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The protective effects of procyanidin C-1 on bisphenol A-induced testicular dysfunction in aged mice

Food Science and Human Wellness 2022年第4期11卷 965-974页

作者： Mastura Abd Malek Razif Dasiman nor-ashikin mohamed noor khan Sofee mohamed-Akhlak Mohd-Hafi zi Mahmud Maternofetal and Embryo Research Group(MatE) Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh Campus47000 Sungai BulohSelangorMalaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam Campus42300 Puncak AlamSelangorMalaysia

The number and quality of sperm are decreased due to bisphenol A(BPA) exposure, an endocrine-disrupting chemical on the male reproductive system, especially in advanced paternal age(APA). Procyanidin C-1(PCY-1), an antioxidant from grape seed(Vitis vinifera L.), has demonstrated anti-viral, anti-melanogenic and immunostimulatory effects. Therefore, this study aims to determine the effects of PCY-1 intervention on sperm parameters, testis morphological changes, serum testosterone, oestradiol, and luteinizing hormone(LH) concentrations and the expression of apoptotic(Bax and Bcl-2) and mitochondria-related(Mfn1 and Opa1) genes in BPA-exposed aged mice. Results revealed that PCY-1 intervention improves aged male fertility in BPA-exposed conditions by decreasing abnormal sperms percentage and increasing spermatogenic cell diameter and epithelial height. PCY-1 also decreased oestradiol, and increased LH and testosterone levels. The gene expression of Bax was significantly down-regulated by PCY-1 intervention. In contrast, Bcl-2 was substantially up-regulated. Expression of Mfn1 and Opa1 genes were also significantly up-regulated in the PCY intervention group. Hence, it is demonstrated that PCY-1 was able to mitigate the adverse effects of BPA on reproductive parameters of aged mice. Collectively, we postulated that PCY-1 has a potential role in protecting the ageing male reproductive system against the damaging impacts of BPA.

关键词： Apoptosis Bisphenol A Procyanidin Mitochondrial dynamics Testis

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Vitamin E supplementation may negatively affect preimplantation development and mitochondrial ultrastructure of vitrified murine embryos

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Asian pacific Journal of Reproduction 2021年第3期10卷 137-144页

作者： Mimi-Sophia Sarbandi nor-ashikin mohamed noor khan nor-Shahida Abdul Rahman Zolkapli Eshak Fathiah Abdullah Mastura Abd Malek Aqila-Akmal Mohammad Kamal Maternofetal and Embryo Research Group Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh Campus47000 Sungai BulohSelangorMalaysia Faculty of Applied Sciences Universiti Teknologi MARAPerak BranchTapah Campus35400 Tapah RoadPerakMalaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam42300 Kuala SelangorSelangorMalaysia Faculty of Pharmacy Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam42300 Kuala SelangorSelangorMalaysia

Objective:To observe the effects of vitamin E on post-vitrification preimplantation development,gross morphology as well as mitochondrial distribution and ***:Twenty-four female C57BL/6NTac mice,aged 12-16 weeks,were randomly divided into four *** A did not receive any treatment and served as the control *** B was treated with corn oil stripped of tocopherols and served as the vehicle *** C was treated with 60 mg/kg body weight of tocotrienol-rich-fraction with corn oil stripped of *** D was treated with 60 mg/kg body weight of alpha-tocopherol with corn oil stripped of *** treatments were administered orally for 7 consecutive *** superovulation and mating with fertile males,2-cell stage embryos were harvested for *** vitrification development in vitro,gross morphology and ultrastructure were compared between ***:The number of 2 and 8-cell embryo,and blastocysts in the treatment and control groups were not significantly different(P>0.05).Following vitrification,all 2-cell embryos had equal-sized blastomeres and intact zona *** aggregation toward the perinuclear region was seen in all of the treatment *** groups C and D had vacuolated mitochondria,which was reflected in the trend of preimplantation development ***:Vitamin E supplementation of 60 mg/kg body weight does not improve the viability of healthy embryos according to this *** a result,the most effective dose of vitamin E supplementation may be determined by the initial quality of the embryos.

