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Multidisciplinary therapy for treatment of patients with peritoneal carcinomatosis from gastric cancer

World Journal of Gastrointestinal Oncology 2010年第2期2卷 85-97页

作者： Yutaka Yonemura Ayman Elnemr Yoshio Endou Mitsumasa Hirano Akiyoshi Mizumoto nobuyuki takao Masumi Ichinose Masahiro Miura NPO Organization to Support Peritoneal Dissemination Treatment KishiwadaOsaka 596-0032Japan Department of Experimental Therapeutics Cancer Research InstituteKanazawa University Department of Surgery Kusatsu General Hospital Department of Anatomy School of Medicine Ooita University

There is no standard treatment for peritoneal carcinomatosis (PC) from gastric cancer.A novel multidisciplinary treatment combining bidirectional chemotherapy [neoadjuvant intraperitoneal-systemic chemotherapy protocol (NIPS)],peritonectomy,hyperthermic intraperitoneal chemoperfusion (HIPEC) and early postoperative intraperitoneal chemotherapy has been *** this article,we assess the indications,safety and eff icacy of this treatment,review the relevant studies and introduce our *** aims of NIPS are stage reduction,the eradication of peritoneal free cancer cells,and an increased incidence of complete cytoreduction (CC-0) for PC.A complete response after NIPS was ob-tained in 15 (50%) out of 30 patients with ***,a signif icantly high incidence of CC-0 can be obtained in patients with a peritoneal cancer index (PCI) ≤ *** a multivariate analysis to examine the survival benef it,CC-0 and NIPS are identified as significant indicators of a good ***,the high morbidity and mortality rates associated with peritonectomy and perioperative chemotherapy make stringent patient selection *** best indications for multidisciplinary therapy are localized PC (PCI≤6) from resectable gastric cancer that can be completely removed during a *** and complete cytoreduction are essential treatment modalities for improving the survival of patients with PC from gastric cancer.

关键词： Gastric cancer Peritoneal carcinomatosis Chemotherapy

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Effect of Fluidic Diode on Performance of Unidirectional Impulse Turbine

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Journal of Thermal Science 2024年第3期33卷 807-814页

作者： DODDAMANI Hithaish ABDUS Samad MANABU takao SHINYA Okuhara M M ASHRAFUL Alam Department of Ocean Engineering Indian Institute of Technology MadrasChennai600036India Department of Mechanical Engineering National Institute of TechnologyMatsue CollegeShimane6908518Japan Center of Support Practical Education National Institute of TechnologyMatsue CollegeShimane6908518Japan Department of Transportation Engineering Osaka Sangyo UniversityDaito5748530Japan

A pair of unidirectional turbines(UT)can operate in oscillatory airflow without additional ***,this arrangement suffers from poor flow rectification.A fluidic diode(FD)offers variable hydrodynamic resistance based on the flow direction,and this can be coupled with UT to improve flow *** this work,a numerical investigation on the effect of FD with UT is presented using the commercial fluid dynamics software ANSYS Fluent 16.1 with k-ωSST turbulence closure *** domains of UT and FD are numerically validated individually with experimental ***,both are coupled to obtain the combined effect,and these results are compared with the analytical *** was observed that coupling FD with UT improved the unit's performance at the lower flow coefficient(<1),but its performance decreased as the flow coefficient *** to the diode's presence,fluid leaving the turbine experiences higher resistance at a higher flow coefficient,which decreases the overall performance of the combined unit.

关键词： wave energy oscillating water column unidirectional impulse turbine fluidic diode flow rectification

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Peritoneal mesothelioma

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 114-125页

作者： Yutaka Yonemura Haruaki Ishibashi Akiyoshi Mizumoto Takuji Fujita Yang Liu Satoshi Wakama Syouzou Sako nobuyuki takao Toshiyuki Kitai Kanji Katayama Yasuyuki Kamada Keizou Taniguchi Daisuke Fujimoto Asian School of Peritoneal Surface Malignancy Treatment Kyoto CityKyoto 600-8189 Japan Department of Regional Cancer Therapy Peritoneal Dissemination CenterKishiwada Tokushukai HospitalKishiwada CityOosaka 596-8522 Japan Department of Regional Cancer Therapy Peritoneal Dissemination CenterKusatsu General HospitalKusatsu CityShiga 525-8585 Japan Department of Surgery Mizonokuchi HospitalTeikyo UniversitySchool of MedicineKawasakiKanagawa 213-8507Japan

