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Outcome of trabeculectomy in hospital Melaka,Malaysia

International Journal of Ophthalmology(English edition) 2012年第3期5卷 384-388页

作者： Moon Heng Hah Raja norliza Raja Omar Juliana Jalaluddin nor fadzillah abd jalil Anusiah Selvathurai Department of Ophthalmology Hospital MelakaMalaysia

AIM:To study the success and outcome of trabeculectomy in Hospital Melaka.· METHODS:Medical records of all patients who underwent trabeculectomy between January 1,2007 and October 31,2010 whom were followed up for at least 6 months postoperatively in Hospital Melaka were retrospectively reviewed.· RESULTS:A total number of 117 eyes of 91 patients with the age range between 12 to 84 years underwent primary trabeculectomy(n =20,17.1%),combine trabeculectomy with cataract surgery(n =90,76.9%),repeat trabeculectomy(n=5,4.3%),and combine repeat trabeculectomy with cataract surgery(n =2,1.7%).The disease spectrum includes primary open-angle glaucoma(POAG)(54 patients,59.3%),priamry angle-closure glaucoma(PACG)(14 patients,15.4%),secondary glaucomas(19 patients,20.9%) and juvenile glaucomas(4 patients,4.4%).Preoperative mean intraocular pressure(IOP) was(24.69±8.67)mmHg as compared to postoperative mean IOP of(15.81±6.66)mmHg,(15.07±4.72)mmHg and(15.68±3.65)mmHg at 6-month,12-month and 24-month ***-two point one percent of eyes(n =96) achieved complete success(CS),12.8%(n =15) with qualified success(QS) and only 5.1%(n = 6) failed at 6 month with two of them warrant other filtering *** twelve months,trabeculectomy with CS was 71.6%(n =63),QS in 22.7%(n =20) and failure in 5.7%(n = 5).Sixty-seven point five percent(n =27) attained CS,20.0%(n =8) with QS while 12.5%(n =5) failed at 24 month postoperative.· CONCLUSION:As the understanding of the lower the IOP,the better the patients retaining the visual function,trabeculectomy is significantly a choice of treatment in uncontrolled *** study concluded that trabeculectomy performed in Hospital Melaka has produced significant success as compared to other studies.·

关键词： trabeculectomy glaucoma success rate

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亚洲少年眼和肾结节病1例(英文)

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国际眼科杂志 2010年第9期10卷 1659-1661页

作者： Roslinah Muji Muzaliha Mohd nor Anusiah Selvathurai Raja norliza Raja Omar Juliana Jalaluddin nor fadzillah abd jalil Ismail Shatriah 马六甲医院眼科马来西亚马六甲市75400 马来西亚理科大学医学院眼科马来西亚吉兰丹市16150

结节病通常导致年轻人患双侧肺门淋巴腺病,肺实质疾病和/或皮肤损伤等。儿童结节病是一种相对罕见的疾病,尤其是眼和肾脏同时受累的儿童患者。我们这里呈现了一个双侧复发性前葡萄膜炎伴发肾功能衰竭的结节病的少年亚裔病情。口服类固... 详细信息

结节病通常导致年轻人患双侧肺门淋巴腺病,肺实质疾病和/或皮肤损伤等。儿童结节病是一种相对罕见的疾病,尤其是眼和肾脏同时受累的儿童患者。我们这里呈现了一个双侧复发性前葡萄膜炎伴发肾功能衰竭的结节病的少年亚裔病情。口服类固醇与甲氨喋呤后临床症状得到明显改善。因顽固性青光眼行小梁切除术后双眼视力令人满意。因此,给予及时的诊断及迅速适当的处理能避免这类罕见疾病的眼部发病率。

关键词：眼肾结节亚洲少年

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The flow behavior of powder stearin-based methyl ester sulfonates and the effect of glidant

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Particuology 2023年第9期80卷 148-156页

作者： Zulina abd Maurad Luqman Chuah abdullah Mohd Shamsul Anuar nor Nadiah abdul Karim Shah Zainab Idris Malaysian Palm Oil Board 6Persiaran InstitusiBandar Baru Bangi43000SelangorMalaysia Department of Chemical and Environmental Engineering Faculty of EngineeringUniversiti Putra MalaysiaSerdangSelangor43400Malaysia Department of Process and Food Technology Faculty of EngineeringUniversiti Putra MalaysiaSerdangSelangor43400Malaysia

