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SOX9 in biliary atresia: New insight for fibrosis progression

Hepatobiliary & Pancreatic Diseases International 2021年第2期20卷 154-162页

作者： Hanaa Ahmed El-Araby Magdy Anwar Saber noha mohamed radwan Doha Maher Taie Nermin mohamed Adawy Ahmad mohamed Sira Department of Pediatric Hepatology Gastroenterologyand NutritionNational Liver InstituteMenoufia University32511 Shebin El-koomMenoufiaEgypt Department of Pathology National Liver InstituteMenoufia University32511 Shebin El-koomMenoufiaEgypt

Background:Liver fibrosis is a hallmark determinant of morbidity in biliary atresia(BA)even in successfully operated *** factors for this rapid progression of fibrosis are not completely *** expression of the transcription factor SOX9 and hepatic progenitor cells(HPCs)proliferation have roles in fibrogenesis in cholestatic ***,they were not investigated sufficiently in *** aimed to delineate the relation of SOX9 and HPCs to fibrosis and its progression in ***:Forty-eight patients with BA who underwent an initial diagnostic liver biopsy(LB)and consequent intraoperative LB were recruited and compared to 28 cases with non-BA cholestasis that had an LB in their diagnostic *** fibrosis,tissue SOX9 and HPC expressions were studied in both BA and non-BA-cholestasis *** fibrosis,SOX9,and HPCs’dynamic changes in BA cases were *** of fibrosis and its progression to SOX9 and HPCs in BA was ***:SOX9 and HPCs in ductular reaction(DR)form were expressed in 100%of BA and their grades increased significantly in the second *** rapidly progressive fibrosis in BA,represented by fibrosis grade of the intraoperative LB,correlated significantly to SOX9-DR and HPC-DR at the diagnostic(r=0.420,P=0.003 and r=0.405,P=0.004,respectively)and the intraoperative(r=0.460,P=0.001 and r=0.467,P=0.001,respectively)*** the other hand,fibrosis,SOX9-DR,and HPC-DR were significantly lower in non-BA cases at a comparable age(P<0.001,P=0.006,and P=0.014,respectively).Conclusions:Fibrosis in BA is rapidly progressive within a short time and is significantly correlated to SOX9 and *** of targeting SOX9 and HPCs on fibrosis progression is warranted.

关键词： Biliary atresia Fibrosis Hepatic progenitor cells Immunohistochemistry Neonatal cholestasis SOX9

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Advances in clinical applications of bioceramics in the new regenerative medicine era

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World Journal of Clinical Cases 2024年第11期12卷 1863-1869页

作者： noha Elshazly Fayza Eid Nasr Ayat Hamdy Safa Saied mohamed Elshazly Tissue Engineering Laboratory Faculty of DentistryAlexandria UniversityAlexandria 21526Egypt Department of Biochemistry Faculty of ScienceAlexandria UniversityAlexandria 21526Egypt Public Dental Clinic Central Administration of DentistryMinistry of Health and PopulationAlexandria 21554Egypt Department of Surgery Faculty of Veterinary MedicineAlexandria 21526Egypt

In this editorial,we comment on the hard and soft tissue applications of different ceramic-based scaffolds prepared by different mechanisms such as 3D printing,sol-gel,and *** new concept of regenerative medicine relies on biomaterials that can trigger in situ tissue regeneration and stem cell recruitment at the defect site.A large percentage of these biomaterials is ceramic-based as they provide the essential requirements of biomaterial principles such as tailored multisize porosity,antibacterial properties,and angiogenic *** these previously mentioned properties put bioceramics on top of the hierarchy of biomaterials utilized to stimulate tissue regeneration in soft and hard tissue *** clinical applications registered the use of these materials in triggering soft tissue regeneration in healthy and diabetic patients such as bioactive glass *** results were promising and opened new frontiers for utilizing these materials on a larger *** same results were mentioned when using different forms and formulas of bioceramics in hard defect *** bioceramics were used in combination with other polymers and biological scaffolds to improve their regenerative and mechanical *** this progress will enable a larger scale of patients to receive such services with ease and decrease the financial burden on the government.