This review provides an overview of articles about peritoneal mesothelioma(PM)to analyze the effect of treatment modalities on response rates,post-treatment side effects,morbidity and mortality,and *** survival in months following systemic chemotherapy(SC)ranged from 8.7 to 26.8 ***,no patient was reported to have survived for more than five years with SC *** contrast,comprehensive treatment that included cytoreductive surgery(CRS)+perioperative chemotherapy(POC)showed a significantly longer median survival time than SC ***,CRS+POC demonstrated 10-year survival rates of 12%-35%.Accordingly,CRS+POC is an innovative treatment that provides long-term survival in selected patients with *** criteria are performance status(ECOG PS≤1),the absence of extraperitoneal metastasis,PCI less than cutoff levels(from<10 to<28),MIB-1 index(<10),and histologic type(epithelioid type).Postoperative morbidity and mortality rates after CRS+POC were significantly higher than with more conventional ***,CRS and POC should be done at the specialized peritoneal surface malignancy centers.

关键词： Peritoneal mesothelioma mesothelioma intraperitoneal chemotherapy HIPEC peritonectomy

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Using orbital sensitivity analysis to pinpoint the role of orbital interactions in thermoelectric power factor

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npj Computational Materials 2023年第1期9卷 937-945页

作者： Wenhao Zhang Jean-François Halet takao Mori WPI Center for Materials Nanoarchitectonics(MANA) National Institute for Materials ScienceTsukubaJapan Graduate School of Pure and Applied Sciences University of TsukubaTsukubaJapan CNRS-Saint-Gobain-NIMS Laboratory for Innovative Key Materials and Structures(LINK)National Institute for Materials ScienceTsukubaJapan

The modification of the electronic band structure is of critical importance for thermoelectric materials whose heat to electricity power generation is related to carrier effective mass and alignment of semiconductor band *** approach to optimize the electronic band structure is by modification of orbital interactions through doping or *** the current ab-initio quantum chemical calculations can help us to investigate orbital components of electronic bands,they reveal little information on the relative tunability of electronic states and transport properties with respect to orbital *** this work,we present a method,based on a symmetry-adapted tight-binding model and sensitivity analysis,that can pinpoint the role of orbital interactions in determining electronic band structure and transport *** an application,a systematic theoretical analysis is used to show how the power factor of PbTe can/cannot be improved by playing with interatomic orbital *** orbital interaction sensitivity analysis introduced in this work can easily be applied to other compounds or properties.

关键词： properties orbital symmetry

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P-Frobenius问题与p-对称数值半群

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浙江理工大学学报（自然科学版） 2024年第2期51卷 265-270页

作者：应皓天小松尚夫浙江理工大学理学院杭州310018

针对p-Frobenius问题中出现的非对称性问题,利用数值半群理论以及Apery集等工具研究了p-Frobenius问题对应的p-对称数值半群。首先利用数值半群和Apery集等工具对p-Frobenius问题进行预处理,得到了对应数值半群和Apery集的各个变量;并... 详细信息

针对p-Frobenius问题中出现的非对称性问题,利用数值半群理论以及Apery集等工具研究了p-Frobenius问题对应的p-对称数值半群。首先利用数值半群和Apery集等工具对p-Frobenius问题进行预处理,得到了对应数值半群和Apery集的各个变量;并将这些变量与对称数值半群和Frobenius问题进行对比,由此定义了p-对称数值半群,并给出了p-对称性的刻画。在此基础上,首先给出了两大类p-对称数值半群,其次研究了对称数值半群与p-对称数值半群的p化关联性。这两类p-对称数值半群给出了大量具体实例,而p化关联性则可用于处理p-Frobenius问题中出现的非对称问题。

关键词：数值半群线性丢番图方程 Apery集对称性 Frobenius问题

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Recent progress in solution-processed flexible organic photovoltaics

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npj Flexible Electronics 2022年第1期6卷 871-884页

作者： Lulu Sun Kenjiro Fukuda takao Someya Thin-Film Device Laboratory RIKEN2-1 HirosawaWakoSaitama 351-0198Japan Center for Emergent Matter Science(CEMS) RIKEN2-1 HirosawaWakoSaitama 351-0198Japan Department of Electrical Engineering and Information Systems School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

The certified power conversion efficiency(PCE)of organic photovoltaics(OPV)fabricated in laboratories has improved dramatically to over 19%owing to the rapid development of narrow-bandgap small-molecule acceptors and wide bandgap polymer donor *** next pivotal question is how to translate small-area laboratory devices into large-scale commercial *** requires the OPV to be solution-processed and flexible to satisfy the requirements of high-throughput and large-scale production such as roll-to-roll *** review summarizes and analyzes recent progress in solution-processed flexible *** a detailed discussion from the perspective of the behavior of the narrow bandgap small-molecule acceptor and wide bandgap polymer donor active layer in solution-processed flexible devices,the existing challenges and future directions are discussed.

