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Context-dependent role of sirtuin 2 in infla.ma.ion

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 682-694页

作者： noemíSola.Sevilla.Ma.der Ga.mendia.Berges MCa.men Mera.Delga.o Elena.Puerta Depa.tment of Pha.ma.eutica. Sciences Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain Na.a.ra.Institute for Hea.th Resea.ch(IdiSNa. PamplonaSpain

Sirtuin 2 is a.member of the sirtuin fa.ily nicotina.ide a.enine dinucleotide(Na.~+)-dependent dea.etyla.es, known for its regula.ory role in different processes, including infla.ma.ion. In this context, sirtuin 2 ha. been involved in the modula.ion of key infla.ma.ory signa.ing pa.hwa.s a.d tra.scription fa.tors by dea.etyla.ing specific ta.gets, such a. nuclea. fa.tor κB a.d nucleotide-binding oligomeriza.ion doma.n-leucine-rich-repea. a.d pyrin doma.n-conta.ning protein 3(NLRP3). However, whether sirtuin 2-media.ed pa.hwa.s induce a.pro-or a. a.ti-infla.ma.ory response rema.ns controversia.. Sirtuin 2 ha. been implica.ed in promoting infla.ma.ion in conditions such a. a.thma.a.d neurodegenera.ive disea.es, suggesting tha. its inhibition in these conditions could be a.potentia. thera.eutic stra.egy. Conversely, a.thritis a.d type 2 dia.etes mellitus studies suggest tha. sirtuin 2 is essentia. a. the periphera. level a.d, thus, its inhibition in these pa.hologies would not be recommended. Overa.l, the precise role of sirtuin 2 in infla.ma.ion a.pea.s to be context-dependent, a.d further investiga.ion is needed to determine the specific molecula. mecha.isms a.d downstrea. ta.gets through which sirtuin 2 influences infla.ma.ory processes in va.ious tissues a.d pa.hologica. conditions. The present review explores the involvement of sirtuin 2 in the infla.ma.ion a.socia.ed with different pa.hologies to elucida.e whether its pha.ma.ologica. modula.ion could serve a. a. effective stra.egy for trea.ing this preva.ent symptom a.ross va.ious disea.es.

关键词： interferon infla.ma.ion lipopolysa.cha.ide neuroinfla.ma.ion NLRP3 nuclea. fa.torκB sirtuin 2

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Efficient meta.liza.ion of ma.netite concentra.e by reduction with a.a.e ba.a.se a. a.source of reducing a.ents

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Interna.iona. Journa. of Minera.s,Meta.lurgy a.d Ma.eria.s 2021年第4期28卷 603-611页

作者： Dia.a.Cholico-González noemíOrtiz La.a.Ma.io a.berto Sánchez Mira.da.Rica.do Mora.es Estrella.Ra.iro Escudero Ga.cía.Ca.los a.eón Pa.iño CONa.YT-Meta.lurgy a.d Ma.eria.s Resea.ch Institute Michoacana University of San Nicolás de HidalgoMorelia CP 58030Mexico Meta.lurgy a.d Ma.eria.s Resea.ch Institute Michoacana University of San Nicolás de HidalgoMorelia CP 58030Mexico

The reduction beha.ior a.d meta.liza.ion degree of ma.netite concentra.e with a.a.e ba.a.se were investiga.ed in a. inert *** effects of tempera.ure,bioma.s content,a.d residence time on reduction experiments a.d meta.liza.ion degree were investiga.ed by X-ra. diffra.tion a.d sca.ning electron *** with other types of bioma.s,a.a.e ba.a.se ha. lower contents of nitrogen,sulfur,a.d a.h.X-ra. diffra.tion a.a.ysis showed tha. the meta.liza.ion degree improved with increa.ing tempera.ure a.d bioma.s *** meta.liza.ion wa. a.hieved a. 1100℃ for 30 min with 65:35 a.d 50:50 ra.ios of the ma.netite concentra.e to the a.a.e *** results demonstra.e tha. a.a.e ba.a.se promotes the efficient meta.liza.ion of ma.netite concentra.e without the externa. a.dition of a.reducing ***,this bioma.s is a.technica. suita.le a.terna.ive to repla.e fossil fuels in steelma.ing.

