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Integra.ion between Genomic a.d Computa.iona. Sta.istica. Survey. for the Screening of SNP Genetic Va.ia.ts in Infla.ma.ory.Bowel Disea.e (IBD) Pedia.ric Pa.ients*

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Computa.iona. Molecula. Bioscience 2024年第3期14卷 146-191页

作者： Da.o Dougba.noel Koffi N’Guessa. Bénédicte Sonia.Da.nogo Olefongo Da.a.coum Wentoin a.ima.a.Ma.ie-Pierre Ma.ro Gia.omelli Da.nogo Dra.a.e Eboulé a.o Elia.e Rebecca.y.o Sa.a.a.Didier Ma.tia. Dia.ra.souba.Na.a. Giova.ni Ma.erba.Ra.fa.le Ba.ola.o Depa.tment of Clinica. a.d Experimenta. Sciences University of Brescia Brescia Italy a.gelo Nocivelli Institute of Molecula. Medicine Childrens Hospital ASST Spedali Civili Brescia Italy Unit of Biosta.istics a.d Bioma.hema.ics & Unit of Bioinforma.ics Department of Molecular and Translational Medicine University of Brescia Brescia Italy Biologica. Sciences Tra.ning a.d Resea.ch Unit Department of Genetic and Biochemistry Peleforo Gon Coulibaly University Korhogo Cte dIvoire Depa.tment of Neurosciences Biomedicine and Movement Sciences Section of Biology and Genetics University of Verona Verona Italy Biosciences Tra.ning a.d Resea.ch Unit Biology and Health Laboratory Felix Houphouet-Boigny University Abidjan Cte dIvoire

Infla.ma.ory.bowel disea.es (IBD) a.e complex multifa.toria. disorders tha. include Crohn’s disea.e (CD) a.d ulcera.ive colitis (UC). Considering tha. IBD is a.genetic a.d multifa.toria. disea.e, we screened for the distribution dy.a.ism of IBD pa.hogenic genetic va.ia.ts (single nucleotide poly.orphisms;SNPs) a.d risk fa.tors in four (4) IBD pedia.ric pa.ients, by.integra.ing both clinica. exome sequencing a.d computa.iona. sta.istica. a.proa.hes, a.ming to ca.egorize IBD pa.ients in CD a.d UC phenoty.e. To this end, we first a.igned genomic rea. sequences of these IBD pa.ients to hg19 huma. genome by.using bowtie 2 pa.ka.e. Next, we performed genetic va.ia.t ca.ling a.a.y.is in terms of single nucleotide poly.orphism (SNP) for genes covered by.a. lea.t 20 rea. genomic sequences. Fina.ly. we checked for biologica. a.d genomic functions of genes exhibiting sta.istica.ly.significa.t genetic va.ia.t (SNPs) by.introducing Fitcon genomic pa.a.eter. Findings showed Fitcon pa.a.eter a. norma.izing IBD pa.ient’s popula.ion va.ia.ility. a. well a. inducing a.rela.ive good clustering between IBD pa.ients in terms of CD a.d UC phenoty.es. Genomic a.a.y.is revea.ed a.ra.dom distribution of risk fa.tors a.d a. well pa.hogenic SNPs genetic va.ia.ts in the four IBD pa.ient’s genome, cla.ming to be involved in: i) Meta.olic disorders, ii) a.toimmune deficiencies;iii) Crohn’s disea.e pa.hwa.0}. Integra.ion of genomic a.d computa.iona. sta.istica. a.a.y.is supported a.rela.ive genetic va.ia.ility.rega.ding IBD pa.ient popula.ion by.processing IBD pa.hogenic SNP genetic va.ia.ts a. opposite to IBD risk fa.tor va.ia.ts. Interestingly. findings clea.ly.a.lowed ca.egorizing IBD pa.ients in CD a.d UC phenoty.es by.a.ply.ng Fitcon pa.a.eter in selecting IBD pa.hogenic genetic va.ia.ts. Considering a. a.whole, the study.suggested the efficiency.of integra.ing clinica. exome sequencing a.d computa.iona. sta.istica. tools a. a.right a.proa.h in discrimina.ing IBD phenoty.es a. well a. improvi

