检索结果-南通市图书馆

雄激素受体负面调节GATA3在膀胱癌中的抑癌作用

在线全文

学校读者我要写书评

暂无评论

雄激素受体负面调节GATA3在膀胱癌中的抑癌作用

Azathioprine is essential following cyclosporine for patients with steroid-refractory ulcerative colitis

2015年浙江省泌尿外科学男科学学术年会

作者：李祎 Hitoshi ishiguro Takashi Kawahara Yurina Miyamoto Koji Izumi Hiroshi Miyamoto 浙江大学医学院附属二院泌尿外科

目的:研究GATA3是否抑制膀胱良性尿路上皮细胞的致瘤作用,以及是否受雄激素影响。方法:首先我们分别对多种含有雄激素受体(AR)的恶性膀胱尿路上皮细胞及表达AR的良性膀胱尿路上皮细胞加用雄激素处理后。通过蛋白免疫印迹(western blotti...

目的:研究GATA3是否抑制膀胱良性尿路上皮细胞的致瘤作用,以及是否受雄激素影响。方法:首先我们分别对多种含有雄激素受体(AR)的恶性膀胱尿路上皮细胞及表达AR的良性膀胱尿路上皮细胞加用雄激素处理后。通过蛋白免疫印迹(western blotting)和QPCR等方法检测其GATA3的不同表达;其次,通过将雄性小鼠分为三组,并相应做了去势、去势+外源性雄激素补充、及假手术等不同治疗方法,观察各组小鼠膀胱组织对GATA3的不同表达。最后,通过利用MCA等强致癌物,在体外诱发良性尿路上皮细胞恶变,且分别加用不同的药物后,观察尿路上皮细胞体外致癌性的差异。并比较各组有关抑癌及致癌基因的不同表达水平。结果:雄激素在蛋白及mRNA水平均可以下调良性尿路上皮细胞内GATA3的表达。雄性老鼠膀胱中GATA3表达相对较雌性者低。GATA3可以抑制良性细胞恶变,同时可以上调抑癌基因表达,下调原癌基因表达。结论:GATA3可以抑制尿路上皮细胞恶变。而雄激素可以抑制GATA3的表达。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第1期21卷 254-261页

作者： Nobuyuki Miyake Takafumi Ando Kazuhiro ishiguro Osamu Maeda Osamu Watanabe Yutaka Hirayama Keiko Maeda Kazuhiro Morise Masanobu Matsushita Kazuhiro Furukawa Kohei Funasaka Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoya CityAichi 466-8550Japan Department of Gastroenterology Fujita Health University School of MedicineToyoakeAichi 470-1192Japan

AIM: To evaluate long-term prognosis following cyclosporine treatment by examining the rate of surgery avoidance among cyclosporine ***: We retrospectively reviewed clinical records for 29 patients diagnosed with severe steroid-refractory ulcerative colitis in our hospital from August 1997 to August 2008 and treated with cyclosporine by continuous intravenous *** patients were treated with intravenous corticosteroids for more than 5 d prior to cyclosporine *** was continued for up to 21 d under serum monitoring to maintain cyclosporine levels between 400 and 600 ng/*** activity was assessed before and after cyclosporine therapy using the clinical activity index score,with a reduction of ≥ 5 considered to indicate a *** responders,we defined cases not requiring surgery for more than 5 years as exhibiting long-term efficacy of *** considered to be possibly predictive of long-term efficacy of cyclosporine were sex,age,disease duration,clinical activity index score,C-reactive protein level,hemoglobin level,disease extent,endoscopic findings,and clinical ***: Cyclosporine was not discontinued due to side effects in any ***(65.5%) of 29 patients were considered responders.A statistically significant(P = 0.004) inverseas sociation wa s observed between an endoscopic finding of "mucosal bleeding" and responsive ***(9 males,6 females) of these 19 patients were followed for 5 years or more,of whom 9(60%) exhibited long-termefficacy of *** the 10 non-responders,9(90%) underwent surgery within 6 mo of cyclosporine *** of the following factors had a significant impact on the long-term efficacy of cyclosporine: sex,age,duration of disease,clinical activity index score,C-reactive protein level,hemoglobin level,extent of disease,endoscopic findings,or clinical *** contrast,a significant association was observed for maintenance therapy with azat

关键词： Ulcerative colitis Cyclosporine Maintenance therap

糖皮质激素受体表达减少可预测膀胱肿瘤复发与进展

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

临床与实验病理学杂志 2015年第2期31卷 228-228页

作者： ishiguro H Kawahara T Zheng Y 胡舜摘余英豪南京军区福州总医院病理科福州350025

糖皮质激素受体（ GR）的状态及其预后意义目前尚不清楚，为评估GR的表达水平对预测膀胱肿瘤预后的价值，作者采用GR抗体（H300）对149例膀胱尿路上皮肿瘤及94例来自肿瘤周围非肿瘤性膀胱组织进行免疫组化染色对比研究。