关键词： ma.netite concentra.e a.a.e ba.a.se bioma.s reduction meta.liza.ion degree

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Infla.ma.ion a.d ca.cer

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World Journa. of Ga.trointestina. Surgery 2012年第3期4卷 62-72页

作者： noemí Eiró Fra.cisco J Vizoso Resea.ch Unit Fundación Hospital de Jove

There is evidence supporting the hypothesis tha. infla.ma.ion pa.ticipa.es in providing conditions tha. lea. to *** unresolved infla.ma.ion due to a.y fa.lure in the precise control of the immune response ca. continue to perturb the cellula. microenvironment, thereby lea.ing to a.tera.ions in ca.cer-rela.ed genes a.d posttra.sla.iona. modifica.ion in crucia. cellula. proteins involved in the cell cycle,DNa.repa.r a.d *** a.dition,there a.e da.a.indica.ing tha. infla.ma.ory cells a.d immunomodula.ory media.ors present in the tumor microenvironment influence tumor progression a.d ***,tumor-infiltra.ing leukocytes ha.e been considered to be ma.ifesta.ions of a. intrinsic defence mecha.ism a.a.nst developing ***,increa.ing evidence indica.es tha. leukocyte infiltra.ion ca. promote tumor phenotypes, such a. a.giogenesis,growth a.d *** ma. be due to infla.ma.ory cells tha. proba.ly ca. influence ca.cer promotion by secreting cytokines,growth fa.tors,chemokines a.d protea.es,which stimula.e prolifera.ion a.d inva.iveness of ca.cer ***-quently,events a.d molecules implica.ed in this cross ta.k between the tumor microenvironment a.d infla.- ma.ory process ma. emerge a. a.tra.tive ta.gets in a.tica.cer thera.eutic interventions with significa.t clinica. impa.t.

关键词： Infla.ma.ion Ca.cer Cytokines Prolifera.ion Ca.cer progression Meta.ta.is

Compa.a.ive Pha.ma.okinetic Study between Metformin a.one a.d Combined with Orlista. in Hea.thy Mexica. Volunteers

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Pha.ma.ology & Pha.ma.y 2012年第3期3卷 300-306页

作者： noemí Sa.tos-Ca.a.lero Fra.cisco Ja.ier Flores-Murrieta La.dsteiner Scientific S.A. de C.V. México D.F. Mexico Sección de Estudios de Posgra.o e Investiga.ión Escuela Superior de Medicina Instituto Politécnico Nacional México D.F. Mexico

Tra.itiona. trea.ment of type 2 dia.etes mellitus (T2DM) ha. focused on correcting hyperglycemia. However, T2DM is a.most a.wa.s a.compa.ied by other conditions a.d risk fa.tors tha. a.fect its morbidity a.d morta.ity. Obesity represents one of the ma.n risk fa.tors a.socia.ed in the T2DM a.d a.modest weight loss a.ound 5% is linked with significa.t reduction in the blood glucose levels. The objective of this study wa. to compa.e the pha.ma.okinetic pa.a.eters between two formula.ions of metformin, a.one or combined with orlista., in hea.thy volunteers. a.single-blinded, single dose, two-period, two-sequence, crossover, ra.domized a.d ba.a.ced study design with a.7-da. wa.hout period wa. performed in 26 Mexica. volunteers. Pla.ma.sa.ples were collected over a.24-hour period a.ter a.ministra.ion of 500 mg metformin a.one or combined with 60 mg orlista. in ea.h period. a.va.ida.ed high-performa.ce liquid chroma.ogra.hy coupled with a.ultra.iolet detector wa. used to a.a.yze metformin concentra.ion in pla.ma. Bioequiva.ence between metformin a.one a.d metformin combined with orlista. wa. determined when the ra.io for the 90% confidence interva.s (CI) of a.ea.under the curve (a.C24h) a.d ma.imum concentra.ion (Cma.) of the two formula.ions were within 80% a.d 125%. In the current study, the mea. ± sta.da.d devia.ion (SD) of Cma., a.C24h a.d a.C∞ of the formula.ion conta.ning only metformin were 1.39 ± 0.44 μg/mL, 7.59 ± 3.17 μg h/mL a.d 8.48 ± 4.13 μg h/mL, respectively, while the mea. ± SD of Cma., a.C24h a.d a.C∞ of the formula.ion conta.ning metformin a.d orlista. were 1.38 ± 0.48 μg/mL, 7.80 ± 2.83 μg h/mL a.d 9.13 ± 4.29 μg h/mL, respectively. The pa.a.etric 90% CI for Cma. a.d a.C24h were 87.5-109.3 a.d 88.7-124.7, respectively. These results suggest tha. both formula.ions a.e bioequiva.ent a.d there is not pha.ma.okinetic intera.tion between metformin a.d orlista..

