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Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs

World Journal of Stem Cells 2020年第9期12卷 938-951页

作者： Nazmul Haque Ismail M Fareez Liew Fong Fong Chanchal Mandal noor hayaty abu kasim Kranthi RajaKacharaju Pratiwi Soesilawati Department of Oral Biology and Biomedical Sciences Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia Biotechnology and Genetic Engineering Discipline Life ScienceKhulna UniversityKhulna 9208Bangladesh Faculty of Dentistry University Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Faculty of Dental Medicine Universitas AirlanggaSurabaya 411007Indonesia Department of Conservative Dentistry Faculty of Dentistry MAHSA UniversitySelangor 42610Malaysia Department of Oral Biology Faculty of Dental MedicineUniversitas AirlanggaSurabaya 60115Indonesia

In recent years,several studies have reported positive outcomes of cell-based therapies despite insufficient engraftment of transplanted *** findings have created a huge interest in the regenerative potential of paracrine factors released from transplanted stem or progenitor ***,this notion has also led scientists to question the role of proteins in the secretome produced by cells,tissues or organisms under certain conditions or at a particular time of regenerative *** studies have revealed that the secretomes derived from different cell types contain paracrine factors that could help to prevent apoptosis and induce proliferation of cells residing within the tissues of affected *** could also facilitate the migration of immune,progenitor and stem cells within the body to the site of *** these different paracrine factors present within the secretome,researchers have given proper consideration to stromal cell-derived factor-1(SDF1)that plays a vital role in tissue-specific migration of the cells needed for *** researchers recognized that SDF1 could facilitate site-specific migration of cells by regulating SDF1-CXCR4 and/or HMGB1-SDF1-CXCR4 pathways which is vital for tissue *** in this study,we have attempted to describe the role of different types of cells within the body in facilitating regeneration while emphasizing the HMGB1-SDF1-CXCR4 pathway that orchestrates the migration of cells to the site where regeneration is needed.

关键词： C-X-C motif chemokine 12 Mesenchymal stem cells Monocytes Neutrophils Peripheral blood mononuclear cells Receptor for advanced glycation end products

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