The preparation and behavior of powder stearin-based methyl ester sulfonates(MES)with the addition of builder as a glidant agent was *** is an anionic surfactant and its performance is equivalent to petroleum-based linear alkylbenzene sulfonates(LAS),the workhorses of the detergent *** the same time,zeolites or soda ash were the alternative builders for non-phosphate-based *** behavior of powder MES properties was measured in terms of morphology,particle size,cohesion,caking,and *** that,these palm stearin-based MES of carbon chain 16–18 with ratios of 98:2,80:20,and 60:40 in flakes were ground using a high shear mixer by 23,000 rpm to produce powder *** the particle size of MES powder can reduce the powder's cohesion,caking,and *** addition of zeolite or soda ash as a glidant in powdered MES can improve the caking *** high stearic in MES greatly influenced getting fine particle powders and required more glidant *** powder MES with excellent powder characteristics can perform well as a bio-based cleaning product.

关键词： Methyl ester sulfonates Caking Compaction Cohesion Glidant

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Glutathione (GSH) improves sperm quality and testicular morphology in streptozotocin-induced diabetic mice

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Asian Journal of Andrology 2021年第3期23卷 281-287页

作者： Fathiah abdullah Mohamed Noor Khan nor-Ashikin Renu Agarwal Yuhaniza Shafinie Kamsani Mastura abd Malek nor Salmah Bakar Aqila-Akmal Mohammad Kamal Mimi-Sophia Sarbandi nor-Shahida abdul Rahman Nurul Huda Musa Maternofetal and Embryo Research Group(MatE) Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh CampusSungai Buloh 47000SelangorMalaysia Faculty of Applied Sciences Universiti Teknologi MARAPerak BranchTapah CampusTapah Road 35400PerakMalaysia Faculty of Medicine Universiti Teknologi MARASelangor BranchSungai Buloh CampusSungai Buloh 47000SelangorMalaysia School of Medicine International Medical UniversityBukit JalilKuala Lumpur 57000Malaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam 42300SelangorMalaysia Centre of Foundation Studies Universiti Teknologi MARASelangor BranchDengkil CampusDengkil 43800SelangorMalaysia

Diabetes mellitus(DM)is known to cause reproductive *** men,it has been linked to altered sperm quality and testicular *** stress(OS)plays a pivotal role in the development of DM ***(GSH)is a part of a nonenzymatic antioxidant defense system that protects lipid,protein,and nucleic acids from oxidative ***,the protective effects of exogenous GSH on the male reproductive system have not been comprehensively *** study determined the impact of GSH supplementation in ameliorating the adverse effect of type 1 DM on sperm quality and the seminiferous tubules of diabetic C57BL/6NTac *** at the doses of 15 mg kg^(-1)and 30 mg kg^(-1)was given intraperitoneally to mice weekly for 6 consecutive *** mice were then weighed,euthanized,and had their reproductive organs *** diabetic(D Group)showed significant impairment of sperm quality and testicular histology compared with the nondiabetic(ND Group).Diameters of the seminiferous lumen in diabetic mice treated with 15 mg kg^(-1) GSH(DGSH15)were decreased compared with the D *** motility was also significantly increased in the DGSH15 *** in testicular morphology might be an early indication of the protective roles played by the exogenous GSH in protecting sperm quality from effects of untreated type 1 DM or diabetic *** investigation using different doses and different routes of GSH is necessary to confirm this suggestion.

关键词： diabetes mellitus glutathione mice sperm quality testis histology

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Phenolics-saponins rich fraction of defatted kenaf seed meal exhibits cytotoxicity towards cancer cell lines

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 404-409页

作者： Latifah Saiful Yazan Napsiah abd Rahman Kim Wei Chan Wan nor Hafiza Wan abd Ghani Yin Sim Tor Jhi Biau Foo Laboratory of Molecular Biomedicine Institute of BioscienceUniversiti Putra Malaysia (UPM) Department of Biomedical Science Faculty of Medicine and Health SciencesUniversiti Putra Malaysia (UPM)

Objectives: To determine the cytotoxicity of crude ethanolic extract, n-butanol fraction and aqueous fraction on selected cancer cell lines, and to observe the morphological changes of the cancer cells treated with n-butanol ***: The cytotoxic effect of n-butanol fraction, crude ethanolic extract and aqueous fraction on breast cancer(MCF-7 and MDA-MB-231), colon cancer(HT29), lung cancer(A549), cervical cancer(He La) and normal mouse fibroblast(3T3) cell lines was determined using MTT assay. The morphological changes of the treated cells were observed under an inverted light ***: n-Butanol fraction was the most cytotoxic towards HT29 and MCF-7 cells in a dose-dependent manner compared to crude ethanolic extract and aqueous fraction(P < 0.05). The IC50 of n-butanol fraction for HT29 and MCF-7 was(780.00 ± 28.28)and(895.00 ± 7.07) mg/m L, respectively. Cell shrinkage, membrane blebbing and formation of apoptotic bodies were noted following treatment of HT29 cells with n-butanol ***: In conclusion, n-butanol fraction was more cytotoxic than crude ethanolic extract and aqueous fraction towards the selected cancerous cell lines and induced apoptosis in HT29 cells.

