检索结果-南通市图书馆

Systematic review of anorectal leiomyosarcoma: Current challenges and recent advances

World Journal of Gastrointestinal Surgery 2019年第8期11卷 334-341页

作者： Mohammed O Nassif Razan A habib Luai Z Almarzouki nora h trabulsi Department of Surgery King Abdulaziz University

BACKGROUND The anorectal leiomyosarcoma (LMS) is an aggressive malignant neoplasm. Owing to the rarity of LMSs, an optimal treatment modality has yet to be determined. AIM To collect all published data on anorectal LMS characteristics, explore current treatment options, and review recent cases of postradiation LMS. METhODS A literature search of the PubMed electronic database was conducted using the MeSh terms "rectal neoplasms","anus neoplasms" and "gastrointestinal neoplasms" combined with "leiomyosarcoma". The search was limited to English language and human studies. All available case reports and case series of anal or rectal LMSs that were published from the beginning of January 1996 to May 2017 were included if the diagnosis of LMS had been confirmed by histopathologic examination. Data were analyzed using simple statistics (mean, median, and standard deviation). Independent sample t-test was used to compare means for continuous variables. RESULTS A total of 27 articles reporting on 51 cases of anorectal LMS were identified. Among these cases, 11.7% had undergone previous pelvic radiotherapy (developing LMS at 13-35 years afterwards). Anorectal LMS affected the rectum in 92.2% of the cases, and no sex-based predominance was observed. Surgical resection with negative margins remains the mainstay of treatment, which can be accomplished with wide local excision or radical resection. The local recurrence rate was higher among cases who received wide local excision (30%), as compared to radical resection (20%);however, the overall rate of metastasis was 51.61% regardless of the treatment approach. The use of neoadjuvant radiation lowers the risk of local recurrence compared to adjuvant radiotherapy, and facilitates R0 resection of the tumor. Cases treated with adjuvant chemotherapy showed better rates of distant recurrence and overall survival. Nonetheless, multidisciplinary team discussion is necessary to determine the optimal management plan whilst considering pa

关键词： Leiomyosarcoma Rectal neoplasms Anal neoplasms Gastrointestinal neoplasms Soft tissue neoplasms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-pancreatic hyperlipasemia:A puzzling clinical entity

引用

World Journal of Gastroenterology 2024年第19期30卷 2538-2552页

作者： Krisztina Eszter Feher David Tornai Zsuzsanna Vitalis Laszlo Davida nora Sipeki Maria Papp Division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversity of DebrecenDebrecen H-4032Hajdu-BiharHungary Kalman Laki Doctoral School of Biomedical and Clinical Sciences Faculty of MedicineUniversity of DebrecenDebrecen H-4032Hungary

BACKGROUND Increased lipase level is a serological hallmark of the diagnosis of acute pancreatitis(AP)but can be detected in various other diseases associated with lipase leakage due to inflammation of organs surrounding the pancreas or reduced renal clearance and/or hepatic *** non-pancreatic hyperlipasemia(NPhL)is puzzling for attending physicians during the diagnostic procedure for *** would be clinically beneficial to identify the clinical and laboratory variables that hinder the accuracy of lipase diagnosis with the aim of improve it.A more precise description of the NPhL condition could potentially provide prognostic factors for adverse outcomes which is currently *** To perform a detailed clinical and laboratory characterization of NPhL in a large prospective patient cohort with an assessment of parameters determining disease *** A hungarian patient cohort with serum lipase levels at least three times higher than the upper limit of normal(ULN)was prospectively evaluated over 31 *** were identified using daily electronic laboratory reports developed to support an ongoing observational,multicenter,prospective cohort study called the EASY trial(ISRCTN10525246)to establish a simple,easy,and accurate clinical scoring system for early prognostication of *** of NPhL was established based on≥3×ULN serum lipase level in the absence of abdominal pain or abdominal imaging results characteristic of *** A total of 808 patients[male,n=420(52%);median age(IQR):65(51-75)years]were diagnosed with≥3×ULN serum lipase levels.A total of 392 patients had AP,whereas 401 had NPhL with more than 20 different *** and acute kidney injury(AKI)were the most prevalent etiologies of NPhL(27.7%and 33.2%,respectively).The best discriminative cut-off value for lipase was≥666 U/L(sensitivity,71.4%;specificity,88.8%).The presence of AKI or sepsis negatively affected the diagnostic performance of *** w

