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CD4^(+)T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij J.P.Welters Tom de Wit Ellen Schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris L.Vos Charlotte L.Zuur noel F.C.C.de Miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTL)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IFNβvia the STING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer *** cooperation with CD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CTL response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CTL priming Tumor control

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Obtaining 2D Soil Geotechnical Profiles from Cokriging Interpolation of Sample Data and Electrical Resistivity Tomography (ERT)—Applications in Mass Movements Studies

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International Journal of Geosciences 2024年第7期15卷 525-548页

作者： Cassiano Antonio Bortolozo noel Howley Andy Legg Tristan Pryer Danielle Silva de Paula Tatiana Sussel Gonçalves Mendes Daniel Metodiev Marcio Roberto Magalhães de Andrade Silvio Jorge Coelho Simões Maiconn Vinicius de Moraes Marcio Augusto Ernesto de Moraes Luana Albertani Pampuch Rodolfo Moreda Mendes Harideva Marturano Egas Institute of Science and Technology So Paulo State University (UNESP) So Jos dos Campos Brazil Cemaden-National Center for Monitoring and Early Warning of Natural Disasters General Coordination of Research and Development So Jos dos Campos Brazil Institute for Mathematical Innovation University of Bath Bath UK department of Mathematical Sciences University of Bath Bath UK

Brazil annually faces significant challenges with mass movements, particularly in areas with poorly constructed housing, inadequate engineering, and lacking sanitation infrastructure. Campos do Jordão, in São Paulo state, is a city currently grappling with these issues. This paper details a study conducted within a pilot area in Campos do Jordão, where geophysical surveys and geotechnical borehole data were integrated. The geophysical surveys provided 2D profiles, and samples were collected to analyse soil moisture and plasticity. These datasets were combined using a Cokriging-based model to produce an accurate representation of the subsurface conditions. The enhanced modelling of subsurface variability facilitates a deeper understanding of soil behavior, which can be used to improve landslide risk assessments. This approach is innovative, particularly within the international context where similar studies often do not address the complexities associated with urban planning deficits such as those observed in some areas of Brazil. These conditions, including the lack of proper sanitation and irregular housing, significantly influence the geological stability of the region, adding layers of complexity to subsurface assessments. Adapting geotechnical evaluation methods to local challenges offers the potential to increase the efficacy and relevance of geological risk management in regions with similar socio-economic and urban characteristics.

关键词： Mass Movements Geophysics ERT Geotechnical Surveys Campos do Jordão Cokriging

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Human osteoclast formation and resorptive function on biomineralized collagen

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Bioactive Materials 2022年第2期7卷 241-252页

作者： Daniel de Melo Pereira noel Davison Pamela Habibovic department of Instructive Biomaterials Engineering MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ERMaastrichtThe Netherlands

Biomineralized collagen composite materials pose an intriguing alternative to current synthetic bone graft substitutes by offering a biomimetic composition that closely resembles native *** hypothesize that this composite can undergo cellular resorption and remodeling similar to natural *** investigate the formation and activity of human osteoclasts cultured on biomineralized collagen and pure collagen membranes in comparison to cortical bone *** monocytes/macrophages from peripheral blood differentiate into multinucleated,tartrate-resistant alkaline phosphatase(TRAP)-positive osteoclast-like cells on all *** cells form clear actin rings on cortical bone,but not on biomineralized collagen or pure collagen *** form resorption pits in cortical bone,resulting in higher calcium ion concentration in cell culture medium;however,osteoclast resorption of biomineralized collagen and collagen membranes does not measurably *** of osteoclast enzymes-TRAP,carbonic anhydrase II(CA-II),and cathepsin-K(CTS-K)-is similar on all substrates,despite phenotypic differences in actin ring formation and *** mesh-like structure,relatively low stiffness,and lack of RGD-containing binding domains are likely the factors responsible for preventing formation of stable actin rings on and resorption of(biomineralized)collagen *** insight helps to guide further research toward the optimized design of biomineralized collagen composites as a more biomimetic bone-graft substitute.

