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Fenofibrate for the prevention of progression of non-proliferative diabetic retinopathy:review,consensus recommendations and guidance for clinical practice

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 2001-2008页

作者： Nor Fariza Ngah Nor Asiah Muhamad Roslin Azni Abdul Aziz Shelina Oli Mohamed Nor Azita Ahmad Tarmizi Azian Adnan Zalifah Zakiah Asnir Zanariah Hussein Hui Foo Siew Masni Mohamed noor aliza lodz Vijayamala Valayatham Institute for Clinical Research National Institutes of HealthSetia AlamSelangor 40790Malaysia Hospital Shah Alam Selangor 40000Malaysia Sector for Evidence-Based Healthcare National Institutes of HealthSetia AlamSelangor 40790Malaysia Hospital Kuala Lumpur Wilayah Persekutuan Kuala Lumpur 50586Malaysia Hospital Selayang Selangor 68100Malaysia Hospital Ampang Selangor 68000Malaysia Hospital Putrajaya Wilayah Persekutuan Putrajaya 62250Malaysia Institute for Public Health National Institutes of HealthSetia AlamSelangor 40790Malaysia

The prevalence of diabetic retinopathy(DR),and associated morbidity is high in the Asia-Pacific *** evidence suggests a potential role for fenofibrate in the prevention of progression of DR,especially in patients with cardiovascular risk,and pre-existing mild-to-moderate *** has also been found to reduce maculopathy,and the need for laser treatment in these *** these benefits of fenofibrate,a group of experts from the fields of endocrinology and ophthalmology convened in May 2017,to discuss on the the mechanism of action,and clinical efficacy of fenofibrate in *** findings from key clinical studies on fenofibrate in DR were reviewed by the experts,and consensus statements were derived to define the role of fenofibrate in the prevention and treatment of *** statements were rated based on the GRADE *** algorithm was also developed for the screening and treatment of DR in patients with type 2 diabetes(T2D),and the place of fenofibrate was defined in the *** expert recommendations,and the algorithm provided in this review will serve as a guide to the clinicians to reconsider the adjunctive use of fenofibrate for preventing the progression of DR in selected T2D patients.

关键词： diabetic retinopathy fenofibrate consensus recommendations

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Ambient Air Pollution and Pulmonary Tuberculosis in Malaysia

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Health 2018年第12期10卷 1634-1649页

作者： Mohd Hatta Abdul Mutalip Tee Guat Hiong Stefanie Ebelt Sarnat Mohd Hazrin Hashim noor aliza lodz Sayan Pan Mohd Shahrul Mohd Nadzir Asmah Razali Center for Communicable Disease Research Institute for Public Health Ministry of Health Malaysia Kuala Lumpur Malaysia Department of Environmental Health Emory University Rollins School of Public Health Atlanta GA USA Food Safety Division Perlis State Health Department Kangar Malaysia Institute of Climate Change Universiti Kebangsaan Malaysia Bangi Malaysia TB Sector Disease Control Division Ministry of Health Malaysia Federal Government Administration Centre Putrajaya Malaysia

Introduction: The possible impact of ambient air pollution exposure on the development of active tuberculosis (TB) remains obscure. This study investigated the potential role of ambient air pollution in activating pulmonary TB (PTB) compared to extrapulmonary TB (EPTB). Materials and Methods: Data on TB cases were obtained from national surveillance data in Malaysia during 2013 and air pollution data were obtained from 52 air-monitoring stations around the country for the 3-year period of 2011-2013. Analyses were performed to estimate the odds of PTB vs. EPTB with changes in the 3-year (2011-2013) average Air Pollutant Index (API) and specific ambient air pollutants. Results: Results showed that the 95th-percentile of API levels during 2011-2013 was moderate and it was not associated with PTB. However, the odds of active PTB compared to EPTB was significantly elevated with the 95th-percentile levels for particulate matter with an aerodynamic diameter of 10 μm or less (aOR = 1.006, 95% CI: 1.002, 1.011), p-value Conclusions: These results provide suggestive evidence of the effects of ambient air pollution on development of active pulmonary TB compared to extrapulmonary TB. Additional research on the impacts of ambient air pollution on TB is warranted.

