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Nano Materials Science 2020年第1期2卷 83-95页

作者： Reza Gholizadeh Daisuke Terada Akinobu Shibata nobuhiro Tsuji Department of Materials Science and Engineering Kyoto UniversityYoshida HonmachiSakyo-kuKyoto606-8501Japan ESISM(Elements Strategy Initiative for Structural Materials) Kyoto UniversityYoshida HonmachiSakyo-kuKyoto606-8501Japan Department of Advanced Materials Science and Engineering Chiba Institute of TechnologyTsudanumaNarashino275-0016Japan

Single-phase bcc-ferrite in an interstitial free(IF)steel was deformed to different strains in a wide range from low to high strains(ε=1–7)by torsion under different Zener-Hollomon(Z)*** specimens were rapidly quenched after the torsion to preserve microstructures formed under different deformation *** results showed that during high-Z(low-temperature)deformation,grains were subdivided by geometrically necessary boundaries(GNBs)via the grain subdivision *** to high strains(ε>5)led to the ultrafine lamellar structures(with grain sizes1μm)were realized with decreasing *** significance of the grain subdivision and the thermally activated phenomena on the formation of various microstructures under different deformation conditions is discussed.

关键词： Severe plastic deformation Grain subdivision Ultrafine grains Zener-Hollomon parameter Boundary migration Electron backscattering diffraction(EBSD)

Human platelets inhibit liver fibrosis in severe combined immunodeficiency mice

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World Journal of Gastroenterology 2013年第32期19卷 5250-5260页

作者： Kazuhiro Takahashi Soichiro Murata Kiyoshi Fukunaga nobuhiro Ohkohchi Department of Surgery University of Tsukuba

AIM:To investigate the role of human platelets in liver ***:Severe combined immunodeficiency(SCID)mice were administered CCl4and either phosphate-buffered saline(PBS group)or human platelet transfusions(hPLT group).Concentrations of hepatocyte growth factor(HGF),matrix metallopeptidases(MMP)-9,and transforming growth factor-β(TGF-β)in the liver tissue were compared between the PBS and the hPLT groups by enzyme-linked immunosorbent assay(ELISA)and Western *** effects of a human platelet transfusion on liver fibrosis included the fibrotic area,hydroxyproline content,and-smooth muscle actin(α-SMA)expression,which were evaluated by picrosirius red staining,ELISA,and immunohistochemical staining using an anti-mouse-SMA antibody,*** of mesenchymal-epithelial transition factor(Met)and SMAD3,downstream signals of HGF and TGF-β,were compared between the two groups by Western blotting and were quantified using *** apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick end ***,the accumulation of human platelets in the liver 2 h after platelet transfusion was compared between normal and fibrotic livers by immunohistochemical staining using an anti-human CD41 ***:The fibrotic area and hydroxyproline content in the liver were both significantly lower in the hPLT group when compared to the PBS group(fibrotic area,1.7%±0.6%vs 2.5%±0.6%,P=0.03;hydroxyproline content,121±26 ng/g liver vs 156±47 ng/g liver,P=0.04).There was less α-smooth muscle actin staining in the hPLT group than in the PBS group(0.5%±0.1%vs 0.8%±0.3%,P=0.02).Hepatic expression levels of mouse HGF and MMP-9were significantly higher in the hPLT group than in the PBS group(HGF,109±13 ng/g liver vs 88±22 ng/g liver,P=0.03;MMP-9,113%±7%/GAPDH vs 92%±11%/GAPDH,P=0.04).In contrast,the concentration of mouse TGF-β in the liver tissue was significantly lower in the hPLT group than in the PBS group(22±5ng/g

关键词： Human platelet Liver fibrosis Hepatocyte apoptosis Hepatocyte growth factor Transforming growth factor-β Matrix metallopeptidases

Phase decomposition behavior and its impact on mechanical properties in bulk nanostructured Cu-20 at.%Fe supersaturated solid solution