关键词： Osteoclastogenesis Osteoclast resorption Biomineralized collagen Intrafibrillar mineral Bone graft substitute

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Evaluating and quantifying the effect of various spruce budworm intervention strategies on forest carbon dynamics in Atlantic Canada

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Forest Ecosystems 2022年第4期9卷 547-557页

作者： Zelin Liu Changhui Peng David AMacLean Louis de Grandpre Jean-noel Candau Daniel Kneeshaw School of Geographic Sciences Hunan Normal UniversityChangsha410081China department of Biological Sciences University of Qu�ebec at MontrealMontrealQC H3C 3P8Canada Faculty of Forestry and Environmental Management University of New BrunswickFrederictonNB E3B 5A3Canada Laurentian Forestry Centre Canadian Forest ServiceNatural Resources CanadaQC G1V 4C7Canada Great Lake Forestry Centre Canadian Forest ServiceNatural Resources CanadaON P6A 2E5Canada

Spruce budworm (SBW) outbreaks are one of the most devastating natural disturbances in spruce-balsam fir forests of eastern North America. Both early intervention strategy (EIS) and foliage protection strategy (FP) are being tested to limit forest losses, but the quantitative impact on forest carbon (C) dynamics is still unclear. In this study, we designed 19 separate scenarios of no intervention or varying success of EIS, FP, and their combination on SBW caused defoliation and mortality. We then used the TRIPLEX-Insect model to quantify their effects on forest C dynamics in the forests of the four provinces of Atlantic Canada. A scenario applying FP to 10%of the area with the greatest potential C losses of living biomass, protecting foliage in 10%of the forests is more realistic than higher proportion of FP given the high cost and large areas involved, resulted in reducing average cumulative net ecosystem productivity (NEP) from 2020 to 2039 by 56%–127%compared to a no outbreak *** results showed that FP would have to be applied everywhere to reduce tree mortality and increase NEP more than 8 years of successful EIS applied. However, if EIS can be successfully implemented for 12 years, it will maintain more forest C than FP applied everywhere during a moderate outbreak. We also found that the combination of EIS followed by FP in 10%of the areas disturbed by the SBW could maintain average cumulative NEP at similar levels to no defoliation in every province of Atlantic Canada. Black/red spruce forests younger than 60years old underwent the smallest changes in C dynamics whether using EIS, FP, or both. This highlights the importance of forest species, forest age, and their interactions on the effectiveness of a treatment during SBW outbreak. Overall, 31%–76%of the study area in Atlantic Canada could convert from a C sink to a source by 2039,if no protective measures are used under the worst-case scenarios, thus contributing to future climate warming.

关键词： Annual defoliation Natural disturbance Forest protection Net ecosystem productivity TRIPLEX-Insect Conifers

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Rib Osteosynthesis for Sub-Acute Management of a Flail Chest in a Tertiary Centre in a Low-Middle Income Country of Sub-Saharan Africa: Case Report at Douala Laquintinie Hospital

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Open Journal of Thoracic Surgery 2024年第1期14卷 1-16页

作者： Fabrice Stéphane Arroye Betou Nyankoue Mebouinz Ferdinand Guy Aristide Bang Kobe Folkabo Zephany Banga Nkomo Douglas Moussa Seck Diop Abdoul Lahad Mbeng Marcella derboise Christelle Biyouma noel Essomba Souleyman Diatta Handy Eone Daniel Arthur Essomba Hassan Ndiaye Maurice Aurelien Sosso department of Surgery and Specialties Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé (UYI) Yaoundé Cameroon department of Surgery and Affiliated Disciplines Douala Laquintinie Hospital Douala Cameroon department of Surgery and Specialties Yaoundé General Hospital Yaoundé Cameroon department of Surgery and Specialties Faculty of Medicine and Pharmaceutical Sciences (FMPS) University of Dschang Dschang Cameroon Service de Chirurgie Thoracique et Cardiovasculaire Centre Hospitalier Universitaire de Fann Faculté de Médecine de Pharmacie et d’Odontologie Université de Cheikh Anta Diop Dakar Sénégal UFR des Sciences de la Santé Ziguinchor Sénégal

