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Location-based prediction model for Crohn’s disease regarding a novel serological marker,anti-chitinase 3-like 1 autoantibodies

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World Journal of Gastroenterology 2023年第42期29卷 5728-5750页

作者： nora Sipeki Patricia Julianna Kovats Claudia Deutschmann Pe.e. Schierack Dirk Roggenbuck Maria Papp Division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversity of DebrecenDebrecen H-4032Hungary Kálmán Laki Doctoral School Faculty of MedicineUniversity of DebrecenDebrecen H-4032Hungary Institute of Biotechnology Faculty Environment and Natural SciencesBrandenburg University of Technology Cottbus-SenftenbergSenftenberg 01968Germany Faculty of Health Sciences Brandenburg Brandenburg University of Technology Cottbus-SenftenbergSenftenberg 01968Germany Medipan GmbH&GA Ge.e.ic Assays GmbH Dahlewitz-Berlin 15827Germany

BACKGROUND De.e.tive neutrophil regulation in inflammatory bowel disease(IBD)is thought to play an important role in the onset or manifestation of IBD,as it could lead to damage of the intestinal mucosal barrier by the infiltration of neutrophils in the inflamed mucosa and the accumulation of *** neutrophils in the context of innate immune responses,immunoglobulin A(IgA)as an acquired immune response partakes in the de.e.se of the intestinal *** normal conditions,IgA contributes to the.e.imination of microbes,but in connection with the loss of tolerance to chitinase 3-like 1(CHI3L1)in IBD,IgA could participate in CHI3L1-mediated improved adhesion and invasion of potentially pathogenic *** tolerance brake to CHI3L1 and the occurrence of IgA autoantibodies to this particular target,the.e.act role and underlying mechanisms of CHI3L1 in the pathoge.e.is of IBD are still *** To de.e.mine the predictive potential of Ig subtypes of a novel serological marker,anti-CHI3L1 autoantibodies(aCHI3L1)in de.e.mining the disease phenotype,therapeutic strategy and long-term disease course in a prospective re.e.ral cohort of adult IBD *** Sera of 257 Crohn’s disease(CD)and 180 ulcerative colitis(UC)patients from a tertiary IBD re.e.ral center of Hungary(Division of Gastroenterology,Department of Internal Medicine,Faculty of Medicine,University of Debre.e.)we.e.assayed for IgG,IgA,and secretory IgA(sIgA)type aCHI3L1 by enzyme-linked immunosorbent assay using recombinant CHI3L1,along with 86 healthy controls(HCONT).ReSULTS The IgA type was more prevalent in CD than in UC(29.2%vs 11.1%)or HCONT(2.83%;Pe.e.,sIgA subtype aCHI3L1 positivity was higher in both CD and UC patients than in HCONT(39.3%and 32.8%vs 4.65%,respectively;Pe pre.e.ce of both IgA and sIgA aCHI3L1 antibodies was associated with colonic involve.e.t(Pespectively)in patients with *** disease behavior a

关键词： Chitinase 3-like 1 autoantibodies Crohn’s disease Ulcerative colitis Disease progression Immunoglobulin subtypes enzyme-linked immunosorbent assay

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Characterizing the optimal operation of photocatalytic degradation of BDe-209 by nano-sized TiO_2

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Journal of environmental Sciences 2012年第9期24卷 1670-1678页

作者： Ka Lai Chow Yu Bon Man Jin Shu Zheng Yan Liang nora Fung Yee Tam Ming Hung Wong Croucher Institute for environmental Sciences and Department of Biology Hong Kong Baptist University Hong Kong SAR China Department of Biology and Chemistry City University of Hong Kong Hong Kong SAR China

Brominated flame retardants have been widely used in industry. The.e.is a rapid growing public concern for their availabilities in the.e.vironment. Advanced oxidation process （AOP） is a promising and efficient technology which may be used to remove.e.erging chemicals such as brominated flame retardants. This study aims at investigating optimal operational conditions for the removal of BDe-209 using nano-scaled titanium（IV） oxide. The residual PBDe conge.e.s after photocatalytical degradation of BDe-209 by TiO2 we.e.analysed by gas chromatography-mass spectrometry （GC-MS）. It was found that the degradability of BDe-209 by TiO2 was attributed to its photocatalytic activity but not the small size of the particles. The half-life of removing BDe-209 by TiO2 was 3.05 days under visible light. Tetra- and penta-BDes we.e.the major degraded products of BDe-209. Optimum conditions for photocatalytical degradation of BDe-209 was found to be at pH 12 （93% ± 1%）, 5, 10, 20 mg/L （93.0% ± 1.70%, 91.6% ± 3.21%, 91.9% ± 0.952%, respectively）, respectively of humic acid and in the form of anatase/rutile TiO2 （82% ± 3%）. Hence, the.e.ficiency of removing BDe-209 can be maximized while being cost effective at the said operating conditions.