关键词： Regenerative medicine Bioceramics Chronic wounds Bone defects Clinical applications

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Protectivity of Freeze Dried Inactivated Rift Valley Fever Vaccine

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Open Journal of Veterinary Medicine 2024年第2期14卷 21-37页

作者： Diana M. Abulmagd mohamed Hassan Atwa noha Ezz Aldin Marwa Yehia Hammad Taradi Abdel Fattah Said Rift Valley Fever Vaccine Research Department Veterinary Serum and Vaccine Research Institute Agriculture Research Center (ARC) Cairo Egypt

Background: Vaccinations for animals are crucial for food production, animal welfare, public health, and animal health. They are an affordable way to stop animal sickness, increase food production efficiency, and lessen or stop the spread of zoonotic diseases to humans. Animal vaccines that are both safe and efficacious are vital to modern culture. The vaccine should induce a strong, protective and prolonged immune response against the antigenic factor. In order to achieve these goals, novel vaccination techniques and an efficient adjuvant are required to render the vaccine immunogenically protective and trigger a strong immune response. Aim: Our study aims to promote and enhance the immunogenicity against RVF virus disease through lyophilized inactivated RVF vaccine through induction of early cellular, high and prolonged humeral immunity in vaccinated animals using cabopol as stabilizer and Saponin or normal saline as a diluent at time of vaccination. Moreover, manufacturing of these vaccines is easy to be done. Results: The gained results revealed that RVF freeze-dried vaccine with Carbopol that reconstituted using Saponin elicited better immune response than that reconstituted using normal saline (NaCl). The cell mediated immune response as represented by lymphocyte blastogenesis and phagocytic activity were markedly increased with high levels when we used Saponin as a diluent than that in group vaccinated with vaccine diluted with NaCl, on the other side the humeral immune response in group vaccinated using the Saponin as diluent is more detected and stayed within the protective level till the end of 11th month post vaccination (1.5 TCID50) while the immune response induced after using normal saline as a diluent stayed within the protective level till the end of 10th month post vaccination (1.8 TCID50). Conclusion: The use of Saponin as a diluent for reconstitution of the freeze dried RVF vaccine is preferable than the

关键词： Rift Valley Fever Saponin Cabopol Binary Ethylenemine Serum Neutralization Test

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Biochemical Liver Functions and Molecular Identification of Fasciola hepatica from Experimentally Infected Rat Model

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Open Journal of Animal Sciences 2024年第2期14卷 88-100页

作者： Omnia M. Kandil Emad B. Ata Margarita P. Gabrashanska Hatem A. Shalaby Tamer H. Abd El-Aziz noha M. F. Hassan Soad M. Nasr mohamed A. Helal Ebtesam M. Al-Olayan Department of Parasitology & Animal Diseases Veterinary Research Institute National Research Centre Giza Egypt Institute of Experimental Morphology Pathology and Anthropology with Museum Bulgarian Academy of Sciences Sofia Bulgaria Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The current study was performed to evaluate the liver function status as well as molecular characterization of the recovered worms in rats experimentally infected with F. hepatica. Sixteen male Wister rats aged 30 days were randomly allocated into two groups (n = 8). The first group was infected orally with 15 viable encysted metacercaria of F. hepatica per animal. The other group was kept non-infected (control group). At zero time (before infection), the 2nd, 4th, 6th, 8th, 10th, 12th and 14th weeks post-infection (WPI), blood and serum samples were collected via puncture of retro-orbital plexus of veins from each rat. Serum enzyme level (AST and ALT) and total protein were measured, and the serum protein profile was carried out using agarose gel electrophoresis. During the period of the experiment, serum ALT and AST activities and serum total globulins significantly increased while serum total proteins and albumin markedly decreased in the infected group. On the 14th WPI, the data of the electropherogram showed that globulin fractions (α1-, β- and γ-globulin) levels were significantly increased while α2-globulin was markedly decreased in the infected group. The molecular analysis confirmed the amplification of the ITS1, ITS2 and NDI genes of F. hepatica recovered from the infected liver of rats with amplicon sizes of 630, 510 and 560 bp, respectively. Sequencing of the amplified ITS gene resulted in the determination of 3 strains (PP108836, PP108837, and PP108838). Also, analysis of the ITS2 gene resulted in obtaining 3 isolates under the accession numbers (PP109065, PP109066, and PP109067). In conclusion, fasciolosis in the rat model is suitable for routine experimental infections and caused a pronounced liver dysfunction with discharging of the Fasciola eggs in the faeces and the development of adult stages in the bile ducts. Furthermore, molecular techniques are a sensitive

关键词： Fasciola hepatica Liver Functions Serum Enzymes Serum Protein Electrophoresis Molecular Characterization

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Prevelance of Bovine Cysticercosis in Egypt and the Cysticidal Effect of Two Extracts Obtained from Balanites aegyptiaca and Moringa oleifera on Mice Model Affected with T. saginata Cysticerci

