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Molecular Plant 2017年第8期10卷 1095-1106页

作者： noelia Pastor-Cantizano Maria Jesus Garcia-Murria Cesar Bernat-Silvestre Maria Jesus Marcote Ismael Mingarro Fernando Aniento Departamento de Bioquimica y Biologia Molecular Universitat de Valencia 46100 Burjassot Spain Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED) Universitat de Valencia 46100 Burjassot Spain

The K/HDEL receptor ERD2 mediates the transport of soluble endoplasmic reticulum （ER）-resident proteins containing a C-terminal K/HDEL signal from the Golgi apparatus back to the ER via COPI （COat Protein I）-coated vesicles. Sorting of ERD2 within COPI vesicles is facilitated by p24 proteins. In Arabidop- sis, p24δ5 has been shown to interact directly with ERD2 via its luminal GOLD （GOLgi Dynamics） domain and with COPI proteins via its cytoplasmic C-terminal tail at the acidic pH of the Golgi apparatus. Several members of the p24 family in mammals and yeast have been shown to be glycosylated, but whether Arabidopsis p24 proteins are glycosylated and the role of the sugar moiety in p24 function remain unclear. Here, we show that Arabidopsis p24δ5 protein is N-glycosylated in its GOLD domain. Furthermore, we demonstrate that this post-translational modification is important for its coupled transport with p241β2 at the ER-Golgi interface, for its interaction with the K/HDEL receptor ERD2, and for retrograde transport of ERD2 and K/HDEL ligands from the Golgi apparatus back to the ER.

关键词： K/HDEL receptor COPI （COat Protein I） p24 proteins N-glycosylation

Histopathological Characteristics of Folliculo-stellate Cells in Pituitary Glands of Wild Type,Obese and High-fat Diet Induced Mice

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Journal of Endocrinology Research 2022年第2期4卷 1-9页

作者： JoséFilipe Melo Gonçalo Borrecho noelia Martínez-Sánchez Francisco Tortosa Instituto de Anatomia Patológica Faculdade de MedicinaUniversidade de LisboaLisbon1649-028Portugal Center for Interdisciplinary Research Egas Moniz(CiiEM) Monte da CaparincaCaparica2829-511Portugal Oxford Centre for Diabetes Endocrinology and MetabolismUniversity of OxfordOxfordOX37LEUK

The anterior pituitary gland regulates growth,metabolism,and reproduction by secreting hormones.Folliculo-stellate cells(FSC)are non-endocrine cells located among hormone-producing cells in the anterior pituitary glands,but little is known about the exact roles of those cells.Although,with their net organization,they seem to have an important role in the hormonal cells regulation and maintenance.In this work,the first ever made in this area,33 pituitaries of three groups of mice(18 wild type[WT],11 genetically obese[OB]and 4 under a high-fat diet[HFD])were studied in order to determine if there was any relation between the number of FSC and alterations of the basal metabolism in each group of mice.For that,immunohistochemical staining using the S-100 protein was used and also the Image-J software,to calculate the percentage of FSC present in each sample.The authors found that,although there wasn’t any significant difference between WT and OB mice,the group of HFD mice tend to have substantially higher percentage of FSC than the mice from other groups.This might suggest some yet unknown link between diet,precisely with a high-fat diet,and the presentation of FSC in the anterior pituitary.

关键词： Folliculo-stellate cells(FSC) S-100 protein Basal metabolism Pituitary

Low-cost disordered carbons for Li/S batteries： A high- performance carbon with dual porosity derived from cherry pits

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Nano Research 2018年第1期11卷 89-100页

作者： Celia Hernandez-Rentero Rafael Cordoba noelia Moreno Alvaro Caballero Julian Morales Mara Olivares-Marin Vicente Gomez-Serrano Dpto. Ouimica Inorgdnica e Ingenierfa Quimica Instituto de Quimica Fina y Nanoqufmica Universidad de C6rdoba 14071 C6rdoba Spain Dpto. Quimica Inorg6nica Facultad de Ciencias Universidad de Extremadura 06006 Badajoz Spain

一微 -- 并且从樱桃坑废物获得并且与 H 3 PO 4 酸为 Li/S 电池作为硫主人被学习了。碳有 1,662 m 2 灀楡的一个高特定的表面区域吗？

关键词：碳源电池樱桃表演双孔生物资源电气化学 mAh

Petrogenesis of Quebrada de la Mina and Altar North porphyries (Cordillera of San Juan, Argentina): Crustal assimilation and metallogenic implications

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Geoscience Frontiers 2017年第5期8卷 1135-1159页

