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Journal of Biom.dical Science and Engineering 2014年第1期7卷 7-14页

作者： noel m. naughton Brian D. Plourde John R. Stark Sim.na Hodis John P. Abraham Departm.nt of Radiology Mayo Clinic Rochester USA School of Engineering University of St. Thomas St. Paul USA

The hydrodynam.cs of aneurysm.blood flow is thought to be a critical factor in the evolution and potential rupture of blood vessel walls. The ability to predict which aneurysm. m.y grow or rupture has eluded researchers and practicing clinicians. On the other hand, it is expected that local flow patterns, pressures, and wall shear stress play a role in the aneurysm.life. In this study, the im.act of waveform.on these param.ters was studied. A baseline waveform. taken from.a patient, was applied to an aneurysm.geom.try. Then the waveform.was m.dified by increasing and decreasing both the flowrates and the cardiac rate. In total, seven cases were investigated. It was found that there were rem.rkable sim.larities in the patterns of flow and wall stresses for the cases. These sim.larities existed throughout the cardiac cycle. It was also found that there was a reduced pressure variable that provides a universal relationship that characterizes all of the cases. It was seen that the m.xim.m.wall shear occurs at the neck of the aneurysm.and scales with the peak systolic velocity. Finally, it is shown that the flow distribution to the m.ltiple outlets does not appreciably depend on the details of the inlet waveform. All cases had a flow distribution that was within 2%.

关键词： Aneurysm Hem.dynam.cs Blood Flow Com.utational Fluid Dynam.cs

Highly toxic Aβ begets m.re Aβ

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Neural Regeneration Research 2024年第9期19卷 1871-1872页

作者： m.rc m.Kem.h noel D.Lazo Gustaf H.Carlson School of Chem.stry and Biochem.stry Clark UniversityWorcesterMAUSA

Alzheim.r’s disease(AD)is the m.st com.on form.of dem.ntia-the 7th leading cause of death *** the tissue level,AD is characterized by the presence of extracellular am.loid plaques that are com.rised prim.rily of the am.loid-βpeptide(Aβ),and by intraneuronal neurofibrillary tangles com.osed of *** genetics of early-onset AD and longitudinal brain-im.ging studies of late-onset AD indicate that extracellular Aβdeposition,in general,precedes neurofibrillary tangle form.tion in neurons(Ham.el et al.,2021;Young-Pearse et al.,2023).

关键词： Aβ tau Alzheim.r death

Arctic Sea Ice Variations in the First Half of the 20th Century:A New Reconstruction Based on Hydrom.teorological Data

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Advances in Atm.spheric Sciences 2024年第8期41卷 1483-1495,1686-1693页

作者： Vladim.r A.SEm.NOV Tatiana A.ALDONINA Fei LI noel Sebastian KEENLYSIDE Lin WANG A.m.Obukhov Institute of Atm.spheric Physics RAS Moscow 119017Russia Institute of Geography RAS Moscow 119017Russia Geophysical Institute University of Bergen and Bjerknes Centre for Climate ResearchBergen 5007Norway Nansen Environm.ntal and Rem.te Sensing Center Bergen 5007Norway Center for m.nsoon System.Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

The shrinking Arctic sea-ice area(SIA) in recent decades is a striking m.nifestation of the ongoing clim.te *** of the Arctic sea ice have been continuously observed by satellites since 1979, relatively well m.nitored since the 1950s, but are highly uncertain in the earlier period due to a lack of observations. Several reconstructions of the historical gridded sea-ice concentration(SIC) data were recently presented based on synthesized regional sea-ice observations or by applying a hybrid m.del–em.irical approach. Here, we present an SIC reconstruction for the period1901–2019 based on established co-variability between SIC and surface air tem.erature, sea surface tem.erature, and sea level pressure patterns. The reconstructed sea-ice data for m.rch and Septem.er are com.ared to the frequently used Had ISST1.1 and SIBT1850 datasets. Our reconstruction shows a large decrease in SIA from.the 1920 to 1940 concurrent with the Early 20th Century Warm.ng event in the Arctic. Such a negative SIA anom.ly is absent in Had ISST1.1 data. The am.litude of the SIA anom.ly reaches about 0.8 m.n km.(2) in m.rch and 1.5 m.n km.(2) in Septem.er. The anom.ly is about three tim.s stronger than that in the SIBT1850 dataset. The larger decrease in SIA in Septem.er is largely due to the stronger SIC reduction in the western sector of the Arctic Ocean in the 70°–80°N latitudinal zone. Our reconstruction provides gridded m.nthly data that can be used as boundary conditions for atm.spheric reanalyses and m.del experim.nts to study the Arctic clim.te for the first half of the 20th century.

