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npj Computational Materials 2020年第1期6卷 1446-1454页

作者： Akiko Ueda Yijin Zhang nobuyuki Sano Hiroshi Imamura Yoshihiro Iwasa National Institute of Advanced Industrial Science and Technology(AIST) Spintronics Research CenterTsukuba 305-8568Japan Department of Electrical Engineering Columbia UniversityNew YorkNYUSA The Institute of Scientific and Industrial Research Osaka UniversityOsaka 067-0047Japan Max Planck Institute for Solid State Research 70569 StuttgartGermany Institute of Applied Physics University of TsukubaTsukuba 305-8573Japan Department of Applied Physics and Quantum-Phase Electronics(QPEC)Center The University of TokyoTokyo 113-8656Japan RIKEN Center for Emergent Matter Science(CEMS)Wako 351-0198Japan

Ionic gating is known as a powerful tool for investigation of electronic functionalities stemming from low voltage transistor operation to gate-induced electronic phase control including ***-dimensional(2D)material is one of the archetypal channel materials which exhibit a variety of gate-induced ***,the device simulations on such iongated transistor devices have never been reported,despite its importance for the future design of device *** this paper,we developed a drift-diffusion(DD)model on a 2D material,WSe2 monolayer,attached with an ionic liquid,and succeeded in simulating the transport properties,potential profile,carrier density distributions in the transistor configuration.

关键词： transistor bipolar diffusion

Reductive transformation of CO_2:Fluoride-catalyzed reactions with waste silicon-based reducing agents

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Chinese Journal of Catalysis 2017年第3期38卷 434-439页

作者： Ken Motokura Masaki Naijo Sho Yamaguchi Akimitsu miyaji Toshihide Baba 东京工业大学材料和化工技术学院化工科学与工程系日本横滨226-8502

CO_2 is one of the most important ＂renewable＂ carbon *** transform CO_2 to useful organic compounds,we examined the reactivity of two model silicon-based ＂waste＂ materials,disilanes and metallic Si powder,as reducing *** these reactions,fluoride salts were found to be active catalysts：CO_2 was converted to formic acid at atmospheric pressure in the presence of H_2O as a proton source and the silicon-based reducing *** on in-situ NMR and kinetics analyses,a hydrosilane and penta-coordinate Si species are proposed as the reaction intermediate and active species,respectively.

关键词： Carbon dioxide Fluoride Homogeneous catalysis Formic acid Disilane

Predictive factors for efficacy of testosterone replacement therapy for late-onset hypogonadism in Japanese men:a preliminary report

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Asian Journal of Andrology 2023年第5期25卷 587-590页

作者： nobuyuki Kondoh Yohei Kaizuka Seiji Nagasawa Yoshikazu Togo Shingo Yamamoto Department of Urology Kawanishi City Medical CenterKawanishiHyogo 6660017Japan Department of Urology Hyogo Medical UniversityNishinomiyaHyog 6638501Japan

Although testosterone replacement therapy(TRT)is the first-choice method used worldwide for late-onset hypogonadism(LOH),clinical benefits are not seen in all *** study was conducted to determine the predictors of TRT efficacy for ***-six patients who visited our Men’s Health Clinic(Kawanishi City Medical Center,Kawanishi and Hyogo Medical University,Nishinomiya,Hyogo,Japan)between November 2003 and June 2021 with data available before and after TRT were *** were divided into responders(Group 1;n=45,accounting for 80.4%)and nonresponders(Group 2;n=11,accounting for 19.6%)based on the clinical response to TRT,including patient *** noted before TRT included age,body mass index,aging males’symptoms score,sexual health inventory for men,luteinizing hormone,follicular-stimulating hormone,testosterone,free testosterone,prolactin(PRL),estradiol(E2),and testosterone/estradiol(T/E2)ratio in *** statistical analysis,a multivariable logistic regression model was *** analysis revealed PRL(odds ratio TORI:0.9624;95%confidence interval[Cl]:0.9316-0.9943,P<0.05),E2(OR:0.8692;95%Cl:0.7745-0.9754,P<0.05),and T/E2 ratio(OR:1.1312;95%Cl:1.0106-1.2661,P<0.05)to be predictive *** analyses showed that T/E2 ratio was an independent predictive factor(OR:1.1593;95%Cl:1.0438-1.2875,P<0.01).The present results suggest that a low value for T/E2 ratio may predict a reduced response to *** T/E2 ratio threshold to predict nonresponders based on receiver-operating characteristics(ROC)curve analysis was shown to be *** additional studies with larger number of patients are necessary,we propose the determination of serum E2 level and testosterone level prior to performing TRT.