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Journal of Materials Science & Technology 2024年第18期185卷 207-220页

作者： Maowen Liu Ruixiao Zheng Hongxing Li Qiuming Wei Chaoli Ma nobuhiro Tsuji Tianmushan Laboratory Yuhang DistrictHangzhou 311115China Research Institute for Frontier Science Beihang UniversityBeijing 100191China School of Materials Science and Engineering Beihang UniversityBeijing 100191China Department of Materials Science and Engineering Kyoto UniversityYoshida HonmachiSakyo-kuKyoto 606-8501Japan Department of Mechanical Engineering University of North Carolina at Charlotte9201 University City BoulevardCharlotteNC 28223-0001USA Elements Strategy Initiative for Structural Materials(ESISM) Kyoto UniversityYoshida HonmachiSakyo-kuKyoto 606-8501Japan

Extended solid solution of immiscible systems,achieved by extreme processing approaches,can be trans-formed into nanostructured composites via phase decomposition,which are drawing great research atten-tion for their excellent thermal stability and high *** we fabricated the supersaturated solid solution of Cu-20 at.%Fe,a typical immiscible alloy,in bulk state by high pressure torsion,which pro-vides a great freedom over powders for studying the microstructure evolution and mechanical properties in the process of the phase decomposition in immiscible *** found that in the Cu-Fe solid solu-tion,spinodal decomposition of the Fe phases took place at the initial stage of annealing through volume *** process gives rise to:(1)metastableγ-Fe particles in the Cu grains with coherent Fe/Cu interface,and(2)the more stableα-Fe phase at the grain *** process was accompanied by moving boundary reaction which first proceeded in the pattern of spinodal decomposition and then changed into classical nucleation-growth mode with the depletion of Fe atoms in *** resultant Cu-Fe nanocomposites were jointly strengthened by the ultrafine Cu andα-Fe grains according to the rule of mixture,including grain boundary strengthening and the hardening of nanoscaleγ-Fe precipitates in the Cu *** effects of different strengthening mechanisms were scrutinized and their contributions to mechanical properties were quantitatively *** work sheds light onto the opportunity of designing and fabricating nanostructured composites via phase decomposition in immiscible systems.

关键词： immiscible alloy high pressure torsion annealing phase decomposition mechanical property

In-situ observation of twinning and detwinning in AZ31 alloy

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Journal of Magnesium and Alloys 2022年第12期10卷 3418-3432页

作者： Wu Gong Ruixiao Zheng Stefanus Harjo Takuro Kawasaki Kazuya Aizawa nobuhiro Tsuji J-PARC Center Japan Atomic Energy Agency2-4 Shirane ShirakataTokaiNakaIbaraki 319-1195Japan Center for Elements Strategy Initiative for Structural Materials Kyoto UniversityYoshidahonmachiSakyo-kuKyoto 606-8501Japan Department of Materials Science and Engineering Kyoto UniversityYoshida-honmachiSakyo-kuKyoto 606-8501Japan School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Twinning and detwinning behavior of a commercial AZ31 magnesium alloy during cyclic compression–tension deformation with a total strain amplitude of 4%(±2%) was evaluated using the complementary techniques of in-situ neutron diffraction, identical area electron backscatter diffraction, and transmission electron microscopy. In-situ neutron diffraction demonstrates that the compressive deformation was dominated by twin nucleation, twin growth, and basal slip, while detwinning dominated the unloading of compressive stresses and subsequent tension stage. With increasing number of cycles from one to eight: the volume fraction of twins at-2% strain gradually increased from 26.3% to 43.5%;the residual twins were present after 2% tension stage and their volume fraction increased from zero to 3.7% as well as a significant increase in their number;and the twinning spread from coarse grains to fine grains involving more grains for twinning. The increase in volume fraction and number of residual twins led to a transition from twin nucleation to twin growth, resulting in a decrease in yield strength of compression deformation with increasing cycles. A large number of-component dislocations observed in twins and the detwinned regions were attributed to the dislocation transmutation during the twinning and detwinning. The accumulation of barriers including twin boundaries and various types of dislocations enhanced the interactions of migrating twin boundary with these barriers during twinning and detwinning, which is considered to be the origin for increasing the work hardening rate in cyclic deformation of the AZ31 alloy.

