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The Effect of Atrial Septal Defect Closure on Cardiac Volumetric Changes in Adults, Transcatheter Versus Surgical Closure, a Pilot Cardiac magnetic Resonance Study

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Congenital Heart Disease 2023年第6期18卷 679-691页

作者： Amr mansour noha m.gamal Alaa m.Nady Amr Ibraheem Dalia m.Salah Khaled m.El-maghraby Cardiology Department Congenital and Structural Heart Disease UnitAin Shams University HospitalsFaculty of MedicineAin Shams UniversityCairoEgypt Cardiology Department Faculty of MedicineAssuit UniversityAssuitEgypt Cardiothoracic Surgery Department Faculty of MedicineAssuit UniversityAssuitEgypt Anesthesia Department Faculty of MedicineAssuit UniversityAssuitEgypt

Background:Closure of an atrial septal defect(ASD)reduces right-side heart volumes by abolishing shunting with simultaneous improvement of the left ventricle(LV)ﬁlling and functions due to ventricular interdependence,thereby improving ***,studies conducted on atrial volume changes after ASD closure are *** magnetic resonance(CmR)is considered as the gold standard method for measuring cardiac volume and ***:We aimed to study the effect of transcatheter and surgical closure of secundum ASD on cardiac volumes and systolic functions as well as the fate of tricuspid regurgitation(TR),using CmR ***:We prospectively enrolled 30 adult patients with isolated secundum ASD who were referred to ASD *** evaluation of cardiac chambers indexed volumes,systolic function,myocardial mass index,and tricuspid regurgitant fraction were done at before and 6 months after ***:RV volumes decreased in both groups when compared to baseline(p-value 0.001),the device group had more reduction in volumes and more improvement in RV function after closure(p-value 0.001)when compared to the surgical *** changes in the RV mass index were insigniﬁcant between both groups(p-value 0.31).Functional TR improved to the same extent in both *** ventricular end diastolic volume index(LVEDVI)and LV mass index increased sig-niﬁcantly in both groups when compared to baseline in both groups but with no difference between groups p-value 0.01),left ventricular end systolic volume index(LVESVI)changes were insigniﬁ*** systolic function improved in patients who underwent device closure only(63.53±3.85 vs.67.13±4.34,p-value 0.01).There was a signiﬁcant reduction in right atrial(RA)volumes and an insigniﬁcant decrease in left atrial(LA)volumes,with no difference between ***:Transcatheter and surgical secundum ASD closure resulted in volumetric changes in some cardiac chambers with better improvement in bi-ventricular

关键词： Atrial septal defect closure cardiac volumetric changes functional tricuspid regurgitation cardiac CmR

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A statistical approach to enhance the productivity of Streptomyces baarensis mH-133 for bioactive compounds

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Synthetic and Systems Biotechnology 2024年第2期9卷 196-208页

作者： mohamed H.Kalaba gamal m.El-Sherbiny Osama m.Darwesh Saad A.moghannem Botany and microbiology Department Faculty of Science(Boys)Al-Azhar UniversityCairo 11884Egypt Agricultural microbiology Department National Research CentreDokkiCairoEgypt

The goal of this study was to use statistical optimization to change the nutritional and environmental conditions so that Streptomyces baarensis mH-133 could make more active *** trials were used to screen for critical variables influencing productivity using the Placket-Burman Design *** mH-133 is significantly influenced by elicitation,yeast extract,inoculum size,and incubation period in terms of antibacterial activity.A total of 27 experimental trials with various combinations of these factors were used to carry out the response surface technique using the Box-Behnken *** analyses revealed that the model was highly significant(pmination(R2)of ***,the model predicted that the response as inhibition zone diameter would reach a value of 27 *** optimal conditions,*** mH-133 produced 18.0 g of crude extract to each 35L and was purified with column *** active fraction exhibiting antibacterial activity was characterized using spectroscopic *** mIC and mBC values varied between 37.5 and 300μg/ml and 75 and 300μg/ml,*** conclusion,the biostatistical optimization of the active fraction critical variables,including environmental and nutritional conditions,enhances the production of bioactive molecules by Streptomyces species.