作者： Laura Maydagán Marta Franchini Massimo Chiaradia Verónica Bouhier noelia Di Giuseppe Roger Rey Luis Dimieri Centro Patagónico de Estudios Metalogenéticos-CONICET Argentina INGEOSUR-CONICET Departamento de Geología Universidad Nacional del Sur San Juan 670 8000 Bahía Blanca Argentina Instituto de Investigación en Paleobiología y Geología Universidad Nacional de Río Negro Av. Roca 1242 8332 Roca Argentina Departamento de Geología y Petróleo Facultad de Ingeniería Universidad Nacional del Comahue Buenos Aires 1400 8300 Neuquén Argentina Section of Earth and Environmental Sciences University of Geneva Switzerland Minera Peregrine Argentina S.A Santa Fe (Oeste) 117 Piso 4B Edificio Derby Ciudad San Juan Argentina

We investigate the geology of Altar North(Cu-Au) and Quebrada de la Mina(Au) porphyry deposits located in San Juan Province(Argentina), close to the large Altar porphyry copper deposit(995 Mt,0.35% Cu, 0.083 g/t Au), to present constraints on the magmatic processes that occurred in the parental magma chambers of these magmatic-hydrothermal systems. Altar North deposit comprises a plagioclase-amphibole-phyric dacite intrusion(Altar North barren porphyry) and a plagioclaseamphibole-biotite-phyric dacite stock(Altar North mineralized porphyry, 11.98 ± 0.19 Ma). In Quebrada de la Mina, a plagioclase-amphibole-biotite-quartz-phyric dacite stock(QDM porphyry,11.91±0.33 Ma) crops out. High Sr/Y ratios(92-142) and amphibole compositions of Altar North barren and QDM porphyries reflect high magmatic oxidation states(fO_2= NNO+1.1 to+1.6) and high fH_2O conditions in their magmas. Zones and rims enriched in anorthite(An_(37-48))), SrO(0.22-0.33 wt.%)and FeO(0.21-0.37 wt.%) in plagioclase phenocrysts are evidences of magmatic recharge processes in the magma chambers. Altar North and Quebrada de la Mina intrusions have relatively homogeneous isotopic compositions(^(87)Sr/^(86)Sr_(t)= 0.70450-0.70466, ε_(ND)(t) = +0.2 to +1.2) consistent with mixed mantle and crust contributions in their magmas. Higher Pb isotopes ratios(^(207)Pb/^(204)Pb=15.6276-15.6294) of these intrusions compared to other porphyries of the district, reflect an increase in the assimilation of high radiogenic Pb components in the magmas. Ages of zircon xenocrysts(297,210,204,69 Ma) revealed that the magmas have experienced assimilation of Miocene, Cretaceous, Triassic and Carboniferous crustal rocks.Fluids that precipitated sulfides in the Altar deposit may have remobilized Pb from the host rocks, as indicated by the ore minerals being more radiogenic(207Pb/204 Pb = 15.6243-15.6269) than their host intrusions. Au/Cu ratio in Altar porphyries(average Au/Cu ratio of 0.14 ×10^(-4)by weight in Altar Central)is higher than in the giant Miocene porphyry deposits

关键词： Porphyry High sulfidation epithermal Magmatic recharge Radiogenic isotopes Crustal assimilation Argentinian Andes

Soil fertilization does not alter plant architectural effects on arthropod communities

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Journal of Plant Ecology 2017年第5期10卷 800-807页

作者： M.noelia Barrios-Garcia Mariano A.Rodriguez-Cabal Jennifer A.Rudgers Gregory M.Crutsinger CONICET CENAC-APNFagnano 244BarilocheRio Negro CP.8400Argentina Grupo de Ecología de Invasiones INIBIOMA-CONICETUniversidad Nacional del ComahueAv.de los Pioneros 2350BarilocheRio Negro CP.8400Argentina Department of Biology University of New MexicoCastetter Hall 286AlbuquerqueNM 87131USA Department of Zoology University of British Columbia#4200-6270 University Blvd.VancouverBritish Columbia V6T 1Z4Canada