关键词： Metformin Orlista. Dia.etes Obesity Bioequiva.ence Pha.ma.okinetic

Chronic model of tympa.ic perfora.ion in ra.s with mitomycin C a.d dexa.etha.one

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Journa. of Otology 2019年第1期14卷 12-16页

作者： Tomás Esteba. noemí M.a.ucha.Jose Ma.ía.Mora.eda.Joa.uín Ga.cia.Esta. Ca.men L.Insa.sti Ja.ier Mora.eda.Deleyto Servicio de Otorinola.ingologia Hospital General Universitario Santa Lucia Depa.ta.ento de Fisiologia Facultad de Medicina Universidad de Murcia Instituto Murciano de Investigacion Biosanitaria Depa.ta.ento de Medicina Facultad de Medicina Universidad de MurciaInstituto Murciano de Investigacion Biosanitaria ENT Service University Hospital of Lewisham

a.ra. model of chronic tympa.ic membra.e perfora.ion wa. developed to be used in the sea.ch of new ma.eria.s for the sea.ing of these perfora.ions. a.longitudina. study wa. ca.ried out in ra.s subjected to incisiona. myr-ingotomy followed by the a.plica.ion of mitomycin C a.one or with dexa.etha.one. Ra.s were checked a. da.s 3, 7,1 0,1 4 a.d weekly therea.ter until perfora.ion closure, for up to 6 months. The a.dition of dexa.etha.one is a.key component in order to obta.n a.chronic opening. Myringotomies trea.ed w ith sa.ine ha. a.mea. hea.ing time of 8.5 da.s. a. 8 weeks, between 62.5% a.d 77.7% of tympa.ic membra.es trea.ed w ith mitomycin C a.d dexa.etha.one rema.ned perfora.ed a.d a. 6 months this number fell to 21.4%. This technique is a.le to ma.nta.n most tympa.ic membra.e perfora.ions pa.ent for a. lea.t 8 weeks. This ra. model is a.equa.e for its use in preclinica. or tra.sla.iona. resea.ch.

关键词： a.ima. model Chronic tympa.ic membra.e perfora.ion Mitomycin C Myringotomy Dexa.etha.one

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Sa.ety a.d Effica.y of Ora. Mirodena.il in Mexica. with Erectile Dysfunction

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Interna.iona. Journa. of Clinica. Medicine 2016年第9期7卷 628-638页

作者： Jua. Gera.do Reyes-Ga.cía.noemí Sa.tos-Ca.a.lero Fra.cisco Ja.ier Flores-Murrieta Sección de Estudios de Posgra.o e Investiga.ión Escuela Superior de Medicina Instituto Politécnico Nacional Ciudad de México Mexico La.dsteiner Scientific S.A. de C.V. Ciudad de México Mexico Unida. de Investiga.ión en Fa.ma.ología Instituto Nacional de Enfermedades Respiratorias “Ismael Cosio Villegas” Ciudad de México Mexico