关键词：糖皮质激素受体膀胱组织肿瘤复发表达减少预测膀胱尿路上皮肿瘤免疫组化染色肿瘤预后

Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第27期19卷 4300-4308页

作者： Ryu Ishihara Hiromitsu Kanzaki Hiroyasu Iishi Kengo Nagai Fumi Matsui Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Noriya Uedo Masaharu Tatsuta Yasuhiko Tomita Shingo ishiguro Department of Gastrointestinal Oncology Osaka Medical Center for Cancer and Cardiovascular Diseases Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Department of Pathology Osaka Medical Center for Cancer and Cardiovascular Diseases PCL Osaka Inc.

AIM:To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. METHODS:In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by endoscopic resection were included in the study. Areas of mucosa with and without the pink-color sign were evaluated histologically. The following histologic features that were possibly associated with the pinkcolor sign were evaluated. The keratinous layer and basal cell layer were classified as present or absent. Cellular atypia was classified as high grade, moderate grade or low grade, based on nuclear irregularity, mitotic figures, loss of polarity, chromatin pattern and nuclear/cytoplasmic ratio. Vascular change was assessed based on dilatation, tortuosity, caliber change and variability in shape. Vessels with these four findings were classified as positive for vascular change. Endoscopic images of the lesions were captured immediately after iodine staining, 2-3 min after iodine staining and after complete fading of iodine staining. Quantitative analysis of color changes after iodine staining was also performed. RESULTS:A total of 61 superficial esophageal neoplasms in 54 patients were included in the study. The lesions were located in the cervical esophagus in one case, the upper thoracic esophagus in 10 cases, the mid-thoracic esophagus in 33 cases, and the lower thoracic esophagus in 17 cases. The median diameter of the lesions was 20 mm (range:2-74 mm). Of the 61 lesions, 28 were classified as pink-color sign positive and 33 as pink-color sign negative. The histologic diagnosis was high-grade intraepithelial neoplasia (HGIN) or cancer invading into the lamina propria in 26 of the 28 pink-color sign positive lesions. There was a significant association between pink-color sign positive epithelium and HGIN or invasive cancer (P = 0.0001). Univariate

关键词： Chromoendoscopy Esophageal cancer Esophageal squamous neoplasia Iodine staining Pinkcolor sign

Perceptions of post-transplant recidivism in liver transplantation for alcoholic liver disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2014年第11期6卷 812-817页

作者： Yoshikuni Kawaguchi Yasuhiko Sugawara nobuhisa Akamatsu Junichi Kaneko Tomohiro Tanaka Sumihito Tamura Taku Aoki Yoshihiro Sakamoto Kiyoshi Hasegawa Norihiro Kokudo Artificial Organ and Transplantation Surgery Division Department of Surgery Graduate School of Medicine University of Tokyo Organ Transplantation Service University of Tokyo

Although alcoholic liver disease(ALD) is regarded as a common indication for liver transplantation(LT), debatable issues exist on the requirement for preceding alcoholic abstinence, appropriate indication criteria, predictive factors for alcoholic recidivism, and outcomes following living-donor LT. In most institutions, an abstinence period of six months before LT has been adopted as a mandatory selection criterion. Data indicating that pre-transplant abstinence is an associated predictive factor for alcoholic recidivism supports the reasoning behind this. However, conclusive evidence about the benefit of adopting an abstinence period is yet to be established. On the other hand, a limited number of reports available on living-donor LT experiences for ALD patients suggest that organ donations from relatives have no suppressive effect on alcoholic recidivism. Prevention of alcoholic recidivism has proved to be the most important treatment after LT based on the resultant inferior long-term outcome of patients. Further evaluations are still needed to establish strategies before and after LT for ALD.

关键词： Abstinence Alcoholic liver disease Liver transplantation Six-month rule

2011年日本东北地区近海大地震最大位移区的应力状态

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际地震动态 2013年第8期34卷 6-11页

作者： Weiren Lin Marianne Conin J Casey Moore Frederick M Chester Yasuyuki Nakamura James J Mori Louise Anderson Emily E Brodsky nobuhisa Eguchi 343勘查队科技人员冯万鹏(译) 许忠淮(校) 不详中国地震局地球物理研究所

2011年MW9.0的日本东北地区近海大地震在日本海沟附近产生了最大超过50m的同震滑动,这可能导致该区域进入了应力近乎完全卸载的状态。为检验上述假设,我们利用综合大洋钻探计划在震后1年左右时间得到的钻孔资料,以及对震前应力状态的推... 详细信息