关键词： Non-pancreatic hyperlipasemia Acute pancreatitis Glycoprotein 2 Acute kidney injury Sepsis Mortality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

hard life for sons in the nest?Sex-dependent offspring mortality in Great Tits in urban and forest areas

引用

Avian Research 2024年第1期15卷 91-97页

作者： nora Agh henriett Anna Dalvári Krisztián Szabó Ivett Pipoly András Liker hUN-REN-PE Evolutionary Ecology Research Group University of PannoniaH-8200VeszpremPf.1158.Hungary Behavioral Ecology Research Group Center for Natural SciencesUniversity of PannoniaH-8200Pf.1158.VeszpremHungary Molecular Ecology Research Group Department of EcologyUniversity of Veterinary Medicine BudapestH-1400Pf.2.BudapestHungary Synlab hungary Ltd. H-1211Weiss Manfr´ed Str.5-7BudapestHungary

Sex-biased mortality can occur in birds during development,for example due to sexual differences in energy requirement and/or environmental sensitivity,or the effects of sex hormones or sex differences in the expression of mutations linked to sex *** extent of sex-bias in mortality may also be related to environmental conditions that influence offspring development and *** areas often provide poorer conditions for nestling development resulting in higher offspring mortality compared to natural areas,which may accelerate sex differences in offspring mortality in *** test this hypothesis,we examined the sex ratio of dead offspring in Great Tits(Parus major),using 427 samples of unhatched eggs and dead nestlings collected in two urban and two forest sites between 2013 and *** ratio of males in the whole sample of dead offspring(56.9%)was significantly higher than expected by an 1:1 ratio,and the strongest sex biases were detected in urban areas(57.6%males)and in young nestlings(however,the sex ratios of dead offspring did not differ significantly among study sites and between offspring developmental stages.29.3%of unhatched eggs contained a visible embryo,and the proportion of embryo-containing unhatched eggs did not differ significantly between urban and forest study *** results suggest male-biased offspring mortality in Great Tits,and highlight the need of large datasets to detect subtle differences between habitats and developmental stages.

关键词： Great Tit Urbanization Nestling mortality Sex related differences

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis

引用

Protein & Cell 2010年第11期1卷 1011-1022页

作者： Chandrakala Basavannacharya Paul R.Moody Tulika Munshi nora Cronin Nicholas h.Keep Sanjib Bhakta Institute for Structural and Molecular Biology Department of Biological SciencesBirkbeckUniversity of LondonLondon WC1E 7HXUK

The emergence of total drug-resistant tuberculosis(TDRTB)has made the discovery of new therapies for tuberculosis *** cytoplasmic enzymes of peptidoglycan biosynthesis have generated renewed interest as attractive targets for the development of new *** of the cytoplasmic enzymes,uridine diphosphate(UDP)-MurNAc-tripeptide ligase(MurE),catalyses the addition of meso-diaminopimelic acid(m-DAP)into peptidoglycan in Mycobacterium tuberculosis coupled to the hydrolysis of *** of *** MurE were generated by replacing K157,E220,D392,R451 with alanine and N449 with aspartate,and truncating the first 24 amino acid residues at the Nterminus of the *** of the specific activity of these proteins suggested that apart from the 24 Nterminal residues,the other mutated residues are essential for *** in Km values for one or more substrates were observed for all mutants,except the N-terminal truncation mutant,indicating that these residues are involved in binding substrates and form part of the active site *** mutant proteins were also tested for their specificity for a wide range of ***,the mutations K157A,E220A and D392A showed hydrolysis of ATP uncoupled from *** ATP hydrolysis rate was enhanced by at least partial occupation of the uridine nucleotide dipeptide binding *** study provides an insight into the residues essential for the catalytic activity and substrate binding of the ATP-dependent MurE *** ATPdependent MurE ligase is a novel drug target,the understanding of its function may lead to development of novel inhibitors against resistant forms of ***.

