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Duodenal-type follicular lymphoma more than 10 years after treatment intervention:A retrospective single-center analysis

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1552-1561页

作者： Makoto Saito Akio Mori Shihori Tsukamoto Takashi Ishio emi Yokoyama Koh Izumiyama Masanobu Morioka Takeshi Kondo Hirokazu Sugino Blood Disorders Center Aiiku HospitalSapporo 064-0804Japan Department of Cancer Pathology Hokkaido UniversityFaculty of MedicineSapporo 060-8638Japan

BACKGROUND Duodenal-type follicular lymphoma(D-FL)has been recognized as a rare entity that accounts for approximately 4%of primary gastrointestinal lymphomas.D-FL follows an indolent clinical course compared with common nodal FL and is generally considered to have a better ***,the“watch and wait”approach is frequently adopted as the treatment ***,there is an option to actively intervene in ***,the long-term outcomes of such cases are poorly *** To clarify the clinical outcomes after long-term follow-up in cases of D-FL with treatment *** We retrospectively analyzed patients who met the following criteria:the lesion was confirmed by endoscopy,the diagnosis of D-FL was confirmed histopathologically,and the patient was followed-up for more than 10 years after the intervention at our *** We identified 5 cases of *** patients showed a small amount of bone marrow involvement(Stage IV).Rituximab was used as a treatment for remission in all 5 *** was also used in combination with chemotherapy in 2 Stage IV patients as well as for maintenance *** therapy was performed in 2 cases,which was followed by complete remission(CR).Eventually,all 5 patients achieved CR and survived for more than 10 ***,3 patients experienced *** patient achieved a second CR by retreatment,and in another case,the lesion showed spontaneous *** remaining patient had systemic widespread recurrence 13 years after the first *** results suggested that the FL lesions were transformed into diffuse large B-cell *** patient died 4 years later despite receiving various *** In this study,the treatment for patients of D-FL in Stage IV was *** the future,criteria for how to treat“advanced”D-FL should be established based on additional *** study of patients with D-FL indicates that whole-body follow-up examinations shou

关键词： Duodenal-type follicular lymphoma Treatment Long-term follow-up Radiation Rituximab Chemotherapy

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Phlegmonous gastritis developed during chemotherapy for acute lymphocytic leukemia:A case report

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World Journal of Clinical Cases 2021年第22期9卷 6493-6500页

作者： Makoto Saito Masanobu Morioka Koh Izumiyama Akio Mori Reiki Ogasawara Takeshi Kondo Toru Miyajima emi Yokoyama Satoshi Tanikawa Department of Internal Medicine and Hematology Aiiku HospitalSapporo 0640804HokkaidoJapan Department of Cancer Pathology Hokkaido UniversityFaculty of MedicineSapporo 0608638HokkaidoJapan Institute for Chemical Reaction Design and Discovery(WPI-ICReDD) Hokkaido UniversitySapporo 001-0021HokkaidoJapan

BACKGROUND Phlegmonous gastritis(PG)is a rare bacterial infectious disease characterized by neutrophil-based purulent inflammation of the gastric *** most representative causative bacterium is Streptococcus pyogenes,followed by Staphylococcus,Pneumococcus and *** portal venous gas(HPVG)is considered a potentially fatal condition and is rarely associated with *** SUMMARY The white blood cell count of a 70-year-old woman with acute lymphocytic leukemia in complete remission dropped to 100/μL after consolidation *** vital signs were consistent with septic *** blood culture revealed the presence of Bacillus *** computed tomography(CT)and esophagogastroduodenoscopy(EGD)showed marked thickening of the gastric *** with the other findings,CT was suggestive of HPVG,and EGD showed pseudomembrane-like tissue covering the superficial *** examination of gastric biopsy specimens showed mostly necrotic tissue with lymphocytes rather than *** of gastric specimens revealed the presence of Bacillus *** finally diagnosed this case as PG with Bacillus cereus-induced sepsis and *** patient recovered successfully with conservative treatment,chiefly by using carbapenem *** The histopathological finding of this gastric biopsy specimen should be called"neutropenic necrotizing gastritis".