关键词： estradiol late-onset hypogonadism predictive factor testosterone treatment

Ultrafiltration recovery of alginate: Membrane fouling mitigation by multivalent metal ions and properties of recycled materials

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Chinese Journal of Chemical Engineering 2020年第11期28卷 2881-2889页

作者： Daqi Cao Jingyi Jin QunhuiWang Xin Song Xiaodi Hao Eiji Iritani nobuyuki Katagiri Sino-Dutch R&D Centre for Future Wastewater Treatment Technologies/Key Laboratory of Urban Stormwater System and Water Environment Beijing University of Civil Engineering and ArchitectureBeijing 100044China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants University of Science and Technology BeijingBeijing 100083China Department of Chemical Engineering Nagoya UniversityFuro-choChikusa-kuNagoya-shiAishi 464-8603Japan

Recovery of alginate extracted from aerobic granular sludge(AGS)has given rise to a novel research ***,these extracted alginate solutions have a water content of nearly 100%.Alternately,ultrafiltration(UF)is generally used for concentration of ***,the introduction of multivalent metal ions into alginate may provide a promising method for the development of novel *** this study,membrane fouling mitigation by multivalent metal ions,both individually and in combination,and properties of recycled materials were investigated for UF recovery of sodium alginate(SA).The filtration resistance showed a significantly negative correlation with the concentration of metal ions,arranged in the order of Mg^2+Fe^3++Ca^2+>Ca^2+>Mg^2+.Three mechanisms were proposed in the presence of Fe^3+,such as the decrease of SA concentration,change in p H,and production of hydroxide iron colloids from *** properties of recycled materials(filter cake)were investigated via optical microscope observation,dynamic light scattering,Fourier transform infrared,X-ray photoelectron spectroscopy(XPS),and scanning electron *** results provide further insight into UF recoveries of alginate extracted from AGS.

关键词： Ultrafiltration Recovery Alginate Membrane fouling mitigation Multivalent metal ion Cake property

Dermatomyositis associated with hepatocellular carcinoma in an elderly female patient with hepatitis C virus-related liver cirrhosis

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World Journal of Gastroenterology 2006年第10期12卷 1641-1644页

作者： nobuyuki Toshikuni Rikako Torigoe Mikio Mitsunaga Akiyoshi Omoto Koji Nakashima Department of Internal Medicine Ako Central Hospital AkoJapanDepartment of Internal MedicineHimeji Red Cross HospitalHimejiJapan Department of Dermatology Ako Central Hospital AkoJapan Department of Internal Medicine Ako Central Hospital AkoJapan

A 79-year-old female patient with hepatitis C virusrelated liver cirrhosis was diagnosed as having hepatocellular carcinoma （HCC） with a diameter of 2.0 cm. She refused therapy for HCC. Nine months after the diagnosis, she developed dermatomyositis when the HCC enlarged to a diameter of 6.0 cm. She underwent therapy for dermatomyositis, and then transcatheter arterial chemoembolization for HCC. Although the manifestations of dermatomyositis improved and entire tumor necrosis was achieved, she died of pneumonia 2 mo after the treatment of HCC. HCC and/or chronic hepatitis C virus infection might be involved in the pathogenesis of dermatomyositis.