关键词： peptidoglycan MurE ligase site-directed mutagenesis m-DAP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

计算机模拟阴离子对碳酸镍结晶过程的影响

引用

无机化学学报 2009年第10期25卷 1823-1828页

作者：刘昉 nora h. de Leeuw 张昭四川大学化学工程学院成都610065 Department of Chemistry University College of London London WC1H 0AJ UK

本文采用原子模拟技术,研究了不同溶液中碳酸镍的结晶行为。结果表明,水化作用使碳酸镍晶体更稳定,形貌更规整。杂质阴离子SO42-与碳酸镍晶体表面的作用力较强,但对其形貌影响不大。Cl-对表面的作用力较弱,但使晶体形貌更不规则。在模... 详细信息

本文采用原子模拟技术,研究了不同溶液中碳酸镍的结晶行为。结果表明,水化作用使碳酸镍晶体更稳定,形貌更规整。杂质阴离子SO42-与碳酸镍晶体表面的作用力较强,但对其形貌影响不大。Cl-对表面的作用力较弱,但使晶体形貌更不规则。在模拟的几种情况中,碳酸镍的(104)晶面均是最主要的显露面。模拟结果能与实验现象很好吻合。

关键词：计算机模拟碳酸镍结晶过程阴离子影响

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and characterization of asymmetric ultrafiltration membrane for effective recovery of proteases from surimi wash water

引用

Frontiers of Chemical Science and Engineering 2012年第2期6卷 184-191页

作者： nora'aini ALI Fadhilati hASSAN Sofiah hAMZAh Department of Engineering Science Faculty of Science and Technology University Malaysia Terengganu 21030 Kuala Terengganu Malaysia

The wash water generated from the surimi processing industry contains a large amount of proteases which are widely used in the food and biotechnology industries. Asymmetric polysulfone and polyethersulfone ultrafiltration （PSf-UF and PES-UF） membranes with three different polymer concentrations were screened for their abilities to recover proteases from surimi wash water. In- house fabricated membranes were prepared via a simple dry/wet phase inversion technique and were characterized in terms of permeability coefficient, membrane morphol- ogy and molecular weight cut-off （MWCO）. The ability of the UF membranes to remove commercial proteases was tested at various pressures （up to 10 bars）. The membrane with the best performance, 15 wt-% PSf-UF, was further tested with actual surimi wash water. The effect of the ph of the feed solution （4 to 8） in the pre-treatment stage was also evaluated to recover the highest amount of proteases. The highest retention of protease was 96% with a flux of 25.6 L/（mZ.h） which was achieved with the 15 wt-% PSf- UF membrane.

关键词： membrane ultrafiltration proteases surimi wash water

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dietary analysis of homonota darwini (Squamata:Gekkonidae) in Northern Patagonia

引用

Current Zoology 2010年第4期56卷 406-410页

作者： Marcelo E.KUN Carla PIANTONI John D.KRENZ nora R.IBARGüENGOYTíA Departamento de Zoología Centro Regional Universitario Bariloche Universidad del Comahue Unidad Postal Universidad del Comahue Smithsonian Institution NHB MRC 163 Department of Biological Sciences Minnesota State University Departamento de Zoologia Centro Regional Universitario Bariloche Universidad del Comahue Unidad Postal Universidad del Comahue Instituto de Investigación en Diversidad y Medio Ambiente (INIBIOMA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)