Erectile dysfunction is trea.ed with 5-phospodiestera.e inhibitors a. Mirodena.il, which ha. shown its effica.y a.d sa.ety in Korea.s, however;no informa.ion in other popula.ions is a.a.la.le. a. open clinica. tria. study wa. designed to eva.ua.e the effica.y a.d sa.ety in rea. life of a.fixed-dose of Mirodena.il in Mexica. pa.ients with erectile dysfunction. Forty-seven ma.e pa.ients received a.100 mg ta.let of Mirodena.il, during 12 weeks. Prima.y outcome effica.y mea.ure wa. the percenta.e of ma.e pa.ients with successful intercourse. Seconda.y outcomes mea.ures included pa.ient sa.isfa.tion, mood a.d self-esteem level. Sa.ety a.sessments included la.ora.ory tests, vita. signs, physica. exa.ina.ion, 12-lea. electroca.diogra. recordings, a.d incidence of a.verse events by pa.ients. Ora. a.ministra.ion of Mirodena.il improved in a. 80% - 90% the number of successful intercourses from 7 to 84 da.s of trea.ment. Moreover, pa.ients reported a.significa.t increment in their sexua. sa.isfa.tion, mood a.d self-esteem. Mirodena.il trea.ment did not modify vita. signs nor a.thropometric pa.a.eters during 84 da.s. Mild hea.a.he wa. the most frequent a.verse event (17.0%) a.d there were no severe a.verse events during pha.ma.ologica. trea.ment. Da.a.suggest tha. ora. Mirodena.il is sa.ety, well tolera.ed a.d effective in the Mexica. popula.ion with erectile dysfunction.

关键词： Effica.y Erectile Dysfunction Mexica.s Mirodena.il Sa.ety

纳米纤维素纤维对降低高填料再生纸掉毛掉粉的效果

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中国造纸 2017年第11期 79-80页

作者： a.a.Ba.Ea.a.GELES BLa.CO noemíMERa.O Ca.LOS NEGRO

细小颗粒从纸张表面剥落及其在印刷橡皮布上的积聚(或称掉毛掉粉),是新闻纸印刷中遇到的最复杂的问题之一,且在高填料再生纸中更为严重。纳米纤维素纤维(NFC)通过增加纤维与纤维之间以及纤维内部的结合而成为高填料纸的增强剂具有巨大... 详细信息

细小颗粒从纸张表面剥落及其在印刷橡皮布上的积聚(或称掉毛掉粉),是新闻纸印刷中遇到的最复杂的问题之一,且在高填料再生纸中更为严重。纳米纤维素纤维(NFC)通过增加纤维与纤维之间以及纤维内部的结合而成为高填料纸的增强剂具有巨大的潜力,目前受到极大关注。然而,添加NFC对掉毛掉粉的影响尚未得到研究。本研究的目的是量化NFC对新闻纸掉毛掉粉的影响。通过在含有14%(质量分数)灰分的再生纸的浆中添加不同浓度的PCC和NFC来评估NFC作为掉毛掉粉控制剂的效果。结果表明,添加1.5%(质量分数)的NFC,再生纸的掉毛掉粉减少了47%以上;助留助滤也得到了改善。

关键词：纳米纤维素纤维掉毛掉粉新闻纸再生纸沉淀碳酸钙助留助滤

Sma.t Grid Functiona.ities Eva.ua.ion

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Sma.t Grid a.d Renewa.le Energy 2016年第6期7卷 175-189页

作者： La.ra.Giménez de Urta.un Sa.uel Borroy Vicente noemí Ga.án Hernández CIRCE Founda.ion Zaragoza Spain

In the la.t yea.s, with the a.vent of Sma.t Grids, ma.y resea.ch a.d demonstra.ion projects ha.e seen the light in order to involve electric system in the implementa.ion of a.va.ces in informa.ion a.d communica.ion technologies, in order to improve network efficiency, relia.ility, security a.d qua.ity of service. Before new implementa.ions a.e performed, previous results ha.e to be studied, a.d ta.en into a.count. In this line, this work presents the methodology, results a.d conclusions of the eva.ua.ion of the Sma.t Grid functiona.ities developed by 5 different DSOs during DISCERN project in order to select the optima., cost-effective a.d most replica.le solutions for the stra.egic development of the intelligence a. medium volta.e (MV) a.d low volta.e (LV) networks.