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Open Journal of Animal Sciences 2024年第2期14卷 39-55页

作者： Omnia M. Kandil noha M. F. Hassan Doaa Sedky Hatem A. Shalaby Heba M. Ashry Nadia M. T. Abu El Ezz Sahar M. Kandeel mohamed S. Abdelfattah L. Ying Ebtesam M. Al-Olayan Parasitology and Animal Diseases Department Veterinary Research Institute National Research Centre Dokki Cairo Egypt Chemistry of Natural Compounds Department Pharmaceutical and Drugs Industries Research Institute National Research Centre Dokki Cairo Egypt Chemistry Department Faculty of Science Helwan University Cairo Egypt State Key Laboratory of Plateau Ecology and Agriculture Qinghai University Xining China College of Agriculture and Animal Husbandry Qinghai University Xining China Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The aim of the present study was to determine the prevalence of bovine cysticercosis in both cattle and buffloas, in Egypt and to assess the cysticidal efficacy of Balanites aegyptiaca fruits (B. aegyptiaca) and Moringa oleifera seeds (M. oleifera) extracts in experimentally infected mice. The study detected the level of tumor necrosis factor (TNF-α) to monitor the immune and inflammatory responses of experimentally infected mice. Through meat inspection, a total number of 2125 male bovine, 2 to 5 years old, (1125 cattle and 1000 buffloes) were examined under the authority of Albsatine and Alwaraq official abattoirs in Cairo Governorate, Egypt covering the period extended from March 2022 to April 2023. The overall prevalence of the disease among bovine was 7.8% (6.31% of cattle and 9.5% of buffloes). Besides, B. aegyptiaca and M. oleifera extracts showed cysticidal activity in experimentally infected mice. A decrease in the numbers of cysticerci was found in all treated mice groups, and up to 88% reduction was achieved in the B. aegyptiaca-treated group;higher than that was recorded in both M. oleifera (72.23%) and albendazole-treated ones (80.56%). Postmortem findings proved that M. oleifera and B. aegyptiaca reduced cysticerci numbers comparable to a commercial anthelmintic. The study showed a significant decrease (P 0.001) in TNF-α levels after treatment with Balanites and Moringa extracts, compared with the untreated control and the albendazole-treated groups.

关键词： Prevalence Balanites aegyptiaca Moringa oleifera Mice T. saginata Cysticerci

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Free radical scavenging activity of three different flowers-Hibiscus rosa-sinensis,Quisqualis indica and Senna surattensis

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Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 771-777页

作者： Abd El-Moneim mohamed radwan Afify Hazem mohamed Mahmoud Hassan Biochemistry Department Faculty of AgricultureCairo University

Objective:To evaluate three flowers of Hibiscus rosa-sinensis(***-sinensis),Quisqualis indica(***) and Senna surattensis(***) for their antioxidant activity by different methods in addition to total phenolic,flavonoid and pigment ***:Antioxidant activity of water,ethanol and absolute ethanol extracts of three flowers; ***-sinensis,*** and *** was *** antioxidant activity was assessed by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging activity,ferrous chelating activity,reducing power,nitric oxide scavenging activity,hydroxyl radical scavenging activity as well as total antioxidant *** flavonoids,total phenols and total pigments including chlorophylls and carotenoids were measured for the three ***:The results showed that the highest total antioxidant capacity at concentration of 500 mg/L was found in *** as 0.479 ± *** activity of ***,*** and *** flower extracts against 1,1-diphenyl-2-picrylhydrazyl radical showed the highest activity of(90.20 ± 0.29)% with 500 mg/*** screening of the three flowers extracts were carried out for alkaloids,flavonoids,saponins,tannins,steroids,glycosides,terpenoids,amino acid and ***-sinensis showed the total phenolic in water extract of(235.77 ± 14.31) mg/100 g,the other two flowers *** and *** had the total phenolic in ethanol extracts of(937.70 ± 25.06) and(850.30 ± 13.81) mg/100 g,*** the other hand total flavonoids were identified in absolute ethanol extracts in the three flowers[(32.83 ± 1.34),(49.24 ± 4.87) and(2.79 ± 0.23) mg/100 g,respectively].Conclusions:The extracts in the constituents of the three flowers could be used as additives as supplement fractions in foods.