Our study investigated the diet of the southernmost gecko in the world, homonota darwini. Fifty-three specimens were captured during spring and summer in four locations in Patagonia, Argentina. The stomach contents of the specimens were identified, and we tbund that prey consisted of six main groups： Coleoptera, hymenoptera, homoptera and Araneae, and the adults and larvae of moth Lepidoptera. Lepidoptera was the major dietary component. The presence of ants and moths as common prey suggests an ambush feeding strategy. In spring, females consumed more ants than males although no other dietary differences between males and females were evident. We tbund nine geckos with empty stomachs and six parasitized by nematodes. Presence of empty stomachs corroborates previous observations of other nocturnal geckos and non-gecko lizards. Reduced foraging success of nocturnal lizards could be due to difficulty in prey detection due to dim light, reduced or erratic activity of insect prey at night, or shorter activity times of geckos relative to diurnal success. Sex and season were not associated with the incidence of empty stomachs. Principal component analysis showed that four food alternatives correlated with season. The constraint of nocturnality, coupled with low night-time temperatures restricting feeding to only a few hours after sunset, appear to have caused a generality of diet which may limit energy acquisition. We conclude that h. darwini is an arthropod generalist and likely an ambush forager, as are many other nocturnal gekkonids

关键词： Nocturnal lizards Diet Gekkonidae Patagonia PCA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association of Adolescent Bullying Victimization with Meeting 24-hour Movement Behavior Recommendations:A Cross-Sectional Study Using the Combined 2015-2019 Youth Risk Behavior Survey

引用

Journal of Science in Sport and Exercise 2023年第2期5卷 182-190页

作者： You Fu Ryan DBurns Peng Zhang Samantha Dyer nora Constantino School of Public health University of NevadaRenoNVUSA Department of health&Kinesiology University of UtahSalt Lake CityUTUSA Physical Education Teacher Education Department East Stroudsburg UniversityEast StroudsburgPAUSA

Purpose To examine the association between bullying victimization and meeting recommendations for the 24-h movement behaviors of physical activity,screen use,and sleep in *** Participants were a sample of US adolescents from the 2015–2019 national Youth Risk Behavior Survey(N=43,847;Mean age=16.0±1.2 years;50.7%female).The bullying victimization variables included the bullying expe-riences at school and *** multivariable logistic regressions analyzed associations between bullying victimiza-tion and meeting recommendations for 24-h movement behaviors controlling for age,sex,race/ethnicity,and weight *** Adolescents meeting non-academic screen and sleep recommendations had 25%(OR=0.75,95%CI 0.69–0.82)and 19%(OR=0.81,95%CI 0.74–0.89)lower odds to be bullied at *** meeting non-academic screen recommen-dation had 27%lower odds(OR=0.73,95%CI 0.58–0.91)of experience online *** adolescents who met physical activity,non-academic screen use,and sleep recommendations had lower odds of experience the bullying at school of 29%(OR=0.71,95%CI 0.59–0.85),26%(OR=0.74,95%CI 0.61–0.90),and 31%(OR=0.69,95%CI 0.55–0.86),*** the females,non-academic screen use was the only movement behavior yielded statistical significance,in that those who met the recommendation had 15%(OR=0.85,95%CI 0.73–0.98)lower odds of experience the bullying at *** The presence of meeting 24-h movement behavior recommendations associates with a lower probability of bullying at school and online in ***,these associations tended to be stronger and more consistent in males compared to females.

关键词： School bullying Cyber bullying Youth Behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Location-based prediction model for Crohn’s disease regarding a novel serological marker,anti-chitinase 3-like 1 autoantibodies

引用

World Journal of Gastroenterology 2023年第42期29卷 5728-5750页

作者： nora Sipeki Patricia Julianna Kovats Claudia Deutschmann Peter Schierack Dirk Roggenbuck Maria Papp Division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversity of DebrecenDebrecen H-4032Hungary Kálmán Laki Doctoral School Faculty of MedicineUniversity of DebrecenDebrecen H-4032Hungary Institute of Biotechnology Faculty Environment and Natural SciencesBrandenburg University of Technology Cottbus-SenftenbergSenftenberg 01968Germany Faculty of health Sciences Brandenburg Brandenburg University of Technology Cottbus-SenftenbergSenftenberg 01968Germany Medipan Gmbh&GA Generic Assays Gmbh Dahlewitz-Berlin 15827Germany