关键词： Ambient Air Pollution Air Pollutant Index Pulmonary TB Malaysia

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Translation, Cross-Cultural Adaptation, Reliability and Validity of the Malay Version of Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) V3.1

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Health 2018年第7期10卷 985-997页

作者： Nor Asiah Muhamad Omar Mihat Rushidi Ramly Aniza Abdul Aziz Rozanim Kamaruddin Wan Nor Arifin Wan Mansor noor Hashimah Abdullah Mohd Arif Mohd noor Rohaida Ismail Widya Astrina Wisman noor aliza lodz Muhammad Fadhli Mohd Yusoff Institute for Public Health Ministry of Health Kuala Lumpur Malaysia Non Communicable Disease Section Ministry of Health Putrajaya Malaysia Universiti Sultan Zainal Abidin Terengganu Malaysia Lembah Pantai District Health Office Ministry of Health Kuala Lumpur Malaysia Hospital Universiti Sains Malaysia Kubang Kerian Malaysia Kelantan State Health Department Ministry of Health Kota Bharu Malaysia Hospital Raja Perempuan Zainab II Ministry of Health Kota Bharu Malaysia

Introduction: A psychoactive substance has become an overwhelming public health burden globally. It causes social problems for the user and surrounding people which may affect work or study and cause negative economic impact. Objective: This study aims to translate and culturally adapt the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) into Malay and to assess its reliability and validity. Methods: The Malay version of the ASSIST v 3.1 was developed after the translation and back-translation, which included the stages recommended by Beaton. The ASSIST v 3.1 was administered to 125 respondents. The Malay ASSIST v 3.1 was completed twice by each respondent 7 to 14-day intervals to assess test-retest reliability based on the intra-rater and interrater correlation coefficient. Results: Majority of the respondents were male, Malay and currently employed. The intra-rater reliability is 0.84 and the test-retest reliability (ICC = 0.97) were excellent. Conclusion: Malay ASSIST v3.1 was a valid and reliable tool to screen substances abuse at varying degree. Nonetheless, further studies are needed to assess its responsiveness.

关键词： Substance Use Translation Reliability Validity ASSIST

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Modeling and Comprehensive Review of Signaling Storms in 3GPP-Based Mobile Broadband Networks:Causes,Solutions,and Countermeasures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 123-153页

作者： Muhammad Qasim Khan Fazal Malik Fahad Alturise noor Rahman Department of Computer Science Iqra National UniversityPeshawar25000Pakistan Department of Cybersecurity College of ComputerQassim UniversityBuraydah52555Saudi Arabia Department of Computer Science and Engineering Al-Fayha CollegeAl Jubayl31961Saudi Arabia

Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband ***,they consume important and scarce network resources such as bandwidth and processing *** have been several reports of these control signaling turning into signaling storms halting network operations and causing the respective Telecom companies big financial *** paper draws its motivation from such real network disaster incidents attributed to signaling *** this paper,we present a thorough survey of the causes,of the signaling storm problems in 3GPP-based mobile broadband networks and discuss in detail their possible solutions and *** provide relevant analytical models to help quantify the effect of the potential causes and benefits of their corresponding *** important contribution of this paper is the comparison of the possible causes and solutions/countermeasures,concerning their effect on several important network aspects such as architecture,additional signaling,fidelity,etc.,in the form of a *** paper presents an update and an extension of our earlier conference *** our knowledge,no similar survey study exists on the subject.

关键词： Signaling storm problems control signaling load analytical modeling 3GPP networks smart devices diameter signaling mobile broadband data access data traffic mobility management signaling network architecture 5G mobile communication

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Unveiling the impact:COVID-19's influence on bacterial resistance in the Kingdom of Bahrain

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World Journal of Virology 2025年第1期14卷 83-98页

作者： Nermin K Saeed Safiya K Almusawi noor A Albalooshi Mohammed Al-Beltagi Medical Microbiology Section Department of PathologySalmaniya Medical ComplexGovernmental HospitalsManama 12Bahrain Medical Microbiology Section Department of PathologyRoyal College of Surgeons in Ireland-Medical University of BahrainBusaiteen 15503MuharraqBahrain Department of Paediatrics Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671AlgharbiaBahrain

