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High performance micromachining of sapphire by laser induced plasma assisted ablation(LIPAA)using GHz burst mode femtosecond pulses

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Opto-Electronic Science 2024年第6期3卷 20-29页

作者： Kotaro Obata Shota Kawabata Yasutaka Hanada Godai miyaji Koji Sugioka RIKEN Center for Advanced Photonics(RAP) Wako-shiSaitama 351-0198Japan Faculty of Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyo 184-8588Japan Graduate School of Science and Technology Hirosaki UniversityHirosakiAomori 036-8561Japan

GHz burst-mode femtosecond(fs)laser,which emits a series of pulse trains with extremely short intervals of several hundred picoseconds,provides distinct characteristics in materials processing as compared with the conventional irradiation scheme of fs laser(single-pulse mode).In this paper,we take advantage of the moderate pulse interval of 205 ps(4.88 GHz)in the burst pulse for high-quality and high-efficiency micromachining of single crystalline sapphire by laser induced plasma assisted ablation(LIPAA).Specifically,the preceding pulses in the burst generate plasma by ablation of copper placed behind the sapphire substrate,which interacts with the subsequent pulses to induce ablation at the rear surface of sapphire *** a result,not only the ablation quality but also the ablation efficiency and the fabrication resolution are greatly improved compared to the other schemes including single-pulse mode fs laser direct ablation,single-pulse mode fs-LIPAA,and nanosecond-LIPAA.

关键词： femtosecond laser GHz burst mode ablation LIPAA laser induced plasma assisted ablation sapphire

Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease

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World Journal of Gastroenterology 2024年第28期30卷 3428-3446页

作者： Aritoshi Koizumi Kosuke Kaji Norihisa Nishimura Shohei Asada Takuya Matsuda Misako Tanaka nobuyuki Yorioka Yuki Tsuji Koh Kitagawa Shinya Sato Tadashi Namisaki Takemi Akahane Hitoshi Yoshiji Department of Gastroenterology Nara Medical UniversityKashihara 634-8521Japan

BACKGROUND Alcohol-associated liver disease(ALD)is a leading cause of liver-related morbidity and mortality,but there are no therapeutic targets and modalities to prevent ALD-related liver *** proliferator activated receptor(PPAR)α and δ play a key role in lipid metabolism and intestinal barrier homeostasis,which are major contributors to the pathological progression of ***,elafibranor(EFN),which is a dual PPARαand PPARδagonist,has reached a phase III clinical trial for the treatment of metabolic dysfunctionassociated steatotic liver disease and primary biliary ***,the benefits of EFN for ALD treatment is *** To evaluate the inhibitory effects of EFN on liver fibrosis and gut-intestinal barrier dysfunction in an ALD mouse *** ALD-related liver fibrosis was induced in female C57BL/6J mice by feeding a 2.5% ethanol(EtOH)-containing Lieber-DeCarli liquid diet and intraperitoneally injecting carbon tetrachloride thrice weekly(1 mL/kg)for 8 ***(3 and 10 mg/kg/day)was orally administered during the experimental *** and molecular analyses were performed to assess the effect of EFN on steatohepatitis,fibrosis,and intestinal barrier *** EFN effects on HepG2 lipotoxicity and Caco-2 barrier function were evaluated by cell-based *** The hepatic steatosis,apoptosis,and fibrosis in the ALD mice model were significantly attenuated by EFN *** promoted lipolysis and β-oxidation and enhanced autophagic and antioxidant capacities in EtOH-stimulated HepG2 cells,primarily through PPARα***,EFN inhibited the Kupffer cell-mediated inflammatory response,with blunted hepatic exposure to lipopolysaccharide(LPS)and toll like receptor 4(TLR4)/nuclear factor kappa B(NF-κB)*** improved intestinal hyperpermeability by restoring tight junction proteins and autophagy and by inhibiting apoptosis and proinflammatory *** protective effect on intestinal bar

关键词： Liver fibrosis Ethanol Gut barrier function Apoptosis Autophagy Peroxisome proliferator activated receptor

碳布用于锂离子电池三维一体化柔性正极的可行性研究

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材料工程 2024年第3期52卷 192-198页

作者：闫时建郭锦同阳今西诚之太原科技大学材料科学与工程学院太原030024 三重大学材料化学系津市514-8507日本

研究碳纤维编织布用于锂离子电池三维一体化正极的可行性,对三种经过热处理碳布的石墨化程度进行定性分析和定量计算。以锂金属作为对电极,石墨化的碳布电极在0.1~0.5 V的电压下首次放电比容量分别为83.6,94.5mAh·g^(-1)和115.2 mAh·g... 详细信息