关键词： Phlegmonous gastritis Chemotherapy neutropenia Bacillus cereus Histopathology Case report

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Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients

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World Journal of Gastroenterology 2015年第16期21卷 4933-4945页

作者： Makoto Meguro Toru Mizuguchi Toshihiko Nishidate Kenji Okita Masayuki Ishii Shigenori Ota Tomomi Ueki emi Akizuki Koichi Hirata Department of Surgery Surgical Oncology and ScienceSapporo Medical University School of Medicine

AIM:To clarify the utility of using des-γ-carboxy prothrombin(DCP)andα-fetoprotein(AFP)levels to predict the prognosis of hepatocellular carcinoma(HCC)in patients with hepatitis B virus(HBV)and the hepatitis C virus(HCV)***:A total of 205 patients with HCC(105patients with HBV infection 100 patients with HCV infection)who underwent primary hepatectomy between January 2004 and May 2012 were enrolled *** AFP and DCP levels were used to create interactive dot diagrams to predict recurrence within 2 years after hepatectomy,and cutoff levels were *** in the HBV and HCV groups were classified into three groups:a group with low AFP and DCP levels(LL group),a group in which one of the two parameters was high and the other was low(HL group),and a group with high AFP and DCP levels(HH group).Liver function parameters,the postoperative recurrence-free survival rate,and postoperative overall survival were compared between *** survival curves were compared by logrank test using the Kaplan-Meier *** analysis using a Cox forward stepwise logistic regression model was conducted for a ***:The preoperative AFP cutoff levels for recurrence within 2 years after hepatectomy in the HBV and HCV groups were 529.8 ng/m L and 60 m AU/m L,respectively;for preoperative DCP levels,the cutoff levels were 21.0 ng/m L in the HBV group and 67 m AU/m L in the HCV *** HBV group was significantly different from the other groups in terms of vascular invasion,major hepatectomy,volume of intraoperative blood loss,and surgical *** differences were found between the LL group,the HL group,and the HH group in terms of both mean disease-free survival time(MDFST)and mean overall survival time(MOST):64.81±7.47 vs 36.63±7.62 vs 18.98±6.17mo(P=0.001)and 85.30±6.55 vs 59.44±7.87 vs46.57±11.20 mo(P=0.018).In contrast,the HCV group exhibited a significant difference in tumor size,vascular invasion,volu

关键词： Hepatocellular carcinoma Hepatitis B Hepatitis C Des-γ-carboxy prothrombin α-fetoprotein

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Diamond Particles Deposited among Nickel/Copper Particles in Energy Controlled CH4/H2RF Discharge Plasmas

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Journal of Surface Engineered Materials and Advanced Technology 2012年第3期2卷 158-162页

作者： Junichi emi Satoru Iizuka Department of Electrical Engineering Graduate School of Engineering Tohoku University Sendai Japan.

Formation of diamond particles was investigated in an energy-controlled CH4/H2 radio-frequency (RF) discharge plasma. Here, in particular, it was examined how diamond particles grew on a nickel substrate under an influence of Cu vapor that was supplied from a heated Cu wire. Here, the plasma was generated by a hollow-magnetron-type (HMT) RF plasma source at the frequency of 13.56 MHz. Total pressure was kept at 100 mTorr. Diamond particles grew besides Ni and Cu particles. From Raman spectrum the substrate surface was covered with thin graphite film deposited as a background layer. It was shown that diamond could grow in a self-organized manner even when the other atomic gas species such as Ni and Cu were contained in the gas at the same time during the growth process.

关键词： Diamond Microparticle Diamond Growth Self-Organization Graphite Cu Particle

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持续性细胞皱缩在人上皮细胞凋亡过程中的必要性(英文)

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生理学报 2007年第4期59卷 512-516页

作者： SHIMIZU Takahiro MAENO emi OKADA Yasunobu 国立生理学研究所细胞生理学部

持续性细胞皱缩是凋亡发生的一个主要标志。近期研究发现细胞皱缩在细胞凋亡过程中并不是一个被动的次要事件。在各种细胞中,包括人上皮细胞,凋亡因子(apoptogen)刺激后马上发生全细胞皱缩,又称为凋亡性容积减小(apoptotic volume decre... 详细信息

持续性细胞皱缩是凋亡发生的一个主要标志。近期研究发现细胞皱缩在细胞凋亡过程中并不是一个被动的次要事件。在各种细胞中,包括人上皮细胞,凋亡因子(apoptogen)刺激后马上发生全细胞皱缩,又称为凋亡性容积减小(apoptotic volume decrease,AVD),继而发生caspase激活、DNA片段化、细胞破裂死亡。K^+和Cl^-通道的激活导致KCl外流,诱导AVD发生。抑制AVD发生可以抑制细胞凋亡。AVD与调节性容积增加(regulatory volume increase,RVI)异常相伴发生时,人上皮性HeLa细胞发生持续性细胞皱缩。RVI功能受损时,高渗本身就能诱导HeLa细胞持续性细胞皱缩,继而凋亡。即使在正常渗透压、无凋亡因子刺激的情况下,将HeLa细胞置于缺乏Na^+或Cl^-的溶液也会导致细胞持续性皱缩,继而凋亡。因此,AVD诱导和RVI异常所导致的持续性细胞皱缩是人上皮细胞发生凋亡的首要条件。