关键词： Mitochondria Preimplantation Embryo Vitrification Vitamin E Alpha-tocopherol Tocotrienol-richfraction,Transmission electron microscopy

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Novel energy recovery from an integrated municipal solid waste and leachate treatment system

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Waste Disposal and Sustainable Energy 2024年第1期6卷 53-61页

作者： Siti Salwa Khamis Hadi Purwanto Hamzah Mohd Salleh Alya Naili Rozhan mohamed Abdur Rahman Mahammadsalman Warimani noor Alam Faculty of Engineering International Islamic University MalaysiaJalan Gombak53100Kuala LumpurMalaysia Department of Engineering Management Universitas Internasional Semen IndonesiaGresikIndonesia Halalan Thayyiban Research Centre Sultan Sharif Ali Islamic UniversityBandar Seri BegawanBrunei Department of Mechanical Engineering P.A.College of EngineeringMangaloreKarnataka574153India Department of Mechanical Engineering Malaysia-Japan International Institute of TechnologyUniversity of Technology Malaysia54100Kuala LumpurMalaysia

Population growth,waste generation,and massive waste mismanagement have led to environmental *** of municipal solid waste(MSW)requires an efficient and sustainable integrated *** integrated thermal processing of MSW is one of the best waste management *** this study,energy analysis of MSW is carried out based on the material and energy balance of 2000 kg wet MSW,which contains 50%*** the leachate is removed,the dry MSW is sent for carbon content enhancement in carbonization to produce MSW-based ***,the combustion of MSW-based char provided high heat and syngas to be used in a hydrothermal process for MSW leachate *** result shows that the char fuel of MSW produces a sufficient amount of energy,13501.29 MJ(84.55%),in the form of synthetic gas by-product,which has a big potential as an energy *** novelty of the proposed integrated thermal system is to produce 84.55%synthetic gas by-product,which is used for electricity production,cooking,food,and heat energy for industrial *** proposed applications of this paper offer insightful information for policymaking regarding novel MSW techniques,which are economical,energy-efficient,and environmentally ***,it increases the effectiveness of MSW utilization.

关键词： Energy Carbonization Hydrothermal Municipal solid waste Integrated system

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Cardiovascular risk factors among older persons with cognitive frailty in middle income country

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World Journal of Clinical Cases 2024年第17期12卷 3076-3085页

作者： Azianah Mohamad Ibrahim Devinder Kaur Ajit Singh Arimi Fitri Mat Ludin noor Ibrahim mohamed Sakian Nurul Fatin Malek Rivan Suzana Shahar Centre for Healthy Ageing and Wellness Faculty of Health SciencesUniversiti Kebangsaan MalaysiaWilayah Persekutuan Kuala Lumpur 50300Malaysia Basic Medical Sciences University of CyberjayaSelangor Darul EhsanMalaysia 63000Malaysia

BACKGROUND Cognitive frailty,characterized by the coexistence of cognitive impairment and physical frailty,represents a multifaceted challenge in the aging *** role of cardiovascular risk factors in this complex interplay is not yet fully *** To investigate the relationships between cardiovascular risk factors and older persons with cognitive frailty by pooling data from two cohorts of studies in *** A comprehensive approach was employed,with a total of 512 communitydwelling older persons aged 60 years and above,involving two cohorts of older persons from previous *** related to cardiovascular risks,namely sociodemographic factors,and cardiovascular risk factors,including hypertension,diabetes,hypercholesterolemia,anthropometric characteristics and biochemical profiles,were pooled for *** frailty was defined based on the Clinical Dementia Rating scale and Fried frailty *** risk was determined using Framingham risk *** analyses were conducted using SPSS version *** Of the study participants,46.3%exhibited cognitive *** risk factors including hypertension(OR:1.60;95%CI:1.12-2.30),low fat-free mass(OR:0.96;95%CI:0.94-0.98),high percentage body fat(OR:1.04;95%CI:1.02-1.06),high waist circumference(OR:1.02;95%CI:1.01-1.04),high fasting blood glucose(OR:1.64;95%CI:1.11-2.43),high Framingham risk score(OR:1.65;95%CI:1.17-2.31),together with sociodemographic factors,i.e.,being single(OR 3.38;95%CI:2.26-5.05)and low household income(OR 2.18;95%CI:1.44-3.30)were found to be associated with cognitive *** Cardiovascular-risk specific risk factors and sociodemographic factors were associated with risk of cognitive frailty,a prodromal stage of *** identification and management of cardiovascular risk factors,particularly among specific group of the population might mitigate the risk of cognitive frailty,hence preventing dementia.