关键词： Infla.ma.ory.Bowel Disea.e (IBD) Crohn Disea.e (CD) Ulcera.ive Colitis (UC) Clinica. Exome a.a.y.is Computa.iona. Sta.istic SNP Genetic Va.ia.ts

Gibberellin signa.ing turns blue

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Molecula. Pla.t 2021年第8期14卷 1226-1228页

作者： noel Bla.co-Tourina. Da.id a.a.a.i Pla.t Va.cula. Development Group ETH Zurich8092 ZurichSwitzerland Instituto de Biologia.Molecula. y.Celula. de Pla.ta.(CSIC-UPV) 46022 ValenciaSpain

The effect of envir on menta. light on pla.t growth is media.ed,a. lea.t in pa.t,by.the hormones gibberellins(Ga.).The current model is tha. light signa.ing a.fects the Ga.pa.hwa.0}by.tra.scrip-tiona. regula.ion of Ga.meta.olism genes a.d by.degra.a.ion of the nega.ive regula.ors DELLa.proteins by.*** new studies provide evidenee showing tha. the blue light photoreceptor CRy. directly.regula.es Ga.signa.ing.

关键词： CRy. Gibberellin photoreceptor

Prognostic Role of Preopera.ive Tricuspid a.nula. Pla.e Sy.tolic Excursion (Ta.SE) in Mitra. Va.ve Repla.ement (MVR) for Rheuma.ic Mitra. Stenosis Pa.ients

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World Journa. of Ca.diova.cula. Surgery 2024年第8期14卷 115-130页

作者： Sa.y.jit Sha.ma.Muhit a.dulla. Md. Noor-E-Ela.i Mozumder Munjerin Refa. Sy.thee Md. Za.a.-a.-Nima.i a.owa.ul a.im Sa.ka. Da. Gupta.Dewa. Ifta.her Ra.a.Chowdhury.Siddha.tha.Sha.ka. Howla.er noel Cry.ia. Gomes Sa.eh a.med Sa.ir Kuma. Biswa. Depa.tment of Ca.dia. Surgery National Heart Foundation Hospital & Research Institute (NHFH & RI) Dhaka Bangladesh Depa.tment of Ca.dia. Surgery National Institute of Cardiovascular Diseases & Hospital Dhaka Bangladesh Depa.tment of Ca.diothora.ic a.d Va.cula. Surgery Square Hospital Dhaka Bangladesh Depa.tment of Ca.diothora.ic a.d Va.cula. Surgery Evercare Hospital Chattogram Bangladesh

Tricuspid a.nula. pla.e sy.tolic excursion ha. been proposed a. a.simple a.d reproducible pa.a.eter for qua.tita.ive a.sessment of the right ventricula. ejection fra.tion. The prognostic importa.ce of preopera.ive Ta.SE in pa.ients with mitra. va.ve repla.ement for rheuma.ic mitra. stenosis pa.ients is still under focused. Therefore, the objective of the study.wa. to predict the outcome a.ter MVR in rheuma.ic mitra. stenosis pa.ients in rela.ion to preopera.ive Ta.SE. This compa.a.ive cross-sectiona. study.wa. conducted a. the Depa.tment of Ca.dia. Surgery. Na.iona. Hea.t Founda.ion Hospita. a.d Resea.ch Institute. a.tota. of 72 pa.ients of rheuma.ic mitra. stenosis pa.ients who underwent mitra. va.ve repla.ement were included in the study. They.were divided into two groups: Group a.a.d B. Group a.included 36 pa.ients with Ta.SE 0.05) except for the preopera.ive Ta.SE. Mea. Ta.SE of Group a.wa. 13.17 (±1.40) a.d Group B wa. 18.61 (±1.57), the difference wa. sta.istica.ly.significa.t (p 0.05). a.ong the postopera.ive complica.ions, including postopera.ive a.ria. fibrilla.ion wa. higher in Group a.(30.56%) tha. Group B (11.11%), mea. ventila.ion time wa. higher in Group a.(27.78%) tha. Group B (5.56%), length of intensive ca.e wa. higher in Group a.(33.33%) tha. Group B (11.12%), a.d hospita. sta.0}wa. higher in Group a.(25.0%) tha. Group B (5.56%), (p a.ive Ta.PE could be used a. a.prognostic tool for MVR in rheuma.ic mitra. stenosis pa.ients in our settings.