关键词：凋亡凋亡性容积减小持续性细胞皱缩细胞容积调节人上皮细胞

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Relationship of Stress Coping Behaviors and Changes in Resilience during an Integrated Nursing Practicum

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Open Journal of Nursing 2020年第11期10卷 1026-1037页

作者： Etsuko Imoto emi Yoshioka Sayuri Kaneko Faculty of Nursing Nagano College of Nursing Komagane Japan

This study aims to clarify what kinds of resilience and coping strategies students employ to successfully complete their clinical practicum and provide suggestions for instruction that will allow students to carry out effective learning activities. The study subjects were 86 students enrolled at Nursing University A for the 2019 school year and planning to take the integrated nursing practicum. The survey was conducted using an anonymous, self-administered questionnaire. The Wilcoxon signed-rank test was used to determine the amount of change in resilience factors from the surveys before and after the practicum. Subsequently, multiple regression analysis was carried out with stress coping behaviors that were significantly associated with resilience factors in univariate analysis as independent variables and the amount of change in resilience factors before and after the practicum as dependent variables. A total of 56 responses were received (response rate 65.8%) from the 85 survey subjects. Innate resilience factors increased significantly from 41 pre-practicums to 44 post-practicums. Acquired resilience factors also increased significantly from 32 pre-practicums to 35 post-practicums (p −0.456, p < 0.01) were significantly associated with innate resilience factors. Examining the relationship between the amount of change in student resilience and stress coping behaviors revealed that the stress coping behavior of “changing point of view” was associated with innate resilience. This finding suggests that resilience may be increased by changing one’s perspective on an event by taking on a new way of thinking. The results suggested that helping students transform realizations made during reflection into learning and create a sense of mea

关键词： Stress Coping Behaviors Resilience Integrated Nursing Practicum Nursing Students

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The Influence of Environmental Stimuli upon the Human Body in Summer

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Health 2020年第7期12卷 781-803页

作者： Yoshihito Kurazumi emi Kondo Kenta Fukagawa School of Life Studies Sugiyama Jogakuen University Nagoya Japan Department of Comprehensive Engineering Kindai University Technical College Nabari Japan Department of Architecture Kyushu Sangyo University Fukuoka Japan

Green building practices benefit many users because it imposes less of a burden both on people and the environment and plays a central role in achieving a sustainable lifestyle. Covering rooftops with tall evergreen trees increases evaporation and reduces energy consumption by heating and air conditioning systems. Japan has a cereal-crop culinary culture and rice cultivation is a primary activity. According to the Biophilia Hypothesis exposure to a lush greenery environment conducive to survival facilitates more effective relaxation and recovery from fatigue than simple elimination of stress. The impact of rice paddies is not only about reduction of energy consumption, but also about mitigating the urban environment and its physiological and psychological effects on the human body. Focusing on the spread of the rice canopy and exposure of water surfaces, clarified the reaction of the human body to thermal sensory perception and outdoor thermal environments, and the correlation between them. Rice fields where the rice canopy was smaller, and where ample standing water surfaces received short wavelength solar radiation, have a high heat capacity, which works to increase the longwave length thermal radiation in the time period when the accumulated amount of short wavelength solar radiation increases. Meanwhile, where the spread of the rice canopy was greater, and the surface of the standing irrigation water covered with rice plants, a mitigation effect on the outdoor thermal environment evaluation index of ETFe (enhanced conduction-corrected modified effective temperature) through reduction of long wavelength thermal radiation came into play, and it became clear that thermal sensory perception improved through visual stimuli that engendered images of humidity. The purpose of this study was to clarify the environmental mitigation effect of rice fields in an urban environment. In addition to the physical environmental mitigation effect, it was also shown that ri

关键词： ETFe Outdoor Environment Paddy Field Summer Thermal Comfort Thermal Sensation

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Glutathione Production by Yarrowia lipolyticaShowing Both Methyglyoxal Resistance and a High Activity of Glutathione Synthetase

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Advances in Microbiology 2012年第2期2卷 171-180页

