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Congenital Heart Disease in Newborns: Epidemiological and Clinical Particularities in a Neonatology Department in Mali

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Open Journal of Pediatrics 2022年第5期12卷 857-866页

作者： Abdoul Karim Doumbia Oumou Koné Adama Dembélé Noumou Sidibé noel banou Hawa Gouro Diall Pierre Togo Oumar Coulibaly Karamoko Sacko Djéneba Konaté Tati Simaga Lala Ndrainy Sidibé Fatoumata Léonie Diakité Boubacar Diarra Guédiouma Dembélé Belco Maïga Mohamed Elmouloud Cissé Hawa Konaré Aminata Doumbia Ibrahim Ahamadou Abdoul Aziz Diakité Fatoumata Dicko Traoré Boubacar Togo Department of the CHU Gabriel Touré Bamako Mali

Introduction: Congenital heart disease is an important cause of mortality, chronic morbidity, and disability in children in poor countries. The objective of this study was to highlight the diversity of congenital heart defects in the neonatology department. Methodology: This work had taken place in a neonatology service over a period of six months from January 2019 to June 2019. It was a prospective descriptive study with information collected from the medical records of newborns with congenital heart disease. Results: Of 1478 neonates hospitalized during the study period, 41 had congenital heart disease, for a hospitalization rate of 2.77%. CHD accounted for 2.77% of neonatal hospitalizations. The sex ratio was 1.73 (26 boys/15 girls). Consanguinity was found in 19% of cases. The average time to consultation was 11 days. The main clinical signs were heart murmur (58%), respiratory distress (56%) and extracardiac malformations (54%). The main cardiac malformations found were atrial septal defect (46%), patent ductus arteriosus (44%), ventricular septal defect (17%), complete atrioventricular canal (15%), and transposition of the great vessels (5%). The case fatality rate was 29%. Conclusion: Delayed diagnosis, generally related to the long delay in consultation, and lack of surgical management partly explain this high case fatality.

关键词： Congenital Heart Disease Neonates Management

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Highly toxic Aβ begets more Aβ

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Neural Regeneration Research 2024年第9期19卷 1871-1872页

作者： Merc M.Kemeh noel D.Lazo Gustaf H.Carlson School of Chemistry and Biochemistry Clark UniversityWorcesterMAUSA

Alzheimer’s disease(AD)is the most common form of dementia-the 7th leading cause of death worldwide.At the tissue level,AD is characterized by the presence of extracellular amyloid plaques that are comprised primarily of the amyloid-βpeptide(Aβ),and by intraneuronal neurofibrillary tangles composed of tau.Molecular genetics of early-onset AD and longitudinal brain-imaging studies of late-onset AD indicate that extracellular Aβdeposition,in general,precedes neurofibrillary tangle formation in neurons(Hampel et al.,2021;Young-Pearse et al.,2023).

关键词： Aβ tau Alzheimer death

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Neonatal References: Epidemiology and Prognosis in a Malian Context

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Open Journal of Pediatrics 2021年第3期11卷 479-489页

作者： Fatoumata L. F. Diakité Djénèba Konaté Nouhoum L. Traoré noel banou Lala N. Sidibé Oumar Coulibaly Belco Maiga Karamoko Sacko Fousseyni Traoré Abdoul K. Doumbia Hawa G. Diall Leila Maiga Ibrahim Ahamadou Alou Traoré Adama Koné Guediouma Dembélé Djita Ba-Sidibé Pierre Togo Adama Dembélé El Mouloud Cissé Abdoul A. Diakité Boubacar Togo Mariam Sylla Fatoumata Dicko-Traoré Department of Pediatrics of the University Hospital Gabriel Toure Bamako Mali Reference Health Center of Commune IV Bamako Mali Pediatrician Doctor Practicing in Private Bamako Mali Hospital Mother-Child “Luxembourg” Bamako Mali Mali Hospital Bamako Mali Reference Health Center of Commune III Bamako Mali

