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Dismicrobism in inflammatory bowel disease and colorectal cancer: Changes in response of colocytes

World Journal of Gastroenterology 2014年第48期20卷 18121-18130页

作者： Giovanni Tomasello Pietro Tralongo Provvidenza Damiani Emanuele Sinagra Benedetto Di Trapani Marie noelle Zeenny Inaya Hajj Hussein Abdo Jurjus Angelo Leone IEMEST Euro-Mediterranean Institute of Science and Technology 90139 Palermo Italy Department of Experimental Biomedicine and Clinical Neurosciences Section of Histology University of Palermo 90133 Palermo Italy AOUP "P Giaccone" School of Medicine University of Palermo 90139 Palermo Italy Fondazione Istituto S. Raffaele-G. Giglio Gastroenterology and Endoscopy Unit Cefalù 90146 Italy Unit of Surgery "Clinica Torina" 9010Palermo Italy Deparment of Anatomy Cell Biology and Physiology American University of Beirut Beirut 1107-2020 Lebanon Department of Biomedical Sciences Oakland University William Beaumont School of Medicine Rochester MI 48309 United States

Patients with inflammatory bowel disease (IBD) have an increased risk of 10%-15% developing colorectal cancer (CRC) that is a common disease of high economic costs in developed countries. The CRC has been increasing in recent years and its mortality rates are very high. Multiple biological and biochemical factors are responsible for the onset and progression of this pathology. Moreover, it appears absolutely necessary to investigate the environmental factors favoring the onset of CRC and the promotion of colonic health. The gut microflora, or microbiota, has an extensive diversity both quantitatively and qualitatively. In utero, the intestine of the mammalian fetus is sterile. At birth, the intestinal microbiota is acquired by ingesting maternal anal or vaginal organisms, ultimately developing into a stable community, with marked variations in microbial composition between individuals. The development of IBD is often associated with qualitative and quantitative disorders of the intestinal microbial flora (dysbiosis). The healthy human gut harbours about 10 different bacterial species distributed in colony forming units which colonize the gastrointestinal tract. The intestinal microbiota plays a fundamental role in health and in the progression of diseases such as IBD and CRC. In healthy subjects, the main control of intestinal bacterial colonization occurs through gastric acidity but other factors such as endoluminal temperature, competition between different bacterial strains, peristalsis and drugs can influence the intestinal microenvironment. The microbiota exerts diverse physiological functions to include: growth inhibition of pathogenic microorganisms, synthesis of compounds useful for the trophism of colonic mucosa, regulation of intestinal lymphoid tissue and synthesis of amino acids. Furthermore, mucus seems to play an important role in protecting the intestinal mucosa and maintaining its integrity. Changes in the microbiota composition are mainly influenced

关键词： Dismicrobism Inflammatory bowel disease Colorectal Cancer Dysbiosis Eubiosis Heat shock proteins

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SPS制备纳米晶Bi_(0.75)Er_(0.25)O_(1.5)固体电解质

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功能材料 2010年第11期41卷 1857-1860页

作者：李榕甄强袁强 Michel Drache Rose-noelle Vannier 鲁雄刚上海大学材料科学与工程学院上海200444 法国里尔科技大学固体化学与催化国家实验室法国里尔59652 上海大学纳米科学与技术研究中心上海200444

以分析纯Bi2O3和Er2O3为原料,采用反向滴定共沉淀法合成Bi和Er的氢氧化物前驱体,并对共沉淀的pH值条件进行了分析。将该前驱体在500℃焙烧3h后得到Bi0.75Er0.25O1.5的纳米粉体,高温XRD结果表明该粉体主要为β相,谢乐公式计算平均晶粒尺... 详细信息

以分析纯Bi2O3和Er2O3为原料,采用反向滴定共沉淀法合成Bi和Er的氢氧化物前驱体,并对共沉淀的pH值条件进行了分析。将该前驱体在500℃焙烧3h后得到Bi0.75Er0.25O1.5的纳米粉体,高温XRD结果表明该粉体主要为β相,谢乐公式计算平均晶粒尺寸为10nm,并且随温度升高在650℃转变为δ相。通过热力学计算,确定了SPS下烧结Bi0.75Er0.25O1.5陶瓷适宜的温度和氧分压条件,最后在测试温度为500℃保温1min得到了相对密度达到96%的δ相纳米晶的Bi0.75Er0.25O1.5陶瓷,平均晶粒尺寸为18nm。