Background: Costal fracture surgical is still a debate, therefore we shall select between early and delay surgical management. Case Report: We are reporting two cases of post road traffic clash delay ribs fractures osteosynthesis involving a 63-year-old man with multistage fractures on the left and pulmonary pinning of one of the costal arches, complicated by a homolateral haemothorax and a 41-year-old man with a bilateral flail chest. Conclusion: The simple postoperative course and the immediate postoperative improvement in the patient’s clinical respiratory condition enabled us to discuss the time frame for management, in this case the indication for early or later surgery.

关键词： Flail Chest Fixation Plate Rib Fracture Osteosynthesis

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Variant of Wellen’s syndrome in type 1 diabetic patient: A case report

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世界心脏病学杂志:英文版(电子版) 2023年第9期15卷 462-468页

作者： Mukosolu Florence Obi Manjari Sharma Vikhyath Namireddy Paul Gargiulo Chelsea noel Cho Hyun Blossom de Gale Internal Medicine Wyckoff Heights Medical CenterBrooklynNY 11237United States Clinical Rotations St Georges UniversitySchool of MedicineTrue Blue 96038Grenada

BACKGROUND Wellen’s syndrome is a form of acute coronary syndrome associated with proximal left anterior descending artery(LAD)stenosis and characteristic electro-cardiograph(ECG)patterns in pain free *** abnormal ECG pattern is classified into type A(biphasic T waves)and type B(deeply inverted T waves),based on the T wave pattern seen in the pericodial chest *** SUMMARY We present the case of a 37-year-old male with history of type 1 diabetes mellitus(T1DM),gastroparesis,mild peripheral artery disease and right toe cellulitis on IV antibiotics who presented to the emergency department with nausea,vomiting and abdominal pain for 3 d and as a result couldn’t take his *** to have fasting blood sugar 392 mg/*** for diabetic *** the hospital course,the patient was asymptomatic and denied any chest *** admission,No ECG and troponin draws were *** day 2,the patient became hypoxic with oxygen saturation 80%on room air,intermittent mild right-sided chest pain which he attributed to vomiting from his *** ECG done was significant for Biphasic T wave changes in leads V2 and V3 and elevated high sensitivity *** was transitioned to cardiac intensive care unit and cardiac catheterization performed with result significant for extensive coronary artery *** This case highlights an exceptional manifestation of Wellen's syndrome,wherein the right coronary artery and circumflex artery display a remarkable 100%constriction,alongside a proximal LAD stenosis of 90%-95%.Notably,this occurrence transpired in a patient grappling with extensive complications arising from ***,it underscores the utmost significance of promptly recognizing the presence of Wellen's syndrome and swiftly initiating appropriate medical intervention.

关键词： Wellens’s syndrome Biphasic T waves deeply inverted T waves Precordial leads Left anterior descending artery Pseudo-normalization Right coronary artery Left circumflex artery Case report

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COVAD: Content-oriented video anomaly detection using a self attention-based deep learning model

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Virtual Reality & Intelligent Hardware 2023年第1期5卷 24-41页

作者： Wenhao SHAO Praboda RAJAPAKSHA Yanyan WEI Dun LI noel CRESPI Zhigang LUO College of Computer National University of Defense TechnologyChangsha 410073China Telecom SudParis IMTInstitut Polytechnique de ParisPalaiseau 91764France Zhengzhou College of Finance and Economics Zhengzhou 450000China

Background Video anomaly detection has always been a hot topic and has attracted increasing *** of the existing methods for video anomaly detection depend on processing the entire video rather than considering only the significant context. Method This paper proposes a novel video anomaly detection method called COVAD that mainly focuses on the region of interest in the video instead of the entire video. Our proposed COVAD method is based on an autoencoded convolutional neural network and a coordinated attention mechanism,which can effectively capture meaningful objects in the video and dependencies among different objects. Relying on the existing memory-guided video frame prediction network, our algorithm can significantly predict the future motion and appearance of objects in a video more effectively. Result The proposed algorithm obtained better experimental results on multiple datasets and outperformed the baseline models considered in our analysis. Simultaneously, we provide an improved visual test that can provide pixel-level anomaly explanations.