Aims While a growing number of studies have demonstrated the impor-tance of intraspecific differences within plant species on associ-ated arthropod communities,little is known regarding the relative strength of these effects compared to environmental factors.In this study,we examined whether intraspecific plant differences and nutrient fertilization interact to shape the arthropod community of a dominant coastal shrub,Baccharis pilularis(coyote bush).Methods We overlaid a fertilization treatment on a 12-year-old common garden experiment planted with erect and prostrate architectural morphs of Baccharis in california,USA.to collect the associated arthropod community,we vacuum sampled the crown of each Baccharis and identified individuals to species or morphospecies.Important Findings We found that arthropod richness and abundance were 2-to 3-fold greater on prostrate Baccharis than on erect morphs,but observed no main effects of fertilizer addition on the over-all arthropod communities.Predators responded as strongly as herbivores to plant morph,and both were unaffected by nutrient additions.Only the specialist stem galler,Gnorimoschema bac-charisella,showed an interactive response to plant morph and fertilization.Nitrogen,phosphorous and potassium addition had opposite effects on the two morphs,increasing stem gall abun-dance by 50%on prostrate morphs,but reducing galling by 20%on erect morphs.the architectural complexity of prostrate morphs could be the driving mechanism of differences in arthropod assemblages.Overall,our results demonstrate that communitylevel consequences of intraspecific differences in plants are strong,rather than being context dependent,and are generally maintained under different resource environments.the growing number of studies showing strong genotype than nutrient effects on associated arthropod communities suggests that this might be a generalized pattern.

关键词： Baccharis pilularis community genetics G×E interactions galling insects nutrient fertilization

Non-guided self-learning program for high-proficiency optical diagnosis of diminutive and small colorectal lesions: A single-endoscopist pilot study

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World Journal of Gastroenterology 2019年第10期25卷 1278-1287页

作者： Marco Bustamante-Balén Carla Satorres Lorena Puchades Belén Navarro Natalia García-Morales noelia Alonso Marta Ponce Lidia Argüello Vicente Pons-Beltrán Gastrointestinal Endoscopy Research Group Gastrointestinal Endoscopy UnitDigestive Diseases DepartmentLa Fe Polytechnic University Hospital Digestive Diseases Department La Fe Polytechnic University Hospital Gastrointestinal Endoscopy Unit Digestive Diseases DepartmentLa Fe Polytechnic University Hospital

BACKGROUND The implementation of optical diagnosis(OD) of diminutive colorectal lesions in clinical practice has been hampered by differences in performance between community and academic settings. One possible cause is the lack of a standardized learning tool. Since the factors related to better learning are not well described, strong evidence upon which a consistent learning tool could be designed is lacking. We hypothesized that a self-designed learning program may be enough to achieve competency in OD of diminutive lesions of the colon.AIM To assess the accuracy of OD of diminutive lesions in real colonoscopies after application of a self-administered learning program.METHODS This was a single-endoscopist prospective pilot study, in which an experienced endoscopist followed a self-designed, self-administered learning program in OD of colorectal lesions. An assessment phase divided in two halves with a 6-mo period in between without performance of OD was developed in a populationbased colorectal cancer screening program. The accomplishment of the Preservation and Incorporation of Valuable Endoscopic Innovations criteria and performance measures were calculated overall and in the two halves of the assessment phase, assessing their response to the 6-mo stopping period. The evolution of performance through blocks of 50 lesions was also assessed.RESULTS Overall, 152 patients and 522 lesions(≤ 5 mm: 399, and 6-9 mm: 123) were included. The negative predictive value for the OD of adenoma in rectosigmoid lesions diagnosed with high confidence was 91.7% [95% confidence interval(CI):87.3-96.6]. The proportion of agreement on surveillance interval between OD and pathological diagnosis was higher than 95%. Overall accuracy for diminutive lesions diagnosed with high confidence was 89.5%(95%CI: 86.3-92.7). The overall accuracy of OD was similar in the two halves of the assessment phase [90.1(95%CI: 85.6-94.7) vs 88.2(95%CI: 87.9-95.9)]. All the other performance parameters were also equivalent, except for specificity. Spec

关键词： Optical diagnosis Accuracy Learning Polyp Colonoscopy Education

Whole Chia Flour as Yield Enhancer, Potential Antioxidant and Input of n-3 Fatty Acid in a Meat Product

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Food and Nutrition Sciences 2016年第10期7卷 855-865页

作者： Carola noelia Riernersman Romero Ana Marí a Consejo Nacional de Investigaciones Cientí ficas y Té cnicas (CONICET) Roque S&aacute enz Peñ a Argentina Universidad Nacional del Chaco Austral (UNCAus) Roque S&aacute enz Peñ a Argentina

In this paper, the effect of the addition of whole chia flour and water at cooked fish burgers on yield, water and fat retention, n-3 fatty acids content and oxidative stability were studied. The results showed that 94% of yield, 92% of water retention and 97% of fat retention were achieved with the addition of 5.92 g of whole chia flour and 15 g of water per 100 g of burger. The n-3 fatty content increased from 704.57 ± 21.66 mg to 1551.71 ± 47.71 mg/100g of cooked burger when the chia flour was added, enhancing nutritional quality indices of lipid. A good oxidative stability, with minimum formation of conjugated dienes, hydroperoxides and thiobarbituric acid reactive substances during 30 days frozen storage was obtained too, probably due to the presence of polyphenolic compounds with antiradical activity and reducing power in the fibrous fraction of the flour chia. The results from the present study highlight remarkable technological applications of whole chia flour as food ingredient in the design of healthier fish meat commodities.