关键词：反向滴定共沉淀纳米晶Bi0.75Er0.25O1.5 SPS 相转变优势区图

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Thin films of binary amorphous Zn-Zr alloys developed by magnetron co-sputtering for the production of degradable coronary stents:A preliminary study

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Bioactive Materials 2018年第4期3卷 385-388页

作者： Nathalie Annonay Fatiha Challali Marie-noelle Labour Valerie Bockelee A.Garcia-Sanchez Florent Tetard Marie-Paule Besland Philippe Djemia Frederic Chaubet Laboratoire de Science des Materiaux et des Procedes UPR CNRS 3407Universite Paris 13Sorbonne-Paris-CiteInstitut Galilee99 av J.B.Clement93430VilletaneuseFrance Laboratory for Vascular Translational Science Inserm U1148Universite Paris 13Universite Paris-DiderotSorbonne-Paris-CiteInstitut Galilee99 av J.B.Clement93430VilletaneuseFrance Institut des Materiaux Jean Rouxel(IMN)UMR CNRS 6502 Universite de Nantes2rue de la HoussiniereB.P.3222944322Nantes Cedex 3France

*** Vascular stents are endo-prostheses that allow the restoration of blood flow in case of obstruction of a vessel.A stent usually consists of a corrosion-resistant metal such as Nitinol,316L steel or a CoCr alloy[1].Many studies have been undertaken for the production of polymer degradable stents[2,3]or metallic stents[4,5]and,among these,devices made of pure zinc or crystallized alloy based on zinc obtained by molding and extrusion are promising in terms of biodegradability,biocompatibility and mechanical properties[6],but also concerning the degradation rate of the stent which should to be effective until arterial remodeling and tissue healing are complete[5].The objective of this preliminary study is the comparison of the degradation in simulated biological medium and the endothelial cytotoxicity of amorphous and crystallized thin ZnZr films according to their composition and *** this work,the thin layers were deposited on silicon substrates by magnetron *** technology is already used to make metal stents[7,8].

关键词： alloy alloys corrosion

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Self-organized metal-semiconductor epitaxial graphene layer on off-axis 4H-SiC（0001）

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Nano Research 2015年第3期8卷 1026-1037页

作者： Debora Pierucci Haikel Sediri Mahdi Hajlaoui Emilio Velez-Fort Yannick J. Dappe Mathieu G. Silly Rachid Belkhou Abhay Shukla Fausto Sirotti noelle Gogneau Abdelkarim Ouerghi CNRS- Laboratoire de Photonique et de Nanostructures Route de Nozay 91460 Marcoussis France Synchrotron-SOLEIL Saint-Aubin BP48 F91192 Gifsur Yvette Cedex France Universite Pierre et Marie Curie (CNRS - IMPMC) 4 PI. Jussieu 75005 Paris France Service de Physique de rEtat Condense (CNRS URA2464) IRAMIS CEA Saclay 91191 Gif-Sur-Yvette France

The remarkable properties of graphene have shown promise for new perspectives in future electronics, notably for nanometer scale devices. Here we grow graphene epitaxially on an off-axis 4H-SiC（0001） substrate and demonstrate the formation of periodic arrangement of monolayer graphene on planar （0001） terraces and Bernal bilayer graphene on （1120） nanofacets of SiC. We investigate these lateral superlattices using Raman spectroscopy, atomic force microscopy/ electrostatic force microscopy （AFM/EFM） and X-ray and angle resolved photoemission spectroscopy （XPS/ARPES）. The correlation of EFM and ARPES reveals the appearance of permanent electronic band gaps in AB-stacked bilayer graphene on （1120） SiC nanofacets of 150 meV. This feature is confirmed by density functional theory （DFT） calculations. The charge transfer between the substrate and graphene bilayer results in an asymmetric charge distribution between the top and the bottom graphene layers opening an energy gap. This surface organization can be thus defined as self-organized metal-semiconductor graphene.

关键词： epitaxial graphene layer monolayer bilayer band gap opening Bernal stacking off-axis silicon carbide electronic properties

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Reflets 2

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2002年

作者： Guy Capelle noelle Gidon

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ISBN: (纸本)201155120X

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China's Bitcoin Revolution

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城市漫步（上海版、英文） 2016年第10期 52-58页

作者： noelle Mateer Holly Li Emma Huang Xinyu Li 不详

When Eric Mu says that the village of Moyu in western Sichuan is remote,he means *** more Tibetan than Han,the tiny settlement s让s in a valley among soaring mountains and deep *** village is only connected to neighboring com・munities by a rickety suspension bridge,which wobbles above river rapids *** crossed it ***'ll never cross it *** was terrifying,he *** in Moyu is *** Mu is there,he runs-passing along winding roads and through tunnels that pierce the mountains,some as long as 3 *** coworkers entertain themselves with mahjong and *** of the villagers grow corn.