关键词： S.baarensis mH-133 Placket-Burman designBox-Behnken design ESKAPE Antibacterial activity

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Effect of nutrition-related infodemics and social media on maternal experience: A nationwide survey in a low/middle income country

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World Journal of Clinical Pediatrics 2024年第1期13卷 93-106页

作者： marwa m Zein noha Arafa mortada H F El-Shabrawi Nehal mohammed El-Koofy Department of Public Health and Community medicine Cairo UniversityCairo 515211Egypt Department of Pediatric Endocrinology and Diabetes Children's HospitalKasralainy Medical SchoolCairo UniversityCairo 515211Egypt Department of Pediatrics Cairo UniversityCairo 12411Egypt Department of Pediatrics The Children's HospitalCairo UniversityCairo 12411Egypt

BACKGROUND Undernutrition is a crucial cause of morbidity and mortality among children in low-or middle-income countries(LmICs).A better understanding of maternal general healthy nutrition knowledge,as well as misbeliefs,is highly essential,especially in such *** the current era of infodemics,it is very strenuous for mothers to select not only the right source for maternal nutrition information but the correct information as *** To assess maternal healthy nutritional knowledge and nutrition-related misbeliefs and misinformation in an LmIC,and to determine the sources of such information and their assessment *** This cross-sectional analytical observational study enrolled 5148 randomly selected Egyptian mothers who had one or more children less than 15 years *** data were collected through online questionnaire forms:One was for the general nutrition knowledge assessment,and the other was for the nutritional myth *** of information and ways of evaluating internet sources using the Currency,Relevance,Authority,Accuracy,and Purpose test were additionally *** The mean general nutrition knowledge score was 29±9,with a percent score of 70.8%±12.1%(total score:41).The median myth score was 9(interquartile range:6,12;total score:18).The primary sources of nutrition knowledge for the enrolled mothers were social media platforms(55%).Half of the mothers managed information for currency and authority,except for considering the author's contact *** than 60%regularly checked information for accuracy and *** mothers with significant nutrition knowledge checked periodically for the author's contact information(P=0.012).The nutrition myth score was significantly lower among mothers who periodically checked the evidence of the information(P=0.016).mothers dependent on their healthcare providers as the primary source of their general nutritional knowledge were less likely to hold myths by 13%(P=0.044).However,usi

关键词： Nutrition Infodemics maternal knowledge myth Low/middle income country

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Ultralong hydroxyapatite-based forward osmosis membrane for freshwater generation

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 37-49页

作者： mohamed gamal Gomaa Hamdy maamoun Abdel-Ghafar Francesco Galiano Francesca Russo Alberto Figoli El-Sayed Ali Abdel-Aal Abdel-Hakim Taha Kandil Bahaa Ahmed Salah Central metallurgical Research and Development Institute(CmRDI) 11421 CairoEgypt Chemistry Department Faculty of ScienceHelwan University11795 CairoEgypt Institute on membrane Technology(CNR-ITm) 87036 RendeItaly

Increasing global water shortages are accelerating the pace of membrane manufacturing,which generates many environmentally harmful *** challenges need a radical rethink of developing innovative membranes that can address freshwater production without generating environmentally harmful *** work utilized the synthesized ultra-long hydroxyapatite(UHA)by the solvothermal method using the green solvent oleic acid in preparing UHA-based forward osmosis *** membranes were developed using different loading ratios of graphene oxide(GO)by vacuum-assisted filtration *** prepared GO/UHA membranes were identified using X-ray diffraction,scanning electron microscope,Fourier-transform infrared spectroscopy,and X-ray photoelectron *** contact angle and pore size distribution were determined for the obtained GO/UHA *** obtained hierarchical porous structure in the prepared membranes with interconnected channels results in a stable water flux with reverse salt *** best water flux rate of 42±2 L·m^(–2)·h^(–1)was achieved using the 50 mg GO/UHA membrane,which is 3.3 times higher than the pristine membrane,and a reverse salt flux of 67 g·m^(-2)·h^(–1).The obtained results showed a promising capability of a new generation of sustainable inorganic-based membranes that can be utilized in freshwater generation by energy-efficient techniques such as forward osmosis.