关键词： Cognitive frailty Older persons Cardiovascular risk factors Frailty Mild cognitive impairment

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Fenofibrate for the prevention of progression of non-proliferative diabetic retinopathy:review,consensus recommendations and guidance for clinical practice

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 2001-2008页

作者： nor Fariza Ngah nor Asiah Muhamad Roslin Azni Abdul Aziz Shelina Oli mohamed nor Azita Ahmad Tarmizi Azian Adnan Zalifah Zakiah Asnir Zanariah Hussein Hui Foo Siew Masni mohamed noor Aliza Lodz Vijayamala Valayatham Institute for Clinical Research National Institutes of HealthSetia AlamSelangor 40790Malaysia Hospital Shah Alam Selangor 40000Malaysia Sector for Evidence-Based Healthcare National Institutes of HealthSetia AlamSelangor 40790Malaysia Hospital Kuala Lumpur Wilayah Persekutuan Kuala Lumpur 50586Malaysia Hospital Selayang Selangor 68100Malaysia Hospital Ampang Selangor 68000Malaysia Hospital Putrajaya Wilayah Persekutuan Putrajaya 62250Malaysia Institute for Public Health National Institutes of HealthSetia AlamSelangor 40790Malaysia

The prevalence of diabetic retinopathy(DR),and associated morbidity is high in the Asia-Pacific *** evidence suggests a potential role for fenofibrate in the prevention of progression of DR,especially in patients with cardiovascular risk,and pre-existing mild-to-moderate *** has also been found to reduce maculopathy,and the need for laser treatment in these *** these benefits of fenofibrate,a group of experts from the fields of endocrinology and ophthalmology convened in May 2017,to discuss on the the mechanism of action,and clinical efficacy of fenofibrate in *** findings from key clinical studies on fenofibrate in DR were reviewed by the experts,and consensus statements were derived to define the role of fenofibrate in the prevention and treatment of *** statements were rated based on the GRADE *** algorithm was also developed for the screening and treatment of DR in patients with type 2 diabetes(T2D),and the place of fenofibrate was defined in the *** expert recommendations,and the algorithm provided in this review will serve as a guide to the clinicians to reconsider the adjunctive use of fenofibrate for preventing the progression of DR in selected T2D patients.

关键词： diabetic retinopathy fenofibrate consensus recommendations

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Glutathione (GSH) improves sperm quality and testicular morphology in streptozotocin-induced diabetic mice

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Asian Journal of Andrology 2021年第3期23卷 281-287页

作者： Fathiah Abdullah mohamed noor khan nor-ashikin Renu Agarwal Yuhaniza Shafinie Kamsani Mastura Abd Malek nor Salmah Bakar Aqila-Akmal Mohammad Kamal Mimi-Sophia Sarbandi nor-Shahida Abdul Rahman Nurul Huda Musa Maternofetal and Embryo Research Group(MatE) Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh CampusSungai Buloh 47000SelangorMalaysia Faculty of Applied Sciences Universiti Teknologi MARAPerak BranchTapah CampusTapah Road 35400PerakMalaysia Faculty of Medicine Universiti Teknologi MARASelangor BranchSungai Buloh CampusSungai Buloh 47000SelangorMalaysia School of Medicine International Medical UniversityBukit JalilKuala Lumpur 57000Malaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam 42300SelangorMalaysia Centre of Foundation Studies Universiti Teknologi MARASelangor BranchDengkil CampusDengkil 43800SelangorMalaysia

Diabetes mellitus(DM)is known to cause reproductive *** men,it has been linked to altered sperm quality and testicular *** stress(OS)plays a pivotal role in the development of DM ***(GSH)is a part of a nonenzymatic antioxidant defense system that protects lipid,protein,and nucleic acids from oxidative ***,the protective effects of exogenous GSH on the male reproductive system have not been comprehensively *** study determined the impact of GSH supplementation in ameliorating the adverse effect of type 1 DM on sperm quality and the seminiferous tubules of diabetic C57BL/6NTac *** at the doses of 15 mg kg^(-1)and 30 mg kg^(-1)was given intraperitoneally to mice weekly for 6 consecutive *** mice were then weighed,euthanized,and had their reproductive organs *** diabetic(D Group)showed significant impairment of sperm quality and testicular histology compared with the nondiabetic(ND Group).Diameters of the seminiferous lumen in diabetic mice treated with 15 mg kg^(-1) GSH(DGSH15)were decreased compared with the D *** motility was also significantly increased in the DGSH15 *** in testicular morphology might be an early indication of the protective roles played by the exogenous GSH in protecting sperm quality from effects of untreated type 1 DM or diabetic *** investigation using different doses and different routes of GSH is necessary to confirm this suggestion.