关键词： PBDes TiO2 photocatalysis hydroxyl radicals

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essential residues for the.e.zyme activity of ATP-de.e.dent Mure ligase from Mycobacterium tuberculosis

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Protein & Cell 2010年第11期1卷 1011-1022页

作者： Chandrakala Basavannacharya Paul R.Moody Tulika Munshi nora Cronin Nicholas H.Keep Sanjib Bhakta Institute for Structural and Molecular Biology Department of Biological SciencesBirkbeckUniversity of LondonLondon WC1E 7HXUK

The.e.ergence of total drug-resistant tuberculosis(TDRTB)has made the discovery of new therapies for tuberculosis *** cytoplasmic enzymes of peptidoglycan biosynthesis have ge.e.ated re.e.ed inte.e.t as attractive targets for the de.e.opment of new *** of the cytoplasmic enzymes,uridine diphosphate(UDP)-MurNAc-tripeptide ligase(Mure),catalyses the addition of meso-diaminopimelic acid(m-DAP)into peptidoglycan in Mycobacterium tuberculosis coupled to the hydrolysis of *** of *** Mure we.e.ge.e.ated by replacing K157,e220,D392,R451 with alanine and N449 with aspartate,and truncating the first 24 amino acid residues at the Nterminus of the *** of the specific activity of the.e.proteins suggested that apart from the 24 Nterminal residues,the other mutated residues are.e.sential for *** in Km values for one or more substrates we.e.observed for all mutants,except the N-terminal truncation mutant,indicating that the.e.residues are involved in binding substrates and form part of the active site *** mutant proteins we.e.also tested for their specificity for a wide range of ***,the mutations K157A,e220A and D392A showed hydrolysis of ATP uncoupled from *** ATP hydrolysis rate was enhanced by at least partial occupation of the uridine nucleotide dipeptide binding *** study provides an insight into the residues essential for the catalytic activity and substrate binding of the ATP-de.e.dent Mure *** ATPde.e.dent Mure ligase is a novel drug target,the understanding of its function may lead to de.e.opment of novel inhibitors against resistant forms of ***.

关键词： peptidoglycan Mure ligase site-directed mutage.e.is m-DAP

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Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism

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World Journal of Stem Cells 2016年第10期8卷 306-315页

作者： Taylor C Peak nora M Haney William Wang Kenneth J DeLay Wayne J Hellstrom Department of Urology School of MedicineTulane University

The production of testosterone occurs within the Leydig cells of the testes. When production fails at this le.e. from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been de.e.oped, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular de.e.opment, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, re.e.rchers and physicians will be able to de.e.op stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of re.e.erating this steroidogenic process and the problems remain unresolved. In summary, the.e.appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves diffe.e.tiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while.e.iminating the need for transplantation.

关键词： Stem cell therapy Leydig cells Primary hypogonadism Stem Leydig cells Testosterone Bone marrow-derived stem cells Adipose-derived me.e.chymal stem cells

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GC-MS analysis,de.e.mination of total phenolics,flavonoid content and free radical scavenging activities of various crude.e.tracts of Moringa pe.e.rina(Forssk.) Fiori leaves

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Asian Pacific Journal of Tropical Biomedicine 2014年第12期4卷 964-970页

作者： Mooza Al-Owaisi nora Al-Hadiwi Shah Alam Khan Department of Pharmacy Oman Medical College

Objective:To perform phytochemical screening,estimate total phenolics,flavonoids and to evaluate antioxidant potential of Moringa pe.e.rina(***) ***:The dried powde.e. leaves of ***(150 g) we.e.extracted exhaustively by Soxhlet with ethanol and then fractionated into hexane,chloroform,ethy alacetate and *** the prepared extracts we.e.also analyzed by gas chromatography-mass spectrometry to identify and characterize the chemical compounds pre.e.t in the crude ***- Ciocalteu reagent and aluminium chloride colorimetric methods we.e.used to estimate total phenolic and flavonoid content of *** peroxide and 1,1 diphenyl-2-picrylhydrazyl we.e.used to de.e.mine in vitro antioxidant ***:Phytochemical analysis of ethanol extract showed pre.e.ce of major classes of *** chromatography-mass spectrometry results re.e.led pre.e.ce of 19 phytoconstituents in hexane.e.tract,6 in ethyl acetate and 7 compounds in methanolic *** extract was found to contain the highest phenolic content and *** vitro antioxidant activities of all crude.e.tracts we.e.significant and comparable with the standard ascorbic ***:Results of this study show that the leaves of *** are the rich source of phenolic compounds that can play an important role in pre.e.ting the progression of many diseases.