关键词： forward osmosis ultra-long hydroxyapatite graphene oxide inorganic-based membrane

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Ensemble machine Learning to Enhance Q8 Protein Secondary Structure Prediction

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Computers, materials & Continua 2022年第11期73卷 3951-3967页

作者： moheb R.Girgis Rofida m.gamal Enas Elgeldawi Computer Science Department Faculty of ScienceMinia University61519MiniaEgypt

Protein structure prediction is one of the most essential objectives practiced by theoretical chemistry and bioinformatics as it is of a vital importance in medicine,biotechnology and *** secondary structure prediction(PSSP)has a significant role in the prediction of protein tertiary structure,as it bridges the gap between the protein primary sequences and tertiary structure *** secondary structures are classified into two categories:3-state category and 8-state *** the 3 states and the 8 states of secondary structures from protein sequences are called the Q3 prediction and the Q8 prediction problems,*** 8 classes of secondary structures reveal more precise structural information for a variety of applications than the 3 classes of secondary structures,however,Q8 prediction has been found to be very challenging,that is why all previous work done in PSSP have focused on Q3 *** this paper,we develop an ensemble machine Learning(mL)approach for Q8 PSSP to explore the performance of ensemble learning algorithms compared to that of individual mL algorithms in Q8 *** ensemble members considered for constructing the ensemble models are well known classifiers,namely SVm(Support Vector machines),KNN(K-Nearest Neighbor),DT(Decision Tree),RF(Random Forest),and NB(Naïve Bayes),with two feature extraction techniques,namely LDA(Linear Discriminate Analysis)and PCA(Principal Component Analysis).Experiments have been conducted for evaluating the performance of single models and ensemble models,with PCA and LDA,in Q8 *** novelty of this paper lies in the introduction of ensemble learning in Q8 PSSP *** experimental results confirmed that ensemble mL models are more accurate than individual mL *** also indicated that features extracted by LDA are more effective than those extracted by PCA.

关键词： Protein secondary structure prediction(PSSP) Q3 prediction Q8 prediction ensemble machine leaning boosting bagging

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Protectivity of Freeze Dried Inactivated Rift Valley Fever Vaccine

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Open Journal of Veterinary medicine 2024年第2期14卷 21-37页

作者： Diana m. Abulmagd mohamed Hassan Atwa noha Ezz Aldin marwa Yehia Hammad Taradi Abdel Fattah Said Rift Valley Fever Vaccine Research Department Veterinary Serum and Vaccine Research Institute Agriculture Research Center (ARC) Cairo Egypt

Background: Vaccinations for animals are crucial for food production, animal welfare, public health, and animal health. They are an affordable way to stop animal sickness, increase food production efficiency, and lessen or stop the spread of zoonotic diseases to humans. Animal vaccines that are both safe and efficacious are vital to modern culture. The vaccine should induce a strong, protective and prolonged immune response against the antigenic factor. In order to achieve these goals, novel vaccination techniques and an efficient adjuvant are required to render the vaccine immunogenically protective and trigger a strong immune response. Aim: Our study aims to promote and enhance the immunogenicity against RVF virus disease through lyophilized inactivated RVF vaccine through induction of early cellular, high and prolonged humeral immunity in vaccinated animals using cabopol as stabilizer and Saponin or normal saline as a diluent at time of vaccination. moreover, manufacturing of these vaccines is easy to be done. Results: The gained results revealed that RVF freeze-dried vaccine with Carbopol that reconstituted using Saponin elicited better immune response than that reconstituted using normal saline (NaCl). The cell mediated immune response as represented by lymphocyte blastogenesis and phagocytic activity were markedly increased with high levels when we used Saponin as a diluent than that in group vaccinated with vaccine diluted with NaCl, on the other side the humeral immune response in group vaccinated using the Saponin as diluent is more detected and stayed within the protective level till the end of 11th month post vaccination (1.5 TCID50) while the immune response induced after using normal saline as a diluent stayed within the protective level till the end of 10th month post vaccination (1.8 TCID50). Conclusion: The use of Saponin as a diluent for reconstitution of the freeze dried RVF vaccine is preferable than the

关键词： Rift Valley Fever Saponin Cabopol Binary Ethylenemine Serum Neutralization Test

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Circulating Levels of Hypoxia-regulating microRNAs in Systemic Lupus Erythematosus Patients with Hemolytic Anemia

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Current medical Science 2022年第6期42卷 1231-1239页

