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Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications

Bone Research 2024年第1期12卷 1-19页

作者： Xiwei Fan Antonia Rujia Sun Reuben S.e.Young isaac O.Afara Brett R.Hamilton Louis Jun Ye Ong Ross Crawford indira Prasadam Centre for Biomedical Technologies Queensland University of TechnologyBrisbaneQLDAustralia School of Mechanical Medical&Process EngineeringQueensland University of TechnologyBrisbaneQLDAustralia Central Analytical Research Facility Queensland University of TechnologyBrisbaneQLDAustralia Molecular Horizons University of WollongongWollongongNSWAustralia Department of Technical Physics University of Eastern FinlandKuopioFinland School of electrical engineering and Computer Science Faculty of EngineeringArchitecture and Information TechnologyUniversity of QueenslandBrisbaneQLDAustralia Centre for Microscopy and Microanalysis University of QueenslandBrisbaneQLDAustralia The Prince Charles Hospital BrisbaneQLDAustralia

Osteoarthritis(oa)is a debilitating degenerative disease affecting multiple joint tissues,including cartilage,bone,synovium,and adipose *** presents diverse clinical phenotypes and distinct molecular endotypes,including inflammatory,metabolic,mechanical,genetic,and synovial ***,innovative technologies are needed to support the development of effective diagnostic and precision therapeutic *** analysis of bulk oa tissue extracts has limitations due to technical constraints,causing challenges in the differentiation between various physiological and pathological phenotypes in joint *** issue has led to standardization difficulties and hindered the success of clinical *** insights into the spatial variations of the cellular and molecular structures in oa tissues,encompassing DNA,RNA,metabolites,and proteins,as well as their chemical properties,elemental composition,and mechanical attributes,can contribute to a more comprehensive understanding of the disease *** resolved biology enables biologists to investigate cells within the context of their tissue microenvironment,providing a more holistic view of cellular *** advances in innovative spatial biology techniques now allow intact tissue sections to be examined using various-omics lenses,such as genomics,transcriptomics,proteomics,and metabolomics,with spatial *** fusion of approaches provides researchers with critical insights into the molecular composition and functions of the cells and tissues at precise spatial ***,advanced imaging techniques,including high-resolution microscopy,hyperspectral imaging,and mass spectrometry imaging,enable the visualization and analysis of the spatial distribution of biomolecules,cells,and *** these molecular imaging outputs to conventional tissue histology can facilitate a more comprehensive characterization of disease *** review summarizes the rec

关键词： insight Spatial enable

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Older Adult Compendium of Physical Activities:energy costs of human activities in adults aged 60 and older

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Journal of Sport and Health Science 2024年第1期13卷 13-17,F0003页

作者： erik A.Willis Stephen D.Herrmann Mary Hastert Chelsea L.Kracht Tiago V.Barreira John M.Schuna Jr. Zhenghua Cai Minghui Quan Scott A.Conger Wendy J.Brown Barbara e.Ainsworth Center for Health Promotion and Disease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA Kansas Center for Metabolism and Obesity Research The University of Kansas Medical CenterKansas CityKS 66160USA Division of Physical Activity and Weight Management Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA Clinical Science Division Pennington Biomedical Research CenterBaton RougeLA 70808USA exercise Science Department Syracuse UniversitySyracuseNY 13244USA School of exercise&Sport Science Oregon State UniversityCorvallisOR 97331USA School of exercise and Health Shanghai University of SportShanghai 200438China Department of Kinesiology Boise State UniversityBoiseID 83725USA School of Human Movement and Nutrition Sciences The University of QueenslandSt.LuciaQLD 4072Australia Faculty of Health Sciences and Medicine Bond UniversityGold CoastQLD 4229Australia College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA

Purpose:To describe the development of a Compendium for estimating the energy costs of activities in adults>60 years(oa Compendium).Methods:Physical activities(PAs)and their metabolic equivalent of task(MeT)values were obtained from a systematic search of studies published in 4 sport and exercise databases(PubMed,embase,SPORTDiscus(eBSCOhost),and Scopus)and a review of articles included in the 2011 Adult Compendium that measured PA in older *** values were computed as the oxygen cost(VO_(2),mL/kg/min)during PA divided by 2.7 m L/kg/min(MeT_(60+))to account for the lower resting metabolic rate in older ***:We identified 68 articles and extracted energy expenditure data on 427 *** these,we derived 99 unique Specific Activity codes with corresponding MeT_(60+)values for older *** developed a website to present the oa Compendium MeT_(60+)values:https://***:The oa Compendium uses data collected from adults>60 years for more accurate estimation of the energy cost of PAs in older *** is an accessible resource that will allow researchers,educators,and practitioners to find MeT_(60+)values for older adults for use in PA research and practice.

关键词： energy expenditure exercise MeT Older adults

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营养与新出现的病毒病

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环境卫生学杂志 1997年第6期24卷 46-47页

作者：ＬｅｖａｎｄｅｒＯＡ

传染病正在全世界回升。在讨论营养与传染病时，营养学家往往只考虑营养对宿主的影响。而最近的研究结果却提示，至少对于ＲＮＡ病毒来说，宿主的营养状况可影响这种病原体的遗传物质构成，从而改变其毒力。组织举办“新出现的病毒病：... 详细信息

传染病正在全世界回升。在讨论营养与传染病时，营养学家往往只考虑营养对宿主的影响。而最近的研究结果却提示，至少对于ＲＮＡ病毒来说，宿主的营养状况可影响这种病原体的遗传物质构成，从而改变其毒力。组织举办“新出现的病毒病：营养扮演什么角色”专题研讨会的目的是，提醒营养学界注意这一发现及其对营养－感染关系研究的可能意义。此次研讨会的专题有：病毒病对公共卫生的威胁、病毒ＲＮＡ基因组的迅速进化、氧化剂和抗氧化剂在病毒病中的作用——发病机制与代谢调节、维生素Ｅ缺乏或硒缺乏引起柯萨奇病毒Ｂ３毒力增加。如果有关柯萨奇病毒的研究结果可更广泛地适用于其它ＲＮＡ病毒，那么这些结果则可能具有很大的公共卫生意义，因为大部分动植物病毒和人类病毒都是ＲＮＡ病毒。

关键词：营养不良突变营养与感染病毒进化病毒

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Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

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Bone Research 2024年第1期12卷 199-214页

作者： Laura J.Brylka Assil-Ramin Alimy Miriam e.A.Tschaffon-Müller Shan Jiang Tobias Malte Ballhause Anke Baranowsky Simon von Kroge Julian Delsmann eva Pawlus Kian eghbalian Klaus Püschel Astrid Schoppa Melanie Haffner-Luntzer David J.Beech Frank Timo Beil Michael Amling Johannes Keller Anita ignatius Timur A.Yorgan Tim Rolvien Thorsten Schinke Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany institute of Orthopedic Research and Biomechanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Department Legal Medicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds institute of Cardiovascular and Metabolic Medicine School of MedicineUniversity of LeedsLS29JT LeedsUK

Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell *** we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in *** we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(oa)*** with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only mildly affected in these mice,oa pathologies were markedly less pronounced compared to littermate controls at 60 weeks of ***,when oa was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage ***,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) *** further observed increased Piezo1 protein abundance in cartilaginous zones of human ***,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in ***,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in oa.

关键词： Piezo1 markedly ossification

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Observations of boundary layer parameters and suspended sediment transport over the intertidal flats of northern Jiangsu, China

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Acta Oceanologica Sinica 2004年第3期23卷 437-448页

作者： WANGYaping GAOShu KeXiankun LaboratoryforCoastandislandDevelopmentoftheministryofeducation NanjingUniversityNanjing210097China DepartmentofGeography UniversityofReginaSaskatchewanS4S0A2Canada