关键词： Video surveillance Video anomaly detection Machine learning deep learning Neural network Coordinate attention

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desorption Behavior and Thermogravimetric Analysis of Bio-Hardeners

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Journal of Renewable Materials 2022年第8期10卷 2015-2027页

作者： Benoit Ndiwe Antonio Pizzi Hubert Chapuis noel Konai Lionel Karga Pierre Girods Raidandi Danwe department of Mechanical Engineering Higher Technical Teacher Training College Douala(ENSET)University of DoualaDoualaCameroon Laboratory of Forest Resources and Wood Valorization(Larefob) ENSET of DoualaDoualaCameroon department of Engineering Science West UniversityTrollhättanSweden LERMAB-ENSTIB University of LorraineEpinal88051France Laboratoire D’Etudes et de Recherche sur le Matériau Bois LERMAB Facultédes Sciences et TechnologiesUniversitéde LorraineNancyFrance Laboratory of Materials Mechanics Structures and Integrated ManufacturingNational Advanced School of EngineeringYaoundé1 UniversityYaoundéCameroon department of Mechanical Petroleum and Gas Engineering Faculty of Mines and Petroleum IndustriesUniversity of MarouaKaéléCameroon Laboratory of Mechanic Materials and BuildingSahel Institute of Maroua UniversityMarouaCameroon

In this work,the thermal degradation and drying of bio-hardeners are *** bio-hardeners based on exudates of Senegalia senegal,Vachellia nilotica,Vachellia seyal,and Acacia siebteriana were analyzed by FTIR and thermogravimetric analysis,and a desorption study was also *** analysis by infrared spectroscopy indicates the existence of oligomers of different types all giving 5-hydroxy-2-hydroxymethylfuran and 2,5-dihydroxymethylfuran which are then the real hardening *** pyrolysis of these extracts reveals three main regions of mass loss,a first region is located between 25℃and 110℃reflecting the loss of water from the adhesive and the formation of some traces of volatile organic compounds such as CO_(2)and CO,a second zone characterized by the release of CO,CO_(2)and CH4 gases with peaks between 110°and 798.8℃.At the end of the analysis,about 22%of the initial mass remains undecomposed,this mass corresponds to the rigid segments of the bio-hardener which are not completely decomposed.

关键词： Exudates pyrolysis FTIR bio-hardener desorption

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Fault Ride-Through(FRT)Behavior in VSC-HVDC as Key Enabler of Transmission Systems Using SCADA Viewer Software

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Energy Engineering 2022年第6期119卷 2369-2406页

作者： Samuel Bimenyimana Chen Wang Godwin Norense Osarumwense Asemota Aphrodis Nduwamungu Francis Mulolani Jean de Dieu Niyonteze Shilpi Bora Chun-Ling Ho noel Hagumimana Theobald Habineza Waqar Bashir Yiyi Mo Intelligence and Automation in Construction Provincial Higher-Educational Engineering Research Centre Huaqiao UniversityXiamen361021China African Centre of Excellence in Energy for Sustainable development University of RwandaKigali4285Rwanda Fujian Province Key Laboratory of Automotive Electronics and Electric Drive Fujian University of TechnologyFuzhou350118China department of Climate Change Observatory Secretariat Ministry of EducationKigali4285Rwanda School of Electrical Engineering and Automation Tianjin Polytechnic UniversityTianjin300000China department of Electrical and Electronics Engineering Copperbelt UniversityKitwe23456Zambia Ajeenkya D Y PatilUniversity LohegaonPune412105India Carnegie Mellon University-Kigali Rwanda Campus Kigali4285Rwanda

