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Communications in Computational Physics 2011年第5期9卷 1323-1334页

作者： Kae tsunematsu Bastien Chopard Jean-Luc Falcone Costanza Bonadonna Department of Mineralogy University of Geneva13 Rue des Maraichers1205 GeneveSwitzerland Department of Computer Science University of Geneva7 Route de Drize1227 CarougeSwitzerland

In order to model the dispersal of volcanic particles in the atmosphere and their deposition on the ground,one has to simulate an advection-diffusionsedimentation process on a large spatial *** we compare a Lattice Boltzmann and a Cellular Automata *** results show that for high Peclet regimes,the cellular automata model produce results that are as accurate as the lattice Boltzmann model and is computationally more effective.

关键词： Cellular automata lattice Boltzmann tephra transport advection-diffusion computational efficiency

Analysis of “care” and “justice” involved in moral reasoning of nurse based on the Gilligan theory: A literature review using the Gilligan’s protocol

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Open Journal of Nursing 2014年第2期4卷 101-109页

作者： Kayoko tsunematsu Atsushi Asai Department of Bioethics Kumamoto University Graduate School of Medical Science Kumamoto Ja-pan Department of Nursing Faculty of Health Science Kumamoto Health Science University Kumamoto Japan Department of Bioethics Kumamoto University Graduate School of Medical Science Kumamoto Ja-pan

The majority of research on the moral development of nurses is in line with Kohlberg’s theory. However, Gilligan noted that care and justice perspectives coexist in moral conflict, and during the growth process, each complements each other and promotes moral development and maturation. Chally, referring to Gilligan’s theory, which has the perspective of relationship-focused care, argued that the moral development of nurses should be considered from both care and justice perspectives. In this paper, we analyzed publications that used Gilligan protocol to conduct research on moral conflicts experienced by nurses. Given the importance of care and justice perspectives in moral reasoning, Gilligan’s theory, which incorporates both perspectives, is useful for analyzing moral reasoning in nurses. Our analysis suggests that attachment and connections based on relationships with patients and self-care are essential elements of care, and self-care is important in moral decision making. The inequality between nurse and physician roles was an issue raised with the justice perspective. Since nurses’ roles are strongly influenced by their affection toward and connections with their patients, it is important not to overemphasize either perspective.

关键词： Care Justice Nurse Moral Perspective Moral Reasoning

Qualitative Rural Indonesian Study of Diabetes Knowledge, Health Beliefs, and Behaviors in Type 2 Diabetes Patients

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Health 2019年第2期11卷 263-275页

作者： Nice Maylani Asril Keiji Tabuchi Miwako tsunematsu Toshio Kobayashi Masayuki Kakehashi Department of Health Informatics Graduate School of Biomedical and Health Science Hiroshima University Hiroshima Japan Department of Education Faculty of Education Ganesha University of Education Bali Indonesia Department of Health Promotion and Development Science Graduate School of Biomedical and Health Science Hiroshima University Hiroshima Japan Department of General Internal Medicine Ishii Memorial Hospital Yamaguchi Japan

This study was aimed at understanding diabetes knowledge, health beliefs, and behaviors among type 2 diabetes patients in Balinese rural areas. The study used the Health Belief Model (HBM) in applied thematic analysis. It involved semi-structured focus groups with 20 patients (M = 49.95 years old, SD 6.7). Three themes formulated: poor diabetes knowledge, diabetes perceived as a life burden, and the factors affecting self-efficacy in practicing healthy lifestyle. The poor diabetes knowledge was due to traditional indigenous beliefs and low health literacy. The perception that diabetes is a life burden was related with physical and psychological condition. The factors affecting the self-efficacy were the perceived barriers and external influence. It is need to understand the traditional indigenous beliefs, burdens, and lacking internal intention as the modifying factors of health beliefs. This study suggests that the development of integrated health promotion of diabetes should consider the HBM’s modifying factors in rural areas.

关键词： Type 2 Diabetes Health Beliefs Health Behaviors Health Promotion Rural Areas

Role of regulatory T cell in the pathogenesis of inflammatorybowel disease

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World Journal of Gastroenterology 2016年第7期22卷 2195-2205页

作者： akiko yamada rieko arakaki masako saito takaaki tsunematsu yasusei kudo naozumi ishimaru Department of Oral Molecular Pathology Tokushima University Graduate SchoolTokushima 770-8504Japan

Regulatory T(Treg) cells play key roles in various immune responses. For example, Treg cells contribute to the complex pathogenesis of inflammatory bowel disease(IBD), which includes Crohn's disease and ulcerative colitis during onset or development of that disease. Many animal models of IBD have been used to investigate factors such as pathogenic cytokines, pathogenic bacteria, and T-cell functions, including those of Treg cells. In addition, analyses of patients with IBD facilitate our understanding of the precise mechanism of IBD. This review article focuses on the role of Treg cells and outlines the pathogenesis and therapeutic strategies of IBD based on previous reports.