关键词： mountains winding Tibetan

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Coronary leukocyte activation in relation to progression of coronary artery disease

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Frontiers of Medicine 2016年第1期10卷 85-90页

作者： Marijke A. de Vries Arash Alipour Erwin Bimie Andrew Westzaan Selvetta van Santen Ellen van der Zwan Anho H. Liem noelle van der Meulen Manuel Castro Cabezas Department of Internal Medicine Centre for Diabetes and Vascular Medicine Rotterdam P.O. Box 10900 3004 BA The Netherlands Department of Statistics and Education Rotterdam P.O. Box 10900 3004 BA The Netherlands Department of Clinical Chemistry Rotterdam P.O. Box 10900 3004 BA The Netherlands Department of Cardiology Sint Franciscus Gasthuis Rotterdam P.O. Box 10900 3004 BA The Netherlands

Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease （CAD） of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CDllb, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase （MPO） in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion （26 patients had single-vessel disease, 18 patients had two- vessel disease and 26 patients had three-vessel disease）. The median follow-up duration was 2242 days （interquartile range： 2142-2358）. During follow-up, 13 patients （13%） developed progression of CAD. Monoeyte CDllb, neutrophil CDllb and CD66b expression and intraceilular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CDllb, neutrophil CDllb and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.

关键词： coronary artery disease inflammation integrin myeloperoxidase leukocyte activation

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Changes in smoking patterns after HIV diagnosis or antiretroviral treatment initiation: a global systematic review and meta-analysis

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Infectious Diseases of Poverty 2020年第2期9卷 14-22页

作者： Jobert Richie Nansseu Dalhia noelle Tounouga Jean Jacques Noubiap Jean Joel Bigna Department of Public Health Faculty of Medicine and Biomedical Sciences of the University of YaoundéIYaoundéCameroon Department for the Control of Disease Epidemics and PandemicsMinistry of Public HealthYaoundéCameroon Centre for Heart Rhythm Disorders University of Adelaide and Royal Adelaide HospitalAdelaideAustralia Department of Epidemiology and Public Health Centre Pasteur of CameroonPO Box 1274YaoundéCameroon School of Public Health Faculty of MedicineUniversity of Paris Sud XILe Kremlin BicêtreFrance

Background:Tobacco consumption is more life-threatening in people living with human immunodeficiency virus(HIV)than within the general population;therefore,people living with HIV(PLWH)should be highly motivated to take action towards quitting smoking at or after HIV *** aim of this systematic review with meta-analysis was to investigate changes in smoking habits among PLWH over *** text:We considered prospective and retrospective cohort studies including PLWH aged 15 years and above,which have measured the prevalence of tobacco smoking(current,former or never)at study initiation and completion,and published between January 1,2000 and April 15,2018 without language or geographical *** searched PubMed,EMBASE,Web of Science,Africa Journal Online,and Global Index *** used a random-effects model to pool *** studies were *** proportion of current and former smokers decreased slightly over time,around 2.5 and 3.8%,***,the proportion of never smokers decreased sharply by 22.5%,and there were 2.1 and 1.5%PLWH who shifted from never and former smoking to current smoking,*** the other hand,10.5%PLWH shifted from current to former smoking,7.1%tried to quit tobacco consumption but failed,and 10.1%stayed in the"never smoking"category over ***:PLWH seem not to change positively their smoking habits towards quitting tobacco *** is urgent need to increase actions aimed at helping this vulnerable population to quit tobacco consumption,including individually tailored therapeutic education,psychosocial and pharmacologic supports.

关键词： Smoking HIV AIDS Tobacco Global health

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BAODING COMES CLEAN Will Bhe Skies Retun to China's Most Polluled City?

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城市漫步（GBA版） 2016年第11期 12-15页

作者： Oscar Holland Dominique Wong noelle Mateer Holly Li 不详

At Green Valley amusement park in Baoding,a rainbow-colored Ferris wheel turns slowly against a clear;cloudless *** the neighboring Botanical Garden,autumn leaves fall around a lake on which tourists pedal out in smal... 详细信息

关键词： hardly slowly colored

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Reflets 1, guide pedagogique

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1999年

作者： Guy Capelle noelle Gidon

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ISBN: (纸本)2011551188

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