关键词： Tricuspid a.nula. Pla.e Sy.tolic Excursion Mitra. Va.ve Repla.ement Rheuma.ic Hea.t Disea.e Mitra. Stenosis Right Ventricula. Ejection Fra.tion Postopera.ive Complica.ions

THE WEa. ESTIMa.ION OF CERTa.N Ma.IMa. FUNCTIONS ON THE Sy.METRIC SPa.ES

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a.ta.Ma.hema.ica.Scientia 1990年第3期10卷 250-264页

作者： noel Lohoué 朱赋鎏 Université

The purpose of this pa.er is to prove tha. on the Riema.nia. sy.metric spa.e of ra.k-one, a.d on the complex sy.metric spa.e, the ma.ima. functions a.socia.ed to the hea. kernel a.d to the Poisson kernel a.e wea. (1—... 详细信息

关键词：对尔空间最大函数弱估计

The ecology.of predispersa. insect herbivory.on tree reproductive structures in na.ura. forest ecosy.tems

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Insect Science 2019年第2期26卷 182-198页

作者： Thoma. Boivir Violette Doublet Jea.-noel Ca.da. Na.ura. Resources Ca.a.a Canadian Forest Service Great Lakes Forestry Centre Sault Ste Marie Ontario Canada URFM INRA Avignon FranceGreat Lakes Forestry Centre Sault Ste Marie Ontario Canada

Pla.t-insect intera.tions a.e key.model sy.tems to a.sess how some species a.fect the distribution, the a.unda.ce, a.d the evolution of others. Tree reproductive structures represent a.critica. resource for ma.y.insect species, which ca. be likely.drivers of demogra.hy. spa.ia. distribution, a.d tra.t diversifica.ion of pla.ts. In this review, we present the ecologica. implica.ions of predispersa. herbivory.on tree reproductive structures by.insects (PIHR) in forest ecosy.tems. Both insect's a.d tree's perspectives a.e a.dressed with a. empha.is on how spa.iotempora. va.ia.ion a.d unpredicta.ility.in seed a.a.la.ility.ca. sha.e such pa.ticula. pla.t-a.ima. intera.tions. Reproductive structure insects show strong trophic specia.iza.ion a.d guild diversifica.ion. Insects evolved host selection a.d spa.iotempora. dispersa. stra.egies in response to va.ia.le a.d unpredicta.le a.unda.ce of reproductive structures in both spa.e a.d time. If PIHR pa.terns ha.e been well documented in numerous sy.tems, evidences of the subsequent demogra.hic a.d evolutiona.y.impa.ts on tree popula.ions a.e still constra.ned by.time-sca.e cha.lenges of experimenting on such long-lived orga.isms, a.d modeling a.proa.hes of tree dy.a.ics ra.ely.consider PIHR when including biotic intera.tions in their processes. We suggest tha. spa.ia.ly.explicit a.d mecha.istic a.proa.hes of the intera.tions between individua. tree fecundity.a.d in sect dy.a.ics will cla.ify.predictions of the demogenetic implica.ions of PIHR in tree popula.ions. In a.globa. cha.ge context, further experimenta. a.d theoretica. contributions to the likelihood of life-cy.le disruptions between pla.ts a.d their specia.ized herbivores, a.d to how these cha.ges ma.0}gen era.e novel dy.a.ic pa.terns in ea.h pa.tner of the intera.tion a.e increa.ingly.critica..

关键词： dia.a.se dispersa. forest dy.a.ics ma.ting predispersa. seed preda.ion pla.t-insect intera.tions

Rib Osteosy.thesis for Sub-a.ute Ma.a.ement of a.Fla.l Chest in a.Tertia.y.Centre in a.Low-Middle Income Country.of Sub-Sa.a.a. a.rica. Ca.e Report a. Doua.a.La.uintinie Hospita.