关键词： Defatted kenaf seed meal Phenolic-saponin rich fraction Cytotoxic Apoptosis

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Zinc and Copper Concentrations in Two Species of Intertidal Crabs from the Middle of the West Coast of Peninsular Malaysia

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湿地科学 2009年第3期7卷 218-229页

作者： Mohammad Mohd Ikram Ahmad Ismail Chee Kong Yap nor Azwady abd Aziz Department of Basic Science and Engineering Faculty of Agriculture and Food Sciences Universiti Putra Malaysia Bintulu Sarawak 97008 Malaysia Department of Biology Faculty of ScienceUniversiti Putra Malaysia UPM 43400 Serdang Selangor Malaysia

A study on Zn and Cu concentrations in 2 species of intertidal crabs,namely Uca annulipes and Dotilla myctiroides collected from the intertidal coastal area of Selangor(5 sites) and Negeri Sembilan(3 sites),west coast of Peninsular Malaysia,was carried *** various localized sources of Zn and Cu discharges towards both the crab species were mentioned.A comparative study between the 2 crab species also revealed that the concentrations of Zn and Cu were significantly(P<0.05) higher in *** when compared to *** difference was related to the organic matter percentage in the crabs' microhabitat sediments since metals can be associated with the organic matter of sediments in which they might ***(P<0.05) higher organic matter content was shown in *** sediments when compared to *** sediments for all *** metal and size relationship in the crabs was also *** relationships between Zn and Cu concentrations with body weight and carapace width of *** and *** were significantly(P<0.01 and P<0.05) correlated although the pair wise was weak.

关键词：沉积物马来西亚半岛有机物质螃蟹

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The protective effects of procyanidin C-1 on bisphenol A-induced testicular dysfunction in aged mice

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Food Science and Human Wellness 2022年第4期11卷 965-974页

作者： Mastura abd Malek Razif Dasiman nor-Ashikin Mohamed Noor Khan Sofee Mohamed-Akhlak Mohd-Hafi zi Mahmud Maternofetal and Embryo Research Group(MatE) Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh Campus47000 Sungai BulohSelangorMalaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam Campus42300 Puncak AlamSelangorMalaysia

The number and quality of sperm are decreased due to bisphenol A(BPA) exposure, an endocrine-disrupting chemical on the male reproductive system, especially in advanced paternal age(APA). Procyanidin C-1(PCY-1), an antioxidant from grape seed(Vitis vinifera L.), has demonstrated anti-viral, anti-melanogenic and immunostimulatory effects. Therefore, this study aims to determine the effects of PCY-1 intervention on sperm parameters, testis morphological changes, serum testosterone, oestradiol, and luteinizing hormone(LH) concentrations and the expression of apoptotic(Bax and Bcl-2) and mitochondria-related(Mfn1 and Opa1) genes in BPA-exposed aged mice. Results revealed that PCY-1 intervention improves aged male fertility in BPA-exposed conditions by decreasing abnormal sperms percentage and increasing spermatogenic cell diameter and epithelial height. PCY-1 also decreased oestradiol, and increased LH and testosterone levels. The gene expression of Bax was significantly down-regulated by PCY-1 intervention. In contrast, Bcl-2 was substantially up-regulated. Expression of Mfn1 and Opa1 genes were also significantly up-regulated in the PCY intervention group. Hence, it is demonstrated that PCY-1 was able to mitigate the adverse effects of BPA on reproductive parameters of aged mice. Collectively, we postulated that PCY-1 has a potential role in protecting the ageing male reproductive system against the damaging impacts of BPA.