关键词： diabetes mellitus glutathione mice sperm quality testis histology

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Generation of OAM Waves and Analysis of Mode Purity for 5G Sub-6 GHz Applications

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Computers, Materials & Continua 2023年第1期74卷 2239-2259页

作者： Shehab khan noor Arif Mawardi Ismail Mohd Najib Mohd Yasin mohamed Nasrun Osman Nurulazlina Ramli Ali H.Rambe J.Iqbal Advanced Communication Engineering(ACE) Centre of ExcellenceFaculty of Electronic Engineering TechnologyUniversiti Malaysia PerlisKangarPerlisMalaysia Centre for Advanced Electrical&Electronic System(CAEES)Faculty of Engineering Built Environment and Information TechnologySEGi University Petaling JayaSelangorMalaysia Department of Electrical Engineering Universitas Sumatera UtaraMedan20155Indonesia School of Electrical and Electronic Engineering Engineering CampusUniversiti Sains MalaysiaNibong Tebal14300PenangMalaysia Faculty of Engineering&Technology Gomal University29050 kpkPakistan

This article presents the generation of Orbital AngularMomentum(OAM)vortex waves with mode 1 using Uniform Circular Array(UCA)*** different designs,namely,UCA-1(4-element array antenna)and UCA-2(8-element array antenna),were designed and fabricated using FR-4 substrate to generate OAM mode 1 at 3.5 GHz(5G mid-band).The proposed antenna arrays comprised rectangular microstrip patch elements with inset fed *** elements were excited by a carefully designed feeding phase shift network to provide similar output energy at output ports with desired phase shift *** generated OAM waves were confirmed by measuring the null in the bore sight of their 2D radiation patterns,simulated phase distribution and intensity *** measurement results agree well with the simulation ***,a detailed mode purity analysis of the generated OAM waves was carried out considering different *** investigation found that the greater the number of elements,the higher the purity of the generated OAM *** with other previous works,the proposed antenna design of this paper is very simple to design and *** addition,the proposed antennas are compact in design even at lower frequency band with very wide bandwidth to meet the requirements of 5G mid-band applications.

关键词： Orbital angular momentum vortex waves fifth generation wireless communications uniform circular array antenna patch antenna

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A Deep Learning Approach for Crowd Counting in Highly Congested Scene

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Computers, Materials & Continua 2022年第12期73卷 5825-5844页

作者： Akbar khan Kushsairy Abdul Kadir Jawad Ali Shah Waleed Albattah Muhammad Saeed Haidawati Nasir Megat norulazmi Megat mohamed noor Muhammad Haris Kaka Khel Electrical Section Universiti Kuala Lumpur British Malaysian InstituteSelangor53100Malaysia Department of Electrical Engineering International Islamic UniversityIslamabad44000Pakistan Department of Information Technology College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Electrical Engineering National University of Computer and Emerging SciencesIslamabad44000Pakistan Computer Engineering Technology Section Universiti Kuala Lumpur Malaysian Institute of Information TechnologyKuala Lumpur50250Malaysia

With the rapid progress of deep convolutional neural networks,several applications of crowd counting have been proposed and explored in the *** congested scene monitoring,a variety of crowd density estimating approaches has been *** understanding of highly congested scenes for crowd counting during Muslim gatherings of Hajj and Umrah is a challenging task,as a large number of individuals stand nearby and,it is hard for detection techniques to recognize them,as the crowd can vary from low density to high *** deal with such highly congested scenes,we have proposed the Congested Scene Crowd Counting Network(CSCC-Net)using VGG-16 as a core network with its first ten layers due to its strong and robust transfer learning rate.A hole dilated convolutional neural network is used at the back end to widen the relevant field to extract a large range of information from the image without losing its original *** dilated convolution neural network is mainly chosen to expand the kernel size without changing other ***,several loss functions have been applied to strengthen the evaluation accuracy of the ***,the entire experiments have been evaluated using prominent data sets namely,ShanghaiTech parts A,B,UCF_CC_50,and UCF_*** model has achieved remarkable results i.e.,68.0 and 9.0 MAE on ShanghaiTech parts A,B,199.1 MAE on UCF_CC_50,and 99.8 on UCF_QNRF data sets respectively.

关键词： Deep learning congested scene crowd counting fully convolutional neural network dilated convolution

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Higher Order OAM Mode Generation Using Wearable Antenna for 5G NR Bands

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Computer Systems Science & Engineering 2023年第10期47卷 537-551页