研究碳纤维编织布用于锂离子电池三维一体化正极的可行性,对三种经过热处理碳布的石墨化程度进行定性分析和定量计算。以锂金属作为对电极,石墨化的碳布电极在0.1~0.5 V的电压下首次放电比容量分别为83.6,94.5mAh·g^(-1)和115.2 mAh·g^(-1),经过50周次循环充放电后比容量分别为55.0,80.0 mAh·g^(-1)和88.0 mAh·g^(-1)左右。将石墨化的碳布负载LiFePO_(4)后,电极的首次放电比容量分别为73.2,109.5 mAh·g^(-1)和130.2 mAh·g^(-1)。对于石墨化程度为76.02%的碳布,经过50周次循环充放电后比容量稳定在90.0 mAh·g^(-1)左右,综合电化学性能较好,更适合用于锂离子电池的一体化柔性正极。通过建立LiFePO_(4)颗粒与碳纤维之间相互作用的力学模型,探讨一体化正极的力学性能、电学性能和电化学性能之间的关系。将碳布用于锂离子电池一体化正极,可以简化锂离子电池的常规生产过程,革新其生产方式。

关键词：锂离子电池碳布石墨化程度三维一体化柔性正极导电性

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用于一体化电极的碳布改性综述

电池 2024年第1期54卷 121-125页

作者：闫时建郭锦同阳今西诚之太原科技大学材料科学与工程学院山西太原030024 三重大学材料化学系日本三重县津市514-8507

由于碳布密度低、柔性高且导电导热性好,在电子器件中应用广泛。当碳布与其他材料复合时,为获得所需的性能,需对其进行改性处理。总结对当前用于电子器件中一体化电极的碳布进行改性的主要方法。从去浆、形貌处理和活性处理等3个方面进... 详细信息

由于碳布密度低、柔性高且导电导热性好,在电子器件中应用广泛。当碳布与其他材料复合时,为获得所需的性能,需对其进行改性处理。总结对当前用于电子器件中一体化电极的碳布进行改性的主要方法。从去浆、形貌处理和活性处理等3个方面进行介绍,并指出每种改性方法的优缺点和选用需考虑的要点。液相反应法对表面活性改变显著,但往往会降低电导率;热空气处理法对形貌改变显著,但操作过程复杂。液相氧化、热空气氧化和高温碳化相结合的改性效果可以更好,形貌改性和活性改性同时进行,可能会得到更好的综合性能。将碳布与活性物质直接复合制成一体化电极而完成改性处理,由于效率高可能成为改性技术的发展趋势。

关键词：一体化电极碳布改性去浆形貌处理活性处理

Impulse controls in optimal harvesting of age-structured populations

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生物数学学报:英文版 2023年第7期16卷 197-218页

作者： Natali Hritonenko nobuyuki Kato Yuri Yatsenko Department of Mathematics Prairie View A&M University PrairieViewTX77446USA Faculty of Electrical and Computer Engineering Kanazawa University Kanazawa920-1192Japan Dunham College of Business Houston Baptist University 7502FondrenHouston TX 77074USA

A nonlinear optimal control problem in the Lotka-McKendrick population model is *** describes rational management of age-structured farmed populations in aquaculture and indoor *** generalized functions,we prove the impulse nature of optimal *** analytic solutions for sustainable harvesting strategies are obtained and used to analyze the optimal dynamics of harvesting age and rotation under technological innovations.

关键词： Age-structured populations aquaculture optimal harvesting relaxed optimal controls Dirac measure

Sodium-glucose cotransporter 2 inhibitors in Asian patients with heart failure

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Chinese Medical Journal 2023年第8期136卷 1004-1005页

作者： Shingo Kato nobuyuki Horita Daisuke Utsunomiya Department of Diagnostic Radiology Yokohama City University Graduate School of MedicineKanagawaJapan Department of Cardiology Kanagawa Cardiovascular and Respiratory CenterKanagawaJapan Chemotherapy Center Yokohama City University HospitalKanagawaJapan

To the Editor:Sodium-glucose cotransporter 2(SGLT-2)inhibitors are recognized as one of the essential drugs for the treatment of heart failure(HF).Recent randomized controlled trials(RCTs)have shown that the SGLT-2 in... 详细信息

关键词： patients drugs mortality

Added value of indocyanine green fluorescence imaging in liver surgery

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 310-317页

作者： nobuyuki Takemura Kyoji Ito Fuyuki Inagaki Fuminori Mihara Norihiro Kokudo Department of Surgery Hepato-Biliary Pancreatic Surgery DivisionNational Center for Global Health and Medicine1-21-1 ToyamaShinjyuku-kuTokyo162-8655Japan

Recently,indocyanine green(ICG)fluorescence imaging has been widely used as a substitute for cholangiography in hepatobiliary surgery,to detect hepatic tumors,for accurate anatomical hepatectomy,and to increase the safety and accuracy of minimally invasive(laparoscopic and robotic)*** clinical relevance of this method has been increasing gradually,as new procedures develop in this *** important roles and the latest added value of ICG fluorescence imaging in liver surgery are discussed in this report.