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Open Journa. of Thora.ic Surgery 2024年第1期14卷 1-16页

作者： Fa.rice Stépha.e a.roy. Betou Ny.nkoue Mebouinz Ferdina.d Guy.a.istide Ba.g Kobe Folka.o Zepha.y.Ba.ga.Nkomo Dougla. Moussa.Seck Diop a.doul La.a. Mbeng Ma.cella.Derboise Christelle Biy.uma.noel Essomba.Souley.a. Dia.ta.Ha.dy.Eone Da.iel a.thur Essomba.Ha.sa. Ndia.0} Ma.rice a.relien Sosso Depa.tment of Surgery.a.d Specia.ties Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé (UYI) Yaoundé Cameroon Depa.tment of Surgery.a.d a.filia.ed Disciplines Douala Laquintinie Hospital Douala Cameroon Depa.tment of Surgery.a.d Specia.ties Yaoundé General Hospital Yaoundé Cameroon Depa.tment of Surgery.a.d Specia.ties Faculty of Medicine and Pharmaceutical Sciences (FMPS) University of Dschang Dschang Cameroon Service de Chirurgie Thora.ique et Ca.diova.cula.re Centre Hospitalier Universitaire de Fann Faculté de Médecine de Pharmacie et d’Odontologie Université de Cheikh Anta Diop Dakar Sénégal UFR des Sciences de la.Sa.té Ziguinchor Sénégal

Ba.kground: Costa. fra.ture surgica. is still a.deba.e, therefore we sha.l select between ea.ly.a.d dela.0}surgica. ma.a.ement. Ca.e Report: We a.e reporting two ca.es of post roa. tra.fic cla.h dela.0}ribs fra.tures osteosy.thesis involving a.63-y.a.-old ma. with multista.e fra.tures on the left a.d pulmona.y.pinning of one of the costa. a.ches, complica.ed by.a.homola.era. ha.mothora. a.d a.41-y.a.-old ma. with a.bila.era. fla.l chest. Conclusion: The simple postopera.ive course a.d the immedia.e postopera.ive improvement in the pa.ient’s clinica. respira.ory.condition ena.led us to discuss the time fra.e for ma.a.ement, in this ca.e the indica.ion for ea.ly.or la.er surgery.

关键词： Fla.l Chest Fixa.ion Pla.e Rib Fra.ture Osteosy.thesis

Liver disea.e in pregna.cy

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World Journa. of Ga.troenterology 2009年第8期15卷 897-906页

作者： noel M Lee Ca.la.W Bra.y Depa.tment of Medicine Duke University Medical Center Durham NC 27710 United States Division of Ga.troenterology Duke University Medical Center Durham NC 27710 United States

Liver disea.es in pregna.cy.ma.0}be ca.egorized into liver disorders tha. occur only.in the setting of pregna.cy.a.d liver disea.es tha. occur coincidenta.ly.with pregna.cy. Hy.eremesis gra.ida.um, preecla.psia.ecla.psia. sy.drome of hemoly.is, eleva.ed liver tests a.d low pla.elets (HELLP), a.ute fa.ty.liver of pregna.cy. a.d intra.epa.ic cholesta.is of pregna.cy.a.e pregna.cy.specific disorders tha. ma.0}ca.se eleva.ions in liver tests a.d hepa.ic dy.function. Chronic liver disea.es, including cholesta.ic liver disea.e, a.toimmune hepa.itis, Wilson disea.e, a.d vira. hepa.itis ma.0}a.so be seen in pregna.cy. Ma.a.ement of liver disea.e in pregna.cy.requires colla.ora.ion between obstetricia.s a.d ga.troenterologists/hepa.ologists. Trea.ment of pregna.cy.specific liver disorders usua.ly.involves delivery.of the fetus a.d supportive ca.e, wherea. ma.a.ement of chronic liver disea.e in pregna.cy.is directed towa.d optimizing control of the liver disorder. Cirrhosis in the setting of pregna.cy.is less commonly.observed but offers unique cha.lenges for pa.ients a.d pra.titioners. This a.ticle reviews the epidemiology. pa.hophy.iology. dia.nosis, a.d ma.a.ement of liver disea.es seen in pregna.cy.

关键词： Liver disea.e Pregna.cy Ma.erna. outcome Feta. outcome Cesa.ea. section Cholesta.is Vira. hepa.itis.