作者： Naofumi Shiomi emi Harada Risako Nabeshima Graduate School of Human Sciences Kobe College Kobe Japan

Although Yarrowia lipolytica is an important host strain, there have so far been few studies on the production of glutathione by the strain. We therefore performed a study to obtain an improved strain of Y. lipolytica ATCC20688, which could produce a high yield of glutathione. First, the capability of glutathione production in the ATCC20688 strain was estimated. In comparison with other yeasts, the yield of this strain was higher than those in Pichia strains. Furthermore, this strain could produce glutathione by assimilating sodium oleate. We next performed mutation and gene cloning to improve the yield. After the yield of glutathione was improved in the isolated methylglyoxal-resistant mutant (MGR3), the glutathione synthetase gene was cloned into the MGR3 strain. By using this recombinant strain, we could reach the maximum yield and intracellular content of glutathione of 54 mg/L-medium and 30 mg/g-dry cell weight, respectively.

关键词： Glutathione Yarrowia lipolytica Glutathione Synthetase GSH2 Methylglyoxal

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Estimating Emotion for Each Personality by Analyzing BVP

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Journal of Mechanics Engineering and Automation 2018年第2期8卷 92-102页

作者： emi Takemoto Yusuke Kajiwara Hiromitsu Shimakawa Graduate School of Information Science and Engineering Ritsumeikan University Kusatsu 525-0059 Japan Faculty of Production Systems Engineering and Sciences Komatsu University Komatsu 923-0921 Japan College of Information Science and Engineering Ritsumeikan University Kusatsu 525-0059 Japan

This research estimates emotions of university students from their BVP （blood volume pulse）. Negative emotion of university students causes school dropout, which is becoming a serious problem in Japan. It is indispensable for school staffs and counselors to know when and where students have negative emotion in the campus. Since BVP signals along with emotion changes vary with personality types, we build a model dependent on personality type, to estimate student emotion from characteristics of blood volume signals. Experimental results show that the model for each personality type improves the accuracy of emotion estimation for new students. Positive or negative emotion estimated from BVP signals contributes to enhancement of campus environment by school counselors.

关键词： Emotion school dropout BVP personality Big Five.

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Transformed gastric mucosa-associated lymphoid tissue lymphoma originating in the colon and developing metachronously after Helicobacter pylori eradication:A case report

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4281-4288页

作者： Makoto Saito Zen-Ichi Tanei Masumi Tsuda Toma Suzuki emi Yokoyama Minoru Kanaya Koh Izumiyama Akio Mori Masanobu Morioka Takeshi Kondo Blood Disorders Center Aiiku HospitalSapporo 064-0804HokkaidoJapan Department of Cancer Pathology Faculty of MedicineHokkaido UniversitySapporo 060-8638HokkaidoJapan

BACKGROUND Helicobacter pylori(***)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been ***,t(11;18)(q21;q21)/API2-MALT1 translocation-positive lesions are a type of primary gastric MALT lymphoma in which a response to eradication treatment is difficult to *** addition,trisomy 18 may be associated with diffuse large B-cell lymphoma(DLBCL)transformation of gastric MALT *** SUMMARY A 66-year-old man was diagnosed with MALT lymphoma in the ascending colon by colonoscopy and *** years later,esophagogastroduodenoscopy revealed chronic atrophic gastritis that was positive for ***,and eradication treatment was *** years and nine months later(at the age of 70),a new ulcerative lesion suggestive of MALT lymphoma appeared in the gastric body,and six months later,a similar lesion was also found in the *** year later(4 years and 3 months after *** eradication),at the age of 72,the lesion in the gastric body had become deeper and had propagated.A biopsy revealed a pathological diagnosis of *** MALT lymphoma lesions in the ascending colon and DLBCL lesions in the stomach were positive for the t(11;18)(q21;q21)/API2-MALT1 translocation,and trisomy 18q21 was also *** 6 courses of R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine and prednisone)chemotherapy,all of the above lesions disappeared[complete remission(CR)],and CR has been maintained for more than 3 *** addition,both the colonic and gastric lesions were proven to have the same *** Because the patient had a MALT1 translocation with trisomy 18q21,it was thought that this gastric MALT lymphoma developed independently of *** infection and progressed.

关键词： Gastric mucosa-associated lymphoid tissue lymphoma Transform Diffuse large B-cell lymphoma Colonic mucosa-associated lymphoid tissue lymphoma Helicobacter pylori eradication MALT1 translocation Case report

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