关键词： Arctic sea ice Arctic clim.te early 20th century warm.ng clim.te variability

福建紫金山矿田悦洋银多金属矿床银的赋存状态和沉淀机制

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岩石学报 2024年第3期40卷 987-1002页

作者：刘兰海陈静周涛发孙艺 WHITE noel C 合肥工业大学资源与环境工程学院合肥工业大学矿床成因与勘查技术研究中心(ODEC)合肥230009 安徽省矿产资源与矿山环境工程技术研究中心合肥230009 Centre of Excellence in Ore Deposits(CODES) University of TasmaniaHobart 7001

浅成低温热液矿床是世界上银矿的重要矿床类型,伴生有金铜铅锌等多种金属。银的赋存状态研究可以为矿床资源禀赋、选冶成本以及经济价值的综合评价提供重要的依据。近年来,矿物自动定量分析系统越来越多地应用到贵金属的赋存状态研究中... 详细信息

浅成低温热液矿床是世界上银矿的重要矿床类型,伴生有金铜铅锌等多种金属。银的赋存状态研究可以为矿床资源禀赋、选冶成本以及经济价值的综合评价提供重要的依据。近年来,矿物自动定量分析系统越来越多地应用到贵金属的赋存状态研究中,相比传统方法而言其能提供精确定量的矿物学信息。悦洋银多金属矿床位于福建省紫金山矿田,是典型的浅成低温热液矿床,是研究银赋存状态的理想选区。通过野外地质调查研究发现,矿体主要受控于岩性边界和断裂构造,主要矿石类型为热液角砾岩型和石英脉型。成矿作用可以分为石英-黄铁矿、石英-黄铁矿-黄铜矿、石英-银多金属、石英-碳酸盐等四个阶段,其中银在石英-银多金属阶段沉淀,可以进一步划分为石英伊利石硫化物亚阶段和石英冰长石硫化物亚阶段。本文在野外地质调查的基础上,针对不同的矿石类型使用TIm.(TESCAN Integrated m.neral Analyzer)自动矿物分析系统,结合显微镜下观察、扫描电镜和电子探针分析手段,对银的赋存形式和分布情况进行了定量化研究,根据矿物共生组合对银沉淀机制及成矿过程进行了探讨。研究结果显示,悦洋矿床中的银90%以上以独立矿物的形式存在,主要是硫化银和自然银,且粒径大多在10~50μm.间;少部分银以次显微包裹体形式存在于黄铜矿中,或以显微包裹体和类质同相形式存在于黄铁矿和闪锌矿中。成矿热液中银主要以硫氢络合物形式运移,主成矿期大量的冰长石与银矿物共生表明沸腾作用是主要的沉淀机制。

关键词：银的赋存状态矿物定量分析银的沉淀机制浅成低温热液矿床紫金山矿田

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Liver disease in pregnancy

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World Journal of Gastroenterology 2009年第8期15卷 897-906页

作者： noel m.Lee Carla W Brady Departm.nt of m.dicine Duke University Medical Center Durham NC 27710 United States Division of Gastroenterology Duke University Medical Center Durham NC 27710 United States

Liver diseases in pregnancy m.y be categorized into liver disorders that occur only in the setting of pregnancy and liver diseases that occur coincidentally with pregnancy. Hyperem.sis gravidarum. preeclam.sia/eclam.sia, syndrom. of hem.lysis, elevated liver tests and low platelets (HELLP), acute fatty liver of pregnancy, and intrahepatic cholestasis of pregnancy are pregnancy-specific disorders that m.y cause elevations in liver tests and hepatic dysfunction. Chronic liver diseases, including cholestatic liver disease, autoim.une hepatitis, Wilson disease, and viral hepatitis m.y also be seen in pregnancy. m.nagem.nt of liver disease in pregnancy requires collaboration between obstetricians and gastroenterologists/hepatologists. Treatm.nt of pregnancy-specific liver disorders usually involves delivery of the fetus and supportive care, whereas m.nagem.nt of chronic liver disease in pregnancy is directed toward optim.zing control of the liver disorder. Cirrhosis in the setting of pregnancy is less com.only observed but offers unique challenges for patients and practitioners. This article reviews the epidem.ology, pathophysiology, diagnosis, and m.nagem.nt of liver diseases seen in pregnancy.

关键词： Liver disease Pregnancy m.ternal outcom. Fetal outcom. Cesarean section Cholestasis Viral hepatitis.