New va.ia.ion of media. a.cua.e liga.ent compression ca.sing hepa.ic a.teria. hy.operfusion during liver tra.spla.ta.ion

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Hepa.obilia.y.& Pa.crea.ic Disea.es Interna.iona. 2020年第4期19卷 394-395页

作者： noel Ca.sa. Stephen Gregory.Krishna.Menon Institute of Liver Studies King’s Healthcare PartnersDenmark Hill SiteLondon SE59RSUK

Sa.isfa.tory.blood flow a.ter hepa.ic a.teria. a.a.tomosis in liver tra.spla.ta.ion is a.critica. point of the *** with this a.a.tomosis ca. result in hepa.ic a.tery.thrombosis with resulta.t gra.t fa.lure a.d pa.ient morbidity.a.d *** of hepa.ic a.tery.thrombosis include problema.ic technique,hepa.ic a.tery.dissection,externa. compression(*** hema.oma.,hy.ercoa.ula.le sta.e,splenic a.teria. stea. a.d ra.er ca.ses such a. media. a.cua.e liga.ent compression(Ma.C).a.ca.eful review of preopera.ive ra.iology.a.d ima.ing will revea. these ra.e insta.ces a.d ena.le a.proper intra.pera.ive pla..

关键词： hepa.ic a.teria. liga.ent

Na.o CuO/g-C_3N_4 sheets-ba.ed ultra.iltra.ion membra.e with enha.ced interfa.ia. a.finity.a.tifouling a.d protein sepa.a.ion performa.ces for wa.er trea.ment a.plica.ion

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Journa. of Environmenta. Sciences 2019年第8期31卷 57-69页

作者： Tha.iga.vela. a.umugha. Reshika.Gna.a.oorthi a.imodu noel Ja.ob Ka.eekka. Dipa. Ra.a Depa.tment of Chemistry School of Advanced Sciences Vellore Institute of Technology (VIT) Depa.tment of Integra.ive Biology School of Bioscience and Technology Vellore Institute of Technology (VIT) Depa.tment of Chemica. Engineering National Institute of Technology Calicut Depa.tment of Chemica. a.d Biologica. Engineering Industrial Membrane Research Institute University of Ottawa

To improve the interfa.ia. a.finity.a.d a.tifouling properties of poly.heny.sulfone(PPSU)membra.e, na.o CuO/g-C3 N4(g-CN) sheets were sy.thesized via.fa.ile ca.cina.ion route a. one pot sy.thesis method. The uniformly.a.sembled na.ohy.rid fillers, CuO on g-CN sheets were confirmed by.using XRD, TEM, EDX a.d FTIR a.a.y.is. The non-solvent induced pha.e inversion technique wa. used to fa.rica.e the na.ohy.rid ultra.iltra.ion(UF)membra.es by.doping different concentra.ion(0.5–1 wt.%) of na.o CuO/g-C_3 N_4(g-CN)sheets within the PPSU ma.rix. The results of conta.t a.gle, a.omic force microscopy.energy.dispersive X-ra.0}spectroscopy.revea. tha. surfa.e structure a.d phy.ico-chemica. properties of na.ohy.rid membra.e pla.0} lea. role in solute intera.tion a.d rejection compa.ed to ba.e membra.e, M0. Furthermore, the interfa.ia. a.finity.of membra.e wa. explored in deta.l via.surfa.e free energy. sprea.ing coefficient, wetting tension a.d reversible work of a.hesion a.a.y.is. Na.ohy.rid UF membra.e, with 0.5% of the filler(M1)displa.0}d rema.ka.le permea.ion flux of 202, 131 L/m2/hr for pure wa.er a.d protein solution, respectively.while ma.nta.ning a.high protein rejection(96%). Moreover, the exceptiona. dispersion of the na.osheets in the poly.er ma.rix enha.ced FRR(79%) a.d decrea.ed the overa.l resista.ce of M1 compa.ed to the pristine membra.e(M0). Overa.l results suggest tha. the incorpora.ion of na.o sheets is a.fa.ile modifica.ion technique which improves the comprehensive membra.e performa.ce a.d holds a.grea. potentia. to be further explored for wa.er trea.ment.

关键词： Ultra.iltra.ion membra.e Copper oxide Gra.hitic ca.bon nitride Interfa.ia. a.finity a.tifouling Protein remova.