关键词： Dermatomyositis Hepatocellular carcinoma Hepatitis C virus

Improvement in bias current redistribution in superconducting strip ion detectors with parallel configuration

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Chinese Physics B 2015年第9期24卷 562-565页

作者： nobuyuki Zen Go Fujii Shigetomo Shiki Masahiro Ukibe Masaki Koike Masataka Ohkubo National Institute of Advanced Industrial Science and Technology (AIST)

In time-of-flight mass spectrometry（TOF MS）, superconducting strip ion detectors（SSIDs） in the parallel configuration are promising for ideal ion detection with a nanosecond-scale time response and a practical large sensitive area. In the parallel configuration, the bias current in one strip is diverted into other parallel strips after each detection event. Under high bias current conditions, the diverted bias current induces cascade switching of all parallel strips. Studies show that cascade switching degrades the ion count rate of SSIDs made from niobium and hence is disliked in TOF MS applications. To suppress the bias current redistribution, we connected resistors in a series with the individual parallel strips using aluminum-bonding wires. Their effect was studied by measuring the pulse height distributions.

关键词： superconducting devices time-of-flight mass spectrometry ion-surface impact

Inducible nitric oxide synthase polymorphism is associated with the increased risk of differentiated gastric cancer in a Japanese population

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World Journal of Gastroenterology 2006年第39期12卷 6361-6365页

作者： Yasuyuki Goto Takafumi Ando Mariko Naito Hidemi Goto nobuyuki Hamajima Depart-ment of Preventive Medicine/Biostatistics and Medical Decision Making Nagoya University Graduate School of Medicine 65 Tsurumai-cho Showa-ku Nagoya 466-8550 Japan Department of Gastroenterology Nagoya University Graduate School of Medicine 65 Tsurumai- cho Showa-ku Nagoya 466-8550 Japan

AIM： To examine the association of inducible nitric oxide synthase （iNOS） C150T polymorphism with gastric cancer, as well as with gastric atrophy and H pylori ***： A single nucleotide polymorphism of iNOS CtSOT was examined for 454 Japanese health checkup examinees （126 males and 328 females） aged 35 to 85 years without a history of cancer and 202 gastric cancer patients （134 males and 68 females） aged 33 to 94 years with pathologically confirmed diagnosis of gastric adenocarcinoma.RESULTS： The iNOS C150T polymorphism was not associated with gastric atrophy or with H pylori seropositivity. The odds ratio （OR） of the C/T ＋T/T for gastric cancer was increased without statistical significance （OR=1.19, 95% confidence interval （CI）： 0.68-2.08）. In the differentiated subgroup （n = 113）, however, the OR of the C/T genotvpe for gastric cancer was significant （OR = 2.02, 95% CI： 1.04-3.92） relative to the C/C genotype. In addition, considering the location of gastric cancer （n = 105）, there were significant differences between the controls and non-cardia group with the ORof 2.13 （95% CI： 1.08-4.18） for C/T and 1.94 （95% CI： 1.00-3.78） for C/T ＋ T/***： The iNOS C150T polymorphism is associated with the risk of H pylori-related gastric cancer in a Japanese population. This polymorphism may play an important role in increasing the risk of gastric cancer in Asian countires with the highest rates of gastric cancer.

关键词： Gastric cancer Inducible nitric oxide synthase Polymorphism H pylori

Development of a System for Location Finding of Low-Level Sound Source by Using Human Acoustic System with Stochastic Resonance

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Journal of Mechanics Engineering and Automation 2014年第5期4卷 403-411页

作者： Kousuke miyaji Katsuyoshi Tsujita Department of Biomedical Engineering Osaka Institute of Technology Osaka 535-8585 Japan Department of Robotics Faculty of Engineering Osaka Institute of Technology Osaka 535-8585 Japan

The purpose of this study is to develop a system that enables location finding of a small sound. The location finding of a small sound has some difficulties such as high computational costs or disturbances from the ambient noises and reflected waves. The proposed system is composed of a biologically-inspired system which uses a hearing mechanism based on the human ear and a mechanism for perceiving weak signals that uses stochastic resonance. The location finding mechanism in the proposed system is based on the time-lag detecting architecture. On the other hand, the stochastic resonance mechanism can pick up the small sound source in the ambient noises. Using this proposed system, we implemented the location finding of small sounds through numerical simulations and hardware experiments. Good results were obtained for the small sound source location finding.