关键词： Antioxidant activity Flavonoid content GC-MS analysis Moringa pe.e.rina Total phenolics

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Quantitative proteomic de.e.mination of diethylstilbestrol action on prostate cancer

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Asian Journal of Andrology 2013年第3期15卷 413-420页

作者： Pierre Bigot Kevin Mouzat Muriel Bahut nora Benhabiles Geraldine Cancel Tassin Abdel-Rahme.e.Azzouzi Olivier Cussenot Department of Urology Angers University Hospital Angers 49933 France Ce.e.P Tenon Hospital Paris 75970 France Department of Biochemistry N'imes University Hospital NTmes 30029 France Plate-Forme Technologique de Biotechnologie Moleculaire Angers University Angers 49933 France 5CeA DSV IRCM SREIT Laboratoire de Cancerologie Experimentale Fontenay-aux-Roses 92265 France

Diethylstilbestrol （DeS） has a direct cellular mechanism inhibition on prostate cancer. Its action is inde.e.dent from the oestrogen re.e.tors and is pre.e.ved after a first-line hormonal therapy. We aimed to identify proteins involved in the direct cellular inhibition effects of DeS on prostate cancer. We used a clonogenic assay to establish the median lethal concentration of DeS on 22RV1 cells. 22RV1 cells we.e.exposed to standard and DeS-enriched medium. After extraction, protein expression le.e.s we.e.obtained by two-dimensional diffe.e.tial in-gel e.e.trophoresis （2D-DIGe） and isotope labelling tags for relative and absolute quantification （iTRAQ）. Proteins of inte.e.t we.e.analysed by quantitative RT-PCR and western blotting. The diffe.e.tially regulated proteins （P〈0.01） we.e.interrogated against a global molecular network based on the ingenuity knowledge base. The 2D-DIGe analyses re.e.led DeS-induced expression changes for 14 proteins （〉 1.3 fold; P〈0.05）. The iTRAQ analyses allowed the identification of 895 proteins. Among the.e.proteins, 65 had a modified expression due to DeS exposure （i.e., 23 ove.e.pressed and 42 unde.e.pressed）. Most of the.e.proteins we.e.implicated in apoptosis and redox processes and had a predicted mitochondrial expression. Additionally, ingenuity pathway analysis placed the OAT and HSBP1 ge.e. at the centre of a highly significant network. RT-PCR confirmed the ove.e.pression of OAT （P=0.006） and HSPB1 （P=0.046）.

关键词： cultured cells DeS diethylstilbestrol ingenuity pathway analysis isotope labelling mass spectrometry prostate cancer proteomics

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In vitro toxicity of particulate matter emissions from residential pellet combustion

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Journal of environmental Sciences 2022年第5期34卷 215-226页

作者： estela D.Vicente Daniela Figueiredo Catia Goncalves Isabel Lopes He.e.a Oliveira nora Kovats Te.e.a Pinheiro Celia A.Alves Department of environment and Planning and CeSAM-Centre for environmental and Marine Studies University of Aveiro3810-193 AveiroPortugal Department of Biology and CeSAM-Centre for environmental and Marine Studies University of Aveiro3810-193 AveiroPortugal Centre of Natural environmental Sciences University of PannoniaEgyetem str.108200 VeszpremHungary Instituto de Bioengenharia e Biociencias Departamento de Engenharia e Ciencias NuclearesInstituto Superior TecnicoUniversidade de LisboaAv.Rovisco Pais 11049-001 LisboaPortugal

Particulate matter emissions(PM10)from the combustion,in a residential stove,of two com-mercial brands of certified(eNplus A1)pellets,a non-certified brand and laboratory made pellets of acacia we.e.tested for their ability to induce.e.otoxic,cytotoxic,and mutagenic re-sponses in unicellular organisms and a human cell *** was evaluated through the Vibrio fischeri bioluminescence inhibition ***,cytotoxicity was assessed at two time points(24-and 48-hr)through two comple.e.tary techniques in order to evaluate the cellular metabolic activity and membrane integrity of human lung epithelial cells *** Ames test using two Salmonella typhimurium strains(TA100 and TA98)was employed to assess the mutagenic potential of the polycyclic aromatic hydrocarbon fraction extracted from the PM10 *** obtained with the bioluminescent bacteria indicated that only particles from the combustion of acacia pellets we.e.*** samples induced im-pairment on the A549 cells metabolic activity,while no significant re.e.se of lactate dehy-drogenase was ***10 emissions from acacia pellets we.e.the most cytotoxic,while samples from both certified pellets evoked significant cytotoxicity at lower ***-icity time-de.e.dency was only observed for PM10 from the combustion of acacia pellets and one of the brands of certified *** activity was not de.e.ted in both *** murium *** study emphasises the role of the raw material for pellet manu-facturing on the toxicological profile of PM *** raw materials should be deeply investigated before their use in pelletisation and combustion in residential appli-ances.

