检索结果-南通市图书馆

Removal of hexavalent chromium from water by Z-scheme photocatalysis using TiO_(2)(rutile)nanorods loaded with Au core-Cu_(2)0 shell particles

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2022年第5期34卷 173-189页

作者： Sayaka Yanagida Takumi Yajima Takahiro Takei nobuhiro Kumada Center for Crystal Science and Technology University of YamanashiKofu 400-8511Japan Advanced Materials Development Sector Tokyo Metropolitan Industrial Technology Research Institute2-4-10AomiKoto-kuTokyo 135-0064Japan

All-solid-state Z-scheme photocatalysts,containing Cu_(2)O,TiO_(2)(rutile),and Au as the elec-tron mediator,were prepared and applied to the reduction of Cr(Ⅵ)in aqueous solutions.The Cu_(2)O-Au-TiO_(2) composites were prepared by loading Au core-Cu_(2)O shell hemisphere particles on TiO_(2)(rutile)nanorods using a two-step photocatalytic deposition process.Un-der ultraviolet-visible(UV-vis)light illumination,the Cu_(2)O-Au-TiO_(2) composites exhibited higher photocatalytic Cr(Ⅵ)reduction activities than those exhibited by single TiO_(2)(rutile)and Cu_(2)O.In this reaction,a precipitate containing Cr,which was considered to be Cr(OH)_(3),was deposited site-selectively on the Au core-Cu_(2)O shell particles of the composites,indi-cating that the reduction site of the composite was Cu_(2)O,and the reaction proceeded accord-ing to the Z-scheme.The Cu_(2)O-Au-TiO_(2) composites also exhibited photocatalytic activity under visible light illumination.The oxidation state of Cu in the Cu_(2)O-Au-TiO_(2) composite gradually changed from Cu(Ⅰ)to Cu(Ⅱ)during the photocatalytic Cr(Ⅵ)reduction.However the composite maintained its high photocatalytic performance even after oxidation.The role of Au in the Cu_(2)O-Au-TiO_(2) composite was examined by comparing the properties of the Cu_(2)O-Au-TiO_(2) composite with those of the Cu_(2)O-TiO_(2) composite prepared via direct Cu_(2)O deposition on TiO_(2).

关键词： Cu_(2)O TiO_(2)(rutile) Z-scheme Photocatalyst Chromium

Dualistic role of platelets in living donor liver transplantation: Are they harmful?

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第9期28卷 897-908页

作者： Chen Liang Kazuhiro Takahashi Kinji Furuya nobuhiro Ohkohchi Tatsuya Oda Gastrointestinal and Hepatobiliary-Pancreatic Surgery University of TsukubaTsukuba 3058575IbarakiJapan

Platelets are anucleate fragments mainly involved in hemostasis and thrombosis,and there is emerging evidence that platelets have other nonhemostatic potentials in inflammation,angiogenesis,regeneration and ischemia/reperfusion injury(I/R injury),which are involved in the physiological and pathological processes during living donor liver transplantation(LDLT).LDLT is sometimes associated with impaired regeneration and severe I/R injury,leading to postoperative complications and decreased patient survival.Recent studies have suggested that perioperative thrombocytopenia is associated with poor graft regeneration and postoperative morbidity in the short and long term after LDLT.Although it is not fully understood whether thrombocytopenia is the cause or result,increasing platelet counts are frequently suggested to improve posttransplant outcomes in clinical studies.Based on rodent experiments,previous studies have identified that platelets stimulate liver regeneration after partial hepatectomy.However,the role of platelets in LDLT is controversial,as platelets are supposed to aggravate I/R injury in the liver.Recently,a rat model of partial liver transplantation(LT)was used to demonstrate that thrombopoietin-induced thrombocytosis prior to surgery accelerated graft regeneration and improved the survival rate after transplantation.It was clarified that platelet-derived liver regeneration outweighed the associated risk of I/R injury after partial LT.Clinical strategies to increase perioperative platelet counts,such as thrombopoietin,thrombopoietin receptor agonist and platelet transfusion,may improve graft regeneration and survival after LDLT.