Neonatal mortality remains a public health problem in Mali. The neonatal referral is a systemic factor determining the neonatal prognosis. This work was initiated to determine the frequency of neonatal referrals and to determine their prognosis. Patients and Methods: A cross-sectional study was carried out from November 1, 2019 to January 31, 2020 in the neonatology service of the pediatrics department of the Gabriel Toure University Hospital in Bamako. All newborns referred by another health structure in the country were included in this stud. All newborns referred by another health structure in the country were included in this study. To determine the risk factors related to the neonatal referral, we performed univariate and multivariate analyzes to determine the odds ratios and fitted with a significant p probability if p 0.05 and the 95% confidence interval. Results: The frequency of referrals was 54.3%. Newborns came from basic structures in 19.3% of cases, from tertiary structures in 6.7%. The main reason for transfer was prematurity (40.2%) followed by perinatal anoxia (15.3%), malformations (15.3%), respiratory distress (15.2%) and infection neonatal (9.1%). The ambulance was the primary means of transfer in 71.3%. <

关键词： Neonatal References Epidemiology Prognosis Malian Context

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Management of early oesophageal cancer:An overview

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1255-1258页

作者： Gavin G Calpin Matthew G Davey noel E Donlon Department of Surgery Royal College of Surgeons in IrelandDublin D2Ireland Department of Upper Gastrointestinal Surgery Beaumont HospitalDublin D09V2N0Ireland

The incidence of esophageal cancer,namely the adenocarcinoma subtype,continues to increase exponentially on an annual basis.The indolent nature of the disease renders a significant proportion inoperable at first presentation,however,with the increased utilisation of endoscopy,many early lesions are now being identified which are suitable for endotherapeutic approaches.This article details the options available for dealing with early esophageal cancer by endoscopic mean obviating the need for surgery thereby avoiding the potential morbidity and mortality of such intervention.

关键词： Esophageal cancer Endotherapy Endoscopic submucosal resection Endoscopic mucosal resection Endoscopy

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Projecting Spring Consecutive Rainfall Events in the Three Gorges Reservoir Based on Triple-Nested Dynamical Downscaling

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Advances in Atmospheric Sciences 2024年第8期41卷 1539-1558页

作者： Yanxin ZHENG Shuanglin LI noel KEENLYSIDE Shengping HE Lingling SUO Department of Atmospheric Science CMA-CUG Joint Centre for Severe Weather and Climate and Hydro-geological Hazards China University of Geosciences Geophysical Institute University of Bergen and Bjerknes Centre for Climate Research Institute of Atmospheric Physics and Climate Change Research Center Chinese Academy of Sciences Three Gorges National Climatological Observatory Nansen Environmental and Remote Sensing Center and Bjerknes Centre for Climate Research Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of Sciences

Spring consecutive rainfall events(CREs) are key triggers of geological hazards in the Three Gorges Reservoir area(TGR), China. However, previous projections of CREs based on the direct outputs of global climate models(GCMs) are subject to considerable uncertainties, largely caused by their coarse resolution. This study applies a triple-nested WRF(Weather Research and Forecasting) model dynamical downscaling, driven by a GCM, MIROC6(Model for Interdisciplinary Research on Climate, version 6), to improve the historical simulation and reduce the uncertainties in the future projection of CREs in the TGR. Results indicate that WRF has better performances in reproducing the observed rainfall in terms of the daily probability distribution, monthly evolution and duration of rainfall events, demonstrating the ability of WRF in simulating CREs. Thus, the triple-nested WRF is applied to project the future changes of CREs under the middle-of-the-road and fossil-fueled development scenarios. It is indicated that light and moderate rainfall and the duration of continuous rainfall spells will decrease in the TGR, leading to a decrease in the frequency of CREs. Meanwhile, the duration, rainfall amount, and intensity of CREs is projected to regional increase in the central-west TGR. These results are inconsistent with the raw projection of MIROC6. Observational diagnosis implies that CREs are mainly contributed by the vertical moisture advection. Such a synoptic contribution is captured well by WRF, which is not the case in MIROC6,indicating larger uncertainties in the CREs projected by MIROC6.

