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New aspects of a small GTPase RAB35 in brain development and function

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Neural Regeneration Research 2025年第7期20卷 1971-1980页

作者： Ikuko Maejima Ken sato Laboratory of Molecular Traffic Institute for Molecular and Cellular RegulationGunma UniversityMaebashiJapan

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or *** processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS *** of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative ***,it is important to understand the physiological and pathological roles of RAB proteins in brain ***35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell ***35 is also involved in neurite outgrowth and turnover of synaptic *** generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and *** mice exhibited defects in anxiety-related behaviors and spatial ***,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal *** contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex *** studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's *** this review,we provide an overview of the current understanding of subcellular functions of *** also provide insights into the phys

关键词： endocytosis endosomes hippocampal development neurodegenerative diseases RAB35

Development of Deformation-Semisolid-Casting (D-SSC) Process and Applications to Some Aluminum Alloys

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Journal of Materials Science & Technology 2008年第1期24卷 12-16页

作者： Tatsuo sato Department of Metallurgy and Ceramics Science Tokyo Institute of Technology 2-12-1O-okayamaMeguro-kuTokyoJapan

Recent advances in the semisolid casting technologies are introduced for aluminum *** advantages of the rheocast and thixocast methods to fabricate alloys with refined spheroidizedα-Al particles are described. The deformation-semisolid-casting （D-SSC） process developed by the author＇s group is *** D-SSC process is extremely effective to produce microstructures of refined intermetallic compound particles as well as the spheroidizedα-Al particles in the Al-Si based alloys containing highly concentrated *** the D-SSC processed Al-Si-Cu alloy high elongation of about 20% was achieved even contained concentrated impurity of *** D-SSC process is also useful to produce wrought aluminum alloys with microstructures of refinedα-Al particles.

关键词： Semisolid casting Rheocast Thixocast Aluminum alloys Intermetallic compound

Near Range Radar and Its Application to Near Surface Geophysics and Disaster Mitigation

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Journal of Earth Science 2015年第6期26卷 858-863页

作者： Motoyuki sato Center for Northeast Asian Studies Tohoku University

In this paper, we discuss about the near range radar applied to various environmental applications and disaster mitigation issues. Synthetic aperture radar（SAR） processing or migration is the key technology in near range radar imaging, which can be used in ground penetrating radar（GPR） and ground-based synthetic aperture radar（GB-SAR）. We demonstrate some applications which include GPR for humanitarian demining, GPR for archaeological survey, GB-SAR for landslide monitoring and nondestructive inspection of wooden buildings. We also demonstrate a new array GPR system “Yakumo”, which was used for archaeological survey for demonstration of advanced multi-static radar signal processing for better radar imaging.

关键词： near range radar GPR GB-SAR disaster mitigation SAR processing migration,multi-static radar.

Parallelization and sustainability of distributed genetic algorithms on many-core processors

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International Journal of Intelligent Computing and Cybernetics 2014年第1期7卷 2-23页

作者： Yuji sato Mikiko sato Faculty of Computer and Information Sciences Hosei UniversityTokyoJapan Graduate School of Engineering Tokyo University of Agriculture and TechnologyTokyoJapan

Purpose–The purpose of this paper is to propose a fault-tolerant technology for increasing the durability of application programs when evolutionary computation is performed by fast parallel processing on many-core processors such as graphics processing units(GPUs)and multi-core processors(MCPs).Design/methodology/approach–For distributed genetic algorithm(GA)models,the paper proposes a method where an island’s ID number is added to the header of data transferred by this island for use in fault ***–The paper has shown that the processing time of the proposed idea is practically negligible in applications and also shown that an optimal solution can be obtained even with a single stuck-at fault or a transient fault,and that increasing the number of parallel threads makes the system less susceptible to ***/value–The study described in this paper is a new approach to increase the sustainability of application program using distributed GA on GPUs and MCPs.

关键词： Evolutionary computation Genetic algorithms Fault identification Many-core processors Parallelization

DESIGN AND PHOTOFUNCTIONS OF DENDRIMER-ENCAPSULATED POLY(PHENYLENEETHYNYLENE)S

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Chinese Journal of Polymer Science 2001年第2期19卷 161-166页

作者： Takafumi sato Takuzo Aida Department of Chemistry and Biotechnology Graduate School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 JapanDepartment of Chemistry and Biotechnology Graduate School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan

A series of dendrimer-encapsulated poly(phenyleneethynylene)s 4～6 were Synthesize d. The light-harvesting antenna functions of dendrimer frameworks together with the blue-light emitting activities of 4～6 were highli... 详细信息

关键词： Dendrimer Poly(phenyleneethynylene) Molecular wire Light-harvesting antenna Energy transfer

Changes in Repetitive Firing Rate Related to Phase Response Curves for Andronov-Hopf Bifurcations

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Chinese Physics Letters 2014年第5期31卷 13-16页