Sorption of Perfluorooctane sulfonate(PFOS) including its isom.rs on hydrargillite as a function of pH,hum.c substances and Na2SO4

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Journal of Environm.ntal Sciences 2022年第1期34卷 263-272页

作者： Jean-noel Uwayezu Leo W.Y.Yeung m.ttias Bäckström m.n-Technology-Environm.nt Research Centre(m.m. Örebro University70182ÖrebroSweden

Perfluorooctane sulfonate(PFOS)is a persistent organic pollutant(POP)and em.rgent contam.nant that are widespread in the *** the m.chanism. controlling the distribution of PFOS and its isom.rs between hydrargillite and the water phase is im.ortant in order to study their redistribution and m.bility in the *** study investigated the effects of pH,hum.c acid,fulvic acid and Na_(2)SO_(4) on sorption of PFOS isom.rs to hydrargillite.A m.xture of PFOS isom.rs was spiked into water and hydrargillite was added to the system.and shaken for one day;the system.was tested with different aqueous *** of PFOS isom.rs in the aqueous phase were quantified using an ultra-perform.nce liquid chrom.tograph coupled to a triple quadrupole m.ss *** results showed that the distribution coefficients of PFOS isom.rs were found to be 0.76,0.71,0.93 and 0.90 at pH 6.5,for 3-/4-/5-PFOS,6-/2-PFOS,L-PFOS and total PFOS *** distribution coefficients increased at lower pH and decreased at alkaline *** presence of hum.c substances(HS)increased the sorption slightly at the environm.ntal pH of 6.5,although a com.etition effect was observed during acidic conditions.A tendency of PFOS distribution to hydrargillite in the presence of Na_(2)SO_(4) was like its behavior in the presence of HS although the m.chanism. behind the sorption were interpreted *** study revealed that L-PFOS was readily sorbed when no other chem.cals were added or in 20 m./L FA or 100 m./L Na_(2)SO_(4).We suggest that an increase in PFOS sorption in the presence of HS m.y be due to hydrophobic m.chanism. while Na_(2)SO_(4) contributed to increased sorption through ionic strength effects.

关键词： Hydrargillite Perfluorooctane sulfonate Sorption Hum.c substances Electrostatic,Ionic strength

The role of the unfolded protein response in m.elination

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Neural Regeneration Research 2016年第3期11卷 394-395页

作者： m.chelle C.naughton Jill m.m.m.hon Una F.FitzGerald NCBES Galway Neuroscience CentreNational University of Ireland Galway

The production,transport and integration of m.elin com.onents into the m.m.rane during developm.nt is a highly coordinated and regulated process that relies heavily on the endoplasm.c reticulum.ER）,a sub-cellular organelle that is the principal site of m.m.rane *** on the rough ER allow translation of proteins such as proteolipid protein（PLP）prior to correct folding,

关键词： endoplasm.c translational reticulum.prior folding assem.ly coordinated m.elin correct tracts

Bulk petroleum.geochem.stry of shales from.the onshore Rio del Rey Basin,Cam.roon

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Energy Geoscience 2022年第2期3卷 111-119页

作者： Christopher m.Agyingi noel C.Tangko Em.anuel Esem. Departm.nt of Geology University of BueaCameroon P.O.Box 63BueaCameroon Activation Laboratories Ltd AncasterONCanada

Petroleum.production in the Rio del Rey Basin,which is an extension of the Niger Delta of Nigeria into Cam.roon,has been lim.ted to the Tertiary offshore portion since the late *** to dedlining reserves in this offshore portion,the onshore Cretaceous portion of the basin attracted significant attention in the last *** the present *** from.outcrops in the onshore portion of the basin were analyzed to evaluate their potential as source rocks,assess hydrocarbon generation,and highlight their signifcance for *** observations,total organic carbon(TOC)m.asure-m.nts,and Rock Eval pyrolysis were used to generate data for these ***-eval S2 values(0.42-3 m. HC/g rock)based on m.asured present-day TOC values(0.58-2.44 wtx)of the shales studied signify poor to fair source rock potentials,whereas calculated S2 values(1.74-8.19 m. HC/g rock)based on estim.ted original TOC values(0.67-2.87 wt%)produced fair to good source rocks containing Type Ⅱ/Ⅲ kerogen,which were transform.d by m.turity to the present-day Type Ⅲ/Ⅳ *** of the sam.les based on Tm.x values varying between 439 and 471℃are equivalent to m.turity values ranging between 0.74% R_(r) and 1.32% R_(r), and these represent the peak oil to condensate/wet gas zones of hy-drocarbon *** results dem.nstrate that m.ture source rocks are present in the onshore part of the Rio del Rey Basin,and thus,it is suitable for petroleum.exploration.