关键词： Free radical Antioxidant Hibiscus rosa-sinensis Quisqualis indica Senna surattensis

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Induction of sub-G0 arrest and apoptosis by seed extract of Moringa peregrina（Forssk.） Fiori in cervical and prostate cancer cell lines

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Journal of Integrative Medicine 2019年第6期17卷 410-422页

作者： Maged mohamed Maher Abou-Hashem Dina mohamed Abo-elmatty noha Mostafa Mesbah Ahmed mohamed Abd EL-Mawgoud Faculty of Pharmacy Pharmacognosy DepartmentZagazig UniversityZagazig 44511Egypt Faculty of Pharmacy Biochemistry DepartmentSuez Canal UniversityIsmailia 41522Egypt Egyptian International Pharmaceuticals Industries Company Tenth of Ramadan City 44629Egypt

Objective: This study investigated cytotoxicity and induction of apoptosis in human cervical cancer cells(HELA) and prostate cancer cells(PC-3) using the most active fraction of Moringa peregrina seed ***: Dried and powdered seeds were extracted using 95% ethanol. The total ethanolic extract was further dissolved in distilled water and separated into petroleum ether, chloroform, ethyl acetate and aqueous extracts. Based on the results of in vitro anticancer studies of all extracts, the most highly active extract was selected for evaluation of apoptosis induction and cell cycle analysis on HELA and PC-3 cells at its half maximal inhibitory concentration using flow cytometry;DNA fragmentation by agarose gel electrophoresis and the expression of protein were measured by Western ***: The chloroform fraction from the ethanolic extract of M. peregrina(CFEE) was the most active antitumor fraction. The selectivity index, determined using the normal Vero cell line, indicated that CFEE had a high degree of selectivity against HELA and PC-3 cells. CFEE induced apoptosis, confirmed by cell cycle arrest at sub-G0 phase and DNA fragmentation. CFEE induced an increase in mRNA expression of caspase-3, a decrease in Bcl-2 mRNA expression, and decreased ATP levels. CFEE increased protein expression of caspase-3 and decreased protein expression of poly-ADP-ribose polymerase-1(PARP-1).Flow cytometric analysis showed an appreciable increase in the number of cells in the early apoptotic stage in CFEE-treated HELA and PC-3 cells. CFEE treatment significantly increased lipid peroxidation(malondialdehyde level) in HELA and PC-3 ***: Seed extract of M. peregrina displayed a significant antitumor effect through apoptosis induction in HELA and PC-3 cells.

关键词： Moringa peregrina Fractionation Antiproliferation Apoptosis

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Techno-economic analysis to develop the first wind farm in the Egyptian western desert at Elkharga Oasis

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Clean Energy 2022年第1期6卷 211-225页

作者： mohamed A.Abdelrahman radwan H.Abdel-Hamid Maged Ahmed Abo Adma mohamed Daowd Electrical Power and Machines Department Faculty of EngineeringHelwan UniversityCairoEgypt

During the past few years,Egypt has increased the share of electricity generation from renewable energy sources to achieve the renewable-energy *** Egyptian Ministry of Electricity and Renewable Energy has set an ambitious target to increase the share of renewable energy among the total energy mix to be 20%by 2022 and 42%by *** target will be achieved using several approved policies such as feed-in tariffs,build-own-operate and independent power producers under a merchant *** paper presents a full analysis of wind-potential characteristics at Elkharga Oasis in Egypt based on an actual wind-measurement campaign taken by a met mast at two height levels of 10 and 25 m,*** measurements show an average annual wind speed of 5.72 m/s at 10-m height and 6.53 m/s at>25-m *** estimated wind speed,however,is 8.38 m/s at 120 m,which is technically convenient to generate electricity from wind *** this paper,the wind potential in the area is assessed using the statistical method of the Weibull probability density *** different methods to estimate the Weibull distribution parameters are presented and the relevant accuracy is verified based on the root mean square error.A techno-economic assessment and selection of the optimal wind-turbine size with ideal micro-sitings are performed using the software package *** cases of study for three typical wind-turbine models with various rotor diameters,power capacity,layout configuration and annual yield are assessed at the *** selection of the most convenient wind turbine is determined based on the IEC 61400 standard criteria and the turbine that produces the lowest levelized cost of electricity.