2011年MW9.0的日本东北地区近海大地震在日本海沟附近产生了最大超过50m的同震滑动,这可能导致该区域进入了应力近乎完全卸载的状态。为检验上述假设,我们利用综合大洋钻探计划在震后1年左右时间得到的钻孔资料,以及对震前应力状态的推断结果,确定了陆楔前缘的原地应力状态。根据孔壁崩落法对水平应力方向与应力大小的估算结果,以及在破裂向海沟轴方向传播过程中同震位移增大的现象,可推断原地水平应力在地震过程中变小了。这种应力变化显示出板块界面的前缘发生了相对自由的滑动,该结论与地震引起了断层弱化和发生了近乎全部的应力降等观测结果是吻合的。

关键词：地应力状态日本海沟东北地区大地震最大位移近海综合大洋钻探计划水平应力

家庭血压测量和动态血压测量确诊的不完全白大衣性高血压或隐蔽性高血压的长期脑卒中风险

在线全文

学校读者我要写书评

暂无评论

中华高血压杂志 2015年第10期23卷 999-999页

作者： Satoh M Asayama K Kikuya M Inoue R Metoki H Hosaka M Tsubota-Utsugi M Obara T ishiguro A Murakami K Matsuda A Yasui D Murakami T Mano N Imai Y Ohkubo T 赵狄练桂丽

白大衣性高血压（white-coathypertension，WCH）的预后意义存在争论，且家庭自测血压与24h动态血压监测的不同结果使得wCH确诊困难。本研究探讨采用不同的诊室外血压测量方法诊断的不完全性或完全性WCH以及隐蔽性高血压（maskedhyper—... 详细信息

白大衣性高血压（white-coathypertension，WCH）的预后意义存在争论，且家庭自测血压与24h动态血压监测的不同结果使得wCH确诊困难。本研究探讨采用不同的诊室外血压测量方法诊断的不完全性或完全性WCH以及隐蔽性高血压（maskedhyper—tension，MH）是否存在不同的长期脑卒中风险。

关键词：白大衣性高血压动态血压测量脑卒中隐蔽性风险确诊家庭 24h动态血压监测

非增强血流抑制技术MR成像检测腔内动脉瘤修复术后内漏并发症:与增强CT对比的可行性研究

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2017年第2期 233-233页

作者： K.Mori T.Saida F.Sato Y.Uchikawa T.Konishi T.ishiguro 赵蕾 Department of Radiology Faculty of Medicine University of Tsukuba

摘要目的评价MR非增强运动敏感稳态(MSDE)准备平衡快速梯度回波(BTFE)序列用于腔内动脉瘤修复术(EVAR)后内漏检测的可行性。方法对46例主动脉和/或髂

关键词：修复术腔内动脉瘤血流抑制技术 MR 内漏 CT

尼可地尔降低非心脏手术过程中或术后心脏事件的发生率

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

首都食品与医药 2015年第22期22卷 151-151页

作者： Satoshi Kashimoto Makoto Seki Toshihiko ishiguro Hitoshi Yoshioka Osamu Nagata Kinya Nishimura Toshihiro Kikuchi Tatsuya Yamada Motoyo Iwade Akibumi Omi Osamu Honda Atsuhiro Sakamoto Yukihiko Ogihara Keiko Fujimoto Nakaigawa Jitsu Kato Akio Watanabe Minoru Nomura Junzo Takeda 王青北京四环科宝制药有限公司 100079

目的评估尼可地尔是否能减少危险手术进行过程中或术后心脏事件的发生。方案多中心研究。试验点日本的13家医院。患者通过心绞痛、心肌梗死病史、心脏衰竭、糖尿病和心电图异常等风险因素来评定的中危患者。给药方案在手术过程中给予这... 详细信息

目的评估尼可地尔是否能减少危险手术进行过程中或术后心脏事件的发生。方案多中心研究。试验点日本的13家医院。患者通过心绞痛、心肌梗死病史、心脏衰竭、糖尿病和心电图异常等风险因素来评定的中危患者。给药方案在手术过程中给予这些患者尼可地尔。试验方法和主要结果术中和术后连续5天监控心脏事件,比较尼可地尔治疗组患者与非治疗组患者心脏事件的发生率。其中,尼可地尔治疗组患者84例,常规治疗组患者237例。与常规治疗相比,术中和术后给予尼可地尔治疗的患者心脏事件发生率均显著降低（术中给予尼可地尔：比值比0.15;95%置信区间,0.03～0.76;P=0.02;术后给予尼可地尔：比值比0.24;95%置信区间,0.06～0.90;P=0.04）。结论在非心脏手术术中或术后给予尼可地尔,均能降低心脏事件的发生率。

关键词：心脏手术过程尼可地尔心脏事件发生率术后试验方法置信区间多中心研究