关键词： Sound source location human acoustic system low-level sound stochastic resonance.

Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure

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Nano Research 2022年第5期15卷 4201-4211页

作者： Tsukasa Akasaka Miho Tamai Yoshitaka Yoshimura Natsumi Ushijima Shinichiro Numamoto Atsuro Yokoyama Hirofumi miyaji Ryo Takata Shuichi Yamagata Yoshiaki Sato Ko Nakanishi Yasuhiro Yoshida Department of Biomaterials and Bioengineering Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Immune Signal Unit Okinawa Institute of Science and Technology Graduate UniversityOkinawa 904-0495Japan Department of Pharmacology Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Support Section for Education and Research Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Oral Functional Prosthodontics Division of Oral Functional ScienceFaculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Periodontology and Endodontology Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Orthodontics Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan

The surface topography of a material can influence osteoclast ***,the surface structural factors that promote osteoclast activity have not yet been investigated in ***,we investigated osteoclastogenesis by testing various defined patterns with different dimensions and *** systematic patterns,made of a cyclo-olefin polymer,were prepared at a micron-,submicron-,and nano-scale with a groove,hole,or pillar shape with a 1:1 pitch ***264.7 cells were cultured on these patterns in the presence of the receptor activator of NF-κB ligand(RANKL).Osteoclast formation was induced in the order:pillar>groove≥*** two-dimensional factors also indicated that submicron-sized patterns strongly induced osteoclast *** optimal pillar dimension for osteoclast formation was 500 nm in diameter and 2μm in ***,we observed two types of characteristic actin structure,i.e.,belt-like structures with small hollow circles and isolated ring-like structures,which formed on or around the pillars depending on size and ***,resorption pits were observed mainly on the top of calcium phosphate-coated ***,osteoclasts prefer convex shapes,such as pillars for differentiation and *** results indicate that osteoclastogenesis can be controlled by designing surfaces with specific morphologies.

关键词： micro/nano-pattern pillar RAW264.7 osteoclast actin structure resorption pit

High-solids anaerobic mono-digestion of riverbank grass under thermophilic conditions

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Journal of Environmental Sciences 2017年第2期29卷 29-38页

作者： Fetra J.Andriamanohiarisoamanana nobuyuki Matsunami Takaki Yamashiro Masahiro Iwasaki Ikko Ihara Kazutaka Umetsu Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Graduate School of Agriculture Science Kobe University

The purpose of this study was to investigate the potential of high-solids anaerobic mono-digestion of riverbank grass under thermophilic conditions, focusing on the effects of the strength and the amount of inoculum. Ensiled grass was inoculated with three different inocula; inoculum from liquid anaerobic digester（LI）, inoculum from dry anaerobic digester（DI）, and mixture of LI and DI（MI）, at feedstock-to-inoculum ratio（FIR） of 1, 2 and 4. The ensiling process of riverbank grass reduced moisture content（p 〉 0.05）, while the hemicellulose content was significantly increased from 30.88% to 35.15%（p 〈 0.05）, on dry matter basis. The highest methane production was at an FIR of 2 with MI（167 L/kg VSadded）,which was significantly higher（p 〈 0.05） than with DI, but not significant compared to LI（p 〉 0.05）. At an FIR of 4, digesters inoculated with LI and DI failed to produce methane,whereas 135 LCH4/kg VSaddedwas obtained with MI. The kinetic studies showed that at an FIR of 1 with LI and MI, the inoculum had less of effects on the hydrolysis rate constant（0.269 day-1and 0.245 day-1） and methane production（135 versus 149 L/kg VSadded）; rather,it affected the lag phase. In a thermophilic HS-AD of riverbank grass, the mixture of inoculum with low and high total solids content（TS） helps increase the TS of inoculum and digestion process. An FIR of 2 was deducted to be the limit for a better startup time and higher volumetric productivity of methane.

关键词： Riverbank grass High-solids anaerobic digestion Inoculum Feedstock-to-inoculum ratio Thermophilic temperature