关键词： Platelet Liver transplantation Regeneration Ischemia/reperfusion injury Kupffer cell Oxidative stress

In-situ observation of twinning and detwinning in AZ31 alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2022年第12期10卷 3418-3432页

作者： Wu Gong Ruixiao Zheng Stefanus Harjo Takuro Kawasaki Kazuya Aizawa nobuhiro Tsuji J-PARC Center Japan Atomic Energy Agency2-4 Shirane ShirakataTokaiNakaIbaraki 319-1195Japan Center for Elements Strategy Initiative for Structural Materials Kyoto UniversityYoshidahonmachiSakyo-kuKyoto 606-8501Japan Department of Materials Science and Engineering Kyoto UniversityYoshida-honmachiSakyo-kuKyoto 606-8501Japan School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Twinning and detwinning behavior of a commercial AZ31 magnesium alloy during cyclic compression–tension deformation with a total strain amplitude of 4%(±2%) was evaluated using the complementary techniques of in-situ neutron diffraction, identical area electron backscatter diffraction, and transmission electron microscopy. In-situ neutron diffraction demonstrates that the compressive deformation was dominated by twin nucleation, twin growth, and basal slip, while detwinning dominated the unloading of compressive stresses and subsequent tension stage. With increasing number of cycles from one to eight: the volume fraction of twins at-2% strain gradually increased from 26.3% to 43.5%;the residual twins were present after 2% tension stage and their volume fraction increased from zero to 3.7% as well as a significant increase in their number;and the twinning spread from coarse grains to fine grains involving more grains for twinning. The increase in volume fraction and number of residual twins led to a transition from twin nucleation to twin growth, resulting in a decrease in yield strength of compression deformation with increasing cycles. A large number of-component dislocations observed in twins and the detwinned regions were attributed to the dislocation transmutation during the twinning and detwinning. The accumulation of barriers including twin boundaries and various types of dislocations enhanced the interactions of migrating twin boundary with these barriers during twinning and detwinning, which is considered to be the origin for increasing the work hardening rate in cyclic deformation of the AZ31 alloy.

关键词： Magnesium Neutron diffraction Twinning Detwinning Dislocation transmutation

Paraneoplastic syndromes associated with lung cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2014年第3期5卷 197-223页

作者： nobuhiro Kanaji Naoki Watanabe Nobuyuki Kita Shuji Bandoh Akira Tadokoro Tomoya Ishii Hiroaki Dobashi Takuya matsunaga Department of Internal Medicine Division of Endocrinology and Metabolism Hematology Rheumatology and Respiratory MedicineFaculty of MedicineKagawa University

Paraneoplastic syndromes are signs or symptoms that occur as a result of organ or tissue damage at locations remote from the site of the primary tumor or metastases. Paraneoplastic syndromes associated with lung cancer can impair various organ functions and include neurologic, endocrine, dermatologic, rheumatologic, hematologic, and ophthalmological syndromes, as well as glomerulopathy and coagulopathy(Trousseau's syndrome). The histological type of lung cancer is generally dependent on the associated syndrome, the two most common of which are humoral hypercalcemia of malignancy in squamous cell carcinoma and the syndrome of inappropriate antidiuretic hormone secretion in small cell lung cancer. The symptoms often precede the diagnosis of the associated lung cancer, especially when the symptoms are neurologic or dermatologic. The proposed mechanisms of paraneoplastic processes include the aberrant release of humoral mediators, such as hormones and hormone-like peptides, cyto-kines, and antibodies. Treating the underlying cancer is generally the most effective therapy for paraneoplastic syndromes, and treatment soon after symptom onset appears to offer the best potential for symptom improvement. In this article, we review the diagnosis, potential mechanisms, and treatments of a wide variety of paraneoplastic syndromes associated with lung cancer.