关键词： donor narrow translate

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Excited state calculations using variational quantum eigensolver with spin-restricted ansätze and automatically-adjusted constraints

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npj Computational Materials 2023年第1期9卷 2204-2212页

作者： Shigeki Gocho Hajime Nakamura Shu Kanno Qi Gao takao Kobayashi Taichi Inagaki Miho Hatanaka School of Fundamental Science and Technology Faculty of Science and TechnologyKeio UniversityYokohama 223-8522Japan Quantum Computing Center Keio UniversityYokohama 223-8522Japan IBM Quantum–IBM Research Tokyo Tokyo 103-8510Japan Mitsubishi Chemical Corporation Science&Innovation CenterYokohama 227-8502Japan

The ground and excited state calculations at key geometries, such as the Frank–Condon (FC) and the conical intersection (CI)geometries, are essential for understanding photophysical properties. To compute these geometries on noisy intermediate-scalequantum devices, we proposed a strategy that combined a chemistry-inspired spin-restricted ansatz and a new excited statecalculation method called the variational quantum eigensolver under automatically-adjusted constraints (VQE/AC). Unlike theconventional excited state calculation method, called the variational quantum deflation, the VQE/AC does not require the pre-determination of constraint weights and has the potential to describe smooth potential energy surfaces. To validate this strategy,we performed the excited state calculations at the FC and CI geometries of ethylene and phenol blue at the complete active spaceself-consistent field (CASSCF) level of theory, and found that the energy errors were at most 2 kcal mol−1 even on the ibm_kawasakidevice.

关键词： properties quantum variational

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Comprehensive treatment for the peritoneal metastasis from gastric cancer

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World Journal of Surgical Procedures 2015年第2期5卷 187-197页

作者： Yutaka Yonemura Emel Canbay Yoshio Endou Haruaki Ishibashi Akiyosi Mizumoto Yan Li Yang Liu Kazuyoshi Takeshita Masumi Ichinose nobuyuki takao Takuya Saitou Kousuke Noguchi Masamitu Hirano Oliver Glehen Bjorn Br?cher Paul H Sugarbaker NPO to Support Peritoneal Surface Malignancy Treatment Department of Regional Cancer Therapies Peritoneal Surface Malignancy Center Kishiwada Tokusyukai Houspital Kusatsu General Hospital Department of Experimental Therapeutics Cancer Research Institute Kanazawa University Department of Surgery Wuhan University Dēpartement de Chirurgie Gēnerale Centre Hospitalier Lyon-Sud Hospices Civils de Lyon Surgical Oncology Department of Surgery T?bingen Comprehensive Cancer center University of T?bingen Center of Gastrointestinal Malignancies Program in Peritoneal Surface Malignancies Med Star Washington Hospital Center

Recently, a novel comprehensive treatment consisting of cytoreductive surgery(CRS) and perioperative chemotherapy(POC) was developed for the treatment of peritoneal metastasis(PM) with a curative intent. In the treatment, the macroscopic disease is completely removed by the peritonectomy techniques in combination with POC. This article reviews the results of the comprehensive treatment for PM from gastric cancer, and verifies the effects of CRS and POC, including neoadjuvant chemotherapy(NAC) and hyperthermic intraoperative intraperitoneal chemotherapy(HIPEC). Completeness of cytoreduction, peritoneal carcinomatosis index(PCI) less than the threshold levels after NAC,absence of ascites, cytologic status, pathologic response after NAC are the independent prognostic factors. Among these prognostic factors, PCI threshold level is the most valuable independent prognostic factor. After staging laparoscopy, patients with PM from gastric cancer are recommended to treat with NAC before CRS. After NAC, indication for CRS is determined by laparoscopy. The indications of the comprehensive treatment are patients with PCI less than the threshold levels, negative cytology, and responders after NAC. Patients satisfy these factors are the candidates for the CRS and HIPEC.