关键词： wind energy wind-resource assessment Weibull distribution windPRO levelized cost of electricity

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Improvement of the shelf life of grey mullet (Mugil cephalus) fish steaks using edible coatings containing chitosan, nanochitosan, and clove oil during refrigerated storage

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Food Production, Processing and Nutrition 2022年第1期4卷 351-364页

作者： Samar Aref Ramadan Habiba noha Morsy mohamed Abdel-Daim Fatma Zayet Department of Food Technology Faculty of AgricultureSuez Canal Univer-sityIsmailiaEgypt Department of Food Technology(Home Economics) Faculty of AgricultureSuez Canal UniversityIsmailiaEgypt Department of Pharmacology Faculty of Veterinary MedicineSuez Canal UniversityIsmailiaEgypt

The effects of edible coatings made of chitosan, or chitosan nanoparticles, and their combinations with clove oil on the physical, chemical, microbiological, and sensory properties of grey mullet (Mugil cephalus) steaks during refriger-ated storage (4 °C) for 24 days were evaluated. The data indicated that metrics for all of these characteristics were improved significantly (P ≤ 0.05) in coated fish steak samples compared to the control sample. The coated steaks texture values were higher than those of control sample through storage time with nanochitosan coating containing clove oil having best value 2.51 kg/cm2 among tested samples at the end of storage period. However, pH values of coated samples were lower, a good indicator, than corresponding one of the control (6.46) with nanochitosan coatings with or without clove oil showed low mean values (6.11-6.13). Similar trend regarding chemical indices, i.e. total volatile basic-nitrogen, trimethylamine, peroxide, and thiobarbituric acid reactive substances values for samples coated with nanochitosan with or without clove oil giving better lower values than control or other treatments. Also, the coating delayed microbial (aerobic plate count, psychrotrophic bacteria, yeasts and molds, and total coliform bacteria) growth during the refrigeration storage period, and coated samples produced better results compared to the control sample. Sensory evaluations showed that the treatment enhanced the scores of fish steak samples compared to the control. The results showed that a nanochitosan coating with clove oil was the best treatment prolonged the shelf life of mullet steaks and efficiently maintained the quality attributes to an acceptable level during refrigerated storage for 24 days. Thus, these findings can be bases for producer to provide consumers with fresh fish steaks with good shelf life at refrigerated temperature for up to 24 days.

关键词： Edible coating Chitosan Nanochitosan Clove oil Grey mullet fish Storage

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Schistosomal(bilharzial)polyps:Travel through the colon and beyond

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World Journal of Gastroenterology 2023年第26期29卷 4156-4165页

作者： mohamed H Emara Aya M Mahros Abdelrahman M Ahmed Rasheda mohamed I radwan Besher mohamed Osama Abdelrazik Mostafa Elazab Hassan Elbatae Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Internal Medicine Gastroenterology UnitSecurity Forces HospitalRyiadh 11481Saudi Arabia Department of Tropical Medicine Zagazig UniversityZagazig 44519Egypt Department of Gastroenterology Surrey and Sussex Hospitals NHS TrustSurrey RH15RHUnited Kingdom Department of Hepato-Gastroenterology and Infectious Diseases Al-Azhar UniversityCairo 11651Egypt

Schistosomiasis(bilharziasis)is a major neglected tropical *** is endemic in many tropical and subtropical *** polyps(***)are not uncommon presentation of this *** the colon is the most commonly affected organ,many other organs are *** are associated with a variable range of morbidity independent of the Schistosomal *** are frequently described in endemic areas and increasingly reported in non-endemic areas mainly among immigrants and visitors to the endemic *** review aimed to increase awareness of practitioners,especially gastroenterologists,for this peculiar type of polyps caused by this neglected infection hence improving patient ***-based search of different databases was conducted for the literature focusing the development of *** in the colon and other organs with analysis of the clinical manifestations,diagnosis and *** following key words were used in the search,“Schistosomiasis”OR“Bilharziasis”AND“Polyps”OR“Polyp”AND“Colon”OR“Small intestine”OR“Duodenum”OR“Stomach”OR“Esophagus”OR”Gallbladder”OR”Pharynx”OR“Larynx”OR“Trachea”OR”Urinary bladder”OR“Ureter”OR“Renal Pelvis”OR“Urethra”.All publication types including case reports,case series,original research,and review articles were retrieved and *** are not infrequent presentation of acute or chronic Schistosomal *** are described in many organs including the bowel,genitourinary tract,skin,gallbladder and the *** of *** is variable and depends on the site,number as well as the polyp *** relationship of *** to malignant transformation is a matter of *** of *** is sometimes the only manifestation of *** polyps can be treated medically with praziquantel,while large accessible polyps are amendable for endoscopic excision through different polyp resection ***,huge,complicated,non-accessible and sus

关键词： Schistosomiasis Bilharziasis Schistosomal polyps Colon Praziquantel

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