作者： Amira m.gamal-Eldeen Cinderella A.Fahmy Bassem m.Raafat Fayez Althobaiti Iman H.Bassyouni Roba m.Talaat Clinical Laboratory Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia High Altitude Research Center Prince Sultan Medical ComplexAl-HawiyahTaif UniversityTaif21944Saudi Arabia Cancer Biology and Genetics Laboratory Centre of Excellence for Advanced SciencesNational Research CentreCairo12622Egypt Biochemistry Department National Research CentreCairo12622Egypt Radiological Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia Biotechnology Department Faculty of ScienceTaif UniversityTaif21944Saudi Arabia Department of Rheumatology and Rehabilitation Faculty of MedicineCairo UniversityEl-Kasr El-Aini HospitalCairo12613Egypt molecular Biology Department Genetic Engineering and Biotechnology Research Institute(GEBRI)Sadat City UniversitySadat City32897Egypt

Objective microRNAs are fine regulators for gene expression during the post-transcriptional stage in many autoimmune ***(miR-210 and miR-21)play an important role in hypoxia and in inflammation-associated *** lupus erythematosus(SLE)is a chronic systemic autoimmune disease that would potentiate many pathological complications,including hemolytic *** study aimed to investigate the role of hypoxamiRs in SLE/hemolytic anemia *** This work was designed to analyze the circulating levels of↱the miR-210 and miR-21 expressions and hypoxia-inducible factor-1α(HIF-α)in SLE/hemolytic anemia *** activity was evaluated for all patients by SLE Disease Activity Index(SLEDAI).Clinical manifestations/complications and serological/hematological investigations were ***-αconcentration was assayed by ELISA and expression of miR-21 and miR-210 was analyzed by *** The results indicated that the fold change of the miR-210/miR-21 expressions in plasma was significantly elevated in SLE/hemolytic anemia patients.A strong positive correlation between the miR-210 and miR-21 expression levels was also *** the associated-disease complications,hypertension,arthritis,oral ulcers,and serositis were associated with a high circulating miR-210 expression,while the occurrence of renal disorders was associated with the increased miR-21 ***,the HIF-αlevel was remarkably elevated in SLE/hemolytic anemia patients.A high positive correlation was recorded between the HIF-αconcentration and miR-210/miR-21 expression *** occurrence of oral ulcers,arthritis,and hypertension was associated with the increased HIF-α*** the other hand,SLEDAI and white blood cell count were positively correlated with miR-21/*** erythrocyte sedimentation rate was positively correlated with *** The dysregulation of the circulating miR-210/miR-210/HIF-1αlevels in SLE/hemolytic anemia pat

关键词： circulating hypoxamiRs miR-210 and miR-21 hypoxia-inducing factor-1α hemolytic anemia systemic lupus erythematosus

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Biochemical Liver Functions and molecular Identification of Fasciola hepatica from Experimentally Infected Rat model

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Open Journal of Animal Sciences 2024年第2期14卷 88-100页

作者： Omnia m. Kandil Emad B. Ata margarita P. Gabrashanska Hatem A. Shalaby Tamer H. Abd El-Aziz noha m. F. Hassan Soad m. Nasr mohamed A. Helal Ebtesam m. Al-Olayan Department of Parasitology & Animal Diseases Veterinary Research Institute National Research Centre Giza Egypt Institute of Experimental morphology Pathology and Anthropology with Museum Bulgarian Academy of Sciences Sofia Bulgaria Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The current study was performed to evaluate the liver function status as well as molecular characterization of the recovered worms in rats experimentally infected with F. hepatica. Sixteen male Wister rats aged 30 days were randomly allocated into two groups (n = 8). The first group was infected orally with 15 viable encysted metacercaria of F. hepatica per animal. The other group was kept non-infected (control group). At zero time (before infection), the 2nd, 4th, 6th, 8th, 10th, 12th and 14th weeks post-infection (WPI), blood and serum samples were collected via puncture of retro-orbital plexus of veins from each rat. Serum enzyme level (AST and ALT) and total protein were measured, and the serum protein profile was carried out using agarose gel electrophoresis. During the period of the experiment, serum ALT and AST activities and serum total globulins significantly increased while serum total proteins and albumin markedly decreased in the infected group. On the 14th WPI, the data of the electropherogram showed that globulin fractions (α1-, β- and γ-globulin) levels were significantly increased while α2-globulin was markedly decreased in the infected group. The molecular analysis confirmed the amplification of the ITS1, ITS2 and NDI genes of F. hepatica recovered from the infected liver of rats with amplicon sizes of 630, 510 and 560 bp, respectively. Sequencing of the amplified ITS gene resulted in the determination of 3 strains (PP108836, PP108837, and PP108838). Also, analysis of the ITS2 gene resulted in obtaining 3 isolates under the accession numbers (PP109065, PP109066, and PP109067). In conclusion, fasciolosis in the rat model is suitable for routine experimental infections and caused a pronounced liver dysfunction with discharging of the Fasciola eggs in the faeces and the development of adult stages in the bile ducts. Furthermore, molecular techniques are a sensitive