关键词： Apoptosis Bisphenol A Procyanidin Mitochondrial dynamics Testis

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Epithelial Layer Estimation Using Curvatures and Textural Features for Dysplastic Tissue Detection

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Computers, Materials & Continua 2021年第4期67卷 761-777页

作者： Afzan Adam abdul Hadi abd Rahman nor Samsiah Sani Zaid abdi Alkareem Alyessari Nur Jumaadzan Zaleha Mamat Basela Hasan Faculty of Information Science and Technology Center for Artificial Intelligence TechnologyUniversiti Kebangsaan MalaysiaBangiSelangor43300Malaysia Faculty of Science and Technology School of Mathematical SciencesUniversiti Kebangsaan MalaysiaBangiSelangor43300Malaysia Department of Information Technology and Computing Faculty of Computer StudiesArab Open UniversityAmmanJordan

Boundary effect in digital pathology is a phenomenon where the tissue shapes of biopsy samples get distorted during the sampling *** morphological pattern of an epithelial layer is greatly ***,the shape deformation model can normalise the distortions,but it needs a 2D *** theory,on the other hand,is not yet tested on digital pathology ***,this work proposed a curvature detection to reduce the boundary effects and estimates the epithelial *** boundary effect on the tissue surfaces is normalised using the frequency of a curve deviates from being a straight *** epithelial layer’s depth is estimated from the tissue edges and the connected nucleolus ***,the textural and spatial features along the estimated layer are used for dysplastic tissue *** proposed method achieved better performance compared to the whole tissue regions in terms of detecting dysplastic *** result shows a leap of kappa points from fair to a substantial agreement with the expert’s ground truth *** improved results demonstrate that curvatures have been effective in reducing the boundary effects on the epithelial layer of ***,quantifying and classifying the morphological patterns for dysplasia can be *** textural and spatial features on the detected epithelial layer can capture the changes in tissue.

关键词： Digital pathology grading dysplasia tissue boundary effect

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Unveiling the potential of space syntax approach for revitalizing historic urban areas:A case study of Yushan Historic District,China

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Frontiers of Architectural Research 2023年第6期12卷 1144-1156页

作者： Yuyan Lyu Mohd Iskandar abd Malek nor Haslina Ja'afar Yina Sima Ziyi Han Zhangjingyi Liu Department of Architecture Faculty of Engineering and Built EnvironmentThe National University of MalaysiaUKM BangiSelangor 43600Malaysia Department of Architecture and Built Environment Faculty of Science and EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100China

Historic urban areas are a crucial component of urban heritage,embodying the collective memory of urban development and possessing distinctive urban textures and cultural ***,the growing impact of globalization on the urban environment poses challenges to historic urban areas,including diminishing social recognition,aging infrastructure,loss of vitality,and cultural *** address these challenges,this study proposes a novel approach to revitalizing historic urban areas by employing space syntax *** study focuses on Yushan Historic District in China as a case study and uses spatial models within space syntax to describe,analyze,and interpret its urban *** objective is to enhance urban vitality while preserving the heritage fabric of historic urban ***,it aims to contribute to the advancement of space syntax research,specifically in the context of urban renewal and revitalization of historic *** findings reveal the spatial factors that contribute to the generation of vitality within the district,identify areas requiring intervention,and provide strategies for revitalizing historic urban *** study demonstrates the potential of utilizing a space syntax approach in urban revitalization,providing valuable guidance for effectively conserving urban heritage within the context of urban renewal.

关键词： Space syntax Urban morphology Historic urban areas Urban revitalization Urban vitality Yushan Historic District

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A Novel Power Curve Prediction Method for Horizontal-Axis Wind Turbines Using Artificial Neural Networks

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Energy Engineering 2021年第3期118卷 507-516页

作者： Vin Cent Tai Yong Chai Tan nor Faiza abd Rahman Chee Ming Chia Mirzhakyp Zhakiya Lip Huat Saw Centre for Modelling and Simulation Faculty of EngineeringBuilt Environment and Information TechnologySEGi UniversityPetaling Jaya47810Malaysia Mechanical Engineering Department Faculty of EngineeringBuilt Environment and Information TechnologySEGi UniversityPetaling Jaya47810Malaysia Lee Kong Chian Faculty of Engineering and Science UTARKajang43200Malaysia

Accurate prediction of wind turbine power curve is essential for wind farm planning as it influences the expected power *** methods require detailed wind turbine geometry for performance evaluation,which most of the time unattainable and impractical in early stage of wind farm *** significant amount of work has been done on fitting of wind turbine power curve using parametric and non-parametric models,little to no attention has been paid for power curve modelling that relates the wind turbine design *** paper presents a novel method that employs artificial neural network to learn the underlying relationships between 6 turbine design parameters and its power curve.A total of 198 existing pitch-controlled and active stall-controlled horizontal-axis wind turbines have been used for model training and *** results showed that the method is reliable and reasonably accurate,with average R^(2)score of 0.9966.

关键词： Wind turbine power curve artificial neural network HAWT

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