关键词： Freshwater Fish Whole Chia Flour Potential Antioxidant Yield Fortified Foods

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21世纪中国工会的角色

21世纪中国工会的角色

作者： PAULA noelia CUENCA 上海外国语大学

学位级别：硕士

本文致力于分析中国工会现状、角色及其相关举措。本文着力于分析两类不同工作人员:建筑工地上的外来务工人员以及就职于科技公司的办公室上班族。鉴于此两类工作人员作为劳动市场上两极化的区块地位,比较来源于此两个组别的相关结果非... 详细信息

本文致力于分析中国工会现状、角色及其相关举措。本文着力于分析两类不同工作人员:建筑工地上的外来务工人员以及就职于科技公司的办公室上班族。鉴于此两类工作人员作为劳动市场上两极化的区块地位,比较来源于此两个组别的相关结果非常有意义。驱使我选择这一主题作为硕士毕业论文研究课题的主要原因是关于业已存在的中国工会结构的一系列讨论,当与其他国家(尤其是西方国家)的工会比较时,二者之间的差异尤其巨大且明显。中国的工会主要职能在于与政府协作,建立并维持参与雇佣劳动关系各方之间的良好关系---这一特征已被广泛讨论,其争论点主要在于,如果工会依赖于政府,工会成员的利益是否能被此种形态代表并实现?在完成相关研究后,我们可以发现,针对中国现阶段国情,工会与政府合作共生这一模式被证明是更加有效率的。并且,工会对劳动市场所产生的影响及其有利结果无疑是被低估了的。此文另一目的在于记录中国工会发生的积极变革,展现其在改善工作环境、稳定雇佣关系及提高工人生活水准等方面做出的贡献。对任何社会来说,工会在平衡雇佣关系中各方利益及稳定劳动力市场方面都有非常重要的作用,然而在中国,这一领域现阶段重要的特征之一就是劳动市场各要素的瞬息万变。因此,工会尝试各种创新及调整自身角色的一系列行为也都显得合情合理,并且确立其社会角色也是工会工作进程中的关键环节,其重要性不应被劳动市场中的各方低估。在此议题中,本文讨论了工会应如何深化其角色及工会向更加全社会导向的方向转变,而不是仅仅聚焦于提高待遇等方面。此外,工会不应仅仅存在于工厂/单位中。此前由于种种因素被忽略的另外一个群体---办公室上班族正在成为劳动力市场的主流,而工会也应着力于为此群体发声,例如私企员工。此项研究取材于于调研上海这样一个集多文化熔炉及金融中心职能于一体的大都市的工人群体。研究过程主要采取面对面采访的形式,获取劳动者们对于工会作用及存在怎样问题的相关观点。通过着一些列信息,我们可以客观地评估工会是否发挥了其职能帮助了劳动者;如果没有,哪些方面可以针对性地进行提高。工会作为劳动力市场双方“传译者”的角色非常重要,劳动者们对于工会的观点对于工会的发展意义重大。如果劳动者失去了对工会的信任,则其所有努力都会付诸东流。本文用一整张的篇幅讨论工会对于工人生活的各方面应有的贡献。就外来务工人员而言,文化生活是这一群体在工作地点及日常工作外的主要需求。外来务工人员缺乏必要的文化生活在某些情况下可能导致外来务工群体遭受歧视的境遇,并带来之后更大的一系列问题,如社会割裂加剧。除此以外,外来务工人员在工作内遇到的最大问题之一是薪水的拖欠。针对这个问题,政府及工会投入了诸多精力,并大大减少了这一现象存在。谈到办公室上班族群体,访谈结果展现给了我们一副完全不同的图景。上班族们通常更担忧健康问题,而非其薪水报酬。他们的工作环境导致了不断增长的健康问题及相关讨论;此外,不良的生活习惯及缺乏锻炼使这一情况更加糟糕。除此以外,上班族群体表现出了对企业福利的更大需求,最重要的是,他们寄希望于工会采取行动帮助其争取此类福利。这个议题与其说是存在的问题,不如说是一个业已存在的、工会组织可以利用来切实帮助并更接近这一群体的机会。研究表明,工会在协助这一群体上并不活跃。上班族群体在需要帮助时会主动寻求工会的帮助,工会组织也做出了相应的回应,给予了这一群体客观的帮助,但是问题在于,在绝大多数案例中都是上班族群体主动寻求工会的援助,而工会很少主动试图了解这一群体的需求并提供援助。研究表明,工会做出了大量努力确保劳动者的权利得到尊重,但是其在推进外来务工人员文化生活提高及解决上班族群体健康问题等议题上的努力并不足够。在相应章节中,本文提出了几条建议,可作为提高改进工会工作的参考意见。除通过面谈获得的相关数据信息外,其他间接信息源包括近期与工会及劳动者权益相关的新闻和学术研究论文。鉴于近期这一领域研究的不足,本文的一个重要目的在于展现当今这一领域的情况。为此,对近期活动的分析占据了本文相当大的篇幅。本文分析了中国工会的真实现状,并记录了近期的一系列变动,因此,本文对于相关领域研究存在着相当可观的潜在贡献。特别是在过去8年,中国的情况发生了巨大的改变。虽然在其他国家也许不同,但近年来的巨大变革使得中国面临着诸多新问题。本文可以被作为一个工具,用来分析全新的形势,以及工会在这样形势下的建设性新角色,尤其是与固有角色的对比。希望此文能对之后涉及此课题的学术研究讨论作出积极贡献。当今社会,工会在各方面变得日益多元化,大众对雇佣双方关系的认知也从固有的“对抗”观念(更关注于雇佣关系双方消极、对抗的一面)向更加积极的方向转变---对双方关系的积极发展吸引更多关注,并对更具成果的对话产生更有信心。工会在当今社会创造了更多涉及社会整体的计划,而非像过去一样仅仅聚焦于劳资双方的冲突以及劳动者群体及其家庭本身。