关键词： Magnesium Neutron diffraction Twinning Detwinning Dislocation transmutation

Understanding the Mechanism for the In-Plane Yielding Anisotropy of a Hot-Rolled Zirconium Plate

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 1066-1076页

作者： Guodong Song Conghui Zhang Yunchang Xin nobuhiro Tsuji Xinde Huang Bo Guan Xiaomei He School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055China Key Laboratory for Light-Weight Materials Nanjing Tech UniversityNanjing210009China Department of Materials Science and Engineering Kyoto UniversityYoshida-honmachiSakyo-kuKyoto606-8501Japan Institute of Applied Physics Jiangxi Academy of ScienceNanchang330029China

Previously,the in-plane mechanical anisotropy of Zr hot-rolled plates is ascribed mainly to the different activities of the deformation modes activated when loading along different *** this work,a quantitative study on the deformation behavior of a pure Zr hot-rolled plate under tension along the rolling direction(RD)and transverse direction(TD)reveals that both the activities of deformation modes and the anisotropy of grain boundary strengthening account for a tensile yield strength anisotropy along the TD and *** plasticity simulations using viso-plastic self-consistent model show that prismatic slip is the predominant deformation mode for tension along the RD(RD-tension),while prismatic slip and basal slip are co-dominant deformation modes under tension along the TD(TD-tension).A low fraction of■under TD-tension,while hardly activated under *** activation of basal slip with a much higher critical resolve shear stress under TD-tension contributes to a higher yield strength along the TD than along the *** grain boundary strengthening effect under tension along the TD and RD were compared by calculating the activation stress difference(△Stress)and the geometric compatibility factor(m′)between neighboring *** results indicate a higher grain boundary strengthening for TD-tension than that for RD-tension,which will lead to a higher yield strength along the *** is,the anisotropy of grain boundary strengthening between TD-tension and RD-tension also plays an important role in the in-plane anisotropy along the RD and ***,the reasons for why there is a grain-boundary-strengthening anisotropy along the TD and RD were discussed.

关键词： Zirconium Strengthening Grain boundary Orientation

In situ neutron diffraction revealing the achievement of excellent combination of strength and ductility in metastable austenitic steel by grain refinement

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Journal of Materials Science & Technology 2024年第9期176卷 69-82页

作者： Wenqi Mao Wu Gong Stefanus Harjo Satoshi Morooka Si Gao Takuro Kawasaki nobuhiro Tsuji J-PARC Center Japan Atomic Energy AgencyIbarakiJapan Department of Materials Science and Engineering Kyoto UniversitySakyo-kuKyotoJapan

The yield stress of Fe-24Ni-0.3C(wt%)metastable austenitic steel increased 3.5 times(158→551 MPa)when the average grain size decreased from 35μm(coarse-grained[CG])to 0.5μm(ultrafine-grained[UFG]),whereas the tensile elongation was kept large(0.87→0.82).In situ neutron diffraction measurements of the CG and UFG Fe-24Ni-0.3C steels were performed during tensile deformation at room temperature to quantitatively elucidate the influence of grain size on the mechanical properties and deformation *** initial stages of plastic deformation in the CG and UFG specimens were dominated by dislocation slip,with deformation-induced martensitic transformation(DIMT)also occurring in the later stage of *** show that grain refinement increases the initiation stress of DIMT largely and suppresses the rate of DIMT concerning the strain,which is attributed to the following effects.(i)Grain refinement increased the stabilization of austenite and considerably delayed the initiation of DIMT in the//LD(LD:loading direction)austenite grains,which were the most stable grains for *** a result,most of the//LD austenite grains in the UFG specimen failed to transform into martensite.(ii)Grain refinement also suppressed the autocatalytic effect of the martensitic ***,the DIMT with the low transformation rate in the UFG specimen was more efficient in increasing the flow stress and more appropriate to maintain uniform deformation than that in the CG specimen during *** above phenomena mutually contributed to the excellent combination of strength and ductility of the UFG metastable austenitic steel.