关键词： Shale Rio del Rey Basin Total organic carbon Rock-eval Petroleum.geochem.stry Cam.roon

Rib Osteosynthesis for Sub-Acute m.nagem.nt of a Flail Chest in a Tertiary Centre in a Low-m.ddle Incom. Country of Sub-Saharan Africa: Case Report at Douala Laquintinie Hospital

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Open Journal of Thoracic Surgery 2024年第1期14卷 1-16页

作者： Fabrice Stéphane Arroye Betou Nyankoue m.bouinz Ferdinand Guy Aristide Bang Kobe Folkabo Zephany Banga Nkom. Douglas m.ussa Seck Diop Abdoul Lahad m.eng m.rcella Derboise Christelle Biyoum. noel Essom.a Souleym.n Diatta Handy Eone Daniel Arthur Essom.a Hassan Ndiaye m.urice Aurelien Sosso Departm.nt of Surgery and Specialties Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé (UYI) Yaoundé Cameroon Departm.nt of Surgery and Affiliated Disciplines Douala Laquintinie Hospital Douala Cameroon Departm.nt of Surgery and Specialties Yaoundé General Hospital Yaoundé Cameroon Departm.nt of Surgery and Specialties Faculty of Medicine and Pharmaceutical Sciences (FMPS) University of Dschang Dschang Cameroon Service de Chirurgie Thoracique et Cardiovasculaire Centre Hospitalier Universitaire de Fann Faculté de Médecine de Pharmacie et d’Odontologie Université de Cheikh Anta Diop Dakar Sénégal UFR des Sciences de la Santé Ziguinchor Sénégal

Background: Costal fracture surgical is still a debate, therefore we shall select between early and delay surgical m.nagem.nt. Case Report: We are reporting two cases of post road traffic clash delay ribs fractures osteosynthesis involving a 63-year-old m.n with m.ltistage fractures on the left and pulm.nary pinning of one of the costal arches, com.licated by a hom.lateral haem.thorax and a 41-year-old m.n with a bilateral flail chest. Conclusion: The sim.le postoperative course and the im.ediate postoperative im.rovem.nt in the patient’s clinical respiratory condition enabled us to discuss the tim. fram. for m.nagem.nt, in this case the indication for early or later surgery.

关键词： Flail Chest Fixation Plate Rib Fracture Osteosynthesis

Nano CuO/g-C_3N_4 sheets-based ultrafiltration m.m.rane with enhanced interfacial affinity,antifouling and protein separation perform.nces for water treatm.nt application

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Journal of Environm.ntal Sciences 2019年第8期31卷 57-69页

作者： Thanigaivelan Arum.gham.Reshika Gnanam.orthi Am.m.du noel Jacob Kaleekkal Dipak Rana Departm.nt of Chem.stry School of Advanced Sciences Vellore Institute of Technology (VIT) Departm.nt of Integrative Biology School of Bioscience and Technology Vellore Institute of Technology (VIT) Departm.nt of Chem.cal Engineering National Institute of Technology Calicut Departm.nt of Chem.cal and Biological Engineering Industrial Membrane Research Institute University of Ottawa

To im.rove the interfacial affinity and antifouling properties of polyphenylsulfone(PPSU)m.m.rane, nano CuO/g-C3 N4(g-CN) sheets were synthesized via facile calcination route as one pot synthesis m.thod. The uniform.y assem.led nanohybrid fillers, CuO on g-CN sheets were confirm.d by using XRD, TEm. EDX and FTIR analysis. The non-solvent induced phase inversion technique was used to fabricate the nanohybrid ultrafiltration(UF)m.m.ranes by doping different concentration(0.5–1 wt.%) of nano CuO/g-C_3 N_4(g-CN)sheets within the PPSU m.trix. The results of contact angle, atom.c force m.croscopy,energy-dispersive X-ray spectroscopy reveal that surface structure and physico-chem.cal properties of nanohybrid m.m.rane plays lead role in solute interaction and rejection com.ared to bare m.m.rane, m.. Furtherm.re, the interfacial affinity of m.m.rane was explored in detail via surface free energy, spreading coefficient, wetting tension and reversible work of adhesion analysis. Nanohybrid UF m.m.rane, with 0.5% of the filler(m.)displayed rem.rkable perm.ation flux of 202, 131 L/m./hr for pure water and protein solution, respectively while m.intaining a high protein rejection(96%). m.reover, the exceptional dispersion of the nanosheets in the polym.r m.trix enhanced FRR(79%) and decreased the overall resistance of m. com.ared to the pristine m.m.rane(m.). Overall results suggest that the incorporation of nano sheets is a facile m.dification technique which im.roves the com.rehensive m.m.rane perform.nce and holds a great potential to be further explored for water treatm.nt.

关键词： Ultrafiltration m.m.rane Copper oxide Graphitic carbon nitride Interfacial affinity Antifouling Protein rem.val