A current-turbidity monitoring system (CTMS) was deployed on the intertidal flat at Wanggang, northern Jiangsu during October 16-17, 2000, to measure the tidal current speeds and seawater turbidities at 5 levels above the seabed. Based upon the logarithmic-profile equation, the boundary layer parameters, i.e., u, z0 and C60, were obtained for 247 tidal flow velocity profiles. Around 90% of the profiles were logarithmic according to the critical correlation coefficient. internal consistency analysis shows that these parameters derived by different methods are consistent with each other. in addition, the height of the bedforms observed is close to the seabed roughness lengths calculated from the velocity profiles, indicating that the boundary layer parameters obtained can reveal the conditions at the sediment-water interface on the intertidal flats. Suspended sediment concentrations were obtained from the 5 CTMS turbidity meters using laboratory and in-situ calibrations. The results show that the in-situ calibrated SSCs have a much higher accuracy than the laboratory calibrated ones. Calculation of suspended sediment fluxes on the intertidal flats, with a magnitude of 104 kg/m per spring tidal cycle, indicates that suspended sediment moves towards the northwest, which is reversal to the transport pattern controlled by the southward Northern Jiangsu Coastal Current in the sub-tidal zone and adjacent shallow waters.

关键词： boundary layer parameter grain size sediment transport intertidal flat Jiangsu coast

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基于正交多项式和稳定图的密集模态参数辨识

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振动．测试与诊断 2010年第4期30卷 429-433页

作者：杨毅青刘强 Munoa Jokin 北京航空航天大学机械工程及自动化学院北京100191 国防科技工业高效数控加工技术研究应用中心北京100191 ideko-达诺巴特集团机械工程系西班牙艾奎巴尔20870

由于正交多项式算法在频响函数模态参数拟合时,模态数目和多项式分子阶次较难确定,无法对拟合过程进行干涉。在原有算法的基础上,通过结合稳定图和模态指示函数,确定了频响函数的模态数目和极点(阻尼及固有频率);在已知极点的基础上,由... 详细信息

由于正交多项式算法在频响函数模态参数拟合时,模态数目和多项式分子阶次较难确定,无法对拟合过程进行干涉。在原有算法的基础上,通过结合稳定图和模态指示函数,确定了频响函数的模态数目和极点(阻尼及固有频率);在已知极点的基础上,由线性最小二乘方法对留数进行估计。此外,该方法被扩展到频响函数的整体拟合。通过将该方法应用于模态耦合严重的频响函数模态参数估计,并与原有正交多项式算法及商业化软件M e’scopeVeS进行对比,表明该算法在避免虚假模态或发生模态遗漏现象的同时,拟合结果准确、稳定,抗干扰能力强。

关键词：正交多项式频响函数模态参数辨识稳定图

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Stable Adult Growth but Reduced Asexual Fecundity in Marginopora vertebralis,under Global Climate Change Scenarios

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Journal of earth Science 2022年第6期33卷 1400-1410页

作者： Claire e.Reymond Frances Patel Sven Uthicke School of earth Sciences China University of GeosciencesWuhan430074China School of Geosciences The University of SydneySydneyNSW2006Australia Australian institute of Marine Science Townsville MCQld4810Australia

Large benthic foraminifera are an integral component of shallow-water tropical habitats and like many marine calcifiers,are susceptible to ocean acidification(oa)and ocean warming(OW).in particular,the prolific Symbiodiniaceae-bearing and high-magnesium calcite Marginopora vertebralis has a low threshold compared to several diatom-bearing and low-magnesium calcite *** this multi-year mesocosm experiment,we tested three RPC 8.5 climate change scenarios(i)present day,(ii)the year 2050,and(iii)*** enable a realistic epiphytic association,these experiments were uniquely conducted using natural carbonate substrate,living calcifying alga,and *** contrast to previous studies,we detected no reduction in surface-area growth under future climate conditions compared with present day *** terms of calcification,***’epiphytic association to primary producers(i.e.,calcifying algae and seagrasses)potentially ameliorates the effects of oa by buffering against declines in boundary layer pH during periods of photosynthesis(i.e.,CO_(2)removal).importantly for population maintenance,we observed a strong reduction in asexual fecundity under the 2100 *** propose the additional energy needed to maintain growth might be one reason for drastically reduced asexual *** alternative explanation could be that the 2℃temperature increase interfered with the environmental synchronization that triggered asexual multiple *** conclude that the low levels of reproduction will reduce populations in a high CO_(2)environment and reduce a valuable source of CaCO_(3) sediment production.