关键词： Ultrafine grain Deformation-induced martensitic transformation Metastable austenitic steel In situ neutron diffraction

Wastewater degradation by iron/copper nanoparticles and the microorganism growth rate

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Journal of Environmental Sciences 2018年第12期30卷 19-31页

作者： Tareq W.M.Amen Osama Eljamal Ahmed M.E.Khalil nobuhiro Matsunaga Earth System Science and Technology Interdisciplinary Graduate School of Engineering Sciences Kyushu University Department of Chemical Engineering Faculty of Engineering Cairo University

Nowadays, trends in wastewater treatment by zero-valent iron（ZVI） were turned to use bimetallic NZVI particles by planting another metal onto the ZVI surface to increase its reactivity. Nano size zero-valent iron/copper（NZVI/Cu0） bimetallic particles were synthesized in order to examine its toxicity effects on the wastewater microbial life, kinetics of phosphorus, ammonia stripping and the reduction of chemical oxygen demand（COD）.Various concentrations of NZVI/Cu0 and operation conditions both aerobic and anaerobic were investigated and compared with pure NZVI experiment. The results showed that addition10 mg/L of NZVI/Cu0 significantly increased the numbers of bacteria colonies under anaerobic condition, conversely it inhibited bacteria activity with the presence of oxygen. Furthermore,the impact of nanoparticles on ammonia stripping and phosphorus removal was also linked to the emitted iron ions electrons. It was found that dosing high concentration of bimetallic NZVI/Cu0 has a negative effect on ammonia stripping regardless of the aeration condition. In comparison to control, dosing only 10 mg/L NZVI/Cu0, the phosphorus removal increased sharply both under aerobic and anaerobic conditions, these outcomes were obtained as a result of complete dissolution of bimetallic nanoparticles which formed copper-iron oxides components that are attributed to increasing the phosphorus adsorption rate.

关键词： Iron bimetallic Wastewater biodegradation Bacterial life Contaminants removal

Potentiality of immunotherapy against hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第36期21卷 10314-10326页

作者： nobuhiro Tsuchiya Yu Sawada Itaru Endo Yasushi Uemura Tetsuya Nakatsura Division of Cancer Immunotherapy Exploratory Oncology Research and Clinical Trial CenterNational Cancer Center Department of Gastroenterological Surgery Graduate School of MedicineYokohama City University

Hepatocellular carcinoma(HCC),the predominant form of primary liver cancer,is the fifth most common cancer worldwide and the second leading cause of cancer-related death. Despite the high incidence,treatment options remain limited for advanced HCC,and as a result prognosis continues to be poor. Current therapeutic options,surgery,chemotherapy and radiotherapy,have only modest efficacy. New treatment modalities to prolong survival and to minimize the risk of adverse response are desperately needed for patients with advanced HCC. Tumor immunotherapy is a promising,novel treatment strategy that may lead to improvements in both treatment-associated toxicity and outcome. The strategies have developed in part through genomic studies that have yielded candidate target molecules and in part through basic biology studies that have defined the pathways and cell types regulating immune response. Here,we summarize the various types of HCC immunotherapy and argue that the newfound field of HCC immunotherapy might provide critical advantages in the effort to improve prognosis of patients with advanced HCC. Already several immunotherapies,such as tumor-associated antigen therapy,immune checkpoint inhibitors and cell transfer immunotherapy,have demonstrated safety and feasibility in HCC patients. Unfortunately,immunotherapy currently has low efficacy in advanced stage HCC patients; overcoming this chal lenge will place immunotherapy at the forefront of HCC treatment,possibly in the near future.