关键词： Paraneoplastic syndrome Small cell lung cancer Non-small cell lung cancer Symptom Diagnosis Treatment Endocrine Neurologic Hematologic Trousseau’s syndrome

New native tissue repair for pelvic organ prolapse:Medium-term outcomes of laparoscopic vaginal stump-round ligament fixation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第15期11卷 3457-3463页

作者： Toshiyuki Kakinuma Ayaka Kaneko Kaoru Kakinuma Ken Imai nobuhiro Takeshima Michitaka Ohwada Department of Obstetrics and Gynecology International University of Health and WelfareNasushiobara 329-2763Japan

BACKGROUND Laparoscopic sacrocolpopexy for pelvic organ prolapse(POP)is a new and widely used approach;however,ever since the United States Food and Drug Administration warned against the use of surgical mesh,repairs performed using patients’tissues[i.***.native tissue repair(NTR)]instead of mesh have attracted much attention.At our hospital,laparoscopic sacrocolpopexy(the Shull method)was introduced in 2017.However,patients with more severe POP who have a long vaginal canal and overextended uterosacral ligaments may not be candidates for this procedure.AIM To validate a new NTR treatment for POP,we examined patients undergoing laparoscopic vaginal stump–round ligament fixation(the Kakinuma method).METHODS The study patients were 30 individuals with POP who underwent surgery using the Kakinuma method between January 2020 and December 2021 and who were followed up for>12 mo after surgery.We retrospectively examined surgical outcomes for surgery duration,blood loss,intraoperative complications,and incidence of recurrence.The Kakinuma method involves round ligament suturing and fixation on both sides,effectively lifting the vaginal stump after laparoscopic hysterectomy.RESULTS The patients’mean age was 66.5±9.1(45-82)years,gravidity was 3.1±1.4(2-7),parity was 2.5±0.6(2-4)times,and body mass index was 24.5±3.3(20.9-32.8)kg/m2.According to the POP quantification stage classification,there were 8 patients with stage Ⅱ,11 with stage Ⅲ,and 11 with stage Ⅳ.The mean surgery duration was 113.4±22.6(88-148)min,and the mean blood loss was 26.5±39.7(10-150)mL.There were no perioperative complications.None of the patients exhibited reduced activities of daily living or cognitive impairment after hospital discharge.No cases of POP recurrence were observed 12 mo after the operation.CONCLUSION The Kakinuma method,similar to conventional NTR,may be an effective treatment for POP.

关键词： Pelvic organ prolapse Native tissue repair Laparoscopic surgery Round ligament Kakinuma method

Development of conversion therapy for advanced hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2023年第3期12卷 453-456页

作者： Ryota Matsuki Masaharu Kogure nobuhiro Hasui Hirokazu Momose Yutaka Suzuki Yoshihiro Sakamoto Department of Hepato-Biliary-Pancreatic Surgery Kyorin University HospitalShinkawaMitaka CityTokyoJapan

Although the number of hepatocellular carcinoma(HCC)patients is decreasing due to the development of hepatic anti-virus therapy,it remains a leading cause of cancer-related death worldwide.The recent development of systemic or locoregional therapy for advanced or unresectable HCC has enabled advanced HCC to be downstaged,and reports of conversion therapy have increased;however,many clinical and scientific subjects rely on the therapeutic strategies of advanced HCC.There is a need to assess the evidence and develop clinical guidelines for conversion therapy for HCC;therefore,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition),consisting of 16 statements,has been developed for clinical practice(1).This consensus addresses treatment strategies for both technically and oncologically unresectable HCCs.We applaud Chinese establishment of this comprehensive and cutting-edge consensus on the treatment of advanced HCC.

关键词： Hepatocellular carcinoma(HCC) conversion therapy Chinese expert consensus

Platelets in liver disease, cancer and regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第18期23卷 3228-3239页

作者： Tomohiro Kurokawa nobuhiro Ohkohchi Department of Surgery Division of Gastroenterological and Hepatobiliary Surgery and Organ Transplantation Faculty of Medicine University of Tsukuba