关键词： Gastric cancer Hyperthermic intraoperative intraperitoneal chemotherapy Peritoneal metastasis Peritonectomy

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Effect of a combination of astaxanthin supplementation, heat stress, and intermittent reloading on satellite cells during disuse muscle atrophy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第11期19卷 844-852页

作者： Toshinori YOSHIHARA takao SUGIURA nobuyuki MIYAJI Yuki YAMAMOTO Tsubasa SHIBAGUCHI Ryo KAKIGI Hisashi NAITO Katsumasa GOTO Daijiro OHMORI Toshitada YOSHIOKA Graduate School of Health and Sports Science Juntendo UniversityInzaiChiba 270-1695Japan Faculty of Education Yamaguchi UniversityYamaguchiYamaguchi 753-8513Japan Toyo Koso Kagaku Co.Ltd. UrayasuChiba 279-0041Japan Institute of Health and Sports Science Kurume UniversityKurumeFukuoka 839-8502Japan Institute of Liberal Arts and Science Kanazawa UniversityKanazawaIshikawa 920-1192Japan Faculty of Medicine Juntendo UniversityBunkyo-kuTokyo 113-0033Japan Graduate School of Health Sciences Toyohashi SOZO UniversityToyohashiAichi 440-8511Japan Department of Chemistry School of MedicineJuntendo UniversityInzaiChiba 270-1695Japan Hirosaki Gakuin University HirosakiAomori 036-8577Japan

We examined the effect of a combination of astaxanthin （AX） supplementation, repeated heat stress, and intermittent reloading （IR） on satellite cells in unloaded rat soleus muscles. Forty-nine male Wistar rats （8-week-old） were divided into control, hind-limb unweighting （HU）, IR during HU, IR with AX supplementation, IR with repeated heat stress （41.0-41.5 ℃ for 30 min）, and IR with AX supplementation and repeated heat stress groups. After the experimental period, the antigravitational soleus muscle was analyzed using an immunohistochemical technique. Our results revealed that the combination of dietary AX supplementation and heat stress resulted in protection against disuse muscle atrophy in the soteus muscle. This protective effect may be partially due to a higher satellite cell number in the atrophied soleus muscle in the IR/AX/heat stress group compared with the numbers found in the other groups. We concluded that the combination treatment with dietary AX supplementation and repeated heat stress attenuates soleus muscle atrophy, in part by increasing the number of satellite cells.

关键词： Antioxidant astaxanthin Disuse muscle atrophy Heat stress Satellite cell

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Saccharomyces cerevisiae in neuroscience:how unicellular organism helps to better understand prion protein?

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Neural Regeneration Research 2021年第3期16卷 489-495页

作者： takao Ishikawa Department of Molecular Biology Institute of BiochemistryFaculty of BiologyUniversity of WarsawWarsawPoland

The baker's yeast Saccharomyces(S.)cerevisiae is a single-celled eukaryotic model organism widely used in research on life *** a unicellular organism,*** has some evident limitations in application to ***,yeast prions are extensively studied and they are known to share some hallmarks with mammalian prion protein or other amyloidogenic proteins found in the pathogenesis of Alzheimer's,Parkinson's,or Huntington's ***,the yeast *** has been widely used for basic research on aggregation properties of proteins in cellulo and on their ***,a yeast-based study revealed that some regions of mammalian prion protein and amyloidβ1–42 are capable of induction and propagation of yeast *** is one of the examples showing that evolutionarily distant organisms share common mechanisms underlying the structural conversion of prion proteins making yeast cells a useful system for studying mammalian prion *** has also been used to design novel screening systems for anti-prion compounds from chemical *** assays are cheap in maintenance and safe for the researcher,making them a very good choice to perform preliminary screening before further characterization in systems engaging mammalian cells infected with *** this review,not only classical red/white colony assay but also yeast-based screening assays developed during last year are *** analysis and research carried out using yeast prions force us to expect that prions are widely present in ***,the last few years brought us several examples indicating that the mammalian prion protein is no more peculiar protein–it seems that a better understanding of prion proteins nature-wide may aid us with the treatment of prion diseases and other amyloid-related medical conditions.

关键词： amyloid artificial prion baker's yeast budding yeast drug screening fusion protein neurodegenerative diseases prion protein yeast-based assay

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