BACKGROUND Antibiotic resistance is a growing global health threat,and understanding local trends in bacterial isolates and their susceptibility patterns is crucial for effective infection control and antimicrobial *** coronavirus disease 2019(COVID-19)pandemic has introduced additional complexities,potentially influencing these *** To analyze trends in bacterial isolates and their antibiotic susceptibility patterns at Salmaniya Medical Complex from 2018 to 2023,with a specific focus on the impact of the COVID-19 pandemic on these *** A retrospective analysis of microbiological data was conducted,covering the period from 2018 to *** study included key bacterial pathogens such as Escherichia coli(***),Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,and Staphylococcus aureus,among *** antibiotic susceptibility profiles of these isolates were assessed using standard laboratory *** contextualize the findings,the findings were compared with similar studies from other regions,including China,India,Romania,Saudi Arabia,the United Arab Emirates,Malaysia,and United *** The study revealed fluctuating trends in the prevalence of bacterial isolates,with notable changes during the COVID-19 *** example,a significant increase in the prevalence of Staphylococcus aureus was observed during the pandemic years,while the prevalence of *** showed a more variable *** resistance rates varied among the different pathogens,with a concerning rise in resistance to commonly used antibiotics,particularly among Klebsiella pneumoniae and ***,the study identified an alarming increase in the prevalence of multidrug-resistant(MDR)strains,especially within Klebsiella pneumoniae and *** *** impact of the COVID-19 pandemic on these trends was evident,with shifts in the frequency,resistance patterns,and the emergence of MDR bacteria among several key ***

关键词： Multidrug-resistant organisms Antibiotic susceptibility COVID-19 pandemic Antimicrobial stewardship Bacterial isolates Salmaniya Medical Complex Bahrain

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Radiative Blood-Based Hybrid Copper-Graphene Nanoliquid Flows along a Source-Heated Leaning Cylinder

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1017-1037页

作者： Siti Nur Ainsyah Ghani noor Fadiya Mohd noor Institute of Mathematical Sciences Faculty of ScienceUniversiti MalayaKuala Lumpur50603Malaysia Center for Data Analytics Consultancy&Services(UM-CDACS) Faculty of ScienceUniversiti MalayaKuala Lumpur50603Malaysia

Variant graphene,graphene oxides(GO),and graphene nanoplatelets(GNP)dispersed in blood-based copper(Cu)nanoliquids over a leaning permeable cylinder are the focus of this *** forms of graphene are highly beneficial in the biological and medical fields for cancer therapy,anti-infection measures,and drug *** non-Newtonian Sutterby(blood-based)hybrid nanoliquid flows are generalized within the context of the Tiwari-Das model to simulate the effects of radiation and heating *** governing partial differential equations are reformulated into a nonlinear set of ordinary differential equations using similar transformational *** equations are then transformed into boundary value problems through a shooting technique,followed by the implementation of the bvp4c tool in *** influences of various parameters on the model’s nondimensional velocity and temperature profiles,reduced skin friction,and reduced Nusselt number are presented for detailed *** results indicated that Cu-GNP/blood and Cu-GO/blood hybrid nanofluids exhibit the lowest and highest velocity distributions,respectively,for increased nanoparticles volume fraction,curvature parameter,Sutterby fluid parameter,Hartmann number,and wall permeability ***,opposite trends are observed for the temperature distribution for all considered parameters,except the mixed convection *** in the reduced skin friction magnitude and the reduced Nusselt number with higher values of graphene/GO/GNP nanoparticle volume fraction are also ***,GNP is identified as the superior heat conductor,with an average increase of approximately 5%and a peak of 7.8%in the reduced Nusselt number compared to graphene and GO nanoparticles in the Cu/blood nanofluids.

关键词： Hybrid nanofluid sutterby fluid tiwari-das model thermal radiation graphene graphene oxides graphene nanoplatelets

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Enhancement of removal efficiency of heavy metal ions by polyaniline deposition on electrospun polyacrylonitrile membranes

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Water Science and Engineering 2021年第2期14卷 129-138页

作者： noor Mohammad Yomen Atassi Department of Applied Physics Higher Institute for Applied Sciences and TechnologyDamascusSyria

This paper describes the preparation of a membrane of polyacrylonitrile(PAN)and its corresponding membrane coated with polyaniline(PANI)for the adsorption of heavy metal *** electron microscopy micrographs revealed that all the membranes exhibited nanofibrous *** prepared membranes were characterized by Fourier transform infrared spectroscopy(FTIR).The prepared membranes were used as an adsorbent for hazardous heavy metal ions Pb^(2+) and Cr_(2)O^(2-)_(7).The adsorption capacity and the removal efficiency of the membranes were examined as function of the initial adsorbate concentration and pH of the *** membranes with PANI showed better adsorption performance and their direct current(DC)conductivities were correlated to heavy metal ion *** isotherms were also performed,and the adsorption process was tested according to the Langmuir and Freundlich *** regeneration and reuse of the prepared membranes to re-adsorb heavy metal ions were also *** enhancement in adsorption performance and reusability of PANI-coated membranes in comparison with non-coated ones is fully *** results show that the maximum adsorption capacities of lead and chromate ions on the PANI-coated membranes are 290.12 and 1202.53 mg/g,respectively.