作者： Shehab khan noor Arif Mawardi Ismail Mohd Najib Mohd Yasin mohamed Nasrun Osman Thennarasan Sabapathy Shakhirul Mat Salleh Ping Jack Soh Ali Hanafiah Rambe Nurulazlina Ramli Advanced Communication Engineering(ACE) Centre of ExcellenceFaculty of Electronic Engineering&TechnologyUniversiti Malaysia PerlisKangarPerlisMalaysia Faculty of Engineering Technology(FTK) Department of Electronic Engineering TechnologyUniversiti Malaysia Perlis(UniMAP)Unicity Alam Campus02100Padang BesarPerlisMalaysia Centre for Wireless Communications(CWC) University of Oulu90570OuluFinland Department of Electrical Engineering Universitas Sumatera UtaraMedan20155Indonesia Centre for Advanced Electrical and Electronic System(CAEES)Faculty of Engineering Built Environment and Information TechnologySEGi University SelangorMalaysia

This paper presents a flexible and wearable textile array antenna designed to generate Orbital Angular Momentum(OAM)waves with Mode+2 at 3.5 GHz(3.4 to 3.6 GHz)of the sub-6 GHz fifth-generation(5G)New Radio(NR)*** proposed antenna is based on a uniform circular array of eight microstrip patch antennas on a felt textile *** contrast to previous works involving the use of rigid substrates to generate OAM waves,this work explored the use of flexible substrates to generate OAM waves for the first *** than that,the proposed antenna was simulated,analyzed,fabricated,and tested to confirm the generation of OAMMode+*** the same design,OAM Mode−2 can be generated readily simply by mirror imaging the feed *** that the proposed antenna operated at the desired frequency of 3.5 GHz with an overall bandwidth of 400 MHz in free ***,mode purity analysis is carried out to verify the generation of OAM Mode+2,and the purity obtained was 41.78%at free space flat ***,the effect of antenna bending on the purity of the generated OAM mode is also ***,the influence of textile properties on OAM modes is examined to assist future researchers in choosing suitable fabrics to design flexible OAM-based *** a comprehensive analysis considering different factors related to wearable applications,this paper demonstrates the feasibility of generating OAMwaves using textile ***,as per the obtained Specific Absorption Rate(SAR),it is found that the proposed antenna is safe to be *** findings of this work have a significant implication for body-centric communications.

关键词： Wearable antenna OAM vortex waves 5G textile antenna microstrip patch antenna specific absorption rate(SAR)

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Demethylbelamcandaquinone B from Marantodes pumilum ***(Blume)Kuntze inhibits osteoclast differentiation in RAW264.7 cells

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Asian Pacific Journal of Tropical Biomedicine 2021年第12期11卷 535-542页

作者： Haryati Ahmad Hairi Jamia Azdina Jamal nor Ashila Aladdin Khairana Husain noor Suhaili Mohd Sofi norazlina mohamed Isa Naina mohamed Ahmad Nazrun Shuid Department of Biochemistry Faculty of MedicineManipal University College MalaysiaJalan Batu HamparBukit Baru75150 MelakaMalaysia Faculty of Pharmacy Universiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz50300 Kuala LumpurMalaysia Department of Pharmacology Faculty of MedicinePreclinical BuildingUniversiti Kebangsaan MalaysiaJalan Yaacob LatiffBandar Tun RazakCheras56000 Kuala LumpurMalaysia Department of Pharmacology Faculty of MedicineUniversiti Teknologi MaraJalan Hospital47000 Sungai BulohSelangorMalaysia

Objective:To investigate the bone-resorbing effect of demethylbelamcandaquinone B(Dmcq B)extracted from Marantodes pumilum *** on osteoclast differentiation in RAW264.7 ***:RAW264.7 macrophages were differentiated using RANKL into osteoclast-like ***,they were treated with 10μg/mL Marantodes pumilum *** crude aqueous extract,5μg/mL dichloromethane fraction,and 0.6μg/mL Dmcq B and 0.06μg/mL ***-resistant acid phosphatase 5b(TRACP 5b)as an osteoclast phenotypic marker was determined by TRACP staining and TRACP 5b colometric assay,and bone-resorbing pits were *** gene expression of pro-inflammatory cytokines(TNF-αand IL-6)was ***,the protein expressions of pro-inflammatory cytokines(TNF-αand IL-6)and estrogen receptors were ***:Marantodes pumilum *** crude aqueous extract and Dmcq B inhibited RANKL-stimulated osteoclast differentiation as evidenced by size reduction of giant multinucleated osteoclast cells,decreased TRACP 5b activity as well as the subsiding of resorbed pit area compared with normal *** addition,they reduced the gene and protein expressions of TNF-αand *** pumilum ***,Dmcq B,and estradiol treatments increased the protein expressions of estrogen receptors alpha and beta in ***:Marantodes pumilum *** and its active compound,Dmcq B can inhibit osteoclast differentiation.

关键词： Marantodes pumilum var.alata Phytoestrogen RAW264.7 induced-osteoclast Bone-resorbing effect

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