关键词： consecutive rainfall events geological hazards projection Three Gorges Reservoir area triple-nested downscaling

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福建紫金山矿田悦洋银多金属矿床银的赋存状态和沉淀机制

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岩石学报 2024年第3期40卷 987-1002页

作者：刘兰海陈静周涛发孙艺 WHITE noel C 合肥工业大学资源与环境工程学院合肥工业大学矿床成因与勘查技术研究中心(ODEC)合肥230009 安徽省矿产资源与矿山环境工程技术研究中心合肥230009 Centre of Excellence in Ore Deposits(CODES) University of TasmaniaHobart 7001

浅成低温热液矿床是世界上银矿的重要矿床类型,伴生有金铜铅锌等多种金属。银的赋存状态研究可以为矿床资源禀赋、选冶成本以及经济价值的综合评价提供重要的依据。近年来,矿物自动定量分析系统越来越多地应用到贵金属的赋存状态研究中... 详细信息

浅成低温热液矿床是世界上银矿的重要矿床类型,伴生有金铜铅锌等多种金属。银的赋存状态研究可以为矿床资源禀赋、选冶成本以及经济价值的综合评价提供重要的依据。近年来,矿物自动定量分析系统越来越多地应用到贵金属的赋存状态研究中,相比传统方法而言其能提供精确定量的矿物学信息。悦洋银多金属矿床位于福建省紫金山矿田,是典型的浅成低温热液矿床,是研究银赋存状态的理想选区。通过野外地质调查研究发现,矿体主要受控于岩性边界和断裂构造,主要矿石类型为热液角砾岩型和石英脉型。成矿作用可以分为石英-黄铁矿、石英-黄铁矿-黄铜矿、石英-银多金属、石英-碳酸盐等四个阶段,其中银在石英-银多金属阶段沉淀,可以进一步划分为石英伊利石硫化物亚阶段和石英冰长石硫化物亚阶段。本文在野外地质调查的基础上,针对不同的矿石类型使用TIMA(TESCAN Integrated Mineral Analyzer)自动矿物分析系统,结合显微镜下观察、扫描电镜和电子探针分析手段,对银的赋存形式和分布情况进行了定量化研究,根据矿物共生组合对银沉淀机制及成矿过程进行了探讨。研究结果显示,悦洋矿床中的银90%以上以独立矿物的形式存在,主要是硫化银和自然银,且粒径大多在10~50μm之间;少部分银以次显微包裹体形式存在于黄铜矿中,或以显微包裹体和类质同相形式存在于黄铁矿和闪锌矿中。成矿热液中银主要以硫氢络合物形式运移,主成矿期大量的冰长石与银矿物共生表明沸腾作用是主要的沉淀机制。

关键词：银的赋存状态矿物定量分析银的沉淀机制浅成低温热液矿床紫金山矿田

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Preface to the Special Topic on Ocean, Sea Ice and Northern Hemisphere Climate:In Remembrance of Professor Yongqi GAO's Key Contributions

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Advances in Atmospheric Sciences 2024年第8期41卷 1463-1464页

作者： noel KEENLYSIDE Shengping HE Fei LI Geophysical Institute University of Bergen and Bjerkenes Centre for Climate Research Nansen Environmental and Remote Sensing Center Nansen-Zhu International Research Center Institute of Atmospheric Physics Chinese Academy of Sciences

This special issue commemorates the life work of Prof. Yongqi GAO who passed away in July 2021, his time cut short by illness. He had many great achievements, but still much more to contribute. The seven articles in this special issue are from research areas where he contributed, and they illustrate how his close colleagues are continuing his work.

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Arctic Sea Ice Variations in the First Half of the 20th Century:A New Reconstruction Based on Hydrometeorological Data

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Advances in Atmospheric Sciences 2024年第8期41卷 1483-1495+1686-1693页

作者： Vladimir A.SEMENOV Tatiana A.ALDONINA Fei LI noel Sebastian KEENLYSIDE Lin WANG A.M.Obukhov Institute of Atmospheric Physics RAS Institute of Geography RAS Geophysical Institute University of Bergen and Bjerknes Centre for Climate Research Nansen Environmental and Remote Sensing Center Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of Sciences