关键词： Membrane Electrospinning Polyaniline Polyacrylonitrile Heavy metal ion removal

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Assessment of water resources in Yarmouk River Basin using geospatial technique during the period 1980–2020

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Journal of Arid Land 2022年第2期14卷 154-166页

作者： noor M AL-KHARABSHEH Department of Water Resources and Environmental Management Al-Balqa Applied UniversityAl-Salt 19117Jordan

It is common knowledge that Yarmouk River Basin(YRB)is shared between Jordan and *** of YRB trans-boundary water resources is attracting increasing interest because it is a strategic water resource for the riparian ***,lack of sharing information regarding hydrological flows and basin’s water management between partners’countries makes it difficult to distinguish between natural and man-made factors affecting the water ***,this study seeks to address and assess the main on-site changes that exert on *** technique and arithmetic equations were combined to carry out an assessment of the changes on water resources in ***,information and field measurements of the basin were aggregated,compiled and presented to determine the extent of changes during the period *** findings showed that precipitation amount in the basin significantly declined during the period 1980-2020 in particularly after the year *** rate of groundwater was 550 x 103 m3/a,exceeding the basin’s safe *** down of static groundwater level over time approached the value of-3.2 m/a due to the over abstraction in the aquifer ***,the evaporation rate reached more than 99%in some regions in the ***,the number of private wells has increased from 98 wells in 1980 to 126 wells in 2020,showing the excessive extraction of *** findings indicate that the study area is subjected to a considerable groundwater depletion in the near future due to extensive abstraction,continuous drilling of illegal wells and decreased annual precipitation under the shadow of the rapid population growth and continuous influx of ***,decision makers-informed scenarios are suggested in the development of water resource portfolios,which involves the combination of management and infrastructural actions that enhance the water productivity of the *** studies are recommended to evaluate the on-sit

关键词： assessment geospatial technique on-site changes water resources Yarmouk River Basin

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Rare earth elements in tropical surface water,soil and sediments of the Terengganu River Basin,Malaysia

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Journal of Rare Earths 2009年第6期27卷 1072-1078页

作者： Khawar Sultan noor Azhar Shazili Institute of Oceanography University Malaysia TerengganuMengabang Telipot21030 Kuala TerengganuTerengganuMalaysia

The 14 stable rare earth element(REE) concentrations and distribution patterns were investigated for surface waters(n=51),soils(n=52) and sediments(n=42) from the tropical Terengganu River basin,*** chondrite normalized REE patterns of soils developed on four geological units showed enrichment of LREE,a pronounced negative Eu,and depletion of HREE with an enrichment order granite>>metasedimentary>alluvium>*** REE patterns in sediments reflected the soil REE patterns with an ove...

关键词： rare earth elements river/lake water soil sediment Malaysia

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Optimum alternate material selection methodology for an aircraft skin

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Chinese Journal of Aeronautics 2023年第7期36卷 476-488页

作者： Fareed AHMAD Mohammed Al AWADH Sahar noor Industrial Engineering Department University of Engineering and TechnologyPeshawar 25000Pakistan Department of Industrial Engineering College of EngineeringKing Khalid UniversityAbha 62529Saudi Arabia

Weight penalty has been a challenge for design engineers of aerospace ***’s high-efficiency combat aircraft undergoes intense stress and strain during flying missions,which require stronger and stiffer materials to retain structural *** metallic materials have been successfully used for the construction of aircraft structures and components,metals still have a low strength-to-weight *** paper aims to develop an alternate optimised material selection methodology to replace the metallic skin of a medium-sized military *** search for the optimum material will result in reduced aircraft weight which will be benefitted by extra payload on the *** selection methodology is comprised of finding design pressure limits on the aircraft skin,and comparison of properties(strength,elastic modulus,shear modulus,etc.)and performance(safety factor,deflection,and stress)of the existing metallic skin with alternate optimised *** comparison was made under aerodynamic pressure,bending force,and twisting *** Fibre Reinforced Polymer/Epoxy(CFRP)Uni-Directional(UD)prepreg(elastic modolus is 209 GPa)was selected as an alternate optimum material to replace the aluminium alloy skin of the aircraft *** selected alternate optimum material resulted in the reduction of aircraft skin weight by 30%.

关键词： Aircraft skin Carbon Fibre Reinforced Plastic(CFRP) Material index Material selection methodology Optimum material

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