关键词： Fasciola hepatica Liver Functions Serum Enzymes Serum Protein Electrophoresis molecular Characterization

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Prevelance of Bovine Cysticercosis in Egypt and the Cysticidal Effect of Two Extracts Obtained from Balanites aegyptiaca and moringa oleifera on mice model Affected with T. saginata Cysticerci

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Open Journal of Animal Sciences 2024年第2期14卷 39-55页

作者： Omnia m. Kandil noha m. F. Hassan Doaa Sedky Hatem A. Shalaby Heba m. Ashry Nadia m. T. Abu El Ezz Sahar m. Kandeel mohamed S. Abdelfattah L. Ying Ebtesam m. Al-Olayan Parasitology and Animal Diseases Department Veterinary Research Institute National Research Centre Dokki Cairo Egypt Chemistry of Natural Compounds Department Pharmaceutical and Drugs Industries Research Institute National Research Centre Dokki Cairo Egypt Chemistry Department Faculty of Science Helwan University Cairo Egypt State Key Laboratory of Plateau Ecology and Agriculture Qinghai University Xining China College of Agriculture and Animal Husbandry Qinghai University Xining China Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The aim of the present study was to determine the prevalence of bovine cysticercosis in both cattle and buffloas, in Egypt and to assess the cysticidal efficacy of Balanites aegyptiaca fruits (B. aegyptiaca) and moringa oleifera seeds (m. oleifera) extracts in experimentally infected mice. The study detected the level of tumor necrosis factor (TNF-α) to monitor the immune and inflammatory responses of experimentally infected mice. Through meat inspection, a total number of 2125 male bovine, 2 to 5 years old, (1125 cattle and 1000 buffloes) were examined under the authority of Albsatine and Alwaraq official abattoirs in Cairo Governorate, Egypt covering the period extended from march 2022 to April 2023. The overall prevalence of the disease among bovine was 7.8% (6.31% of cattle and 9.5% of buffloes). Besides, B. aegyptiaca and m. oleifera extracts showed cysticidal activity in experimentally infected mice. A decrease in the numbers of cysticerci was found in all treated mice groups, and up to 88% reduction was achieved in the B. aegyptiaca-treated group;higher than that was recorded in both m. oleifera (72.23%) and albendazole-treated ones (80.56%). Postmortem findings proved that m. oleifera and B. aegyptiaca reduced cysticerci numbers comparable to a commercial anthelmintic. The study showed a significant decrease (P 0.001) in TNF-α levels after treatment with Balanites and moringa extracts, compared with the untreated control and the albendazole-treated groups.

关键词： Prevalence Balanites aegyptiaca moringa oleifera mice T. saginata Cysticerci

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Double compound combination synchronization among eight n-dimensional chaotic systems

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Chinese Physics B 2018年第8期27卷 150-158页

作者： gamal m mahmoud Tarek m Abed-Elhameed Ahmed A Farghaly Department of mathematics Faculty of Science Assiut University

Depending on double compound synchronization and compound combination synchronization, a new kind of syn- chronization is introduced which is the double compound combination synchronization （DCCS） of eight n-dimensional chaotic systems. This kind may be considered as a generalization of many types of synchronization. In the communica- tion, based on many of drive and response systems, the transmitted and received signals will be more secure. Using the Lyapunov stability theory and nonlinear feedback control, analytical formulas of control functions are obtained to insure our results. The corresponding analytical expression and numerical treatment are used to show the validity and feasibility of our proposed synchronization scheme. The eight memristor-based Chua oscillators are considered as an example. Other examples can be similarly investigated. The proposed synchronization technique is supported using the mATLAB simula- tion outcomes. We obtain the same results of numerical treatment of our synchronization using simulation observations of our example.

关键词： double compound synchronization compound combination synchronization chaotic system Lya-punov stability

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