关键词： ecotoxicity Cytotoxicity Mutagenicity Fuel quality Pellet combustion PM10 emissions

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计算机模拟阴离子对碳酸镍结晶过程的影响

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无机化学学报 2009年第10期25卷 1823-1828页

作者：刘昉 nora H. de Leeuw 张昭四川大学化学工程学院成都610065 Department of Chemistry University College of London London WC1H 0AJ UK

本文采用原子模拟技术,研究了不同溶液中碳酸镍的结晶行为。结果表明,水化作用使碳酸镍晶体更稳定,形貌更规整。杂质阴离子SO42-与碳酸镍晶体表面的作用力较强,但对其形貌影响不大。Cl-对表面的作用力较弱,但使晶体形貌更不规则。在模... 详细信息

本文采用原子模拟技术,研究了不同溶液中碳酸镍的结晶行为。结果表明,水化作用使碳酸镍晶体更稳定,形貌更规整。杂质阴离子SO42-与碳酸镍晶体表面的作用力较强,但对其形貌影响不大。Cl-对表面的作用力较弱,但使晶体形貌更不规则。在模拟的几种情况中,碳酸镍的(104)晶面均是最主要的显露面。模拟结果能与实验现象很好吻合。

关键词：计算机模拟碳酸镍结晶过程阴离子影响

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Nanotechnology as a Sustainable Approach for Achieving Sustainable Future

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World Journal of engineering and Technology 2021年第4期9卷 877-890页

作者： nora Mohammed Rehan Architecture Department Faculty of Engineering Ahram Canadian University Cairo Egypt

The nanotechnology revolution affected positively Architecture. Using nanotechnology is conside.e. one of the most successful modern methods to achie.e.sustainable buildings with high functional efficiency. The discipline is Nano architecture, which uses Nanomaterials, products, or e.e. Nano-shapes in the treatment of structure and construction. Despite the economic and urban advantages of using nanotechnology in the field of architecture and urbanism, we note that using nanotechnology is limited to some buildings uses in the city centers until now such as Administrative, commercial, educational, health, and recreational buildings or residential buildings. In spite of that, we found that nanotechnology was not used in priority buildings as “nuclear power plants” as it is considered one of the most eligible buildings to rely on nanotechnology to achieve safety, security, and functional efficiency requirements which have a great impact on advancing the movement of urban development. e="white-space:normal;font-family:;" "="">From this standpoint, the re.e.rch recommends the ne.e.sity of following a methodology to activate the.e.tablishment of nuclear power plants with such technology to pre.e.ve the safety of construction, reduce.e.ergy consumption, conserve.e.onomic resources and reduce pollution. The re.e.rch is exposed to highlight a set of case studies that used such an effective technique and conclude a group of criteria that are recommended to be followed in the imple.e.tation and construction of the Dabaa plant in egypt to achie.e.a sustainable nuclear power plant. So the re.e.rch objective aims to adopt the idea of applying nanotechnology in various uses, whether it is in the city center or the outskirt of the city in order to de.e.op the.e.urban cities and transform them into

关键词： Nanotechnology Sustainable City Smart Building Nuclear Power Plant

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Immunologic, metabolic and ge.e.ic factors in hepatitis C virus infection

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World Journal of Gastroenterology 2014年第13期20卷 3443-3456页

作者： nora A Fierro Karina Gonzalez-Aldaco Rafael Torres-Valadez erika Martinez-Lopez Sonia Roman Arturo Panduro Department of Molecular Biology in Medicine Civil Hospital of Guadalajara"Fray Antonio Alcalde" and Health Sciences CenterUniversity of GuadalajaraGuadalajara 44280JaliscoMexico

The mechanisms that regulate disease progression during hepatitis C virus(HCV)infection and the response to treatment are not clearly *** studies have demonstrated that a strong host immune response against HCV favors HCV *** addition,ge.e.ic factors and metabolic machinery,particularly cholesterol modulation,are involved in HCV *** is likely that the interplay between all of the.e.factors contributes to the outcome of HCV *** re.e.t years,the world has experienced its largest epidemic of *** and the United States are the leading suffe.e.s from this epidemic at the global *** is associated with the de.e.opment ofnumerous pathologies including hypercholesterolemia which is one of the.e.ght most important risk factors for mortality in *** may be related to the course of HCV infection in this ***,we focus on the urgent need to study the progression of HCV infection in relation to ethnic *** are discussed that hold promise in identifying immune,metabolic and ge.e.ic factors that,in conjunction,could be therapeutic targets or predictors of the progression of HCV infection.

关键词： Hepatitis C virus Immune response Lipids Metabolism Ge.e.ics

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