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A Twenty-Year Follow-up Case Study of an Office Worker Who Returned to Work despite Serious Memory Disorder Caused by Herpes Encephalitis

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Journal of Behavioral and Brain Science 2012年第4期2卷 505-511页

作者： Mitsuko Nakano nobuo miyashita Kazutaka Tanabe Takeshi Yamamoto Department of Neurology Higashi-Matsudo Municipal Hospital Matsudo City Welfare and Medical Center Chiba Japan Department of Neurology Tokyo Metropolitan Matsuzawa Hospital Tokyo Japan Department of Neurosurgery Juntendo University School of Medicine Tokyo Japan miyashita Neurological Clinic Nagano Japan

This study followed a 52-year-old male patient, who had suffered from severe impairment in recent memory due to se- quelae of herpes encephalitis, for 20 years. He returned to his highly intellectual work and performed well despite his doctor’s prediction. While the patient showed consistently poor results on various neuropsychological memory tests, he demonstrated incredible performance at work. This case exemplifies an extreme case that declarative memory is formed with the support of semantic memory, procedural memory, and his strong interests. Additionally, it offers lessons that results on memory tests do not necessarily correspond to the actual level of competence. The focal sites were found on both sides of the medial temporal lobe, predominantly on the left side. The T2-weighted magnetic resonance images (MRI) obtained 9 years after the onset confirmed widespread damage to the left brain including parahippocampal gyrus, hippocampus, spindle gyrus, and amygdaloid complex, with microlesions extending from the right parahippocampal gyrus to its antero-interior rim. However, the damage to hippocampus was presumed to be minor.

关键词： Declarative Memory Semantic Memory Procedural Memory Hippocampal Damage Recent Memory Herpes Encephalitis

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Treatment of Asthma in the Elderly: Questionnaire Survey in Japan

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International Journal of Clinical Medicine 2017年第4期8卷 236-247页

作者： Sahoko Chiba Kimitake Tsuchiya Tomoyuki Ogata Reina Imase Tamon Yagi Yuka Mishima Torahiko Jinta Kazuhito Saito Reiko Taki Susumu Isogai Yasuto Jinn Tsutomu Kawasaki Ichiro Natsume Yoshihiro miyashita Jun Takagiwa nobuo Ishiwata Tomoshige Chiaki Masato Kishi Yoshikazu Tsukada Motohisa Yamasaki Naohiko Inase Department of Respiratory Medicine Tokyo Medical and Dental University Tokyo Japan JA Toride Medical Center Ibaraki Japan St. Luke’s International Hospital Tokyo Japan Tsuchiura Kyoudou General Hospital Ibaraki Japan Japanese Red Cross Musashino Hospital Tokyo Japan Ome Municipal General Hospital Tokyo Japan Hiratsuka Kyosai Hospital Kanagawa Japan Yokohama City Minato Red Cross Hospital Kanagawa Japan Yokosuka Kyosai Hospital Kanagawa Japan Yamanashi Prefectural Central Hospital Yamanashi Japan Tokyo Kyosai Hospital Tokyo Japan Kudanzaka Hospital Tokyo Japan Hokushin General Hospital Nagano Japan Mishima General Hospital Shizuoka Japan Soka Municipal Hospital Saitama Japan Nitobe Memorial Nakano General Hospital Tokyo Japan

Introduction: The prevalence of asthma in the elderly has been increasing due to the aging of the global population. Appropriate treatment for asthma in the elderly is now a major issue, as the disease is often fatal and incurs high medical costs in the elderly population. There have been few recent reports on asthma treatment for the elderly in the real-world clinical settings. Objectives: This study was performed to assess how respiratory physicians manage asthma in elderly patients in clinical settings in Japan. Methods: Respiratory physicians in 16 Japanese hospitals responded to a questionnaire survey on asthma and COPD treatment between December 2014 and February 2015. The analysis was performed using data collected from medical records on 2041 asthma patients. Results: The mean patient age was 61.2 years, and 36.6% of the patients were men. In the breakdown by age, 1018 (49.9%) of the patients were elderly (≥ 65 years). Compared to the non-elderly, the elderly patients had a significantly lower BMI, greater smoking history in pack-years, and poorer pulmonary function. There were no significant differences between the elderly and non-elderly in the prescription rates of common medications such as inhaled corticosteroids, long-acting beta-agonists (LABA) administered via inhaler or transdermal patch, long-acting muscarinic antagonists, or leukotriene receptor antagonists. In contrast, mucoactive drugs (18.7% vs. 12.3%, P P P = 0.02). Conclusions: According to this survey, the prescription rates of mucoactive drugs, macrolides, and transdermal LABA were significantly higher in the elderly than in the non-elderly.

关键词： Asthma Elderly Transdermal LABA Aging

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