关键词： Florescence imaging Indocyanine green Hepatocellular carcinoma Colorectal metastasis Hepatectomy Minimally invasive surgery

Predictive factors for efficacy of testosterone replacement therapy for late-onset hypogonadism in Japanese men:a preliminary report

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Asian Journal of Andrology 2023年第5期25卷 587-590页

作者： nobuyuki Kondoh Yohei Kaizuka Seiji Nagasawa Yoshikazu Togo Shingo Yamamoto Department of Urology Kawanishi City Medical CenterKawanishiHyogo 6660017Japan Department of Urology Hyogo Medical UniversityNishinomiyaHyog 6638501Japan

Although testosterone replacement therapy(TRT)is the first-choice method used worldwide for late-onset hypogonadism(LOH),clinical benefits are not seen in all *** study was conducted to determine the predictors of TRT efficacy for ***-six patients who visited our Men’s Health Clinic(Kawanishi City Medical Center,Kawanishi and Hyogo Medical University,Nishinomiya,Hyogo,Japan)between November 2003 and June 2021 with data available before and after TRT were *** were divided into responders(Group 1;n=45,accounting for 80.4%)and nonresponders(Group 2;n=11,accounting for 19.6%)based on the clinical response to TRT,including patient *** noted before TRT included age,body mass index,aging males’symptoms score,sexual health inventory for men,luteinizing hormone,follicular-stimulating hormone,testosterone,free testosterone,prolactin(PRL),estradiol(E2),and testosterone/estradiol(T/E2)ratio in *** statistical analysis,a multivariable logistic regression model was *** analysis revealed PRL(odds ratio TORI:0.9624;95%confidence interval[Cl]:0.9316-0.9943,P<0.05),E2(OR:0.8692;95%Cl:0.7745-0.9754,P<0.05),and T/E2 ratio(OR:1.1312;95%Cl:1.0106-1.2661,P<0.05)to be predictive *** analyses showed that T/E2 ratio was an independent predictive factor(OR:1.1593;95%Cl:1.0438-1.2875,P<0.01).The present results suggest that a low value for T/E2 ratio may predict a reduced response to *** T/E2 ratio threshold to predict nonresponders based on receiver-operating characteristics(ROC)curve analysis was shown to be *** additional studies with larger number of patients are necessary,we propose the determination of serum E2 level and testosterone level prior to performing TRT.

关键词： estradiol late-onset hypogonadism predictive factor testosterone treatment

Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure

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Nano Research 2022年第5期15卷 4201-4211页

作者： Tsukasa Akasaka Miho Tamai Yoshitaka Yoshimura Natsumi Ushijima Shinichiro Numamoto Atsuro Yokoyama Hirofumi miyaji Ryo Takata Shuichi Yamagata Yoshiaki Sato Ko Nakanishi Yasuhiro Yoshida Department of Biomaterials and Bioengineering Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Immune Signal Unit Okinawa Institute of Science and Technology Graduate UniversityOkinawa 904-0495Japan Department of Pharmacology Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Support Section for Education and Research Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Oral Functional Prosthodontics Division of Oral Functional ScienceFaculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Periodontology and Endodontology Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Orthodontics Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan

The surface topography of a material can influence osteoclast ***,the surface structural factors that promote osteoclast activity have not yet been investigated in ***,we investigated osteoclastogenesis by testing various defined patterns with different dimensions and *** systematic patterns,made of a cyclo-olefin polymer,were prepared at a micron-,submicron-,and nano-scale with a groove,hole,or pillar shape with a 1:1 pitch ***264.7 cells were cultured on these patterns in the presence of the receptor activator of NF-κB ligand(RANKL).Osteoclast formation was induced in the order:pillar>groove≥*** two-dimensional factors also indicated that submicron-sized patterns strongly induced osteoclast *** optimal pillar dimension for osteoclast formation was 500 nm in diameter and 2μm in ***,we observed two types of characteristic actin structure,i.e.,belt-like structures with small hollow circles and isolated ring-like structures,which formed on or around the pillars depending on size and ***,resorption pits were observed mainly on the top of calcium phosphate-coated ***,osteoclasts prefer convex shapes,such as pillars for differentiation and *** results indicate that osteoclastogenesis can be controlled by designing surfaces with specific morphologies.

关键词： micro/nano-pattern pillar RAW264.7 osteoclast actin structure resorption pit