关键词： Cell transfer immunotherapy Cytokine therapy Hepat

Characteristics of multiple nodules in a patient with pulmonary Langerhans cell histiocytosis: A case report

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World Journal of Clinical Cases 2019年第17期7卷 2519-2525页

作者： nobuhiro Kanaji Yoshimasa Tokunaga Ryou Ishikawa Naoki Watanabe Norimitsu Kadowaki Department of Internal Medicine Division of HematologyRheumatology and Respiratory MedicineFaculty of MedicineKagawa UniversityKagawa 761-0793Japan Department of General Thoracic Surgery Breast and Endocrinological SurgeryFaculty of MedicineKagawa UniversityKagawa 761-0793Japan Department of Diagnostic Pathology Faculty of MedicineKagawa UniversityKagawa 761-0793Japan

BACKGROUND The common computed tomography findings of pulmonary Langerhans cell histiocytosis (PLCH) are multiple cysts and micronodules predominantly in middle to upper lung ***-cystic nodules and large nodules are atypical findings of *** SUMMARY The patient was a 48-year-old Japanese man with a smoking history (20 cigarettes/d,28 years) and no *** nodules existed in all lung lobes,predominantly in the right lower *** nodules seemed to be distributed randomly,and others were adjacent to *** nodules were solid;some small ones were *** largest nodule was 22 mm in *** metastatic lung tumors were suspected,thoracoscopic lung biopsy led to the diagnosis of *** 6 months after he quit smoking,all nodules had almost *** investigated the characteristics of nodules at diagnosis in *** 349 nodules in total,116 were in upper and 199 were in lower ***-six (27.5%) were cystic;the remaining 253 (72.5%) were *** prevalence of cystic nodules was higher in upper lobes than in lower lobes (right upper 37.5% vs lower 18.2%,P = 0.0068;left upper 48.1% vs lower 24.4%,P = 0.0078).The average size (dia.) of cystic nodules was smaller than that of noncystic nodules (5.03 mm vs 7.40 mm,respectively,P < 0.0001).CONCLUSION Although multiple non-cystic nodules including large nodules (over 20 mm) are atypical,PLCH should be included in differential *** presence of small cystic nodules predominantly in upper lobes and asymptomatic situation are also important for differential diagnoses to distinguish from metastatic cancers.

关键词： Langerhans cell histiocytosis Multiple Non-cystic Nodule Distribution Size Case report

Holistic approach to health education on AIDS

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Chinese Medical Journal 1999年第2期112卷 74-80页

作者： Ning Wei, Bing Zhang, Tao Li, Abdul Fattah, Miyuki Yamamoto and nobuhiro Maruchi Department of Public Health Shinshu University School of Medicine 3-1-1 Asahi Matsumoto Nagano Japan 390

Objective To identify a method for health education using the example of an educational seminar on AIDS prevention and control at Hebei Medical University in China, *** Our goal is the theoretical formulation of a unified community approach for problem solving through the combination of the self regulative approach and the case analytical approach. “Quality improvement”, “essential quality” and “human ecosystems” provide the basic ideas for better understanding the integration of culture, science and technology within the “cultural norm”.Results The present seminar was successfully organized for Chinese medical students based on the theme of “living with AIDS”. Through this program, we identified that self regulative and case analytical approach were major issues for holistic approach to health education. We also identified that a community approach provides the scientific basis for health education in the *** The present paper generates a healthcare paradigm for surveillance in health/medical education. Through a better understanding of community approach, we related “community care” (emphasizing self, mutual, professional and institutional care) to the “practical norm”; and “preventive epidemiology” (emphasizing the unification of quality and quantity, as well as systems and population) to the “research norm”.

关键词： community care community control cultural norm essential quality holistic approach human ecosystems