The shrinking Arctic sea-ice area（SIA） in recent decades is a striking manifestation of the ongoing climate change.Variations of the Arctic sea ice have been continuously observed by satellites since 1979, relatively well monitored since the 1950s, but are highly uncertain in the earlier period due to a lack of observations. Several reconstructions of the historical gridded sea-ice concentration（SIC） data were recently presented based on synthesized regional sea-ice observations or by applying a hybrid model–empirical approach. Here, we present an SIC reconstruction for the period1901–2019 based on established co-variability between SIC and surface air temperature, sea surface temperature, and sea level pressure patterns. The reconstructed sea-ice data for March and September are compared to the frequently used Had ISST1.1 and SIBT1850 datasets. Our reconstruction shows a large decrease in SIA from the 1920 to 1940 concurrent with the Early 20th Century Warming event in the Arctic. Such a negative SIA anomaly is absent in Had ISST1.1 data. The amplitude of the SIA anomaly reaches about 0.8 mln km2in March and 1.5 mln km2in September. The anomaly is about three times stronger than that in the SIBT1850 dataset. The larger decrease in SIA in September is largely due to the stronger SIC reduction in the western sector of the Arctic Ocean in the 70°–80°N latitudinal zone. Our reconstruction provides gridded monthly data that can be used as boundary conditions for atmospheric reanalyses and model experiments to study the Arctic climate for the first half of the 20th century.

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Physical and Chemical Properties of Horns Sheaths Particles for the Manufacture of Composite Materials

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Journal of Materials Science and Chemical Engineering 2024年第5期12卷 1-9页

作者： Tawe Laynde Zakari Yaou Karga Tapsia Lionel Konai noel Danwe Raidandi Department of Wood Construction University Institute for Wood Technology University of Yaounde 1 Yaounde Cameroon Department of Industrial and Mechanical Engineering National Advance School of Engineering University of Yaounde 1 Yaounde Cameroon Department of Mechanical Petroleum and Gas Engineering National Advance School of Mines and Petroleum Industries University of Maroua Maroua Cameroon

Salvaged cow horns from slaughterhouses have been transformed into fine particles for a physical characterization that has led us to determine the humidity rate (2.34% ± 0.054%), the actual density situated between 0.586 g/cm3 and 0.732 g/cm3, the swelling rate (12%), and one chemical characterization that permitted us to determine the rate of dry matters (97.05%), of mineral matters (2.5%), of protein matters (94.52%). From these weak values, it can easily be seen that cow horn case doesn’t absorb much water and improve the mechanical characteristics of the composite;the high rate of protein shows that keratin which is the structural molecule favors its gripping as reinforcing element in the manufacturing of composite materials.

关键词： Horns Fibers Polymer Loads Physical Properties Chemical Composition

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Recent Ventures in Interdisciplinary Arctic Research:The ARCPATH Project

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Advances in Atmospheric Sciences 2024年第8期41卷 1559-1568页

作者： Astrid E.J.OGILVIE Leslie A.KING noel KEENLYSIDE Fran?ois COUNILLON Brynhildur DAVIDSDóTTIR Níels EINARSSON Sergey GULEV Ke FAN Torben KOENIGK James R.MCGOODWIN Marianne H.RASMUSSON Shuting YANG Swedish Meteorological and Hydrological Institute Danish Meteorological Institute Institute of Arctic and Alpine Research (INSTAAR) University of Colorado Stefansson Arctic Institute Royal Roads University University of Bergen Nansen Environmental and Remote Sensing Centre University of Iceland Shirshov Institute of Oceanology Moscow State University Chinese Academy of Sciences

This paper celebrates Professor Yongqi GAO's significant achievement in the field of interdisciplinary studies within the context of his final research project Arctic Climate Predictions: Pathways to Resilient Sustainable Societies-ARCPATH(https://www.***.is/en/projects/finished-projects/arcpath). The disciplines represented in the project are related to climatology, anthropology, marine biology, economics, and the broad spectrum of social-ecological studies. Team members were drawn from the Nordic countries, Russia, China, the United States, and Canada. The project was transdisciplinary as well as interdisciplinary as it included collaboration with local knowledge holders. ARCPATH made significant contributions to Arctic research through an improved understanding of the mechanisms that drive climate variability in the Arctic. In tandem with this research, a combination of historical investigations and social, economic, and marine biological fieldwork was carried out for the project study areas of Iceland, Greenland, Norway, and the surrounding seas, with a focus on the joint use of ocean and sea-ice data as well as social-ecological drivers. ARCPATH was able to provide an improved framework for predicting the near-term variation of Arctic climate on spatial scales relevant to society, as well as evaluating possible related changes in socioeconomic realms. In summary, through the integration of information from several different disciplines and research approaches, ARCPATH served to create new and valuable knowledge on crucial issues, thus providing new pathways to action for Arctic communities.

关键词： SEA-ICE INITIALIZATION PREDICTION SKILL CLIMATE SCIENCE

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