK

Objectives:Olfactory dysfunction is one of the most recognized symptoms of COVID-19,significantly impacting quality of life,particularly in cases where recovery is *** review aims to explore patterns of olfactory recovery post-COVID-19 infection,with particular focus on delayed *** Sources:Published literature in the English language,including senior author's own work,online and social media platforms,and patients'anecdotal ***:A comprehensive review of the literature was undertaken by the authors with guidance from the senior author with expertise in the field of ***:Based on self-report,an estimated 95%of patients recover their olfactory function within 6 months post-COVID-19 ***,psychophysical testing detects higher rates of persistent olfactory *** has been found to continue for at least 2 years postinfection;negative prognostic indicators include severe olfactory loss in the acute phase,female sex,and older *** in quantitative and qualitative disturbance in prolonged cases likely reflects both peripheral and central pathophysiological *** of many of the reviewed studies reflect lack of psychophysical testing and baseline olfactory ***:Post-COVID-19 olfactory dysfunction remains a significant health and psychosocial *** evidence is improving awareness and knowledge among clinicians to better support patients through their olfactory rehabilitation,with hope of recovery after several months or *** research is needed to better understand the underlying pathogenesis of delayed recovery,identify at risk individuals earlier in the disease course,and develop therapeutic targets.

关键词： anosmia COVID-19 olfaction parosmia recovery

Association of previously irradiated stable brain metastases with outcomes of atezolizumab-treated non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials

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Cancer Communications 2024年第2期44卷 278-281页

作者： Tiantian Guo Yue Zhou Fei Liang Zezhou Wang Vincent Bourbonne Lukas Käsmann nora Sundahl Abraham Jing-Ching Wu Jianjiao Ni Zhengfei Zhu Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Clinical Research Center for Radiation Oncology ShanghaiP.R.China Shanghai Key Laboratory of Radiation Oncology ShanghaiP.R.China Department of Biostatistics Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of Cancer Prevention Fudan University Shanghai Cancer CenterShanghaiP.R.China Radiation Oncology Department University HospitalBrestFrance Department of Radiation Oncology University HospitalLMU MunichMunichGermany Department of Radiation Oncology AZ GroeningeKortrijkBelgium Department of Radiation Oncology Memorial Sloan Kettering Cancer CenterNew YorkNew YorkUSA Institute of Thoracic Oncology Fudan UniversityShanghaiP.R.China

Dear Editor:Brain metastasis(BM)has long been recognized as a prognostic factor associated with poor prognosis for non-small cell lung cancer(NSCLC)in the era of con-ventional chemotherapy and targeted therapy[1].In the era of immunotherapy,controversial findings have been reported regarding the prognostic significance of BM in patients with NSCLC treated with programmed death-1/programmed death-ligand 1(PD-1/PD-L1)inhibitors.

关键词： chemotherapy NSCLC metastasis death

Metasomatism-induced wehrlite formation in the upper mantle beneath the Nógrád-G?m?r Volcanic Field(Northern Pannonian Basin):Evidence from xenoliths

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Geoscience Frontiers 2020年第3期11卷 943-964页

作者： Levente Patko nora.liptai Laszlo Elod Aradi Rita Klebesz Eszter Sendula Robert J.Bodnar Istvan Janos Kovacs Karoly Hidas Bernardo Cesare Attila Novak Balazs Trasy Csaba Szabo Lithosphere Fluid Research Lab Institute of Geography and Earth SciencesEotvos Lor and UniversityBudapestHungary Isotope Climatology and Environmental Research Centre Institute for Nuclear ResearchHungarian Academy of SciencesDebrecenHungary CCFS-GEMOC Department of Earth and Planetary SciencesMacquarie UniversitySydneyAustralia Geodetic and Geophysical Institute Research Centre for Astronomy and Earth SciencesHungarian Academy of SciencesSopronHungary Fluids Research Laboratory Department of GeosciencesVirginia TechBlacksburgVAUnited States MTA CSFK Lendület Pannon LitH2Oscope Research Group Geodetic and Geophysical InstituteResearch Centre for Astronomy and Earth SciencesHungarian Academy of SciencesSopronHungary Instituto Andaluz de Ciencias de La Tierra CSIC&UGRArmillaGranadaSpain Department of Geosciences University of PaduaPaduaItaly Department of Geology Eotvos Lorand UniversityBudapestHungary

Clinopyroxene-enriched upper mantle xenoliths classified as wehrlites are common(~20% of all xenoliths) in the central part of the Nograd-G(o| ")m(o|")r Volcanic Field(NGVF),situated in the northern margin of the Pannonian Basin in northern Hungary and southern *** this study,we thoroughly investigated 12 wehrlite xenoliths,two from each wehrlite-bearing occurrence,to determine the conditions of their *** textural features,including clinopyroxene-rich patches in an olivine-rich lithology,orthopyroxene remnants in the cores of newlyformed clinopyroxenes and vermicular spinel forms all suggest that wehrlites were formed as a result of intensive interaction between a metasomatic agent and the peridotite wall *** on the major and trace element geochemistry of the rock-forming minerals,significant enrichment in basaltic(Fe,Mn,Ti) and high field strength elements(Nb,Ta,Hf,Zr) was observed,compared to compositions of common lherzolite *** presence of orthopyroxene remnants and geochemical trends in rock-forming minerals suggest that the metasomatic process ceased before complete wehrlitization was *** composition of the metasomatic agent is interpreted to be a mafic silicate melt,which was further confirmed by numerical modelling of trace elements using the plate *** model results also show that the melt/rock ratio played a key role in the degree of petrographic and geochemical *** lack of equilibrium and the conclusions drawn by using variable lherzolitic precursors in the model both suggest that wehrlitization was the last event that occurred shortly before xenolith entrainment in the host mafic *** suggest that the wehrlitization and the Plio-Pleistocene basaltic volcanism are related to the same magmatic event.

关键词： Wehrlite xenoliths Upper mantle metasomatism Mafic silicate melt Trace element modelling