关键词： mesocosm experiment ocean acidification ocean warming large benthic foraminifera carbonate production tropical reef asexual reproduction climate change

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Pre-harvest spraying of oxalic acid improves postharvest quality associated with increase in ascorbic acid and regulation of ethanol fermentation in kiwifruit cv. Bruno during storage

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Journal of integrative Agriculture 2019年第11期18卷 2514-2520页

作者： Maratab Ali LiU Meng-meng WANG Zhen-e Li Sheng-e JiANG Tian-jia ZHeNG Xiao-lin College of Food Science and Biotechnology Zhejiang Gongshang University

The kiwifruit trees(Actinidia deliciosa ***)were sprayed with 5 mmol L-1 oxalic acid(oa)or water(as control)at 130,137 or 144 d after full-blossom,and then the fruit were harvested at commercial maturity and stored at room temperature(20±1)℃ for 13 *** effect of pre-harvest spraying of oa on postharvest quality of kiwifruit was evaluated during *** oa spraying slowed the increase in soluble solids content(SSC)and decrease in titratable acid(TA),as well as increased contents of ascorbic acid(AsA)and total-AsA accompanied with higher AsA/DHA ratio in kiwifruit during ***,the oa spraying significantly reduced the contents of acetaldehyde and ethanol in kiwifruit,along with significant decrease in activities of enzymes involved in ethanol fermentation metabolism during the later period of storage,which was beneficial to control off-flavor associated with over accumulation of ethanol during *** was suggested that pre-harvest spraying of oa might maintain the postharvest quality of kiwifruit in relation to delay in fruit ripening,AsA maintenance and regulation of ethanol fermentation.

关键词： ethanol metabolism kiwifruit oxalic acid pre-harvest spraying postharvest quality

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6min步行试验中不同指令对行走距离的影响

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中华高血压杂志 2014年第2期22卷 108-108页

作者：刘莉叶鹏 Weir NA Brown AW Shlobin oa Smith MA Reffett T Battle e Ahmad S Nathan SD

6min步行试验（6-minwalktest，6MWT）作为测定心肺功能的一种方法，一直以使患者走的尽可能远为目标，然而，特定的步行指令对患者6MWT测定的影响尚不清楚。方法：纳入肺动脉高压（pulmonaryarterialhypertension，PAH）、特发性肺间... 详细信息

6min步行试验（6-minwalktest，6MWT）作为测定心肺功能的一种方法，一直以使患者走的尽可能远为目标，然而，特定的步行指令对患者6MWT测定的影响尚不清楚。方法：纳入肺动脉高压（pulmonaryarterialhypertension，PAH）、特发性肺间质纤维化（idiopathicpulmonaryfibrosis，iPF）和其他类型的间质性肺疾病（interstitiallungdisease，iLD）患者，

关键词： 6min步行试验行走距离特发性肺间质纤维化间质性肺疾病肺动脉高压心肺功能患者测定

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石油和天然气污染环境下的高血压发病情况:一项横断面比较研究

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中华高血压杂志 2016年第12期24卷 1198-1198页

作者： ezejimofor MC Uthman oa Maduka O ezeabasili AC Onwuchekwa AC ezejimofor BC Asuquo e Chen YF Stranges S Kandala NB 陈云叶鹏

有关交通空气污染和血压升高之间存在正相关的研究报道已有很多。然而,发生高血压的风险与长期原油污染和天然气燃烧暴露的关系仍未被探索。方法：本横断面调查入选居住在尼日利亚的尼日尔三角洲地区的油气污染社区和无污染社区的2028... 详细信息

有关交通空气污染和血压升高之间存在正相关的研究报道已有很多。然而,发生高血压的风险与长期原油污染和天然气燃烧暴露的关系仍未被探索。方法：本横断面调查入选居住在尼日利亚的尼日尔三角洲地区的油气污染社区和无污染社区的2028名居民（年龄18~80岁）。对2组人群高血压的发生风险和患病率、人体测量指标、生活方式和社会人口学因素、心血管合并症进行检查和比较。

关键词：横断面调查污染环境高血压天然气发病情况社会人口学因素石油人体测量指标

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