关键词：中国工会中国总工会劳动力市场外来务工人员上班族

3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration

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Bioactive Materials 2021年第4期6卷 1073-1082页

作者： María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni Maastricht University MERLN Institute for Technology-Inspired Regenerative MedicineComplex Tissue Regeneration DepartmentUniversiteitssingel 406229ERMaastrichtthe Netherlands TECNALIA Basque Research and Technology Alliance(BRTA)Mikeletegi Pasealekua 220009Donostia-San SebastianSpain Prolabin&Tefarm S.r.l. Via Dell’Acciaio906134PerugiaItaly d Nadir S.r.l.Via Torino155/b30172VeniceItaly Department of Environmental Sciences Informatics and StatisticsCa’Foscari University of VeniceDorsoduro 324630172VeniceItaly Department of Physics and Astronomy Padova UniversityVia Marzolo835131PadovaItaly

Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention.

关键词： Melt extrusion additive manufacturing Antibiotic delivery Lamellar inorganic fillers Bone infection Bone regeneration Human mesenchymal stromal cells

Role of STIM1 in neurodegeneration

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World Journal of Biological Chemistry 2018年第2期9卷 16-24页

作者： Carlos Pascual-Caro noelia Espinosa-Bermejo Eulalia Pozo-Guisado Francisco Javier Martin-Romero Department of Biochemistry and Molecular Biology School of Life Sciences and Institute of Molecular Pathology Biomarkers University of Extremadura Department of Cell Biology School of Medicine and Institute of Molecular Pathology Biomarkers University of Extremadura

STIM1 is an endoplasmic reticulum(ER) protein with a key role in Ca^(2+)mobilization. Due to its ability to act as an ER-intraluminal Ca^(2+) sensor, it regulates store-operated Ca^(2+) entry(SOCE), which is a Ca^(2+) influx pathway involved in a wide variety of signalling pathways in eukaryotic cells. Despite its important role in Ca^(2+) transport, current knowledge about the role of STIM1 in neurons is much more limited. Growing evidence supports a role for STIM1 and SOCE in the preservation of dendritic spines required for long-term potentiation and the formation of memory. In this regard, recent studies have demonstrated that the loss of STIM1, which impairs Ca^(2+) mobilization in neurons, risks cell viability and could be the cause of neurodegenerative diseases. The role of STIM1 in neurodegeneration and the molecular basis of cell death triggered by low levels of STIM1 are discussed in this review.

关键词： Calcium Neurodegeneration Parkinson's disease Alzheimer's disease STIM1 Voltage-operated Ca2+ channels