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Biomimetic artificial cartilage:fibre-reinforcement of PVA hydrogel to promote biphasic lubrication mechanism

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Biosurface and Biotribology 2019年第1期5卷 13-19页

作者： nobuo sakai Seido Yarimitsu Yoshinori Sawae Mochimitsu Komori Teruo Murakami Integrated Systems Engineering Kyushu Institute of TechnologyKitakyushuJapan Intelligent Mechanical Systems System DesignTokyo Metropolitan UniversityTokyoJapan Mechanical Engineering Kyushu UniversityFukuokaJapan Research Center for Advanced Biomechanics Kyushu UniversityFukuokaJapan Medical Technology Teikyo UniversityOmutaJapan

The fibre-reinforced structure in synovial articular cartilage plays an important role in enhancing the fluid load support in the biphasic lubrication mechanism.Poly(vinyl alcohol)(PVA)hydrogel is a potential biomimetic articular cartilage material.In this study,PVA hydrogel was reinforced with PVA fibres to improve its frictional properties.By computational analysis,the position of the PVA fibre layer was examined with a migrating contact condition to reduce the friction coefficient.To improve the fibre reinforcement,a method for fibre placement was developed to retain the initial strain of the fibre in the hydrogel matrix.The experimental results showed that the fibre-reinforced PVA hydrogel with a surface fibre layer had a low friction coefficient of 0.031 in pure water.The fibre-reinforced PVA hydrogel successfully reduced friction coefficient.

关键词： mechanism. material. fibre

Transitional behaviour between biphasic lubrication and soft elastohydrodynamic lubrication of poly(vinyl alcohol)hydrogel using microelectromechanical system pressure sensor

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Biosurface and Biotribology 2018年第1期4卷 24-33页

作者： nobuo sakai Seido Yarimitsu Yoshinori Sawae Mochimitsu Komori Teruo Murakami Integrated System Engineering Kyushu Institute of TechnologyKitakyushuJapan Intelligent Mechanical Systems System DesignTokyo Metropolitan UniversityTokyoJapan Mechanical Engineering Kyushu UniversityFukuokaJapan Research Center for Advanced Biomechanics Kyushu UniversityFukuokaJapan Medical Technology Teikyo UniversityOmutaJapan

The soft hydrogel material is expected for a candidate material as biomimetic artificial cartilage with synergisticfunctionalities of adaptive multimode lubrication.In boundary lubrication mode of hydrogel material,the biphasiclubrication mechanism cooperatively exerts its functionality.In hydrodynamic lubrication mode,it is preferable that thelubricating surfaces be impermeable to trap the fluid pressure in contact surfaces,whereas the actual biphasic materiallike a hydrogel is a permeable material with surface porosity.lt is indicated that the interstitial fluid pressurisation inthe permeable biphasic material can contribute to significant fluid load support under lower sliding speed condition.So,the authors examined how the contrary fluid pressure effect appears in the transition from the boundarylubrication mode to soft elastohydrodynamic lubrication mode.In the experiment,a small pressure sensor was utilisedto measure the in-situ fluid pressure in sliding condition.Although the experimental condition of this study wasselective,the result showed a possibility of the negative effect of the biphasic surface,in which the permeable surfacediminished the hydrodynamic fluid pressure.This means that one should manage and enhance the biphasic lubricationabilities in wide operation range when the hydrogel material was used as a load bearing material.

关键词： hydrogel behaviour synergistic

Erratum to: Influence of synovia constituents on tribological behaviors of articular cartilage

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Friction 2014年第4期2卷 391-391页

Erratum to Friction 1(2):150-162(2013)DOI 10.1007/s40544‐013‐0010‐6 The original version of this article unfortunately contained the incorrect lengend“HA 0.5 wt%+DPPC 0.01 wt%+albumin 1.4 wt%”in Fig.7 on page 155... 详细信息

关键词： Friction tribological behaviors

A Phase II Study of Erlotinib in Patients with Previously Treated Non-Small Cell Lung Cancer

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Advances in Lung Cancer 2014年第1期3卷 10-20页

作者： Tetsuya Kubota Yoshio Okano Mizu sakai Takashi Yamane Naoki Shiota Hiroshi Ohnishi Hisanori Machida nobuo Hatakeyama Eiji Takeuchi Tomoyuki Urata Fumitaka Ogushi Akihito Yokoyama Department of Hematology and Respiratory Medicine School of Medicine Kochi University Kochi Japan Division of Pulmonary Medicine Kochi Medical Center Kochi Japan Division of Pulmonary Medicine Kochi Red Cross Hospital Kochi Japan Division of Pulmonary Medicine NHO Kochi Hospital Kochi Japan