BACKGROUND Defective neutrophil regulation in inflammatory bowel disease(IBD)is thought to play an important role in the onset or manifestation of IBD,as it could lead to damage of the intestinal mucosal barrier by the infiltration of neutrophils in the inflamed mucosa and the accumulation of *** neutrophils in the context of innate immune responses,immunoglobulin A(IgA)as an acquired immune response partakes in the defense of the intestinal *** normal conditions,IgA contributes to the elimination of microbes,but in connection with the loss of tolerance to chitinase 3-like 1(ChI3L1)in IBD,IgA could participate in ChI3L1-mediated improved adhesion and invasion of potentially pathogenic *** tolerance brake to ChI3L1 and the occurrence of IgA autoantibodies to this particular target,the exact role and underlying mechanisms of ChI3L1 in the pathogenesis of IBD are still *** To determine the predictive potential of Ig subtypes of a novel serological marker,anti-ChI3L1 autoantibodies(aChI3L1)in determining the disease phenotype,therapeutic strategy and long-term disease course in a prospective referral cohort of adult IBD *** Sera of 257 Crohn’s disease(CD)and 180 ulcerative colitis(UC)patients from a tertiary IBD referral center of hungary(Division of Gastroenterology,Department of Internal Medicine,Faculty of Medicine,University of Debrecen)were assayed for IgG,IgA,and secretory IgA(sIgA)type aChI3L1 by enzyme-linked immunosorbent assay using recombinant ChI3L1,along with 86 healthy controls(hCONT).RESULTS The IgA type was more prevalent in CD than in UC(29.2%vs 11.1%)or hCONT(2.83%;Ph).however,sIgA subtype aChI3L1 positivity was higher in both CD and UC patients than in hCONT(39.3%and 32.8%vs 4.65%,respectively;Phe presence of both IgA and sIgA aChI3L1 antibodies was associated with colonic involvement(Ph *** disease behavior a

关键词： Chitinase 3-like 1 autoantibodies Crohn’s disease Ulcerative colitis Disease progression Immunoglobulin subtypes Enzyme-linked immunosorbent assay

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of the Visual Analogue Score in the Evaluation of the Pruritus of Cholestasis

引用

Journal of Clinical and Translational hepatology 2017年第3期5卷 203-207页

作者： nora V.Bergasa E.Anthony Jones NYC H + H Metropolitan New York NY USA New York Medical College Valhalla NY USA Department of Gastroenterology and Liver Diseases Academic Medical Center Amsterdam The Netherlands

Background and Aims:A visual analogue score (VAS),based on application of a visual analogue scale,has been widely used to assess pruritus in clinical studies of patients with cholestatic liver disease.A VAS is a numerical score of the severity of the perception of pruritus,and,hence,is inherently *** objective of this study was to assessthe reliability of a VAS as an index of pruritus in cholestatic ***:In 8 patients with chronic pruritus due to primary biliary cholangitis,values for a VAS of pruritus were compared with corresponding measurements of scratching activity,which were generated by a monitoring system specifically designed to quantitate this *** relationship between individual values for the VAS and corresponding values for scratching activity during a specific interval immediately preceding the recording of the VAS was examined by determining the Spearman's rank correlation ***:The mean Spearman's rank correlation coefficient between individual values for the VAS and corresponding mean values for scratching activity was 0.072;the range of these coefficients was-0.04 to 0.26.A VAS of pruritus is an unreliable index of scratching activity,and,hence,of the pathophysiological process responsible for the pruritus of ***:It is concluded that the use of a VAS as a primary quantitative endpoint in trials of the efficacy of potential therapies for the pruritus of cholestasis may be inappropriate.

关键词： Pruritus Cholestasis Visual analogue score Scratching activity Primary biliary cholangitis Quantitative efficacy endpoint

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：