Although viral hepatitis treatments have evolved over the years, the resultant liver cirrhosis still does not completely heal. Platelets contain proteins required for hemostasis, as well as many growth factors required for organ development, tissue regeneration and repair. Thrombocytopenia, which is frequently observed in patients with chronic liver disease(CLD) and cirrhosis, can manifest from decreased thrombopoietin production and accelerated platelet destruction caused by hypersplenism; however, the relationship between thrombocytopenia and hepatic pathogenesis, as well as the role of platelets in CLD, is poorly understood. In this paper, experimental evidence of platelets improving liver fibrosis and accelerating liver regeneration is summarized and addressed based on studies conducted in our laboratory and current progress reports from other investigators. In addition, we describe our current perspective based on the results of these studies. Platelets improve liver fibrosis by inactivating hepatic stellate cells, which decreases collagen production. The regenerative effect of platelets in the liver involves a direct effect on hepatocytes, a cooperative effect with liver sinusoidal endothelial cells, and a collaborative effect with Kupffer cells. Based on these observations, we ascertained the direct effect of platelet transfusion on improving several indicators of liver function in patients with CLD and liver cirrhosis. However, unlike the results of our previous clinical study, the smaller incremental changes in liver function in patients with CLD who received eltrombopag for 6 mo were due to patient selection from a heterogeneous population. We highlight the current knowledge concerning the role of platelets in CLD and cancer and anticipate a novel application of platelet-based clinical therapies to treat liver disease.

关键词：血小板肝肝硬化肝新生癌症 Thrombopoietin Thrombopoietin 收缩筋 Eltrombopag

Ionomic Profiling of Rice Genotypes and Identification of Varieties with Elemental Covariation Effects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rice science 2022年第1期29卷 76-88,I0026-I0030页

作者： ZHANG Chengming nobuhiro TANAKA Maria Stefanie Dw IYANTI Matthew SHENTON Hayato MARUYAMA Takuro SHINANO CHU Qingnan XIE Jun Toshihiro WATANABE Research Faculty of Agriculture Hokkaido UniversitySapporo 060-8589Japan Institute of Crop Science National Agriculture and Food Research OrganizationTsukuba 305-8518Japan Graduate School of Agricultural and Life Sciences The University of TokyoTokyo 113-8657Japan College of Resources and Environment Southwest UniversityChongqing 400715China

Ionomic profiles are primarily influenced by genetic and environmental factors.Identifying ionomic responses to varietal effects is necessary to understand the ionomic variations among species or subspecies and to potentially understand genetic effects on ionomic profiles.We cultivated 120 rice(Oryza sativa)varieties to seedling stage in identical hydroponic conditions and determined the concentrations of 26 elements(including 3 anions)in the shoots and roots of rice.Although the subspecies effects were limited by the genus Oryza pre-framework and its elemental chemical properties,we found significant differences in ionomic variations in most elements among the aus,indica and japonica subspecies.Principal component analysis of the correlations indicated that variations in the root-to-shoot ionomic transport mechanisms were the main causes of ionomic differences among the subspecies.Furthermore,the correlations were primarily associated with the screening of varieties for elemental covariation effects that can facilitate breeding biofortified rice varieties with safe concentrations of otherwise toxic elements.The japonica subspecies exhibited the strongest elemental correlations and elemental covariation effects,therefore,they showed greater advantages for biofortification than the indica and aus subspecies,whereas indica and aus subspecies were likely safer in metal(loid)polluted soils.We also found that geographical and historical distribution significantly defined the ionomic profiles.Overall,the results of this study provided a reference for further association studies to improve the nutritional status and minimize toxicity risks in rice production.

关键词： ionomic profile rice genotype elemental covariation correlation principal component analysis

Discovery of new hazimycin congeners from Kitasatospora sp.P07101

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2015年第6期5卷 564-568页

作者： nobuhiro Koyama Hirofumi Sato Hiroshi Tomoda Graduate School of Pharmaceutical Sciences Kitasato University

In an analytical study of microbial broths,the actinomycete strain Kitasatospora sp.P07101 was found to produce three new congeners,which were designated hazimycins B(1),C(2),and D(3),together with the previously reported hazimycin(renamed hazimycin A(4)).The structures of these hazimycins were examined using various spectroscopic methods including nuclear magnetic resonance(NMR),and the results revealed that 1–3 were analogues of hazimycin with the replacement of one of the two isonitrile groups in 4 by an NH-formyl group in 1,the two isonitrile groups and an amide group by two NH-formyl groups and a nitrile group in 2,and the two isonitrile groups and two amide groups by two NH-formyl groups and two nitrile groups in 3.Only hazimycin A exhibited moderate antimicrobial activities against Gram-positive bacteria and Candida albicans.These results indicated that the presence of two isonitrile groups in the hazimycin structure is essential for antimicrobial activity.

关键词： Hazimycin Isonitrile Nitrile Microbial metabolites Kitasatospora