作者： Yasuomi D. sato Department of Brain Science and Engineering Graduate School of Life Science and Systems Engineering Kyushu Institute of Technology 2-4 Hibikino Wakamatsu Kitakyushu 808-0196 Japan Frankfurt Institute for Advanced Studies (FIAS) Johann Wolfgang Goethe University Ruth-Moufang-Str.1 D60438 Frankfurt am Main Germany Institute of Industrial Science the University of Tokyo 4-6-1 Komaba Meguro Tokyo 153-8505 Japan

We study specific changes in repetitive firing in the two-dimensional Hindmarsh-Rose （2dHR） oscillatory sys- tem that undergoes a bifurcation transition from the supercritical Andronov-Hopf （All） type to the subcritical Andronov-Hopf （SAH） type. We identify dynamical mechanisms which are responsible for changes of the repeti- tive firing rate during the AH to SAH bifurcation transitions. These include frequency-shift functions in response to small perturbations of a timescale parameter, its multiplicative parameter, and an external input current in the 2dHR oscillatory system. The frequency-shift functions are explicitly represented as functions relating to the phase response curves （PRCs）. Then, we demonstrate that when the timescale is normal and relatively fast, the repetitive firing rate slightly increases and decreases respectively during the AH to SAH bifurcation transition with a change of the intrinsic parameter, whereas it decreases during the SAH to AH bifurcation transition with an increase in the timescale. By analyzing the three different frequency-shift functions, we show that such changes of the repetitive firing rate depend largely on changes of the PRC size. The PRC size for the SAH bifurcation shrinks to the PRC size for the AH bifurcation.

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An Optimal Power-Law for Synchrony and Lognormally Synaptic Weighted Hub Networks

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Chinese Physics Letters 2013年第9期30卷 190-193页

作者： Yasuomi D.sato Department of Brain Science and Engineering Graduate School of Life Science and Systems EngineeringKyushu Institute of Technology2-4HibikinoWakamatsuKitakyushu808-0196Japan Frankfurt Institute for Advanced Studies(FIAS) Johann Wolfgang Goethe UniversityRuth-Moufang-Str.1D60438Frankfurt am MainGermany

Details about the structure of a network model are revealed at the spontaneous spike activity level,in which the power-law of synchrony is optimized to that observed in the CA3 hippocampal slice *** network model is subject to spike noise with exponentially distributed interspike *** excitatory(E)and/or inhibitory(I)neurons interact through synapses whose weights show a log-normal *** spike behavior observed in the network model with the appropriate log-normal distributed synaptic weights fits best to that observed in the *** best-fit is then achieved with high activities of I neurons having a hub-like structure,in which the I neurons,subject to optimized spike noise,are intensively projected from low active E neurons.

关键词： app weights network

Temperature Dependence and P/Zn Ratio in Phosphoric Acid Treatment of Zinc Oxide

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Journal of Materials Science & Technology 2016年第5期32卷 432-436页

作者： Hiroaki Onoda Yurie sato Department of Informatics and Environmental Sciences Kyoto Prefectural University1-5Shimogamo Nakaragi-cyoSakyo-kuKyoto 606-8522Japan

Zinc oxide, which has photocatalytic activity, is used as white pigment for cosmetics. A certain degree of sebum on the skin is decomposed by ultraviolet radiation in sunlight. In this work, zinc oxide was shaken with phosphoric acid to synthesize a white pigment for cosmetics. Zinc oxide was set with 0.1 mol/L of phosphoric acid at P/Zn = 1/1 and 1/2, and then shaking in hot water for 1 h. The chemical composition, powder properties, photocatalytic activity, color phase, and smoothness of the obtained powder were studied. The P/Zn ratio in preparation had an effect on the reaction between phosphoric acid and zinc oxide. The photocatalytic activity of zinc oxide was inhibited by phosphoric acid treatment. The obtained samples had enough high reflectance at the visible light region.

关键词： Zinc oxide Photocatalytic activity Powder processing

Tool path generation and optimization for freeform surface diamond turning based on an independently controlled fast tool servo

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International Journal of Extreme Manufacturing 2022年第2期4卷 145-160页

作者： Yusuke sato Jiwang Yan Department of Mechanical Engineering Keio UniversityYokohama 223-8522Japan

Diamond turning based on a fast tool servo(FTS)is widely used in freeform optics fabrication due to its high accuracy and machining *** a new trend,recently developed high-frequency and long-stroke FTS units are independently driven by a separate control system from the machine tool ***,the tool path generation strategy for the independently controlled FTS is far from *** study aims to establish methods for optimizing tool path for the independent control FTS to reduce form errors in a single step of *** from the conventional integrated FTS control system,where control points are distributed in a spiral pattern,in this study,the tool path for the independent FTS controller is generated by the ring method and the mesh method,*** machined surface profile is predicted by simulation and the parameters for the control point generation are optimized by minimizing the deviation between the predicted and the designed *** demonstrate the feasibility of the proposed tool path generation strategies,cutting tests of a two-dimensional sinewave and a micro-lens array were conducted and the results were *** a result,after tool path optimization,the peak-to-valley form error of the machined surface was reduced from 429 nm to 56 nm for the two-dimensional sinewave by using the ring method,and from 191 nm to 103 nm for the micro-lens array by using the mesh method,respectively.

关键词： ultraprecision machining diamond turning fast tool servo freeform surface tool path optimization