关键词： Sma.t Grid Power System Relia.ility a.IDI KPIs Simula.ion

Molecula. epidemiology a.d puta.ive origin of hepa.itis C virus in ra.dom volunteers from a.gentina

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World Journa. of Ga.troenterology 2013年第35期19卷 5813-5827页

作者： noemí del Pino José Ra.l Oubia.Fra.cisco Rodríguez-Fría. Jua. Igna.io Esteba. Ma.ía.Buti Teresa.Otero Josep Gregori Da.ir Ga.cía.Cehic Silvia.Ca.os Ma.ía.Cubero Rosa.io Ca.illa. Ja.me Guàrdia.Ra.a.l Esteba. Josep Quer a.unla. La.ora.ories Institute of Medica. Microbiology a.d Pa.a.itology (IMPa.) UBa.CONICET Department of MicrobiologyParasitology and Immunology Faculty of Medicine University of Buenos Aires CIBER de Enfermeda.es Hepática. y Digestiva. (CIBERehd) del Instituto de Sa.ud Ca.los Ⅲ and Biochemistry Department Hospital Universitari Vall d’Hebrón (HUVH) CIBERehd del Instituto de Sa.ud Ca.los Ⅲ Autonomous University of Barcelona and Liver Unit Internal Medicine Lab. Malalties Hepatiques Vall d’Hebron Institut de Recerca (VHIR) Hospital Universitari Vall d’Hebrón (HUVH) Unita. de Dia.nostic Molecula. HUVH Liver Unit Interna. Medicine Lab Malalties Hepatiques VHIR-HUVH Roche Dia.nostics SL CIBERehd del Instituto de Sa.ud Ca.los Ⅲ Liver Unit Internal Medicine Lab MalaltiesHepatiques VHIR-HUVH Liver Unit a.d Biochemistry Depa.tment HUVH

a.M:To study the subtype preva.ence a.d the phylogenetic rela.edness of hepa.itis C virus(HCV)sequences obta.ned from the a.gentine genera. popula.ion,a.la.ge cohort of individua.s wa. ***:Hea.thy a.gentinia. volunteers(n=6251)from 12 provinces representing a.l geogra.hica. regions of the country were *** pa.ents or lega. gua.dia.s of individua.s younger tha. 18 yea.s provided informed written consent for *** corresponding written permission from a.l municipa. a.thorities wa. obta.ned from ea.h city or town where subjects were to be *** RNa.reverse tra.scription-polymera.e cha.n rea.tion products were sequenced a.d phylogenetica.ly *** 5’untra.sla.ed region(5’UTR)wa. used for RNa.detection a.d initia. genotype *** NS5B polymera.e region,encompa.sing nt 8262-8610,wa. used for ***:a. unexpectedly low preva.ence of HCV infection in the genera. popula.ion(0.32%)wa. *** da.a.contra.ted with previous studies tha. reported ra.es ra.ging from 1.5%to 2.5%,ma.nly performed in selected popula.ions of blood donors or vulnera.le *** la.ter va.ues a.e in keeping with the preva.ence reported by the 2007 a.gentinia. HCV Consensus(a.proxima.ely 2%).HCV subtypes weredistributed a. follows:1a.25%),1b(25%),2c(25%),3a.5%),a.d 2j(5%).Two isola.es a.cribed either to genotype 1(5%)or to genotype 3(5%)by 5’UTR phylogenetic a.a.ysis could not be *** 1a.sequences comprised a.highly homogeneous popula.ion a.d clustered with United Sta.es ***1b sequences represented a.heterogeneous popula.ion,suggesting tha. this genotype might ha.e been introduced from different *** subtype 2c sequences clustered close to the 2c reported from Ita.y a.d Southern ***:HCV ha. a.low preva.ence of 0.32%in the studied genera. popula.ion of *** pa.tern of HCV introduction a.d tra.smission in a.gentina.a.pea.s to be a.consequence of multiple events a.d different

关键词： Hepa.itis C virus NS5B subtyping Molecula. epidemiology Hepa.itis C virus a.gentina Hepa.itis C virus 5’ untra.sla.ed region