The world’s energy consumption and power generation demand will continue to ***,the bulk of the energy resources needed to satisfy the rising demand is far from the load *** aforementioned requires long-distance transmission systems and one way to accomplish this is to use high voltage direct current(HVDC)transmission *** main technical issues for HVDC transmission systems are loss of synchronism,variation of quadrature currents,amplitude,the inability of station 1(rectifier),and station 2(inverter)to either inject,or absorb active,or reactive power in the network in any circumstances(before a fault occurs,during having a fault in network and after a fault cleared),and the variations of power transfer ***,faults impact power quality such as voltage dips and power line outage *** paper presents a method of overcoming the aforementioned technical issues using voltage-source converter(VSC)based HVDC transmission systems with SCADA VIEWER software and dynamic grid *** benefits include having a higher capacity transmission system and proposed best method for control of active and reactive power transfer *** results obtained using MATLAB validated the experimental results from SCADA Viewer *** results indicate that the station’s rectifier or inverter can either inject or absorb either active power or reactive power in any ***,the reverse power flow under different modes of operation can ride through *** a 100.0%power transfer rate,the rectifier injected 775.0 W into the *** a 0.0%power transfer rate,the rectifier injected 164.0 W into the *** a-100.0%rated power,the rectifier injected 1264.0 W into the network and direction was also changed.

关键词： Fault ride through capability dynamic grid fault simulator asymmetric components negative sequence control

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Changes in otolaryngology application requirements and match outcomes:Are we doing any better?

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第2期9卷 144-152页

作者： Emma de Ravin Ariel S.Frost Neal R.Godse Amber D.Shaffer noel Jabbour Barry M.Schaitkin Jason Newman Leila J.Mady department of Otorhinolaryngology-Head and Neck Surgery University of Pennsylvania Health SystemPhiladelphiaPennsylvaniaUSA Head and Neck Institute Cleveland ClinicClevelandOhioUSA Division of Pediatric Otolaryngology Children's Hospital of Pittsburgh of UPMCPittsburghPennsylvaniaUSA department of Otolaryngology University of Pittsburgh Medical CenterPittsburghPennsylvaniaUSA department of Otolaryngology-Head and NeckSurgery Medical Universityof South CarolinaCharlestonSouth CarolinaUSA MUSC Hollings Cancer Center CharlestonSouthCarolinaUSA department of Otolaryngology-Head and Neck Surgery Thomas Jefferson UniversityPhiladelphiaPennsylvaniaUSA Cancer Risk and Control Program of Excellence Sidney Kimmel Cancer CenterPhiladelphiaPennsylvaniaUSA

Objectives:Otolaryngology-specific requirements were piloted to minimize applicant and program *** investigated the impact of introducing and then removing these requirements on Match ***:2014-2021 National Resident Matching Program?data were *** primary outcome was the impact of Otolaryngology Resident Talent Assessment(ORTA;prematch 2017,postmatch 2019)and Program-Specific Paragraph(PSP;implemented 2016,optional 2018)on applicant numbers and match *** survey analysis assessed candidate perceptions of PSP/***:Applicant numbers declined significantly during PSP/ORTA(18.9%;p=0.001).With the optional PSP and postmatch ORTA,applicant numbers increased significantly(39.0%;p=0.002).Examined individually,mandatory PSP was associated with a significant decline in applicants(p=0.007),whereas postmatch ORTA was associated with significant increases in applicants(p=0.010).ORTA and PSP negatively impacted the decision to apply to otolaryngology in 59.8%and 51.3%of applicants,***,match rate success improved significantly from 74.8%to 91.2%during PSP/ORTA(p=0.014),followed by a significant decline to 73.1%after PSP was made optional and ORTA moved to postmatch(p=0.002).Conclusions:ORTA and PSP correlated with decreased applicant numbers and increased match rate *** programs seek ways to remove barriers to applying to otolaryngology,the potential consequences of an increasing pool of unmatched candidates must also be considered.

关键词： academic success internship and residency medical students otolaryngology surveys and questionnaires

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