Background: Erlotinib has been reported to be effective for the treatment of non-small cell lung cancer (NSCLC). To evaluate the efficacy and safety of erlotinib under conditions similar to daily clinical practice, a phase II trial was conducted in Japanese patients with previously treated NSCLC. Methods: The eligibility criteria were stage IIIB/IV NSCLC, a performance status (PS) of 0 - 2, and previous treatment with 1 - 2 non-EGFR-TKI regimens. Patients received erlotinib (150 mg/day) orally until disease progression or intolerable toxicity occurred. The primary endpoint was the objective response rate (ORR). In addition, the disease control rate (DCR), progression-free survival (PFS), overall survival (OS), safety, and EGFR gene mutation status were evaluated. Results: Thirty-eight patients were enrolled, and 37 patients were evaluated. The median age was 69 years (range, 50 - 80 years). Patient characteristics were as follows: 26 were male and 11 were female;12 had a PS of 0, 20 had a PS of 1, and 5 had a PS of 2;and 26 had adenocarcinoma, and 11 had non-adenocarcinoma histology. The ORR and DCR were 21.6% (95% confidence interval [CI], 11.4% - 37.2%) and 54.1% (95% CI, 35.9% - 66.6%), respectively. Twenty-seven patients could be evaluated for EGFR gene status (12, mutated;15, wild-type). The ORR for EGFR-mutated patients was 41.7%, while that for patients with wild-type EGFR was 13.3%. The median PFS was evaluated as 4.4 months (95% CI, 2.2 - 10.7 months). The median OS was 14.9 months (95% CI, 9.2 months - not reached). Common adverse events were tolerable skin toxicities, diarrhea, and stomatitis. In addition, interstitial lung disease occurred in 8.1% of patients. Conclusion: As efficacy and safety were similar to previous studies, erlotinib was found to be effective for Japanese patients with previously treated NSCLC in clinical practice.

关键词： Non-Small Cell Lung Cancer Phase II Study Erlotinib Previously Treated

Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction

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World Journal of Gastroenterology 2016年第14期22卷 3793-3802页

作者： Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide nobuo Toda Iruru Maetani Yuji sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama Department of Gastroenterology JCHO Tokyo Takanawa HospitalTokyo 108-8606Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Gastroenterology Saitama International Medical CenterSaitama Medical UniversitySaitama 350-1298Japan Department of Gastroenterology and Hepatology Saitama Medical University International Medical CenterSaitama 350-8550Japan Department of Gastroenterology Kitasato UniversityKanagawa 252-0375Japan Department of Gastroenterology Jichi Medical UniversityTochigi 329-0498Japan Department of Gastroenterology Tokai UniversityKanagawa 259-1193Japan Department of Gastroenterology Asahi General HospitalChiba 289-2511Japan Department of Internal Medicine Japanese Red Cross Ashikaga HospitalTochigi 326-0843Japan Department of Gastroenterology Kimitsu Central HospitalChiba 292-8535Japan Department of Gastroenterology Yokohama City University Medical CenterKanagawa 232-0024Japan Department of Gastroenterology Showa University Northern Yokohama HospitalKanagawa 242-0032Japan Department of Gastroenterology Saitama City HospitalSaitama 336-8522Japan Department of Gastroenterology Ageo Central General HospitalSaitama 362-8588Japan Division of Gastroenterology Department of MedicineShowa University School of MedicineTokyo 142-8666Japan Department of Gastroenterology Toranomon HospitalTokyo 105-0001Japan Department of Gastroenterology Gunma UniversityGunma 371-0034Japan Department of Gastroenterology Mitsui Memorial HospitalTokyo 101-8643Japan Division of Gastroenterology and Hepatology Department of Internal MedicineToho University Ohashi Medical CenterTokyo 153-0044Japan Department of Gastroenterology Chiba UniversityChiba 260-0856Japan Department of Gastroenterology Tokyo Medical UniversityTokyo 160-0023Japan Department of Gastroenterology Showa University Fujigaoka HospitalKanagawa 227-8501Japan

AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored.

关键词： endoscopic preoperative biliary drainage Malignant distal biliary obstruction Periampullary cancer P