关键词： Inflammatory bowel disease Regulatory Tcell Animal model Therapy

Crucial roles of macrophages in the pathogenesis of autoimmune disease

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World Journal of Immunology 2017年第1期7卷 1-8页

作者： Aya Ushio Rieko Arakaki Akiko Yamada Masako Saito Takaaki tsunematsu Yasusei Kudo Naozumi Ishimaru Department of Oral Mole-cular Pathology Tokushima University Graduate School of Biomedical Sciences Department of Human Genetics Tokushima University Graduate School of Biomedical Sciences Department of Pathology and Laboratory Medicine Tokushima University Graduate School of Biomedical Sciences

Macrophages are key players in various immune responses. In addition to functions in innate immunity such as antigen phagocytosis and cytokine production, antigen presentation by macrophage represents a link between innate and acquired immunity. During inflammatory processes, naive monocytes differentiate into pro-inflammatory M1 and anti-inflammatory M2 macrophages. Resident monocytes/macrophages contribute to immune response that maintains tissue-specific homeostasis. In the target organs of autoimmune diseases, macrophages have dual functions in both the induction and suppression of autoimmune responses, which are mediated by production of various cytokines and chemokines, or by interaction with other immune cells. This review focuses on selected autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, and Sjogren’s syndrome, to illustrate the key roles of macrophages in the cellular or molecular patho-genesis of autoimmunity. In addition, the contribution of macrophages to each autoimmune disease is compared.

关键词： Macrophage Autoimmunity Differentiation Cytokines Chemokines

Relationship between Dietary Habits and Plasma Homocysteine Concentrations in Elderly Japanese Women and Men

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Food and Nutrition Sciences 2018年第5期9卷 595-608页

作者： Hiroaki Kanouchi Kosuke Toyoda Hitomi Miyazaki Eva Mariane Mantjoro Hideshi Niimura Kazuyo Kuwabara Noriko tsunematsu Nakahata Rie Ibusuki Shigeho Maenohara Toshiro Takezaki Department of Veterinary Medicine Joint Faculty of Veterinary Medicine Kagoshima University Kagoshima Japan Health Promotion Center Nakamura Gakuen University Fukuoka Japan Faculty of Public Health Sam Ratulangi University Manado Indonesia Yonemori Hospital Kagoshima Japan Department of Preventive Medicine and Public Health Keio University School of Medicine Tokyo Japan Department of Community Medicine Management Faculty of Medicine Shimane University Shimane Japan Department of International Islands and Community Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan JA Kagoshima Kouseiren Medical Health Care Center Kagoshima Japan

The plasma homocysteine concentration is a good indicator of various diseases such as cardiovascular disease, stroke, and dementia. This study examined the relationship between plasma homocysteine concentrations and dietary habits in a population of elderly Japanese people from the Amami Islands. Data from 1131 participants collected during a baseline survey for the Japan Multi-institutional Collaborative Cohort study, which is a prospective cohort study, were used. Information on dietary habits was collected using a food frequency questionnaire. The plasma homocysteine concentration was associated with age in women only. Smoking in men and menopause were significantly associated with homocysteine concentrations. Analysis of blood biochemical data showed that estimate of glomerular filtration rate negatively correlated with plasma homocysteine in women (R = ?0.91, p < 0.001) and men (R = ?0.49, p < 0.001). There was no common food associated with homocysteine concentrations among the groups, but in each group, some food types were associated with homocysteine concentrations. In men, Chinese tea was a common factor showing a negative correlation with homocysteine concentrations. Natto showed a negative correlation with homocysteine concentrations in non-smoking men (β = ?0.11, p < 0.05) and premenopausal women (β = ?0.20, p < 0.01). Eggs (β = ?0.21, p < 0.01) and food processed from fish eggs (β = ?0.21, p < 0.01) negatively correlated with homocysteine concentrations in smoking men. Miso soup (β = ?0.13, p < 0.01) and yoghurt (β = ?0.10, p < 0.05) negatively correlated with homocysteine concentrations in postmenopausal women. Consumption of folate-rich food did not necessarily correlate with a low plasma Hcy concentration.

关键词： Homocysteine FFQ Vegetables Chinese Tea Natto Egg Miso Soup Yoghurt